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Data from the Look AHEAD clinical trial shows that a long term intentional weight loss intervention was associated with greater bone loss at the hip in men.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Intentional weight loss has been shown to increase bone loss short term and increase frailty fracture risk, but the long-term effects on bone mineral density (BMD) are not known.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data from a subgroup from the Look AHEAD (LA) multicenter, randomized clinical trial was used to evaluate whether a long term intentional weight loss intervention would increase bone loss. In a preplanned substudy, BMD was assessed at 5 of the 16 LA clinical centers using dual-energy X-ray absorptiometry at baseline, year 8, and the observational visit 12.6\u201316.3\u00a0years after randomization (year 12\u201316).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>At year 8, bone density loss (%) was greater in the Intensive Lifestyle Intervention (ILI) group compared with the control group (DSE) for the femoral neck (<jats:italic>p<\/jats:italic>\u2009=\u20090.0122) but this finding was not observed at the year 12\u201316 visit. In analyses stratified by gender, bone density loss (%) was greater at the total hip for men in the ILI group than the DSE group at both the year 8 and year 12\u201316 visits (year 8 <jats:italic>p<\/jats:italic>\u2009=\u20090.0263 and year 12\u201316 <jats:italic>p<\/jats:italic>\u2009=\u20090.0062). This finding was not observed among women.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Long term intentional weight loss was associated with greater bone loss at the hip in men. These results taken with the previously published Look AHEAD data from the entire clinical trial showing increased frailty fracture risk with weight loss in the ILI group suggest that when intentional weight loss is planned, consideration of bone density preservation and fracture prevention strategies is warranted.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial Registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov Identifier: NCT00017953. June 21, 2001<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11657-023-01303-0","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T19:01:45Z","timestamp":1689361305000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The long-term effect of intentional weight loss on changes in bone mineral density in persons with type 2 diabetes: results from the Look AHEAD randomized trial"],"prefix":"10.1007","volume":"18","author":[{"given":"Karen C.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen M.","family":"Beavers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn J.","family":"Crandall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen P.","family":"Hazuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora E.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Lipkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann V.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. 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Johnson, MD, MPH \u2013 The author declares that they have no conflict of interest.Andrea Anderson, MS\u2014The author declares that they have no conflict of interest.Kristen M. Beavers, PhD\u2014The author declares that they have no conflict of interest.Carolyn J. Crandall, MD, MS, CCD\u2014The author declares that they have no conflict of interest.Helen P. Hazuda, PhD\u2014The author declares that they have no conflict of interest.Cora E. Lewis, MD, MSPH \u2013 Reports serving on a Data Safety Monitoring Board for Rush University Medical Center.Edward Lipkin MD, PhD\u2014The author declares that they have no conflict of interest.Ann V. Schwartz, PhD, MPH\u2014The author declares that they have no conflict of interest.F.X. Pi-Sunyer, MD\u2014The author declares that they have no conflict of interest.Qi Zhao, MD, PhD <b>\u2013<\/b> The author declares that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The Look AHEAD study was approved by the appropriate institutional research ethics committees and was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and animal rights"}}],"article-number":"97"}}