{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:26:04Z","timestamp":1792513564539,"version":"4.5.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["112-2314-B-016-041-MY3"],"award-info":[{"award-number":["112-2314-B-016-041-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["113-2314-B-016-051-MY3"],"award-info":[{"award-number":["113-2314-B-016-051-MY3"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["113-2314-B-016-038"],"award-info":[{"award-number":["113-2314-B-016-038"]}],"id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH_D_113137"],"award-info":[{"award-number":["TSGH_D_113137"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH_D_113138"],"award-info":[{"award-number":["TSGH_D_113138"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","award":["TSGH_D_113183"],"award-info":[{"award-number":["TSGH_D_113183"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Osteoporos"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Summary<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>Femoral artery calcification (FAC) is a significant predictor of hip fractures in hemodialysis patients. A higher FAC score is associated with increased fracture risk and poor survival outcomes. Identifying FAC through radiographic assessment may improve fracture risk stratification and clinical management in this high-risk population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients with end-stage renal disease (ESRD) on hemodialysis (HD) are at increased risk for vascular calcification (VC) and bone fractures. While previous studies have linked aortic calcification with hip fractures, the relationship between medium-caliber artery-femoral artery calcification (FAC) and fall-related hip fractures in HD patients remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 170 HD patients who experienced falls and sought treatment in the emergency department (ED) between 2007 and 2014. The FAC score, representing the severity of femoral artery calcification, was calculated as the ratio of the total length of calcification plaques to the length of the femoral vessel visible on plain radiographs of the hip and femur. A logistic regression model assessed the association between FAC score and hip fracture risk, and receiver operating characteristic curve analysis evaluated its predictive power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among the 130 patients meeting inclusion criteria, 55 had fall-related hip fractures. The incidence rate of hip fractures among dialysis patients was 6.18 cases per 1000 person-years by dividing the total number of hip fracture events by the cumulative dialysis duration (in years) of all enrolled patients. Fracture patients were older and had lower serum creatinine, sodium, and albumin levels but higher aspartate aminotransferase levels. The fracture group also had a higher FAC score (0.47 [IQR, 0.28 \u2013 0.76] vs. 0.00 [IQR, 0.00 \u2013 0.40],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Multivariable analysis identified old age, heart failure with reduced ejection fraction (EF), and higher FAC scores as independent risk factors for hip fractures. Survival curves showed increased mortality among patients with higher FAC scores and hip fractures (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). Conclusion.\n                    <\/jats:p>\n                    <jats:p>High FAC scores were associated with an increased risk of hip fractures in HD patients, independent of traditional risk factors, and were linked to poor survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11657-025-01536-1","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T01:33:07Z","timestamp":1754703187000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Femoral artery calcification predicts hip fracture in maintenance hemodialysis patients"],"prefix":"10.1007","volume":"20","author":[{"given":"Shun-Neng","family":"Hsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhao-Jhuang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Huang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Liang","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Juei","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,9]]},"reference":[{"key":"1536_CR1","doi-asserted-by":"publisher","first-page":"891363","DOI":"10.3389\/fmed.2022.891363","volume":"9","author":"PY Wu","year":"2022","unstructured":"Wu PY, Chen SC, Lin YC et al (2022) Role of fracture risk assessment tool and bone turnover markers in predicting all-cause and cardiovascular mortality in hemodialysis patients. Front Med (Lausanne) 9:891363","journal-title":"Front Med (Lausanne)"},{"key":"1536_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s42358-020-0118-0","volume":"60","author":"M Slouma","year":"2020","unstructured":"Slouma M, Sahli H, Bahlous A et al (2020) Mineral bone disorder and osteoporosis in hemodialysis patients. Adv Rheumatol 60:15","journal-title":"Adv Rheumatol"},{"key":"1536_CR3","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1046\/j.1523-1755.2000.00178.x","volume":"58","author":"AM Alem","year":"2000","unstructured":"Alem AM, Sherrard DJ, Gillen DL, Weiss NS, Beresford SA, Heckbert SR, Wong C, Stehman-Breen C (2000) Increased risk of hip fracture among patients with end-stage renal disease. Kidney Int 58:396\u2013399","journal-title":"Kidney Int"},{"key":"1536_CR4","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bone.2014.12.020","volume":"73","author":"MJ Perez-Saez","year":"2015","unstructured":"Perez-Saez MJ, Prieto-Alhambra D, Barrios C, Crespo M, Redondo D, Nogues X, Diez-Perez A, Pascual J (2015) Increased hip fracture and mortality in chronic kidney disease individuals: the importance of competing risks. Bone 73:154\u2013159","journal-title":"Bone"},{"key":"1536_CR5","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s00223-020-00779-z","volume":"108","author":"A Pimentel","year":"2021","unstructured":"Pimentel A, Ure\u00f1a-Torres P, Bover J, Luis Fernandez-Mart\u00edn J, Cohen-Solal M (2021) Bone fragility fractures in CKD patients. Calcif Tissue Int 108:539\u2013550","journal-title":"Calcif Tissue Int"},{"key":"1536_CR6","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1007\/s00198-018-4406-z","volume":"29","author":"J Przedlacki","year":"2018","unstructured":"Przedlacki J, Buczy\u0144ska-Chyl J, Ko\u017ami\u0144ski P et al (2018) The utility of FRAX\u00ae in predicting bone fractures in patients with chronic kidney disease on hemodialysis: a two-year prospective multicenter cohort study. Osteoporos Int J Established Result Cooperation Eur Found Osteoporos Natl Osteoporos Found USA 29:1105\u20131115","journal-title":"Osteoporos Int J Established Result Cooperation Eur Found Osteoporos Natl Osteoporos Found USA"},{"issue":"Suppl 2","key":"1536_CR7","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1365-2362.2006.01665.x","volume":"36","author":"SM Moe","year":"2006","unstructured":"Moe SM (2006) Vascular calcification and renal osteodystrophy relationship in chronic kidney disease. Eur J Clin Invest 36(Suppl 2):51\u201362","journal-title":"Eur J Clin Invest"},{"key":"1536_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1681\/ASN.2007080854","volume":"19","author":"SM Moe","year":"2008","unstructured":"Moe SM, Chen NX (2008) Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 19:213\u2013216","journal-title":"J Am Soc Nephrol"},{"key":"1536_CR9","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3233\/BMR-160700","volume":"29","author":"Z Chen","year":"2016","unstructured":"Chen Z, Yu Y (2016) Aortic calcification was associated with risk of fractures: a meta-analysis. J Back Musculoskelet Rehabil 29:635\u2013642","journal-title":"J Back Musculoskelet Rehabil"},{"key":"1536_CR10","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00774-017-0849-0","volume":"36","author":"D Wei","year":"2018","unstructured":"Wei D, Zheng G, Gao Y, Guo J, Zhang T (2018) Abdominal aortic calcification and the risk of bone fractures: a meta-analysis of prospective cohort studies. J Bone Miner Metab 36:439\u2013446","journal-title":"J Bone Miner Metab"},{"key":"1536_CR11","doi-asserted-by":"publisher","first-page":"1592598","DOI":"10.1155\/2017\/1592598","volume":"2017","author":"TL Chuang","year":"2017","unstructured":"Chuang TL, Li YD, Hsiao FT, Chuang MH, Wang YF (2017) FRAX\u00ae fracture risks are associated with coronary artery calcification score. Dis Markers 2017:1592598","journal-title":"Dis Markers"},{"issue":"ehad655","key":"1536_CR12","first-page":"1267","volume":"44","author":"MB Bjelobrk","year":"2023","unstructured":"Bjelobrk MB, Kovacevic MK, Cankovic MC et al (2023) Impact of coronary artery calcium score level in prediction of major adverse cardiovascular events. Eur Heart J 44(ehad655):1267","journal-title":"Eur Heart J"},{"key":"1536_CR13","doi-asserted-by":"publisher","first-page":"205435812110411","DOI":"10.1177\/20543581211041184","volume":"8","author":"M Jafari","year":"2021","unstructured":"Jafari M, Anwar S, Kour K, Sanjoy S, Goyal K, Prasad B (2021) T Scores, FRAX, Frailty phenotype, falls, and its relationship to fractures in patients on maintenance hemodialysis. Can J Kidney Health Dis 8:20543581211041184","journal-title":"Can J Kidney Health Dis"},{"key":"1536_CR14","doi-asserted-by":"publisher","first-page":"e0158789","DOI":"10.1371\/journal.pone.0158789","volume":"11","author":"HY Chen","year":"2016","unstructured":"Chen HY, Chiu YL, Hsu SP, Pai MF, Yang JY, Peng YS (2016) Relationship between fetuin A, vascular calcification and fracture risk in dialysis patients. PLoS ONE 11:e0158789","journal-title":"PLoS ONE"},{"key":"1536_CR15","first-page":"239","volume":"24","author":"M Rodr\u00edguez-Garc\u00eda","year":"2009","unstructured":"Rodr\u00edguez-Garc\u00eda M, G\u00f3mez-Alonso C, Naves-D\u00edaz M, Diaz-Lopez JB, Diaz-Corte C, Cannata-And\u00eda JB (2009) Vascular calcifications, vertebral fractures and mortality in haemodialysis patients. Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc Eur Ren Assoc 24:239\u2013246","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transplant Assoc Eur Ren Assoc"},{"key":"1536_CR16","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/ca.23390","volume":"33","author":"Y Kawasaki","year":"2020","unstructured":"Kawasaki Y, Kinose S, Kato K, Sakai T, Ichimura K (2020) Anatomic characterization of the femoral nutrient artery: application to fracture and surgery of the femur. Clin Anat 33:479\u2013487","journal-title":"Clin Anat"},{"key":"1536_CR17","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.2147\/TCRM.S171970","volume":"14","author":"J Tan","year":"2018","unstructured":"Tan J, Li Y, Wu Z, Zhao J (2018) Risk of hip fracture in patients on dialysis or kidney transplant: a meta-analysis of 14 cohort studies. Ther Clin Risk Manag 14:1747\u20131755","journal-title":"Ther Clin Risk Manag"},{"key":"1536_CR18","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.ekir.2018.07.001","volume":"3","author":"LJ Hickson","year":"2018","unstructured":"Hickson LJ, Farah WH, Johnson RL, Thorsteinsdottir B, Ubl DS, Yuan BJ, Albright R, Rule AD, Habermann EB (2018) Death and postoperative complications after hip fracture repair: dialysis effect. Kidney Int Rep 3:1294\u20131303","journal-title":"Kidney Int Rep"},{"key":"1536_CR19","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1093\/ndt\/gfm660","volume":"23","author":"ND Toussaint","year":"2008","unstructured":"Toussaint ND, Lau KK, Strauss BJ, Polkinghorne KR, Kerr PG (2008) Associations between vascular calcification, arterial stiffness and bone mineral density in chronic kidney disease. Nephrol Dial Transplant 23:586\u2013593","journal-title":"Nephrol Dial Transplant"},{"key":"1536_CR20","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/s12877-019-1329-2","volume":"19","author":"NG Choi","year":"2019","unstructured":"Choi NG, Choi BY, DiNitto DM, Marti CN, Kunik ME (2019) Fall-related emergency department visits and hospitalizations among community-dwelling older adults: examination of health problems and injury characteristics. BMC Geriatr 19:303","journal-title":"BMC Geriatr"},{"key":"1536_CR21","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/j.jacc.2015.12.056","volume":"67","author":"M Laclaustra","year":"2016","unstructured":"Laclaustra M, Casasnovas JA, Fern\u00e1ndez-Ortiz A et al (2016) Femoral and carotid subclinical atherosclerosis association with risk factors and coronary calcium: the AWHS Study. J Am Coll Cardiol 67:1263\u20131274","journal-title":"J Am Coll Cardiol"},{"key":"1536_CR22","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1161\/ATVBAHA.120.315289","volume":"41","author":"P Szulc","year":"2021","unstructured":"Szulc P, Planckaert C, Foesser D, Patsch J, Chapurlat R (2021) High cardiovascular risk in older men with severe peripheral artery calcification on high-resolution peripheral QCT scans: The STRAMBO Study. Arterioscler Thromb Vasc Biol 41:1818\u20131829","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"1536_CR23","doi-asserted-by":"publisher","first-page":"3567","DOI":"10.3390\/nu13103567","volume":"13","author":"M Fusaro","year":"2021","unstructured":"Fusaro M, Tripepi G, Plebani M et al (2021) The vessels-bone axis: iliac artery calcifications, vertebral fractures and vitamin K from VIKI study. Nutrients 13(10):3567. https:\/\/doi.org\/10.3390\/nu13103567","journal-title":"Nutrients"},{"key":"1536_CR24","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1359\/jbmr.1997.12.2.283","volume":"12","author":"MT Vogt","year":"1997","unstructured":"Vogt MT, Cauley JA, Kuller LH, Nevitt MC (1997) Bone mineral density and blood flow to the lower extremities: the study of osteoporotic fractures. J Bone Miner Res 12:283\u2013289","journal-title":"J Bone Miner Res"},{"key":"1536_CR25","doi-asserted-by":"publisher","first-page":"13601","DOI":"10.1038\/ncomms13601","volume":"7","author":"SK Ramasamy","year":"2016","unstructured":"Ramasamy SK, Kusumbe AP, Schiller M et al (2016) Blood flow controls bone vascular function and osteogenesis. Nat Commun 7:13601","journal-title":"Nat Commun"},{"key":"1536_CR26","first-page":"349","volume":"99","author":"J Kapitola","year":"1998","unstructured":"Kapitola J, Z\u00e1k J (1998) Relation between local blood flow and bone mineralization indicators in the tibia of female rats. Sb Lek 99:349\u2013354","journal-title":"Sb Lek"},{"key":"1536_CR27","first-page":"e14878","volume":"13","author":"F Biri\u015fik","year":"2021","unstructured":"Biri\u015fik F, Bilgin Y, Bayram S, \u00d6zt\u00fcrkmen Y (2021) Does presence of femoral arterial calcification have an effect on postoperative complication and mortality in patients with hip fracture? Cureus 13:e14878","journal-title":"Cureus"},{"key":"1536_CR28","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.bone.2004.02.016","volume":"35","author":"AM Parfitt","year":"2004","unstructured":"Parfitt AM, Qiu S, Rao DS (2004) The mineralization index\u2013a new approach to the histomorphometric appraisal of osteomalacia. Bone 35:320\u2013325","journal-title":"Bone"},{"key":"1536_CR29","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1681\/ASN.V971225","volume":"9","author":"HC Schober","year":"1998","unstructured":"Schober HC, Han ZH, Foldes AJ, Shih MS, Rao DS, Balena R, Parfitt AM (1998) Mineralized bone loss at different sites in dialysis patients: implications for prevention. J Am Soc Nephrol 9:1225\u20131233","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 4","key":"1536_CR30","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1111\/nep.13457","volume":"23","author":"YC Hou","year":"2018","unstructured":"Hou YC, Lu CL, Lu KC (2018) Mineral bone disorders in chronic kidney disease. Nephrology (Carlton) 23(Suppl 4):88\u201394","journal-title":"Nephrology (Carlton)"},{"key":"1536_CR31","first-page":"671","volume":"28","author":"M Zaimi","year":"2024","unstructured":"Zaimi M, Grapsa E (2024) Current therapeutic approach of chronic kidney disease-mineral and bone disorder. Ther Apher Dial\u00a0Off Peer-Reviewed J Int Soc Apher, Jpn Soc Apher, Jpn S Dial Ther 28:671\u2013689","journal-title":"Ther Apher Dial\u00a0Off Peer-Reviewed J Int Soc Apher, Jpn Soc Apher, Jpn S Dial Ther"},{"key":"1536_CR32","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1002\/jcp.31021","volume":"238","author":"N Ding","year":"2023","unstructured":"Ding N, Lv Y, Su H, Wang Z, Kong X, Zhen J, Lv Z, Wang R (2023) Vascular calcification in CKD: new insights into its mechanisms. J Cell Physiol 238:1160\u20131182","journal-title":"J Cell Physiol"},{"key":"1536_CR33","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1161\/CIRCRESAHA.110.238808","volume":"109","author":"AN Kapustin","year":"2011","unstructured":"Kapustin AN, Davies JD, Reynolds JL et al (2011) Calcium regulates key components of vascular smooth muscle cell-derived matrix vesicles to enhance mineralization. Circ Res 109:e1\u201312","journal-title":"Circ Res"},{"key":"1536_CR34","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/s11154-015-9318-z","volume":"16","author":"JE Blau","year":"2015","unstructured":"Blau JE, Collins MT (2015) The PTH-vitamin D-FGF23 axis. Rev Endocr Metab Disord 16:165\u2013174","journal-title":"Rev Endocr Metab Disord"},{"key":"1536_CR35","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s10654-016-0192-0","volume":"31","author":"EO Hoogendijk","year":"2016","unstructured":"Hoogendijk EO, Deeg DJ, Poppelaars J et al (2016) The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings. Eur J Epidemiol 31:927\u2013945","journal-title":"Eur J Epidemiol"},{"key":"1536_CR36","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s11255-017-1758-9","volume":"50","author":"S Disthabanchong","year":"2018","unstructured":"Disthabanchong S, Vipattawat K, Phakdeekitcharoen B, Kitiyakara C, Sumethkul V (2018) Abdominal aorta and pelvic artery calcifications on plain radiographs may predict mortality in chronic kidney disease, hemodialysis and renal transplantation. Int Urol Nephrol 50:355\u2013364","journal-title":"Int Urol Nephrol"},{"key":"1536_CR37","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1093\/ndt\/gfq089","volume":"25","author":"MM Nasrallah","year":"2010","unstructured":"Nasrallah MM, El-Shehaby AR, Salem MM, Osman NA, El Sheikh E, Sharaf El Din UA (2010) Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients. Nephrology, dialysis, transplantation\u202f: official publication of the European Dialysis and Transplant Association - European Renal Association 25:2679\u20132685","journal-title":"Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association"},{"key":"1536_CR38","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1007\/s00198-011-1838-0","volume":"23","author":"L Desjardins","year":"2012","unstructured":"Desjardins L, Liabeuf S, Renard C, Lenglet A, Lemke HD, Choukroun G, Drueke TB, Massy ZA (2012) FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages. Osteoporosis international\u202f: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 23:2017\u20132025","journal-title":"Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA"},{"key":"1536_CR39","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1038\/ki.2013.3","volume":"83","author":"JJ Scialla","year":"2013","unstructured":"Scialla JJ, Lau WL, Reilly MP et al (2013) Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. Kidney Int 83:1159\u20131168","journal-title":"Kidney Int"},{"key":"1536_CR40","doi-asserted-by":"publisher","unstructured":"Duang S, Zhang M, Liu C, Dong Q (2022) Parathyroid hormone-induced vascular smooth muscle cells calcification by endoplasmic reticulum stress. J Physiol Pharmacol\u00a073(5). https:\/\/doi.org\/10.26402\/jpp.2022.5.03","DOI":"10.26402\/jpp.2022.5.03"},{"key":"1536_CR41","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1002\/kjm2.12072","volume":"35","author":"YX Chen","year":"2019","unstructured":"Chen YX, Huang C, Duan ZB, Xu CY, Chen Y (2019) Klotho\/FGF23 axis mediates high phosphate-induced vascular calcification in vascular smooth muscle cells via Wnt7b\/\u03b2-catenin pathway. Kaohsiung J Med Sci 35:393\u2013400","journal-title":"Kaohsiung J Med Sci"},{"key":"1536_CR42","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.3945\/ajcn.112.036418","volume":"97","author":"CP Kovesdy","year":"2013","unstructured":"Kovesdy CP, Kopple JD, Kalantar-Zadeh K (2013) Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy. Am J Clin Nutr 97:1163\u20131177","journal-title":"Am J Clin Nutr"},{"key":"1536_CR43","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1046\/j.1523-1755.1999.00410.x","volume":"55","author":"TA Ikizler","year":"1999","unstructured":"Ikizler TA, Wingard RL, Harvell J, Shyr Y, Hakim RM (1999) Association of morbidity with markers of nutrition and inflammation in chronic hemodialysis patients: a prospective study. Kidney Int 55:1945\u20131951","journal-title":"Kidney Int"},{"key":"1536_CR44","doi-asserted-by":"publisher","first-page":"e0259300","DOI":"10.1371\/journal.pone.0259300","volume":"16","author":"S Lv","year":"2021","unstructured":"Lv S, Ru S (2021) The prevalence of malnutrition and its effects on the all-cause mortality among patients with heart failure: a systematic review and meta-analysis. PLoS ONE 16:e0259300","journal-title":"PLoS ONE"},{"key":"1536_CR45","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1001\/jama.2013.2024","volume":"309","author":"MM Redfield","year":"2013","unstructured":"Redfield MM, Chen HH, Borlaug BA et al (2013) Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. JAMA 309:1268\u20131277","journal-title":"JAMA"},{"key":"1536_CR46","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1001\/jama.2009.2","volume":"301","author":"M Pfisterer","year":"2009","unstructured":"Pfisterer M, Buser P, Rickli H et al (2009) BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial. JAMA 301:383\u2013392","journal-title":"JAMA"},{"key":"1536_CR47","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1053\/jren.2002.29598","volume":"12","author":"K Kalantar-Zadeh","year":"2002","unstructured":"Kalantar-Zadeh K, Kopple JD, Deepak S, Block D, Block G (2002) Food intake characteristics of hemodialysis patients as obtained by food frequency questionnaire. J Ren Nutr 12:17\u201331","journal-title":"J Ren Nutr"},{"key":"1536_CR48","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/1098-240X(200006)23:3<222::AID-NUR6>3.0.CO;2-3","volume":"23","author":"DO McCarthy","year":"2000","unstructured":"McCarthy DO (2000) Tumor necrosis factor alpha and interleukin-6 have differential effects on food intake and gastric emptying in fasted rats. Res Nurs Health 23:222\u2013228","journal-title":"Res Nurs Health"},{"key":"1536_CR49","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1038\/sj.ki.5001841","volume":"70","author":"PA Price","year":"2006","unstructured":"Price PA, Roublick AM, Williamson MK (2006) Artery calcification in uremic rats is increased by a low protein diet and prevented by treatment with ibandronate. Kidney Int 70:1577\u20131583","journal-title":"Kidney Int"},{"key":"1536_CR50","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/ajh\/hpu225","volume":"28","author":"M Agharazii","year":"2015","unstructured":"Agharazii M, St-Louis R, Gautier-Bastien A, Ung RV, Mokas S, Larivi\u00e8re R, Richard DE (2015) Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Am J Hypertens 28:746\u2013755","journal-title":"Am J Hypertens"},{"key":"1536_CR51","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.tcm.2007.02.005","volume":"17","author":"R Westenfeld","year":"2007","unstructured":"Westenfeld R, Jahnen-Dechent W, Ketteler M (2007) Vascular calcification and fetuin-A deficiency in chronic kidney disease. Trends Cardiovasc Med 17:124\u2013128","journal-title":"Trends Cardiovasc Med"},{"key":"1536_CR52","doi-asserted-by":"publisher","first-page":"F744","DOI":"10.1152\/ajprenal.00017.2015","volume":"309","author":"S Yamada","year":"2015","unstructured":"Yamada S, Tokumoto M, Tsuruya K, Tatsumoto N, Noguchi H, Kitazono T, Ooboshi H (2015) Fetuin-A decrease induced by a low-protein diet enhances vascular calcification in uremic rats with hyperphosphatemia. Am J Physiol Renal Physiol 309:F744\u2013754","journal-title":"Am J Physiol Renal Physiol"},{"key":"1536_CR53","doi-asserted-by":"publisher","first-page":"100408","DOI":"10.1016\/j.xkme.2022.100408","volume":"4","author":"S Yamada","year":"2022","unstructured":"Yamada S, Arase H, Yoshida H, Kitamura H, Tokumoto M, Taniguchi M, Hirakata H, Tsuruya K, Nakano T, Kitazono T (2022) Malnutrition-inflammation complex syndrome and bone fractures and cardiovascular disease events in patients undergoing hemodialysis: the Q-Cohort study. Kidney Med 4:100408","journal-title":"Kidney Med"},{"key":"1536_CR54","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1053\/j.ajkd.2017.01.052","volume":"70","author":"S Yamada","year":"2017","unstructured":"Yamada S, Taniguchi M, Tokumoto M, Yoshitomi R, Yoshida H, Tatsumoto N, Hirakata H, Fujimi S, Kitazono T, Tsuruya K (2017) Modified creatinine index and the risk of bone fracture in patients undergoing hemodialysis: the Q-Cohort study. Am J Kidney Dis 70:270\u2013280","journal-title":"Am J Kidney Dis"},{"key":"1536_CR55","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1007\/s11914-009-0023-2","volume":"7","author":"RR McLean","year":"2009","unstructured":"McLean RR (2009) Proinflammatory cytokines and osteoporosis. Curr Osteoporos Rep 7:134\u2013139","journal-title":"Curr Osteoporos Rep"},{"key":"1536_CR56","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1359\/jbmr.070409","volume":"22","author":"JA Cauley","year":"2007","unstructured":"Cauley JA, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB (2007) Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. Journal of bone and mineral research\u202f: the official journal of the American Society for Bone and Mineral Research 22:1088\u20131095","journal-title":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research"},{"key":"1536_CR57","doi-asserted-by":"publisher","unstructured":"Bellasi A, Di Lullo L, Russo D, Ciarcia R, Magnocavallo M, Lavalle C, Ratti C, Fusaro M, Cozzolino M, Di Iorio BR (2021) Predictive value of measures of vascular calcification burden and progression for risk of death in incident to dialysis patients. J Clin Med 10(3):376. https:\/\/doi.org\/10.3390\/jcm10030376","DOI":"10.3390\/jcm10030376"},{"key":"1536_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","volume":"7","author":"KDIGO","year":"2017","unstructured":"KDIGO (2017) Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 7:1\u201359","journal-title":"Kidney Int Suppl"},{"key":"1536_CR59","doi-asserted-by":"publisher","first-page":"106429","DOI":"10.1016\/j.isci.2023.106429","volume":"26","author":"CT Chao","year":"2023","unstructured":"Chao CT, Yeh HY, Hung KY (2023) Chest radiography deep radiomics-enabled aortic arch calcification interpretation across different populations. iScience 26:106429","journal-title":"iScience"},{"key":"1536_CR60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/1471-2369-14-120","volume":"14","author":"D Hong","year":"2013","unstructured":"Hong D, Wu S, Pu L et al (2013) Abdominal aortic calcification is not superior over other vascular calcification in predicting mortality in hemodialysis patients: a retrospective observational study. BMC Nephrol 14:120","journal-title":"BMC Nephrol"},{"key":"1536_CR61","doi-asserted-by":"publisher","first-page":"654","DOI":"10.2215\/CJN.07450714","volume":"10","author":"JL G\u00f3rriz","year":"2015","unstructured":"G\u00f3rriz JL, Molina P, Cerver\u00f3n MJ et al (2015) Vascular calcification in patients with nondialysis CKD over 3 years. Clin J Am Soc Nephrol CJASN 10:654\u2013666","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"1536_CR62","doi-asserted-by":"publisher","unstructured":"Ohtake T, Mitomo A, Yamano M et al (2023) Impact of arterial calcification of the lower limbs on long-term clinical outcomes in patients on hemodialysis. J Clin Med 12(4):1299. https:\/\/doi.org\/10.3390\/jcm12041299","DOI":"10.3390\/jcm12041299"},{"key":"1536_CR63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s43055-020-00176-4","volume":"51","author":"GSG Aly","year":"2020","unstructured":"Aly GSG, Kassem HH, Hashad A, Salem MA, Labib D, Baligh E (2020) Lower extremity arterial calcifications assessed by multislice CT as a correlate to coronary artery disease. Egyptian Journal of Radiology and Nuclear Medicine 51:54","journal-title":"Egyptian Journal of Radiology and Nuclear Medicine"}],"container-title":["Archives of Osteoporosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11657-025-01536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11657-025-01536-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11657-025-01536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T22:01:43Z","timestamp":1766527303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11657-025-01536-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,9]]},"references-count":63,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1536"],"URL":"https:\/\/doi.org\/10.1007\/s11657-025-01536-1","relation":{},"ISSN":["1862-3514"],"issn-type":[{"value":"1862-3514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,9]]},"assertion":[{"value":"11 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"112"}}