{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:08:41Z","timestamp":1790622521440,"version":"4.1.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100007515","name":"Universidad de Valladolid","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007515","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Arch Osteoporos"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>\n                      <jats:italic>Summary<\/jats:italic>\n                    <\/jats:title>\n                    <jats:p>This retrospective cohort study analysed a total of 344 patients from the OSTEOMED registry with matched baseline and follow-up DXA data, finding that comorbidities such as nephrolithiasis, hypertension or coronary heart disease may influence the response to prescribed anti-osteoporotic treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To determine: 1) comorbidities associated with reduced bone mineral density (BMD), T-score and Z-score at the lumbar spine (L1 to L4 vertebrae), femoral neck and total hip; and 2) the role of multimorbidity (\u2265\u20092 comorbidities) in reduced BMD, T-score and Z-score at the lumbar spine, femoral neck and total hip.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study analyzing patients [319 females (92.73%), 25 males (7.27%), age 62.13\u2009\u00b1\u200910.46\u00a0years] from the OSTEOMED registry with matched baseline and follow-up dual-energy X-ray absorptiometry (DXA) data. Patients' sex, age, body mass index (BMI), comorbidities and treatments were collected from their medical records after they had given written informed consent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Considering a least significant change (LSC) of 4.2%, neither comorbidity nor multimorbidity was statistically significantly associated with a reduction in BMD in any of the bone regions studied. However, binary logistic regression analyses adjusted for sex, age, BMI and treatments showed that nephrolithiasis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.044) and coronary heart disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026) were statistically significantly associated with a reduction in total hip T-score and that hypertension (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049) and coronary heart disease (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01) were statistically significantly associated with a reduction in total hip Z-score.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite comorbidity and multimorbidity, patients with osteoporosis are mostly well protected by anti-osteoporotic treatment in daily clinical practice. However, nephrolithiasis, hypertension, and coronary heart disease can influence the response to prescribed anti-osteoporotic treatment, especially at the total hip level.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11657-025-01604-6","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T18:12:28Z","timestamp":1757355148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of comorbidities and multimorbidity on bone mineral density in patients with osteoporosis"],"prefix":"10.1007","volume":"20","author":[{"given":"Luis","family":"Leal-Vega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bego\u00f1a","family":"Coco-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adri\u00e1n","family":"Mart\u00edn-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Bl\u00e1zquez-Cabrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Arranz-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Filgueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Sosa-Henr\u00edquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda \u00c1ngeles","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jos\u00e9","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"D\u00edaz-Curiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Olmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"P\u00e9rez-Castrill\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"OSTEOMED Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"issue":"1","key":"1604_CR1","doi-asserted-by":"publisher","first-page":"19S","DOI":"10.1177\/1559827609335350","volume":"3","author":"RE McKeown","year":"2009","unstructured":"McKeown RE (2009) The Epidemiologic Transition: Changing Patterns of Mortality and Population Dynamics. Am J Lifestyle Med 3(1):19S-26S","journal-title":"Am J Lifestyle Med"},{"issue":"12","key":"1604_CR2","doi-asserted-by":"publisher","first-page":"e599","DOI":"10.1016\/S2468-2667(19)30222-1","volume":"4","author":"J Pearson-Stuttard","year":"2019","unstructured":"Pearson-Stuttard J, Ezzati M, Gregg EW (2019) Multimorbidity-a defining challenge for health systems. Lancet Public Health 4(12):e599\u2013e600","journal-title":"Lancet Public Health"},{"key":"1604_CR3","doi-asserted-by":"publisher","first-page":"143","DOI":"10.2147\/RMHP.S97248","volume":"9","author":"SM McPhail","year":"2016","unstructured":"McPhail SM (2016) Multimorbidity in chronic disease: impact on health care resources and costs. Risk Manag Healthc Policy 9:143\u2013156","journal-title":"Risk Manag Healthc Policy"},{"issue":"8","key":"1604_CR4","doi-asserted-by":"publisher","first-page":"e587","DOI":"10.1016\/S2468-2667(21)00107-9","volume":"6","author":"IS Ho","year":"2021","unstructured":"Ho IS, Azcoaga-Lorenzo A, Akbari A et al (2021) Examining variation in the measurement of multimorbidity in research: a systematic review of 566 studies. Lancet Public Health 6(8):e587\u2013e597","journal-title":"Lancet Public Health"},{"key":"1604_CR5","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s12955-015-0355-9","volume":"13","author":"A Ryan","year":"2015","unstructured":"Ryan A, Wallace E, O\u2019Hara P et al (2015) Multimorbidity and functional decline in community-dwelling adults: a systematic review. Health Qual Life Outcomes 13:168","journal-title":"Health Qual Life Outcomes"},{"issue":"1","key":"1604_CR6","doi-asserted-by":"publisher","first-page":"11643","DOI":"10.1038\/s41598-022-15723-4","volume":"12","author":"LP Rodrigues","year":"2022","unstructured":"Rodrigues LP, Vissoci JRN, Fran\u00e7a DG et al (2022) Multimorbidity patterns and hospitalisation occurrence in adults and older adults aged 50 years or over. Sci Rep 12(1):11643","journal-title":"Sci Rep"},{"key":"1604_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.archger.2016.07.008","volume":"67","author":"BP Nunes","year":"2016","unstructured":"Nunes BP, Flores TR, Mielke GI et al (2016) Multimorbidity and mortality in older adults: A systematic review and meta-analysis. Arch Gerontol Geriatr 67:130\u2013138","journal-title":"Arch Gerontol Geriatr"},{"issue":"2","key":"1604_CR8","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S1297-319X(10)70003-8","volume":"77","author":"C David","year":"2010","unstructured":"David C, Confavreux CB, Mehsen N et al (2010) Severity of osteoporosis: what is the impact of co-morbidities? Joint Bone Spine 77(2):103\u2013106","journal-title":"Joint Bone Spine"},{"issue":"8","key":"1604_CR9","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.1007\/s00198-017-4050-z","volume":"28","author":"C Li","year":"2017","unstructured":"Li C, Zeng Y, Tao L et al (2017) Meta-analysis of hypertension and osteoporotic fracture risk in women and men. Osteoporos Int 28(8):2309\u20132318","journal-title":"Osteoporos Int"},{"key":"1604_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115457","volume":"137","author":"T Vilaca","year":"2020","unstructured":"Vilaca T, Schini M, Harnan S et al (2020) The risk of hip and non-vertebral fractures in type 1 and type 2 diabetes: A systematic review and meta-analysis update. Bone 137:115457","journal-title":"Bone"},{"issue":"11","key":"1604_CR11","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1359\/jbmr.070713","volume":"22","author":"JA Cauley","year":"2007","unstructured":"Cauley JA, Wu L, Wampler NS et al (2007) Clinical risk factors for fractures in multi-ethnic women: the Women\u2019s Health Initiative. J Bone Miner Res 22(11):1816\u20131826","journal-title":"J Bone Miner Res"},{"issue":"8","key":"1604_CR12","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1001\/jamainternmed.2019.0682","volume":"179","author":"KE Ensrud","year":"2019","unstructured":"Ensrud KE, Kats AM, Boyd CM, Study of Osteoporotic Fractures (SOF) Research Group (2019) Association of Disease Definition, Comorbidity Burden, and Prognosis With Hip Fracture Probability Among Late-Life Women. JAMA Intern Med 179(8):1095\u2013103","journal-title":"JAMA Intern Med"},{"key":"1604_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2021.101139","volume":"15","author":"A Barcelos","year":"2021","unstructured":"Barcelos A, Lopes DG, Canh\u00e3o H et al (2021) Multimorbidity is associated with fragility fractures in women 50 years and older: A nationwide cross-sectional study. Bone Rep 15:101139","journal-title":"Bone Rep"},{"issue":"1","key":"1604_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.rce.2020.06.004","volume":"221","author":"JA Bl\u00e1zquez Cabrera","year":"2021","unstructured":"Bl\u00e1zquez Cabrera JA, Sosa Henriquez M, OSTEOMED Group (2021) Profile of patients who consult with internists for an osteoporosis assessment: The OSTEOMED registry. Rev Clin Esp (Barc) 221(1):9\u201317","journal-title":"Rev Clin Esp (Barc)"},{"issue":"6","key":"1604_CR15","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/BF01622200","volume":"4","author":"JA Kanis","year":"1994","unstructured":"Kanis JA (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group Osteoporos Int 4(6):368\u2013381","journal-title":"WHO Study Group Osteoporos Int"},{"issue":"10","key":"1604_CR16","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1007\/s00198-014-2794-2","volume":"25","author":"F Cosman","year":"2014","unstructured":"Cosman F, de Beur SJ, LeBoff MS, National Osteoporosis Foundation (2014) Clinician\u2019s Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int 25(10):2359\u201381","journal-title":"Osteoporos Int"},{"issue":"20","key":"1604_CR17","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"World Medical Association","year":"2013","unstructured":"World Medical Association (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20132194","journal-title":"JAMA"},{"issue":"11","key":"1604_CR18","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.1359\/jbmr.1999.14.11.1952","volume":"14","author":"CC Gl\u00fcer","year":"1999","unstructured":"Gl\u00fcer CC (1999) Monitoring skeletal changes by radiological techniques. J Bone Miner Res 14(11):1952\u20131962","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1604_CR19","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","volume":"17","author":"N Masnoon","year":"2017","unstructured":"Masnoon N, Shakib S, Kalisch-Ellett L et al (2017) What is polypharmacy? A systematic review of definitions. BMC Geriatr 17(1):230","journal-title":"BMC Geriatr"},{"key":"1604_CR20","unstructured":"IBM Corp. Released 2016. IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY: IBM Corp"},{"issue":"10","key":"1604_CR21","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1007\/s00198-010-1516-7","volume":"22","author":"LM Lix","year":"2011","unstructured":"Lix LM, Quail J, Teare G et al (2011) Performance of comorbidity measures for predicting outcomes in population-based osteoporosis cohorts. Osteoporos Int 22(10):2633\u20132643","journal-title":"Osteoporos Int"},{"issue":"5","key":"1604_CR22","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373\u2013383","journal-title":"J Chronic Dis"},{"issue":"1","key":"1604_CR23","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/00005650-199801000-00004","volume":"36","author":"A Elixhauser","year":"1998","unstructured":"Elixhauser A, Steiner C, Harris DR et al (1998) Comorbidity measures for use with administrative data. Med Care 36(1):8\u201327","journal-title":"Med Care"},{"issue":"1","key":"1604_CR24","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00198-015-3215-x","volume":"27","author":"SL Silverman","year":"2016","unstructured":"Silverman SL, Wang A, Cheng L et al (2016) Comorbidity indices for clinical trials: adaptation of two existing indices for use with the FREEDOM trial in women with postmenopausal osteoporosis. Osteoporos Int 27(1):75\u201380","journal-title":"Osteoporos Int"},{"issue":"2","key":"1604_CR25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1002\/art.10993","volume":"49","author":"O Sangha","year":"2003","unstructured":"Sangha O, Stucki G, Liang MH et al (2003) The Self-Administered Comorbidity Questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis Rheum 49(2):156\u2013163","journal-title":"Arthritis Rheum"},{"issue":"4","key":"1604_CR26","doi-asserted-by":"publisher","first-page":"624","DOI":"10.3899\/jrheum.190149","volume":"47","author":"F Wolfe","year":"2020","unstructured":"Wolfe F, Ablin J, Guymer EK et al (2020) The Relation of Physical Comorbidity and Multimorbidity to Fibromyalgia, Widespread Pain, and Fibromyalgia-related Variables. J Rheumatol 47(4):624\u2013631","journal-title":"J Rheumatol"},{"issue":"7","key":"1604_CR27","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nrendo.2014.55","volume":"10","author":"Watts NB; GLOW investigators","year":"2014","unstructured":"Watts NB; GLOW investigators (2014) Insights from the Global Longitudinal Study of Osteoporosis in Women (GLOW). Nat Rev Endocrinol 10(7):412\u2013422","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"1604_CR28","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/jbmr.2023","volume":"29","author":"A D\u00edez-P\u00e9rez","year":"2014","unstructured":"D\u00edez-P\u00e9rez A, Adachi JD, Adami S, Global Longitudinal Study of Osteoporosis in Women (GLOW) Investigators (2014) Risk factors for treatment failure with antiosteoporosis medication: the global longitudinal study of osteoporosis in women (GLOW). J Bone Miner Res 29(1):260\u20137","journal-title":"J Bone Miner Res"},{"issue":"9","key":"1604_CR29","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1007\/s40520-022-02129-5","volume":"34","author":"MB Coco Mart\u00edn","year":"2022","unstructured":"Coco Mart\u00edn MB, Leal Vega L, Bl\u00e1zquez Cabrera JA, OSTEOMED Group (2022) Comorbidity and osteoporotic fracture: approach through predictive modeling techniques using the OSTEOMED registry. Aging Clin Exp Res 34(9):1997\u20132004","journal-title":"Aging Clin Exp Res"},{"issue":"4","key":"1604_CR30","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/ki.2010.473","volume":"79","author":"K Sakhaee","year":"2011","unstructured":"Sakhaee K, Maalouf NM, Kumar R et al (2011) Nephrolithiasis-associated bone disease: pathogenesis and treatment options. Kidney Int 79(4):393\u2013403","journal-title":"Kidney Int"},{"issue":"11","key":"1604_CR31","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1007\/s00198-016-3658-8","volume":"27","author":"P Lucato","year":"2016","unstructured":"Lucato P, Trevisan C, Stubbs B et al (2016) Nephrolithiasis, bone mineral density, osteoporosis, and fractures: a systematic review and comparative meta-analysis. Osteoporos Int 27(11):3155\u20133164","journal-title":"Osteoporos Int"},{"issue":"10","key":"1604_CR32","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1359\/jbmr.2001.16.10.1893","volume":"16","author":"DS Lauderdale","year":"2001","unstructured":"Lauderdale DS, Thisted RA, Wen M et al (2001) Bone mineral density and fracture among prevalent kidney stone cases in the Third National Health and Nutrition Examination Survey. J Bone Miner Res 16(10):1893\u20131898","journal-title":"J Bone Miner Res"},{"key":"1604_CR33","doi-asserted-by":"publisher","first-page":"1142155","DOI":"10.3389\/fpubh.2023.1142155","volume":"11","author":"S Li","year":"2023","unstructured":"Li S, Li L, Feng A et al (2023) The role of hypertension in bone mineral density among males older than 50 years and postmenopausal females: evidence from the US National Health and Nutrition Examination Survey, 2005\u20132010. Front Public Health 11:1142155","journal-title":"Front Public Health"},{"issue":"9183","key":"1604_CR34","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/S0140-6736(99)01437-3","volume":"354","author":"FP Cappuccio","year":"1999","unstructured":"Cappuccio FP, Meilahn E, Zmuda JM et al (1999) High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet 354(9183):971\u20135","journal-title":"Lancet"},{"issue":"7 Pt 1","key":"1604_CR35","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/S0895-7061(01)01303-6","volume":"14","author":"K Tsuda","year":"2001","unstructured":"Tsuda K, Nishio I, Masuyama Y (2001) Bone mineral density in women with essential hypertension. Am J Hypertens 14(7 Pt 1):704\u2013707","journal-title":"Am J Hypertens"},{"issue":"1","key":"1604_CR36","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1186\/s12891-024-07553-4","volume":"25","author":"Y Huang","year":"2024","unstructured":"Huang Y, Ye J (2024) Association between hypertension and osteoporosis: a population-based cross-sectional study. BMC Musculoskelet Disord 25(1):434","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"1604_CR37","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1186\/s12891-021-04124-9","volume":"22","author":"H Chai","year":"2021","unstructured":"Chai H, Ge J, Li L et al (2021) Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women. BMC Musculoskelet Disord 22(1):253","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"1604_CR38","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12902-022-01080-w","volume":"22","author":"HL Wu","year":"2022","unstructured":"Wu HL, Yang J, Wei YC et al (2022) Analysis of the prevalence, risk factors, and clinical characteristics of osteoporosis in patients with essential hypertension. BMC Endocr Disord 22(1):165","journal-title":"BMC Endocr Disord"},{"key":"1604_CR39","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1038\/bonekey.2015.127","volume":"4","author":"EM Alissa","year":"2015","unstructured":"Alissa EM, Alnahdi WA, Alama N et al (2015) Bone mineral density and cardiovascular risk factors in postmenopausal women with coronary artery disease. Bonekey Rep 4:758","journal-title":"Bonekey Rep"},{"key":"1604_CR40","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.2147\/CIA.S168445","volume":"13","author":"XQ Guan","year":"2018","unstructured":"Guan XQ, Xue YJ, Wang J et al (2018) Low bone mineral density is associated with global coronary atherosclerotic plaque burden in stable angina patients. Clin Interv Aging 13:1475\u20131483","journal-title":"Clin Interv Aging"},{"issue":"9","key":"1604_CR41","doi-asserted-by":"publisher","first-page":"4246","DOI":"10.1210\/jc.2003-030964","volume":"89","author":"E Schulz","year":"2004","unstructured":"Schulz E, Arfai K, Liu X et al (2004) Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89(9):4246\u20134253","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"1604_CR42","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1007\/s00198-007-0386-0","volume":"18","author":"U Sennerby","year":"2007","unstructured":"Sennerby U, Farahmand B, Ahlbom A et al (2007) Cardiovascular diseases and future risk of hip fracture in women. Osteoporos Int 18(10):1355\u20131362","journal-title":"Osteoporos Int"},{"issue":"15","key":"1604_CR43","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1001\/jama.2009.1463","volume":"302","author":"U Sennerby","year":"2009","unstructured":"Sennerby U, Melhus H, Gedeborg R (2009) Cardiovascular diseases and risk of hip fracture. JAMA 302(15):1666\u20131673","journal-title":"JAMA"},{"key":"1604_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116651","volume":"168","author":"M Schini","year":"2023","unstructured":"Schini M, Bhatia P, Shreef H et al (2023) Increased fracture risk in Parkinson\u2019s disease - An exploration of mechanisms and consequences for fracture prediction with FRAX. Bone 168:116651","journal-title":"Bone"},{"issue":"7","key":"1604_CR45","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s00198-024-07099-0","volume":"35","author":"B Liu","year":"2024","unstructured":"Liu B, Ng CY, La PBD et al (2024) Osteoporosis and fracture risk assessment in adults with ischaemic stroke. Osteoporos Int 35(7):1243\u20131247","journal-title":"Osteoporos Int"}],"container-title":["Archives of Osteoporosis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11657-025-01604-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11657-025-01604-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11657-025-01604-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T22:01:36Z","timestamp":1766527296000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11657-025-01604-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,8]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1604"],"URL":"https:\/\/doi.org\/10.1007\/s11657-025-01604-6","relation":{},"ISSN":["1862-3514"],"issn-type":[{"value":"1862-3514","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,8]]},"assertion":[{"value":"13 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the Declaration of Helsinki of the World Medical Association and was approved by the Clinical Research Ethics Committee of the Albacete University Hospital Complex (Act 02\/11).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients signed a written informed consent form to be included in the cohort prior to the collection of their personal or clinical data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}},{"value":"Luis Leal-Vega, Mar\u00eda Bego\u00f1a Coco-Mart\u00edn, Adri\u00e1n Mart\u00edn-Guti\u00e9rrez, Jos\u00e9 Antonio Bl\u00e1zquez-Cabrera, Francisca Arranz-Garc\u00eda, Amalia Navarro, Mar\u00eda Jes\u00fas Moro, Jos\u00e9 Filgueira, Manuel Sosa-Henr\u00edquez, Mar\u00eda \u00c1ngeles V\u00e1zquez, Mar\u00eda Jos\u00e9 Montoya, Manuel D\u00edaz-Curiel, Jos\u00e9 Manuel Olmos, and Jos\u00e9 Luis P\u00e9rez-Castrill\u00f3n declare that they have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}],"article-number":"121"}}