{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T12:47:53Z","timestamp":1775047673951,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"DOI":"10.1007\/s11655-026-3838-0","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:46:36Z","timestamp":1775043996000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Electroacupuncture Enhances Effectiveness of Omeprazole in Indomethacin-Induced Gastric Injury Mice via Nrf2 Activation and Vagus Nerve Conduction"],"prefix":"10.1007","author":[{"given":"Yu-jun","family":"Hou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang-nan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si-yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun-zhou","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-peng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-qiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"3838_CR1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.3390\/nu16030389","volume":"16","author":"HJ Kim","year":"2024","unstructured":"Kim HJ, Jin BR, Lee CD, Kim D, Lee AY, Lee S, et al. Antiinflammatory effect of chestnut honey and cabbage mixtures alleviates gastric mucosal damage. Nutrients 2024;16:389.","journal-title":"Nutrients"},{"key":"3838_CR2","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2024.01.004","volume":"187","author":"K Fu","year":"2024","unstructured":"Fu K, Cheung AHK, Wong CC, Liu W, Zhou Y, Wang F, et al. Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice. Cell 2024;187:882\u2013896.","journal-title":"Cell"},{"key":"3838_CR3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.4103\/jrms.JRMS_1035_16","volume":"23","author":"K Sayehmiri","year":"2018","unstructured":"Sayehmiri K, Abangah G, Kalvandi G, Tavan H, Aazami S. Prevalence of peptic ulcer in Iran: systematic review and meta-analysis methods. J Res Med Sci 2018;23:8.","journal-title":"J Res Med Sci"},{"key":"3838_CR4","doi-asserted-by":"publisher","first-page":"e15677","DOI":"10.1016\/j.heliyon.2023.e15677","volume":"9","author":"MB Salem","year":"2023","unstructured":"Salem MB, Elzallat M, Mohammed DM, Samir S, Hammam OA, Abdel-Wareth MTA. Cornu aspersum mucin attenuates indomethacins-induced gastric ulcers in mice via alleviating oxidative stress and inflammation. Heliyon 2023;9:e15677.","journal-title":"Heliyon"},{"key":"3838_CR5","doi-asserted-by":"publisher","first-page":"15486","DOI":"10.3390\/ijms242015486","volume":"24","author":"B Cicek","year":"2023","unstructured":"Cicek B, Dan\u0131sman B, Yildirim S, Yuce N, Nikitovic D, Bolat I, et al. Flavonoid-rich sambucus nigra berry extract enhances Nrf2\/HO-1 signaling pathway activation and exerts antiulcerative effects in vivo. Int J Mol Sci 2023;24:15486.","journal-title":"Int J Mol Sci"},{"key":"3838_CR6","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.3390\/nu13093169","volume":"13","author":"PA Ruiz-Hurtado","year":"2021","unstructured":"Ruiz-Hurtado PA, Gardu\u00f1o-Siciliano L, Dom\u00ednguez-Verano P, Balderas-Cordero D, Gorgua-Jim\u00e9nez G, Canales-\u00c1lvarez O, et al. Propolis and its gastroprotective effects on NSAID-induced gastric ulcer disease: a systematic review. Nutrients 2021;13:3169.","journal-title":"Nutrients"},{"key":"3838_CR7","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.1016\/j.sjbs.2022.01.031","volume":"29","author":"S Harakeh","year":"2022","unstructured":"Harakeh S, Saber SH, Akefe IO, Shaker S, Hussain MB, Almasaudi AS, et al. Saudi honey alleviates indomethacin-induced gastric ulcer via improving antioxidant and anti-inflammatory responses in male albino rats. Saudi J Biol Sci 2022;29:3040\u20133050.","journal-title":"Saudi J Biol Sci"},{"key":"3838_CR8","doi-asserted-by":"publisher","first-page":"124823","DOI":"10.1016\/j.ijpharm.2024.124823","volume":"666","author":"R Mart\u00ednez-Borrajo","year":"2024","unstructured":"Mart\u00ednez-Borrajo R, Rouco H, Virz\u00ec NF, Diaz-Rodriguez P, Landin M. Modulation of IFN-\u03b3 induced macrophage inflammatory responses via indomethacin-loaded NLCs for OA management. Int J Pharm 2024;666:124823.","journal-title":"Int J Pharm"},{"key":"3838_CR9","doi-asserted-by":"publisher","first-page":"9724","DOI":"10.3390\/ijms25179724","volume":"25","author":"M Terasaki","year":"2024","unstructured":"Terasaki M, Yashima H, Mori Y, Saito T, Inoue N, Matsui T, et al. Glucose-dependent insulinotropic polypeptide inhibits AGE-induced NADPH oxidase-derived oxidative stress generation and foam cell formation in macrophages partly via AMPK activation. Int J Mol Sci 2024;25:9724.","journal-title":"Int J Mol Sci"},{"key":"3838_CR10","doi-asserted-by":"publisher","first-page":"112990","DOI":"10.1016\/j.intimp.2024.112990","volume":"141","author":"S Xu","year":"2024","unstructured":"Xu S, Peng Y, Yang K, Liu S, He Z, Huang J, et al. PROTAC based STING degrader attenuates acute colitis by inhibiting macrophage M1 polarization and intestinal epithelial cells pyroptosis mediated by STING-NLRP3 axis. Int Immunopharm 2024;141:112990.","journal-title":"Int Immunopharm"},{"key":"3838_CR11","doi-asserted-by":"publisher","first-page":"113310","DOI":"10.1016\/j.intimp.2024.113310","volume":"143","author":"H Han","year":"2024","unstructured":"Han H, Gao Y, Chen B, Xu H, Shi C, Wang X, et al. Nrf2 inhibits M1 macrophage polarization to ameliorate renal ischemia-reperfusion injury through antagonizing NF-\u03baB signaling. Int Immunopharmacol 2024;143:113310.","journal-title":"Int Immunopharmacol"},{"key":"3838_CR12","doi-asserted-by":"publisher","first-page":"967193","DOI":"10.3389\/fimmu.2022.967193","volume":"13","author":"L Wang","year":"2022","unstructured":"Wang L, He C. Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis. Front Immunol 2022;13:967193.","journal-title":"Front Immunol"},{"key":"3838_CR13","doi-asserted-by":"publisher","first-page":"e00341","DOI":"10.14309\/ctg.0000000000000341","volume":"12","author":"E Csiki","year":"2021","unstructured":"Csiki E, Szab\u00f3 H, Han\u00e1k L, Szak\u00e1cs Z, Kiss S, V\u00f6rhendi N, et al. Oral proton pump inhibitors may be as effective as intravenous in peptic ulcer bleeding: a systematic review and meta-analysis. Clin Trans Gastroenterol 2021;12:e00341.","journal-title":"Clin Trans Gastroenterol"},{"key":"3838_CR14","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.freeradbiomed.2022.02.007","volume":"181","author":"DS Rudra","year":"2022","unstructured":"Rudra DS, Pal U, Chowdhury N, Maiti NC, Bagchi A, Swarnakar S. Omeprazole prevents stress induced gastric ulcer by direct inhibition of MMP-2\/TIMP-3 interactions. Free Radical Biol Med 2022;181:221\u2013234.","journal-title":"Free Radical Biol Med"},{"key":"3838_CR15","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1111\/jvim.15897","volume":"34","author":"SM Jones","year":"2020","unstructured":"Jones SM, Gaier A, Enomoto H, Ishii P, Pilla R, Price J, et al. The effect of combined carprofen and omeprazole administration on gastrointestinal permeability and inflammation in dogs. J Veterinary Intern Med 2020;34:1886\u20131893.","journal-title":"J Veterinary Intern Med"},{"key":"3838_CR16","doi-asserted-by":"publisher","first-page":"102997","DOI":"10.1016\/j.ctim.2023.102997","volume":"79","author":"LQ Sun","year":"2023","unstructured":"Sun LQ, Luo FL, Chen S, Zheng QH, Wang L, Hou YJ, et al. Acupuncture as an adjunctive therapy for gastric ulcer: a modified Delphi consensus study. Complement Therap Med 2023;79:102997.","journal-title":"Complement Therap Med"},{"key":"3838_CR17","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/s41586-021-04001-4","volume":"598","author":"S Liu","year":"2021","unstructured":"Liu S, Wang Z, Su Y, Qi L, Yang W, Fu M, et al. A neuroanatomical basis for electroacupuncture to drive the vagal\u2013adrenal axis. Nature 2021;598:641\u2013645.","journal-title":"Nature"},{"key":"3838_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13020-021-00466-7","volume":"16","author":"J Wang","year":"2021","unstructured":"Wang J, Lu S, Yang F, Guo Y, Chen Z, Yu N, et al. The role of macrophage polarization and associated mechanisms in regulating the anti-inflammatory action of acupuncture: a literature review and perspectives. Chin Med 2021;16:56.","journal-title":"Chin Med"},{"key":"3838_CR19","doi-asserted-by":"publisher","first-page":"813748","DOI":"10.3389\/fimmu.2021.813748","volume":"12","author":"JE Oh","year":"2021","unstructured":"Oh JE, Kim SN. Anti-inflammatory effects of acupuncture at ST 36 point: a literature review in animal studies. Front Immunol 2021;12:813748.","journal-title":"Front Immunol"},{"key":"3838_CR20","doi-asserted-by":"publisher","first-page":"435","DOI":"10.2147\/DMSO.S449112","volume":"17","author":"Y Yang","year":"2024","unstructured":"Yang Y, Pang F, Zhou M, Guo X, Yang Y, Qiu W, et al. Electroacupuncture reduces inflammatory bowel disease in obese mice by activating the Nrf2\/HO-1 signaling pathways and repairing the intestinal barrier. Diabetes Metab Syndr Obes 2024;17:435\u2013452.","journal-title":"Diabetes Metab Syndr Obes"},{"key":"3838_CR21","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.2147\/JIR.S404087","volume":"16","author":"H Jiang","year":"2023","unstructured":"Jiang H, Shang Z, You L, Zhang J, Jiao J, Qian Y, et al. Electroacupuncture pretreatment at Zusanli (ST36) ameliorates hepatic ischemia\/reperfusion injury in mice by reducing oxidative stress via activating vagus nerve-dependent Nrf2 pathway. J Inflam Res 2023;16:1595\u20131610.","journal-title":"J Inflam Res"},{"key":"3838_CR22","doi-asserted-by":"publisher","first-page":"16721","DOI":"10.3390\/ijms242316721","volume":"24","author":"HS Cho","year":"2023","unstructured":"Cho HS, Kwon TW, Kim JH, Lee R, Bae CS, Kim HC, et al. Gintonin alleviates HCl\/ethanol- and indomethacin-induced gastric ulcers in mice. Int J Mol Sci 2023;24:16721.","journal-title":"Int J Mol Sci"},{"key":"3838_CR23","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.lfs.2017.09.016","volume":"189","author":"Y Yang","year":"2017","unstructured":"Yang Y, Yin B, Lv L, Wang Z, He J, Chen Z, et al. Gastroprotective effect of aucubin against ethanol-induced gastric mucosal injury in mice. Life Sci 2017;189:44\u201351.","journal-title":"Life Sci"},{"key":"3838_CR24","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/0016-5085(88)90661-0","volume":"94","author":"L Laine","year":"1988","unstructured":"Laine L, Weinstein WM. Histology of alcoholic hemorrhagic \u201cgastritis\u201d: a prospective evaluation. Gastroenterology 1988;94:1254\u20131262.","journal-title":"Gastroenterology"},{"key":"3838_CR25","doi-asserted-by":"publisher","first-page":"15046","DOI":"10.1021\/acsomega.1c01167","volume":"6","author":"J Fan","year":"2021","unstructured":"Fan J, Zhao XH, Zhao JR, Li BR. Galangin and kaempferol alleviate the indomethacin-caused cytotoxicity and barrier loss in rat intestinal epithelial (IEC-6) cells via mediating JNK\/Src activation. ACS Omega 2021;6:15046\u201315056.","journal-title":"ACS Omega"},{"key":"3838_CR26","doi-asserted-by":"publisher","first-page":"103007","DOI":"10.1016\/j.bioorg.2019.103007","volume":"89","author":"V Sharma","year":"2019","unstructured":"Sharma V, Bhatia P, Alam O, Naim MJ, Nawaz F, Sheikh AA, et al. Recent advancement in the discovery and development of COX-2 inhibitors: insight into biological activities and SAR studies (2008\u20132019). Bioorganic Chem 2019;89:103007.","journal-title":"Bioorganic Chem"},{"key":"3838_CR27","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1007\/s11095-021-03126-5","volume":"38","author":"AAM Sallam","year":"2021","unstructured":"Sallam AAM, Darwish SF, El-Dakroury WA, Radwan E. Olmesartan niosomes ameliorates the Indomethacin-induced gastric ulcer in rats: insights on MAPK and Nrf2\/HO-1 signaling pathway. Pharmaceutical Res 2021;38:1821\u20131838.","journal-title":"Pharmaceutical Res"},{"key":"3838_CR28","doi-asserted-by":"publisher","first-page":"133952","DOI":"10.1016\/j.ijbiomac.2024.133952","volume":"277","author":"X Liu","year":"2024","unstructured":"Liu X, Yang F, Ren P, Lv W, Chen B, Niu B, et al. Study on the mechanism of macrophages activated by phosphoesterified rehmanniae polysaccharide on human gastric cancer cells. Int J Biol Macromol 2024;277:133952.","journal-title":"Int J Biol Macromol"},{"key":"3838_CR29","doi-asserted-by":"publisher","first-page":"e2309331","DOI":"10.1002\/advs.202309331","volume":"17","author":"W Qi","year":"2024","unstructured":"Qi W, Liu C, Shi L, Li H, Hou X, Du H, et al. CD169+ macrophages mediate the immune response of allergic rhinitis through the Keap1\/Nrf2\/HO-1 axis. Adv Sci 2024;17:e2309331.","journal-title":"Adv Sci"},{"key":"3838_CR30","doi-asserted-by":"publisher","first-page":"11624","DOI":"10.1038\/ncomms11624","volume":"7","author":"EH Kobayashi","year":"2016","unstructured":"Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, et al. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Commun 2016;7:11624.","journal-title":"Nature Commun"},{"key":"3838_CR31","first-page":"03009","volume":"80","author":"YQ Li","year":"2024","unstructured":"Li YQ, Yao JP, Yan XY, Wang W, Zhang YP, Lu Y, et al. Advances in acupuncture regulation on the autonomic nervous system from 2013 to 2022: a bibliometric analysis via citespace. Complement Ther Med 2024;80:03009.","journal-title":"Complement Ther Med"},{"key":"3838_CR32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.3389\/fnins.2018.00049","volume":"12","author":"B Bonaz","year":"2018","unstructured":"Bonaz B, Bazin T, Pellissier S. The vagus nerve at the interface of the microbiota\u2013gut\u2013brain axis. Front Neurosci 2018;12:49.","journal-title":"Front Neurosci"},{"key":"3838_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.joim.2024.12.003","volume":"23","author":"M He","year":"2025","unstructured":"He M, Lim XY, Li J, Li L, Zhang T. Mechanisms of acupuncture at Zusanli (ST 36) and its combinational acupoints for stress gastric ulcer based on the correlation between Zang-fu and acupoints. J Integr Med 2025;23:1\u201311.","journal-title":"J Integr Med"},{"key":"3838_CR34","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1177\/0964528420922232","volume":"39","author":"Y Li","year":"2021","unstructured":"Li Y, Xu G, Hu S, Wu H, Dai Y, Zhang W, et al. Electroacupuncture alleviates intestinal inflammation and barrier dysfunction by activating dopamine in a rat model of intestinal ischaemia. Acupunct Med 2021;39:208\u2013216.","journal-title":"Acupunct Med"},{"key":"3838_CR35","doi-asserted-by":"publisher","first-page":"112555","DOI":"10.1016\/j.intimp.2024.112555","volume":"138","author":"A Yang","year":"2024","unstructured":"Yang A, Wu CH, Matsuo S, Umene R, Nakamura Y, Inoue T. Activation of the \u03b17nAChR by GTS-21 mitigates septic tubular cell injury and modulates macrophage infiltration. Int Immunopharmacol 2024;138:112555.","journal-title":"Int Immunopharmacol"},{"key":"3838_CR36","doi-asserted-by":"publisher","first-page":"108652","DOI":"10.1016\/j.jneumeth.2020.108652","volume":"338","author":"N Thompson","year":"2020","unstructured":"Thompson N, Ravagli E, Mastitskaya S, Iacoviello F, Aristovich K, Perkins J, et al. MicroCT optimisation for imaging fascicular anatomy in peripheral nerves. J Neurosci Methods 2020;338:108652.","journal-title":"J Neurosci Methods"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-026-3838-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-026-3838-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-026-3838-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:46:37Z","timestamp":1775043997000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-026-3838-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":36,"alternative-id":["3838"],"URL":"https:\/\/doi.org\/10.1007\/s11655-026-3838-0","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"8 April 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"None declared.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}