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The underlying pathophysiological process is unclear. We provide a detailed characterization of the structural and biochemical properties of bone in a stroke\/TIA cohort. Our findings lay the foundation for a comprehensive understanding of post-stroke osteopathy and its clinical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Patients who have suffered a stroke or transient ischemic attack are at high risk of fractures, which increase mortality and reduce health-related quality of life. Previous studies showed that ischemic stroke leads to unfavorable structural changes in the bones, but the underlying pathophysiological process is still unclear. Our aim was to analyze biomarkers and bone structure with high-resolution peripheral quantitative computed tomography (HR-pQCT) in a stroke\/TIA cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study analyzes the baseline data of a prospective cohort. Patients underwent HR-pQCT scans of the radius and tibia, alongside biochemical bone marker evaluation, within the first days after the acute cerebrovascular event.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women had lower total, cortical, and trabecular volumetric bone mineral density (vBMD) and lower values for most other HR-pQCT parameters. Patients with increasing age had lower total and cortical vBMD, but no difference in trabecular parameters. Active or former smokers had lower total and trabecular vBMD. Higher BMI was associated with greater cortical and trabecular bone areas and higher trabecular density. A positive correlation was found between sclerostin levels and trabecular parameters. Higher osteoprotegerin levels were associated with lower cortical area and thickness. Osteocalcin showed a negative correlation with total vBMD and cortical thickness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study is the first to combine HR-pQCT imaging with bone biomarkers to provide a detailed characterization of the structural and biochemical properties of bone in a stroke\/TIA cohort. Our findings lay the foundation for a comprehensive understanding of post-stroke osteopathy and its clinical implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s11657-026-01767-w","type":"journal-article","created":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T02:21:07Z","timestamp":1787970067000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High-resolution peripheral quantitative computed tomography imaging and bone biomarker characteristics of patients with ischemic stroke or transient ischemic attack\u2014baseline analysis of the Post-stroke Osteopathy study"],"prefix":"10.1007","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9954-9687","authenticated-orcid":false,"given":"Benjamin","family":"Dejakum","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Bereiter-Payr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Felicetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kurt","family":"Moelgg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anel","family":"Karisik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Degenhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Toell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Boehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Mayer-Suess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Pechlaner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maria","family":"Liphardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Schett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiechl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Knoflach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"issue":"10","key":"1767_CR1","first-page":"795","volume":"20","author":"Collaborators, GBD 2019 Stroke","year":"2019","unstructured":"Collaborators, GBD 2019 Stroke (2019) Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. 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Rigorous federal laws and regulations concerning the usage of these data exist. This study was completed in accordance with the Helsinki Declaration as revised in 2013. STROKE-CARD Registry (NCT04582825) and post-stroke osteopathy study (NCT04845269) were approved by the ethics committee of the Medical University of Innsbruck, Austria. All procedures performed were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.","order":1,"name":"Ethics","label":"Ethical approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None.","order":2,"name":"Ethics","label":"Conflicts of interest","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"134"}}