{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T10:26:50Z","timestamp":1786789610954,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Chin. J. Integr. Med."],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1007\/s11655-026-3945-y","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T03:00:15Z","timestamp":1773370815000},"page":"780-788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Astilbin Confers Radioprotection in Lung Injury via p53-Mediated Suppression of Oxidative Damage and Apoptosis"],"prefix":"10.1007","volume":"32","author":[{"given":"Qian-xin","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-qin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-ting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-ting","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-mei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"key":"3945_CR1","first-page":"35","volume":"30","author":"M Amorim","year":"2023","unstructured":"Amorim M, Costa PS, Costa MA. The radiotherapy: basic concepts and recent techniques advances for thoracic malignancies. Port J Card Thorac Vasc Surg 2023;30:35\u201343.","journal-title":"Port J Card Thorac Vasc Surg"},{"key":"3945_CR2","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.jtho.2022.05.003","volume":"17","author":"NW Bucknell","year":"2022","unstructured":"Bucknell NW, Belderbos J, Palma DA, Iyengar P, Samson P, Chua K, et al. Avoiding toxicity with lung radiation therapy: an IASLC perspective. J Thorac Oncol 2022;17:961\u2013973.","journal-title":"J Thorac Oncol"},{"key":"3945_CR3","doi-asserted-by":"publisher","first-page":"307","DOI":"10.21037\/tlcr-22-108","volume":"11","author":"Y Yan","year":"2022","unstructured":"Yan Y, Fu J, Kowalchuk RO, Wright CM, Zhang R, Li X, et al. Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review. Transl Lung Cancer Res 2022;11:307\u2013322.","journal-title":"Transl Lung Cancer Res"},{"key":"3945_CR4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1097\/CM9.0000000000001032","volume":"134","author":"HJ Ying","year":"2020","unstructured":"Ying HJ, Fang M, Chen M. Progress in the mechanism of radiation-induced lung injury. Chin Med J (Engl) 2020;134:161\u2013163.","journal-title":"Chin Med J (Engl)"},{"key":"3945_CR5","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.cell.2009.04.050","volume":"137","author":"JP Kruse","year":"2009","unstructured":"Kruse JP, Gu W. Modes of p53 regulation. Cell 2009;137:609\u2013622.","journal-title":"Cell"},{"key":"3945_CR6","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s11655-023-3694-0","volume":"30","author":"S Kumar","year":"2024","unstructured":"Kumar S, Das A. A cocktail of natural compounds holds promise for new immunotherapeutic potential in head and neck cancer. Chin J Integr Med 2024;30:42\u201351.","journal-title":"Chin J Integr Med"},{"key":"3945_CR7","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.3390\/molecules27092901","volume":"27","author":"JM Al-Khayri","year":"2022","unstructured":"Al-Khayri JM, Sahana GR, Nagella P, Joseph BV, Alessa FM, Al-Mssallem MQ. Flavonoids as potential anti-inflammatory molecules: a review. Molecules 2022;27:2901.","journal-title":"Molecules"},{"key":"3945_CR8","doi-asserted-by":"publisher","first-page":"104894","DOI":"10.1016\/j.phrs.2020.104894","volume":"158","author":"A Sharma","year":"2020","unstructured":"Sharma A, Gupta S, Chauhan S, Nair A, Sharma P. Astilbin: a promising unexplored compound with multidimensional medicinal and health benefits. Pharmacol Res 2020;158:104894.","journal-title":"Pharmacol Res"},{"key":"3945_CR9","doi-asserted-by":"publisher","first-page":"5295","DOI":"10.3390\/molecules25225295","volume":"25","author":"X Zhao","year":"2020","unstructured":"Zhao X, Chen R, Shi Y, Zhang X, Tian C, Xia D. Antioxidant and anti-inflammatory activities of six flavonoids from Smilax glabra Roxb. Molecules 2020;25:5295.","journal-title":"Molecules"},{"key":"3945_CR10","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1002\/jat.3989","volume":"40","author":"X Xu","year":"2020","unstructured":"Xu X, Yan G, Chang J, Wang P, Yin Q, Liu C, et al. Astilbin ameliorates deoxynivalenol-induced oxidative stress and apoptosis in intestinal porcine epithelial cells (IPEC-J2). J Appl Toxicol 2020;40:1362\u20131372.","journal-title":"J Appl Toxicol"},{"key":"3945_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.pupt.2018.03.006","volume":"50","author":"J Zhang","year":"2018","unstructured":"Zhang J, Liu H, Song C, Zhang J, Wang Y, Lv C, et al. Astilbin ameliorates pulmonary fibrosis via blockade of Hedgehog signaling pathway. Pulm Pharmacol Ther 2018;50:19\u201327.","journal-title":"Pulm Pharmacol Ther"},{"key":"3945_CR12","doi-asserted-by":"publisher","first-page":"116364","DOI":"10.1016\/j.ecoenv.2024.116364","volume":"277","author":"G Shi","year":"2024","unstructured":"Shi G, Tai T, Miao Y, Yan L, Han T, Dong H, et al. The antagonism mechanism of astilbin against cadmium-induced injury in chicken lungs via Treg\/Th1 balance signaling pathway. Ecotoxicol Environ Saf 2024;277:116364.","journal-title":"Ecotoxicol Environ Saf"},{"key":"3945_CR13","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1007\/s12272-016-0857-y","volume":"40","author":"HB Zhang","year":"2017","unstructured":"Zhang HB, Sun LC, Zhi LD, Wen QK, Qi ZW, Yan ST, et al. Astilbin alleviates sepsis-induced acute lung injury by inhibiting the expression of macrophage inhibitory factor in rats. Arch Pharm Res 2017;40:1176\u20131185.","journal-title":"Arch Pharm Res"},{"key":"3945_CR14","doi-asserted-by":"publisher","first-page":"2967","DOI":"10.1002\/tox.23931","volume":"38","author":"L Liang","year":"2023","unstructured":"Liang L, Huang Y, Chen L, Shi Z, Wang H, Zhang T, et al. Radioprotective efficacy of astilbin in mitigating radiation-induced lung injury through inhibition of p53 acetylation. Environ Toxicol 2023;38:2967\u20132980.","journal-title":"Environ Toxicol"},{"key":"3945_CR15","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/biomedicines13030689","volume":"13","author":"Z Shi","year":"2025","unstructured":"Shi Z, Liu J, Qin J, Liang X, Ou X, Zhang T, et al. Astilbin alleviates radiation-induced pulmonary fibrosis via circPRKCE targeting the TGF-\u03b2\/Smad7 pathway to inhibit epithelial-mesenchymal transition. Biomedicines 2025;13:689.","journal-title":"Biomedicines"},{"key":"3945_CR16","doi-asserted-by":"publisher","first-page":"117389","DOI":"10.1016\/j.jep.2023.117389","volume":"320","author":"M Wang","year":"2024","unstructured":"Wang M, Feng Y, Zhang P, Shen K, Su J, Zhong Y, et al. Jiawei Maxing Shigan Tang alleviates radiation-induced lung injury via TGF-\u03b2 1\/Smad signaling pathway mediated by regulatory T cells. J Ethnopharmacol 2024;320:117389.","journal-title":"J Ethnopharmacol"},{"key":"3945_CR17","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.freeradbiomed.2019.03.024","volume":"136","author":"Y Izumi","year":"2019","unstructured":"Izumi Y, Nakashima T, Masuda T, Shioya S, Fukuhara K, Yamaguchi K, et al. Suplatast tosilate reduces radiation-induced lung injury in mice through suppression of oxidative stress. Free Radic Biol Med 2019;136:52\u201359.","journal-title":"Free Radic Biol Med"},{"key":"3945_CR18","doi-asserted-by":"publisher","first-page":"102334","DOI":"10.1016\/j.pupt.2024.102334","volume":"87","author":"E Li","year":"2024","unstructured":"Li E, Huang J, Huang J, Zhang F, Li C, Xia M, et al. ALDH2 attenuates radiation-induced lung injury by inhibiting ROS and epithelial-mesenchymal transition mediated by the TGF-\u03b2 1\/Smad pathway. Pulm Pharmacol Ther 2024;87:102334.","journal-title":"Pulm Pharmacol Ther"},{"key":"3945_CR19","doi-asserted-by":"publisher","first-page":"877","DOI":"10.3389\/fonc.2019.00877","volume":"9","author":"L Giuranno","year":"2019","unstructured":"Giuranno L, Ient J, De Ruysscher D, Vooijs MA. Radiation-induced lung injury (RILI). Front Oncol 2019;9:877.","journal-title":"Front Oncol"},{"key":"3945_CR20","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/jrr\/rry105","volume":"60","author":"Z Yin","year":"2019","unstructured":"Yin Z, Yang G, Deng S, Wang Q. Oxidative stress levels and dynamic changes in mitochondrial gene expression in a radiation-induced lung injury model. J Radiat Res 2019;60:204\u2013214.","journal-title":"J Radiat Res"},{"key":"3945_CR21","doi-asserted-by":"publisher","first-page":"3264","DOI":"10.1111\/jcmm.13230","volume":"21","author":"K Cao","year":"2017","unstructured":"Cao K, Lei X, Liu H, Zhao H, Guo J, Chen Y, et al. Polydatin alleviated radiation-induced lung injury through activation of Sirt3 and inhibition of epithelial-mesenchymal transition. J Cell Mol Med 2017;21:3264\u20133276.","journal-title":"J Cell Mol Med"},{"key":"3945_CR22","doi-asserted-by":"publisher","first-page":"25","DOI":"10.4103\/jmp.JMP_119_16","volume":"42","author":"GH Haddadi","year":"2017","unstructured":"Haddadi GH, Rezaeyan A, Mosleh-Shirazi MA, Hosseinzadeh M, Fardid R, Najafi M, et al. Hesperidin as radioprotector against radiation-induced lung damage in rat: a histopathological study. J Med Phys 2017;42:25\u201332.","journal-title":"J Med Phys"},{"key":"3945_CR23","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11655-021-3493-4","volume":"28","author":"JH Wang","year":"2022","unstructured":"Wang JH, Jiang YJ, Li M, Wang N, Cui BN, Liu WL. Effects of Qingre Huoxue Jiedu Formula on nerve growth factor-induced psoriasis. Chin J Integr Med 2022;28:236\u2013242.","journal-title":"Chin J Integr Med"},{"key":"3945_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.fct.2018.02.041","volume":"114","author":"SW Wang","year":"2018","unstructured":"Wang SW, Xu Y, Weng YY, Fan XY, Bai YF, Zheng XY, et al. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food Chem Toxicol 2018;114:227\u2013236.","journal-title":"Food Chem Toxicol"},{"key":"3945_CR25","doi-asserted-by":"publisher","first-page":"e37276","DOI":"10.1016\/j.heliyon.2024.e37276","volume":"10","author":"C Guo","year":"2024","unstructured":"Guo C, Yin Y, Ma Z, Xu F, Wang S. Astilbin exerts a neuroprotective effect by upregulating the signaling of nuclear NF-E2-related factor 2 in vitro. Heliyon 2024;10:e37276.","journal-title":"Heliyon"},{"key":"3945_CR26","first-page":"6039769","volume":"2020","author":"X Liu","year":"2020","unstructured":"Liu X, Fan L, Lu C, Yin S, Hu H. Functional role of p53 in the regulation of chemical-induced oxidative stress. Oxid Med Cell Longev 2020;2020:6039769.","journal-title":"Oxid Med Cell Longev"},{"key":"3945_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12964-023-01398-5","volume":"22","author":"MJ Iqbal","year":"2024","unstructured":"Iqbal MJ, Kabeer A, Abbas Z, Siddiqui HA, Calina D, Sharifi-Rad J, et al. Interplay of oxidative stress, cellular communication and signaling pathways in cancer. Cell Commun Signal 2024;22:7.","journal-title":"Cell Commun Signal"},{"key":"3945_CR28","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1038\/s41419-021-03950-y","volume":"12","author":"Y Cao","year":"2021","unstructured":"Cao Y, Huang W, Wu F, Shang J, Ping F, Wang W, et al. ZFP36 protects lungs from intestinal I\/R-induced injury and fibrosis through the CREBBP\/p53\/p21\/Bax pathway. Cell Death Dis 2021;12:685.","journal-title":"Cell Death Dis"},{"key":"3945_CR29","doi-asserted-by":"publisher","first-page":"4956","DOI":"10.1038\/s41467-023-40617-y","volume":"14","author":"Y Enomoto","year":"2023","unstructured":"Enomoto Y, Katsura H, Fujimura T, Ogata A, Baba S, Yamaoka A, et al. Autocrine TGF-\u03b2-positive feedback in profibrotic AT2-lineage cells plays a crucial role in noninflammatory lung fibrogenesis. Nat Commun 2023;14:4956.","journal-title":"Nat Commun"},{"key":"3945_CR30","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.3390\/cells11233825","volume":"11","author":"M Nagasaka","year":"2022","unstructured":"Nagasaka M, Miyajima C, Aoki H, Aoyama M, Morishita D, Inoue Y, et al. Insights into regulators of p53 acetylation. Cells 2022;11:3825.","journal-title":"Cells"},{"key":"3945_CR31","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1038\/s41388-022-02331-9","volume":"41","author":"Z Xia","year":"2022","unstructured":"Xia Z, Kon N, Gu AP, Tavana O, Gu W. Deciphering the acetylation code of p53 in transcription regulation and tumor suppression. Oncogene 2022;41:3039\u20133050.","journal-title":"Oncogene"},{"key":"3945_CR32","first-page":"1099","volume":"12","author":"R Okazaki","year":"2022","unstructured":"Okazaki R. Role of p53 in regulating radiation responses. Life (Basel) 2022;12:1099.","journal-title":"Life (Basel)"}],"container-title":["Chinese Journal of Integrative Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-026-3945-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11655-026-3945-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11655-026-3945-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T09:56:15Z","timestamp":1786787775000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11655-026-3945-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["3945"],"URL":"https:\/\/doi.org\/10.1007\/s11655-026-3945-y","relation":{},"ISSN":["1672-0415","1993-0402"],"issn-type":[{"value":"1672-0415","type":"print"},{"value":"1993-0402","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"9 May 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}