{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:02:41Z","timestamp":1784264561069,"version":"3.55.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11655-025-4029-0","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T23:37:11Z","timestamp":1765237031000},"page":"495-505","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Qishen Yiqi Dripping Pills Activate HDAC3-Mediated Nrf2-PITX2 Signaling Pathway to Reduce Oxidative Stress and Alleviate Myocardial Infarction Injury in Mice"],"prefix":"10.1007","volume":"32","author":[{"given":"Xin-tong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-wen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-xu","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"4029_CR1","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10741-023-10377-4","volume":"29","author":"P Pastena","year":"2024","unstructured":"Pastena P, Frye JT, Ho C, Goldschmidt ME, Kalogeropoulos AP. Ischemic cardiomyopathy: epidemiology, pathophysiology, outcomes, and therapeutic options. Heart Fail Rev 2024;29:287\u2013299.","journal-title":"Heart Fail Rev"},{"key":"4029_CR2","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.jacc.2021.03.003","volume":"77","author":"HL Dauerman","year":"2021","unstructured":"Dauerman HL, Ibanez B. The edge of time in acute myocardial infarction. J Am Coll Cardiol 2021;77:1871\u20131874.","journal-title":"J Am Coll Cardiol"},{"key":"4029_CR3","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/ehf2.13144","volume":"8","author":"D Jen\u010da","year":"2021","unstructured":"Jen\u010da D, Melenovsk\u00fd V, Stehlik J, Stan\u011bk V, Kettner J, Kautzner J, et al. Heart failure after myocardial infarction: incidence and predictors. ESC Heart Fail 2021;8:222\u2013237.","journal-title":"ESC Heart Fail"},{"key":"4029_CR4","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41569-023-00953-4","volume":"21","author":"M Galli","year":"2024","unstructured":"Galli M, Niccoli G, De Maria G, Brugaletta S, Montone RA, Vergallo R, et al. Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction. Nat Rev Cardiol 2024;21:283\u2013298.","journal-title":"Nat Rev Cardiol"},{"key":"4029_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","volume":"4","author":"H Sies","year":"2015","unstructured":"Sies H. Oxidative stress: a concept in redox biology and medicine. Redox Biol 2015;4:180\u2013183.","journal-title":"Redox Biol"},{"key":"4029_CR6","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","volume":"1865","author":"I Bellezza","year":"2018","unstructured":"Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res 2018;1865:721\u2013733.","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"4029_CR7","doi-asserted-by":"publisher","first-page":"6635460","DOI":"10.1155\/2021\/6635460","volume":"2021","author":"C Yu","year":"2021","unstructured":"Yu C, Xiao JH. The keap1-Nrf2 system: a mediator between oxidative stress and aging. Oxid Med Cell Longev 2021;2021:6635460.","journal-title":"Oxid Med Cell Longev"},{"key":"4029_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","volume":"180","author":"GH Chen","year":"2022","unstructured":"Chen GH, Song CC, Pantopoulos K, Wei XL, Zheng H, Luo Z. Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the Nrf2-ARE pathway. Free Radic Biol Med 2022;180:95\u2013107.","journal-title":"Free Radic Biol Med"},{"key":"4029_CR9","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1080\/08923973.2024.2384904","volume":"46","author":"O Ozmen","year":"2024","unstructured":"Ozmen O, Asci H, Uysal D, Ilhan I, Taner R, Arlioglu M, et al. The prophylactic and therapeutic effects of cannabidiol on lung injury secondary to cardiac ischemia model in rats via PERK\/Nrf2\/CHOP\/BCL2 pathway. Immunopharmacol Immunotoxicol 2024;46:594\u2013603.","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"4029_CR10","doi-asserted-by":"publisher","first-page":"865772","DOI":"10.3389\/fimmu.2022.865772","volume":"13","author":"B Tastan","year":"2022","unstructured":"Tastan B, Arioz BI, Genc S. Targeting NLRP3 inflammasome with Nrf2 inducers in central nervous system disorders. Front Immunol 2022;13:865772.","journal-title":"Front Immunol"},{"key":"4029_CR11","doi-asserted-by":"publisher","first-page":"9573","DOI":"10.1007\/s12035-025-04866-w","volume":"62","author":"Y Li","year":"2025","unstructured":"Li Y, Izhar T, Kanekiyo T. Hdac3 as an emerging therapeutic target for Alzheimer\u2019s disease and other neurological disorders. Mol Neurobiol 2025;62:9573\u20139585.","journal-title":"Mol Neurobiol"},{"key":"4029_CR12","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.jare.2024.10.037","volume":"75","author":"Z Yue","year":"2025","unstructured":"Yue Z, Zhang Y, Zhang W, Zheng N, Wen J, Ren L, et al. Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway. J Adv Res 2025;75:755\u2013764.","journal-title":"J Adv Res"},{"key":"4029_CR13","doi-asserted-by":"publisher","first-page":"e18160","DOI":"10.1016\/j.heliyon.2023.e18160","volume":"9","author":"HP Gu","year":"2023","unstructured":"Gu HP, Wu XF, Gong YT, Mu-Yao W, Shi MY, Sun YM, et al. RGFP966 exerts neuroprotective effect via HDAC3\/Nrf2 pathway after surgical brain injury in rats. Heliyon 2023;9:e18160.","journal-title":"Heliyon"},{"key":"4029_CR14","doi-asserted-by":"publisher","first-page":"4019","DOI":"10.1113\/JP273123","volume":"595","author":"F Syeda","year":"2017","unstructured":"Syeda F, Kirchhof P, Fabritz L. PITX2-dependent gene regulation in atrial fibrillation and rhythm control. J Physiol 2017;595:4019\u20134026.","journal-title":"J Physiol"},{"key":"4029_CR15","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.freeradbiomed.2020.07.031","volume":"159","author":"X Guo","year":"2020","unstructured":"Guo X, Hong S, He H, Zeng Y, Chen Y, Mo X, et al. NF\u03baB promotes oxidative stress-induced necrosis and ischemia\/reperfusion injury by inhibiting Nrf2-ARE pathway. Free Radic Biol Med 2020;159:125\u2013135.","journal-title":"Free Radic Biol Med"},{"key":"4029_CR16","doi-asserted-by":"publisher","first-page":"30625","DOI":"10.1074\/jbc.M114.571984","volume":"289","author":"D Martin","year":"2014","unstructured":"Martin D, Li Y, Yang J, Wang G, Margariti A, Jiang Z, et al. Unspliced X-box-binding protein 1 (XBP1) protects endothelial cells from oxidative stress through interaction with histone deacetylase 3. J Biol Chem 2014;289:30625\u201330634.","journal-title":"J Biol Chem"},{"key":"4029_CR17","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.stemcr.2023.01.015","volume":"18","author":"SJ van Kampen","year":"2023","unstructured":"van Kampen SJ, Han SJ, van Ham WB, Kyriakopoulou E, Stouthart EW, Goversen B, et al. PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy. Stem Cell Reports 2023;18:749\u2013764.","journal-title":"Stem Cell Reports"},{"key":"4029_CR18","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1007\/s11655-022-3288-2","volume":"29","author":"CM Lu","year":"2023","unstructured":"Lu CM, Yang YS, Lu YM, Zhu YP, Zhang A, Lyu SC, et al. Qishen Yiqi Dripping Pills for ardiovascular diseases: effects and mechanisms. Chin J Integr Med 2023;29:857\u2013864.","journal-title":"Chin J Integr Med"},{"key":"4029_CR19","doi-asserted-by":"publisher","first-page":"152949","DOI":"10.1016\/j.phymed.2019.152949","volume":"62","author":"Z Zeng","year":"2019","unstructured":"Zeng Z, Wang Q, Yang X, Ren Y, Jiao S, Zhu Q, et al. Qishen Granule attenuates cardiac fibrosis by regulating TGF-\u03b2\/Smad3 and GSK-3\u03b2 pathway. Phytomedicine 2019;62:152949.","journal-title":"Phytomedicine"},{"key":"4029_CR20","first-page":"139","volume":"17","author":"Y Hong","year":"2025","unstructured":"Hong Y, Wang H, Xie H, Zhong X, Chen X, Yu L, et al. Qishen Granule protects against myocardial ischemia by promoting angiogenesis through BMP2-Dll4-Notch1 pathway. Chin Herb Med 2025;17:139\u2013147.","journal-title":"Chin Herb Med"},{"key":"4029_CR21","doi-asserted-by":"publisher","first-page":"117134","DOI":"10.1016\/j.jep.2023.117134","volume":"319","author":"J Zhang","year":"2024","unstructured":"Zhang J, Li W, Xue S, Gao P, Wang H, Chen H, et al. Qishen Granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3. J Ethnopharmacol 2024;319:117134.","journal-title":"J Ethnopharmacol"},{"key":"4029_CR22","doi-asserted-by":"publisher","first-page":"1001072","DOI":"10.3389\/fcvm.2022.1001072","volume":"9","author":"W Chen","year":"2022","unstructured":"Chen W, Chen J, Wang Y, Yan J, Yan X, Wang D, et al. The role of Qishen Yiqi Dripping Pills in treating chronic heart failure: an overview of systematic reviews and meta-analyses. Front Cardiovasc Med 2022;9:1001072.","journal-title":"Front Cardiovasc Med"},{"key":"4029_CR23","doi-asserted-by":"publisher","first-page":"156530","DOI":"10.1016\/j.phymed.2025.156530","volume":"139","author":"Z Zhou","year":"2025","unstructured":"Zhou Z, Wang S, Fan Z, Zhang Z, Zhang X, Zhao Z, et al. Effect of Qishen Yiqi Dripping Pills on the classification of ejection fraction in patients with ischaemic heart failure: a prospective cohort study. Phytomedicine 2025;139:156530.","journal-title":"Phytomedicine"},{"key":"4029_CR24","doi-asserted-by":"publisher","first-page":"156435","DOI":"10.1016\/j.phymed.2025.156435","volume":"138","author":"J Li","year":"2025","unstructured":"Li J, Zhang X, Hou L, Liu BY, Fan YM, Zhang Y, et al. Proteomic analysis reveals Qishen Yiqi Pills ameliorates ischemia-induced heart failure through inhibition of mitochondrial fission. Phytomedicine 2025;138:156435.","journal-title":"Phytomedicine"},{"key":"4029_CR25","doi-asserted-by":"publisher","first-page":"105460","DOI":"10.1016\/j.phrs.2021.105460","volume":"165","author":"G Xiao","year":"2021","unstructured":"Xiao G, Lyu M, Li Z, Cao L, Liu X, Wang Y, et al. Restoration of early deficiency of axonal guidance signaling by Guanxinning Injection as a novel therapeutic option for acute ischemic stroke. Pharmacol Res 2021;165:105460.","journal-title":"Pharmacol Res"},{"key":"4029_CR26","doi-asserted-by":"publisher","first-page":"1007341","DOI":"10.3389\/fimmu.2022.1007341","volume":"13","author":"G Xiao","year":"2022","unstructured":"Xiao G, Liu J, Wang H, He S, Liu J, Fan G, et al. CXCR1 and its downstream NF-\u03baB inflammation signaling pathway as a key target of Guanxinning Injection for myocardial ischemia\/reperfusion injury. Front Immunol 2022;13:1007341.","journal-title":"Front Immunol"},{"key":"4029_CR27","doi-asserted-by":"publisher","first-page":"109945","DOI":"10.1016\/j.biopha.2020.109945","volume":"125","author":"Y Wang","year":"2020","unstructured":"Wang Y, Xiao G, He S, Liu X, Zhu L, Yang X, et al. Protection against acute cerebral ischemia\/reperfusion injury by Qishen Yiqi via neuroinflammatory network mobilization. Biomed Pharmacother 2020;125:109945.","journal-title":"Biomed Pharmacother"},{"key":"4029_CR28","doi-asserted-by":"publisher","first-page":"981206","DOI":"10.3389\/fphar.2022.981206","volume":"13","author":"M Li","year":"2022","unstructured":"Li M, Wang Y, Qi Z, Yuan Z, Lv S, Zheng Y, et al. Qishen Yiqi Dripping Pill protects against myocardial ischemia\/reperfusion injury via suppressing excessive autophagy and NLRP3 inflammasome based on network pharmacology and experimental pharmacology. Front Pharmacol 2022;13:981206.","journal-title":"Front Pharmacol"},{"key":"4029_CR29","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.jgr.2022.03.003","volume":"47","author":"Z Qi","year":"2023","unstructured":"Qi Z, Yan Z, Wang Y, Ji N, Yang X, Zhang A, et al. Integrative applications of network pharmacology and molecular docking: an herbal formula ameliorates H9c2 cells injury through pyroptosis. J Ginseng Res 2023;47:228\u2013236.","journal-title":"J Ginseng Res"},{"key":"4029_CR30","doi-asserted-by":"publisher","first-page":"1443560","DOI":"10.3389\/fphar.2024.1443560","volume":"15","author":"Z Liu","year":"2024","unstructured":"Liu Z, Fu H, Gan Y, Ye Y, Huang B, Jiang M, et al. UHPLCQ-Orbitrap HRMS and network analysis to explore the mechanisms of Qishen Yiqi Dripping Pill for treating myocardial infarction. Front Pharmacol 2024;15:1443560.","journal-title":"Front Pharmacol"},{"key":"4029_CR31","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.2147\/DDDT.S82146","volume":"9","author":"JR Chen","year":"2015","unstructured":"Chen JR, Wei J, Wang LY, Zhu Y, Li L, Olunga MA, et al. Cardioprotection against ischemia\/reperfusion injury by Qishen Yiqi Pill\u00ae via ameliorate of multiple mitochondrial dysfunctions. Drug Des Devel Ther 2015;9:3051\u20133066.","journal-title":"Drug Des Devel Ther"},{"key":"4029_CR32","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.ijcard.2012.10.042","volume":"168","author":"SQ Lin","year":"2013","unstructured":"Lin SQ, Wei XH, Huang P, Liu YY, Zhao N, Li Q, et al. Qishen Yiqi Pills\u00ae prevent cardiac ischemia-reperfusion injury via energy modulation. Int J Cardiol 2013;168:967\u2013974.","journal-title":"Int J Cardiol"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-4029-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-025-4029-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-025-4029-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:40:16Z","timestamp":1780454416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-025-4029-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4029"],"URL":"https:\/\/doi.org\/10.1007\/s11655-025-4029-0","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"28 October 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors state that they have no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}