{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:50:20Z","timestamp":1780084220985,"version":"3.54.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11655-025-4012-9","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T05:44:44Z","timestamp":1747115084000},"page":"707-716","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plastrum Testudinis Stimulates Bone Formation through Wnt\/\u03b2-catenin Signaling Pathway Regulated by miR-214"],"prefix":"10.1007","volume":"31","author":[{"given":"Qing","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bi-yi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-peng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-hao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-yu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-feng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong-hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,13]]},"reference":[{"key":"4012_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","volume":"10","author":"L Wang","year":"2022","unstructured":"Wang L, You X, Zhang L, Zhang C, Zou W. Mechanical regulation of bone remodeling. Bone Res 2022;10:16\u201330.","journal-title":"Bone Res"},{"key":"4012_CR2","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1186\/s13287-018-0995-x","volume":"9","author":"A Infante","year":"2018","unstructured":"Infante A, Rodr\u00edguez CI. Osteogenesis and aging: lessons from mesenchymal stem cells. Stem Cell Res Ther 2018;9:244\u2013250.","journal-title":"Stem Cell Res Ther"},{"key":"4012_CR3","doi-asserted-by":"publisher","first-page":"139","DOI":"10.2174\/1574888X10666151026114411","volume":"12","author":"LE Sima","year":"2017","unstructured":"Sima LE. Extracellular signals for guiding mesenchymal stem cells osteogenic fate. Curr Stem Cell Res Ther 2017;12:139\u2013144.","journal-title":"Curr Stem Cell Res Ther"},{"key":"4012_CR4","doi-asserted-by":"publisher","first-page":"115617","DOI":"10.1016\/j.bone.2020.115617","volume":"141","author":"Q Guo","year":"2020","unstructured":"Guo Q, Guo Q, Xiao Y, Li C, Huang Y, Luo X. Regulation of bone marrow mesenchymal stem cell fate by long non-coding RNA. Bone 2020;141:115617\u2013115627.","journal-title":"Bone"},{"key":"4012_CR5","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3389\/fcell.2018.00170","volume":"6","author":"KS Houschyar","year":"2019","unstructured":"Houschyar KS, Tapking C, Borrelli MR, Popp D, Duscher D, Maan ZN, et al. Wnt pathway in bone repair and regeneration-what do we know so far. Front Cell Dev Biol 2019;6:170\u2013182.","journal-title":"Front Cell Dev Biol"},{"key":"4012_CR6","doi-asserted-by":"publisher","first-page":"5525","DOI":"10.3390\/ijms20225525","volume":"20","author":"K Maeda","year":"2019","unstructured":"Maeda K, Kobayashi Y, Koide M, Uehara S, Okamoto M, Ishihara A, et al. The regulation of bone metabolism and disorders by wnt signaling. Int J Mol Sci 2019;20:5525\u20135561.","journal-title":"Int J Mol Sci"},{"key":"4012_CR7","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jphs.2020.11.004","volume":"145","author":"R Li","year":"2021","unstructured":"Li R, Ruan Q, Yin F, Zhao K. MiR-23b-3p promotes postmenopausal osteoporosis by targeting MRC2 and regulating the wnt\/\u03b2-catenin signaling pathway. J Pharmacol Sci 2021;145:69\u201378.","journal-title":"J Pharmacol Sci"},{"key":"4012_CR8","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/jbmr.4834","volume":"38","author":"Y Xie","year":"2023","unstructured":"Xie Y, Zhou J, Tian L, Dong Y, Yuan H, Zhu E, et al. miR-196b-5p regulates osteoblast and osteoclast differentiation and bone homeostasis by targeting SEMA3A. J Bone Miner Res 2023;38:1175\u20131191.","journal-title":"J Bone Miner Res"},{"key":"4012_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s13770-018-0118-x","volume":"15","author":"K Du","year":"2018","unstructured":"Du K, Deng J, He X, Liu Z, Peng C, Zhang M. MiR-214 regulates the human hair follicle stem cell proliferation and differentiation by targeting EZH2 and wnt\/\u03b2-catenin signaling way in vitro. Tissue Eng Regen Med 2018;15:341\u2013350.","journal-title":"Tissue Eng Regen Med"},{"key":"4012_CR10","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1186\/s13018-024-04992-6","volume":"19","author":"Y Zhao","year":"2024","unstructured":"Zhao Y, Liu J, Zhang Y, Liang M, Li R, Song Y, et al. Mir-381-3p aggravates ovariectomy-induced osteoporosis by inhibiting osteogenic differentiation through targeting KLF5\/wnt\/\u03b2-catenin signaling pathway. J Orthop Surg Res 2024;19:480\u2013491.","journal-title":"J Orthop Surg Res"},{"key":"4012_CR11","doi-asserted-by":"publisher","first-page":"23475","DOI":"10.1002\/jcp.28916","volume":"234","author":"X Li","year":"2019","unstructured":"Li X, Peng B, Zhu X, Wang P, Sun K, Lei X, et al. MiR-210-3p inhibits osteogenic differentiation and promotes adipogenic differentiation correlated with wnt signaling in ER\u03b1-deficient rBMSCs. J Cell Physiol 2019;234:23475\u201323484.","journal-title":"J Cell Physiol"},{"key":"4012_CR12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nm.3026","volume":"19","author":"X Wang","year":"2013","unstructured":"Wang X, Guo B, Li Q, Peng J, Yang Z, Wang A, et al. miR-214 targets ATF4 to inhibit bone formation. Nat Med 2013;19:93\u2013100.","journal-title":"Nat Med"},{"key":"4012_CR13","first-page":"4777","volume":"21","author":"JP Li","year":"2017","unstructured":"Li JP, Zhuang HT, Xin MY, Zhou YL. MiR-214 inhibits human mesenchymal stem cells differentiating into osteoblasts through targeting \u03b2-catenin. Eur Rev Med Pharmacol Sci 2017;21:4777\u20134783.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4012_CR14","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.biopha.2016.04.068","volume":"82","author":"D Liang","year":"2016","unstructured":"Liang D, Ren H, Qiu T, Shen G, Xie B, Wei Q, et al. Extracts from plastrum testudinis reverse glucocorticoid-induced spinal osteoporosis of rats via targeting osteoblastic and osteoclastic markers. Biomed Pharmacother 2016;82:151\u2013160.","journal-title":"Biomed Pharmacother"},{"key":"4012_CR15","doi-asserted-by":"publisher","first-page":"679345","DOI":"10.3389\/fmolb.2021.679345","volume":"8","author":"X Li","year":"2021","unstructured":"Li X, Cui Y, Lin Q, Wang P, Chen R, Zhu X, et al. MiR-330-5p in small extracellular vesicles derived from plastrum testudinis-preconditioned bone mesenchymal stem cells attenuates osteogenesis by modulating wnt\/\u03b2-catenin signaling. Front Mol Biosci 2021;8:679345\u2013679357.","journal-title":"Front Mol Biosci"},{"key":"4012_CR16","doi-asserted-by":"publisher","first-page":"2121106","DOI":"10.1001\/jamanetworkopen.2021.21106","volume":"4","author":"L Wang","year":"2021","unstructured":"Wang L, Yu W, Yin X, Cui L, Tang S, Jiang N, et al. Prevalence of osteoporosis and fracture in China: the China osteoporosis prevalence study. JAMA Netw Open 2021;4:2121106\u20132121117.","journal-title":"JAMA Netw Open"},{"key":"4012_CR17","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1111\/bcp.13759","volume":"85","author":"MK Skj\u00f8dt","year":"2019","unstructured":"Skj\u00f8dt MK, Frost M, Abrahamsen B. Side effects of drugs for osteoporosis and metastatic bone disease. Br J Clin Pharmacol 2019;85:1063\u20131071.","journal-title":"Br J Clin Pharmacol"},{"key":"4012_CR18","doi-asserted-by":"publisher","first-page":"7623","DOI":"10.3390\/ijms21207623","volume":"21","author":"JY Noh","year":"2020","unstructured":"Noh JY, Yang Y, Jung H. Molecular mechanisms and emerging therapeutics for osteoporosis. Int J Mol Sci 2020;21:7623\u20137645.","journal-title":"Int J Mol Sci"},{"key":"4012_CR19","doi-asserted-by":"publisher","first-page":"2100857","DOI":"10.1002\/mnfr.202100857","volume":"66","author":"X Li","year":"2022","unstructured":"Li X, Lin Q, Cui Y, Wang H, Wang P, Yang L, et al. Glycine acts through estrogen receptor alpha to mediate estrogen receptor signaling, stimulating osteogenesis and attenuating adipogenesis in ovariectomized rats. Mol Nutr Food Res 2022;66:2100857\u20132100868.","journal-title":"Mol Nutr Food Res"},{"key":"4012_CR20","doi-asserted-by":"publisher","first-page":"738000","DOI":"10.3389\/fnut.2021.738000","volume":"8","author":"B He","year":"2021","unstructured":"He B, Xia L, Zhao J, Yin L, Zhang M, Quan Z, et al. Causal effect of serum magnesium on osteoporosis and cardiometabolic diseases. Front Nutr 2021;8:738000\u2013738007.","journal-title":"Front Nutr"},{"key":"4012_CR21","doi-asserted-by":"publisher","first-page":"10817","DOI":"10.1039\/D0FO00787K","volume":"11","author":"C Liu","year":"2020","unstructured":"Liu C, Kuang X, Li K, Guo X, Deng Q, Li D. Effects of combined calcium and vitamin D supplementation on osteoporosis in postmenopausal women: a systematic review and meta-analysis of randomized controlled trials. Food Funct 2020;11:10817\u201310827.","journal-title":"Food Funct"},{"key":"4012_CR22","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1039\/C4FO00799A","volume":"6","author":"H Lu","year":"2015","unstructured":"Lu H, Gui Y, Guo T, Wang Q, Liu X. Effect of the particle size of cellulose from sweet potato residues on lipid metabolism and cecal conditions in ovariectomized rats. Food Funct 2015;6:1185\u20131193.","journal-title":"Food Funct"},{"key":"4012_CR23","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1097\/GME.0000000000001403","volume":"26","author":"A Ambikairajah","year":"2019","unstructured":"Ambikairajah A, Walsh E, Cherbuin N. Lipid profile differences during menopause: a review with meta-analysis. Menopause 2019;26:1327\u20131333.","journal-title":"Menopause"},{"key":"4012_CR24","doi-asserted-by":"publisher","first-page":"114195","DOI":"10.1016\/j.jep.2021.114195","volume":"276","author":"H Chen","year":"2021","unstructured":"Chen H, Shen G, Shang Q, Zhang P, Yu D, Yu X, et al. Plastrum testudinis extract suppresses osteoclast differentiation via the NF-\u03baB signaling pathway and ameliorates senile osteoporosis. J Ethnopharmacol 2021;276:114195\u2013114203.","journal-title":"J Ethnopharmacol"},{"key":"4012_CR25","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1159\/000491541","volume":"47","author":"G Shen","year":"2018","unstructured":"Shen G, Ren H, Huang J, Zhang Z, Zhao W, Yu X, et al. Plastrum testudinis extracts promote BMSC proliferation and osteogenic differentiation by regulating Let-7f-5p and the TNFR2\/PI3K\/AKT signaling pathway. Cell Physiol Biochem 2018;47:2307\u20132318.","journal-title":"Cell Physiol Biochem"},{"key":"4012_CR26","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/jcp.26856","volume":"234","author":"Y Sun","year":"2018","unstructured":"Sun Y, Kuek V, Liu Y, Tickner J, Yuan Y, Chen L, et al. MiR-214 is an important regulator of the musculoskeletal metabolism and disease. J Cell Physiol 2018;234:231\u2013245.","journal-title":"J Cell Physiol"},{"key":"4012_CR27","doi-asserted-by":"publisher","first-page":"6920","DOI":"10.3892\/mmr.2017.7483","volume":"16","author":"Y Yang","year":"2017","unstructured":"Yang Y, Zhao Z, Hou N, Li Y, Wang X, Wu F, et al. MicroRNA-214 targets wnt3a to suppress liver cancer cell proliferation. Mol Med Rep 2017;16:6920\u20136927.","journal-title":"Mol Med Rep"},{"key":"4012_CR28","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.3390\/ijms20081816","volume":"20","author":"F Xi","year":"2019","unstructured":"Xi F, Wei C, Xu Y, Ma L, He Y, Shi X, et al. MicroRNA-214-3p targeting Ctnnb1 promotes 3T3-L1 preadipocyte differentiation by interfering with the wnt\/\u03b2-catenin signaling pathway. Int J Mol Sci 2019;20:1816\u20131833.","journal-title":"Int J Mol Sci"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-4012-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-025-4012-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-4012-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T14:33:12Z","timestamp":1757169192000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-025-4012-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,13]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4012"],"URL":"https:\/\/doi.org\/10.1007\/s11655-025-4012-9","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,13]]},"assertion":[{"value":"5 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}