{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:27:32Z","timestamp":1780104452848,"version":"3.54.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2012,2,29]],"date-time":"2012-02-29T00:00:00Z","timestamp":1330473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1007\/s11682-012-9154-7","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T23:55:49Z","timestamp":1330386949000},"page":"397-403","source":"Crossref","is-referenced-by-count":28,"title":["A resting-state functional magnetic resonance imaging study on the first-degree relatives of persons with schizophrenia"],"prefix":"10.1007","volume":"6","author":[{"given":"Haiyan","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwen","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongzhao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlian","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,2,29]]},"reference":[{"key":"9154_CR1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1176\/appi.ajp.160.4.709","volume":"160","author":"JH Callicott","year":"2003","unstructured":"Callicott, J. H., Egan, M. F., Mattay, V. S., Bertolino, A., Bone, A. D., Verchinksi, B., et al. (2003). Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact sibling of patients with schizophrenia. The American Journal of Psychiatry, 160, 709\u2013719.","journal-title":"The American Journal of Psychiatry"},{"key":"9154_CR2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/oxfordjournals.schbul.a033460","volume":"26","author":"TD Cannon","year":"2000","unstructured":"Cannon, T. D., Bearden, C. E., Hollister, J. M., Rosso, I. M., Sanchez, L. E., & Hadley, T. (2000). Childhood cognitive functioning in schizophrenia patients and their unaffected siblings: a prospective cohort study. Schizophrenia Bulletin, 26, 379\u2013393.","journal-title":"Schizophrenia Bulletin"},{"key":"9154_CR3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1096-8628(200021)97:1<12::AID-AJMG3>3.0.CO;2-U","volume":"97","author":"AG Cardno","year":"2000","unstructured":"Cardno, A. G., & Gottesman, I. I. (2000). Twin studies of schizophrenia: from bow-and-arrow concordances to star wars Mx and functional genomics. American Journal of Medical Genetics, 97, 12\u201317.","journal-title":"American Journal of Medical Genetics"},{"key":"9154_CR4","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","volume":"129","author":"AE Cavanna","year":"2006","unstructured":"Cavanna, A. E., & Trimble, M. R. (2006). The precuneus: a review of its functional anatomy and behavioural correlates. Brain, 129, 564\u2013583.","journal-title":"Brain"},{"key":"9154_CR5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.neubiorev.2009.11.012","volume":"34","author":"RC Chan","year":"2010","unstructured":"Chan, R. C., Xu, T., Heinrichs, R. W., Yu, Y., & Gong, Q. Y. (2010). Neurological soft signs in non-psychotic first-degree relatives of patients with schizophrenia: a systematic review and meta-analysis. Neuroscience and Biobehavioral Reviews, 34, 889\u2013896.","journal-title":"Neuroscience and Biobehavioral Reviews"},{"key":"9154_CR6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.schres.2007.04.002","volume":"94","author":"MT Compton","year":"2007","unstructured":"Compton, M. T., Bollini, A. M., McKenzie Mack, L., Kryda, A. D., Rutland, J., Weiss, P. S., et al. (2007). Neurological soft signs and minor physical anomalies in patients with schizophrenia and related disorders, their first-degree biological relatives, and non-psychiatric controls. Schizophrenia Research, 94, 64\u201373.","journal-title":"Schizophrenia Research"},{"key":"9154_CR7","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.brainresrev.2009.12.004","volume":"62","author":"A Ekstrom","year":"2010","unstructured":"Ekstrom, A. (2010). How and when the fMRI BOLD signal relates to underlying neural activity: the danger in dissociation. Brain Research Reviews, 62, 233\u2013244.","journal-title":"Brain Research Reviews"},{"key":"9154_CR8","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1176\/appi.ajp.160.4.636","volume":"160","author":"II Gottesman","year":"2003","unstructured":"Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymo-logy and strategic intentions. The American Journal of Psychiatry, 160, 636\u2013645.","journal-title":"The American Journal of Psychiatry"},{"key":"9154_CR9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.4088\/JCP.0706e03","volume":"67","author":"MF Green","year":"2006","unstructured":"Green, M. F. (2006). Cognitive impairment and functional outcome in schizophrenia and bipolar disorder. The Journal of Clinical Psychiatry, 67, 3\u20138.","journal-title":"The Journal of Clinical Psychiatry"},{"key":"9154_CR10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1073\/pnas.0135058100","volume":"100","author":"MD Greicius","year":"2003","unstructured":"Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. PNAS, 100, 253\u2013258.","journal-title":"PNAS"},{"key":"9154_CR11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jad.2011.06.048","volume":"135","author":"WB Guo","year":"2011","unstructured":"Guo, W. B., Liu, F., Xue, Z. M., Yu, Y., Ma, C. Q., Tan, C. L., et al. (2011). Abnormal neural activities in first-episode, treatment-na\u00efve, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study. Journal of Affective Disorders, 135, 326\u2013331.","journal-title":"Journal of Affective Disorders"},{"key":"9154_CR12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1176\/ajp.156.2.286","volume":"156","author":"S Kapur","year":"1999","unstructured":"Kapur, S., Zipursky, R. B., & Remington, G. (1999). Clinical and theoretical implications of 5-HT2 and D2 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia. The American Journal of Psychiatry, 156, 286\u2013292.","journal-title":"The American Journal of Psychiatry"},{"key":"9154_CR13","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1001\/archpsyc.1985.01790310032004","volume":"42","author":"KS Kendler","year":"1985","unstructured":"Kendler, K. S., Alan, M., Gruenberg, A. M., & Tsuang, M. T. (1985). Psychiatric illness in first-degree relatives of schizophrenic and surgical control patients. A family study using DSM-III criteria. Archives of General Psychiatry, 42, 770\u2013779.","journal-title":"Archives of General Psychiatry"},{"key":"9154_CR14","first-page":"209","volume":"17","author":"M Liang","year":"2006","unstructured":"Liang, M., Zhou, Y., Jiang, T., Liu, Z., Tian, L., Liu, H., et al. (2006). Widespread functional disconnectivity in schizophrenia with resting-state functional magnetic resonance imaging. Brain Imaging Neuroreport., 17, 209\u2013213.","journal-title":"Brain Imaging Neuroreport."},{"key":"9154_CR15","first-page":"645","volume":"33","author":"LCC Lim","year":"1992","unstructured":"Lim, L. C. C., & Sim, L. P. (1992). The prevalence of schizophrenia in relatives of schizophrenia patients. Singapore Medical Journal, 33, 645\u2013647.","journal-title":"Singapore Medical Journal"},{"key":"9154_CR16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.wnr.0000195666.22714.35","volume":"17","author":"H Liu","year":"2006","unstructured":"Liu, H., Liu, Z., Liang, M., Hao, Y., Tan, L., Kuang, F., et al. (2006). Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport, 17, 19\u201322.","journal-title":"Neuroreport"},{"key":"9154_CR17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mri.2006.09.032","volume":"25","author":"L Ma","year":"2007","unstructured":"Ma, L., Wang, B., & Chen, X. (2007). Detecting functional connectivity in the resting brain: a comparison between ICA and CCA. Magnetic Resonance Imaging, 25, 47\u201356.","journal-title":"Magnetic Resonance Imaging"},{"key":"9154_CR18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.biopsych.2004.09.013","volume":"56","author":"D Malaspina","year":"2004","unstructured":"Malaspina, D., Harkavy-Friedman, J., Corcoran, C., Mujica-Parodi, L., Printz, D., Gorman, J. M., et al. (2004). Resting neural activity distinguishes subgroups of schizophrenia patients. Biological Psychiatry, 56, 931\u2013937.","journal-title":"Biological Psychiatry"},{"key":"9154_CR19","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.brainres.2010.12.004","volume":"1373","author":"K Mankinen","year":"2011","unstructured":"Mankinen, K., Long, X. Y., Paakki, J. J., Harila, M., Rytky, S., Tervonen, O., et al. (2011). Alterations in regional homogeneity of baseline brain activity in pediatric temporal lobe epilepsy. Brain Research, 1373, 221\u2013229.","journal-title":"Brain Research"},{"key":"9154_CR20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1080\/15622970802314815","volume":"10","author":"HJ Nam","year":"2009","unstructured":"Nam, H. J., Kim, N., Park, T., Oh, S., Jeon, H. O., Yoon, S. C., et al. (2009). Cognitive profiles of healthy siblings of schizophrenia patients: application of the cognitive domains of the MATRICS consensus battery. The World Journal of Biological Psychiatry, 10, 452\u2013460.","journal-title":"The World Journal of Biological Psychiatry"},{"key":"9154_CR21","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.tig.2005.06.011","volume":"21","author":"MJ Owen","year":"2005","unstructured":"Owen, M. J., Craddock, N. O., & Donovan, M. C. (2005). Schizophrenia: genes at last? Trends in Genetics, 21, 518\u2013525.","journal-title":"Trends in Genetics"},{"key":"9154_CR22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pscychresns.2011.01.010","volume":"194","author":"C Qiu","year":"2011","unstructured":"Qiu, C., Liao, W., Ding, J., Feng, Y., Zhu, C., Nie, X., et al. (2011). Regional homogeneity changes in social anxiety disorder: a resting-state fMRI study. Psychiatry Research, 194, 47\u201353.","journal-title":"Psychiatry Research"},{"key":"9154_CR23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cne.20752","volume":"493","author":"ME Raichle","year":"2005","unstructured":"Raichle, M. E., & Gusnard, D. A. (2005). Intrinsic brain activity sets the stage for expression of motivated behavior. The Journal of Comparative Neurology, 493, 167\u2013176.","journal-title":"The Journal of Comparative Neurology"},{"key":"9154_CR24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","volume":"98","author":"ME Raichle","year":"2011","unstructured":"Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2011). A default mode of brain function. PNAS, 98, 676\u2013682.","journal-title":"PNAS"},{"key":"9154_CR25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.schres.2011.04.018","volume":"130","author":"AE Sevik","year":"2011","unstructured":"Sevik, A. E., Ya\u011fc\u0131o\u011flu, A. E., Ya\u011fc\u0131o\u011flu, S., Karahan, S., G\u00fcrses, N., & Y\u0131ld\u0131z, M. (2011). Neuropsychological performance and auditory event related potentials in schizophrenia patients and their siblings: a family study. Schizophrenia Research, 130, 195\u2013202.","journal-title":"Schizophrenia Research"},{"key":"9154_CR26","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neulet.2010.03.080","volume":"476","author":"DK Shukla","year":"2010","unstructured":"Shukla, D. K., Keehn, B., & M\u00fcller, R. A. (2010). Regional homogeneity of fMRI time series in autism spectrum disorders. Neuroscience Letters, 476, 46\u201351.","journal-title":"Neuroscience Letters"},{"key":"9154_CR27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/schbul\/sbi048","volume":"32","author":"BE Snitz","year":"2006","unstructured":"Snitz, B. E., Macdonald, A. W., 3rd, & Carter, C. S. (2006). Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophrenia Bulletin, 32, 179\u2013194.","journal-title":"Schizophrenia Bulletin"},{"key":"9154_CR28","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1192\/bjp.162.5.672","volume":"162","author":"ST Varma","year":"1993","unstructured":"Varma, S. T., & Sharma, I. (1993). Psychiatric morbidity in the first-degree relatives of schizophrenic patients. The British Journal of Psychiatry, 162, 672\u2013678.","journal-title":"The British Journal of Psychiatry"},{"key":"9154_CR29","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopsych.2005.11.013","volume":"60","author":"HC Whalley","year":"2006","unstructured":"Whalley, H. C., Simonotto, E., Moorhead, W., McIntosh, A., Marshall, I., Ebmeier, K. P., et al. (2006). Functional imaging as a predictor of schizophrenia. Biological Psychiatry, 60, 454\u2013462.","journal-title":"Biological Psychiatry"},{"key":"9154_CR30","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1073\/pnas.0809141106","volume":"106","author":"S Whitfield-Gabrieli","year":"2009","unstructured":"Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., et al. (2009). Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proceedings of the National Academy of Sciences of the United States of America, 106, 1279\u20131284.","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"9154_CR31","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuroimage.2003.12.030","volume":"22","author":"Y Zang","year":"2004","unstructured":"Zang, Y., Jiang, T., Lu, Y., He, Y., & Tian, L. (2004). Regional homogeneity approach to fMRI data analysis. NeuroImage, 22, 394\u2013400.","journal-title":"NeuroImage"},{"key":"9154_CR32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neulet.2007.02.081","volume":"417","author":"Y Zhou","year":"2007","unstructured":"Zhou, Y., Liang, M., Jiang, T., Tian, L., Liu, Y., Liu, Z., et al. (2007). Functional dysconnectivity of the dorsolateral prefrontal codex in first-episode schizophrenia using resting-state fMRI. Neuroscience Letters, 417, 297\u2013302.","journal-title":"Neuroscience Letters"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-012-9154-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11682-012-9154-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-012-9154-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T20:29:18Z","timestamp":1687292958000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11682-012-9154-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,29]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["9154"],"URL":"https:\/\/doi.org\/10.1007\/s11682-012-9154-7","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"value":"1931-7557","type":"print"},{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,29]]}}}