{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:09:45Z","timestamp":1793185785949,"version":"4.5.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:00:00Z","timestamp":1529107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG0005142"],"award-info":[{"award-number":["P50 AG0005142"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K08 AG022228"],"award-info":[{"award-number":["K08 AG022228"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AG016570"],"award-info":[{"award-number":["P50 AG016570"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11682-018-9913-1","type":"journal-article","created":{"date-parts":[[2018,6,16]],"date-time":"2018-06-16T00:39:21Z","timestamp":1529109561000},"page":"925-932","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["1H MRS spectroscopy in preclinical autosomal dominant Alzheimer disease"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5222-0772","authenticated-orcid":false,"given":"Elizabeth","family":"Joe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis D.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,16]]},"reference":[{"issue":"2","key":"9913_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1097\/RMR.0b013e31821e568f","volume":"21","author":"J Alger","year":"2011","unstructured":"Alger, J. (2011). Quantitative proton magnetic resonance spectroscopy and spectroscopic imaging of the brain: a didactic review. Topics in Magnetic Resonance Imaging, 21(2), 115\u2013128. \n                    https:\/\/doi.org\/10.1097\/RMR.0b013e31821e568f.Quantitative\n                    \n                  .","journal-title":"Topics in Magnetic Resonance Imaging"},{"key":"9913_CR2","doi-asserted-by":"publisher","unstructured":"Baslow, M. H. (2016). An answer to \u201cthe nagging question of the function of N-Acetylaspartylglutamate\u201d. Neuroscience Communications, 2\u20137. \n                    https:\/\/doi.org\/10.14800\/nc.844\n                    \n                  .","DOI":"10.14800\/nc.844"},{"key":"9913_CR3","doi-asserted-by":"publisher","unstructured":"Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., \u2026 & Dominantly Inherited Alzheimer Network. (2012). Clinical and biomarker changes in dominantly inherited Alzheimer\u2019s disease. The New England Journal of Medicine, 367(9), 795\u2013804. \n                    https:\/\/doi.org\/10.1056\/NEJMoa1202753\n                    \n                  .","DOI":"10.1056\/NEJMoa1202753"},{"issue":"4","key":"9913_CR4","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1046\/j.1471-4159.2002.01041.x","volume":"82","author":"SK Fisher","year":"2002","unstructured":"Fisher, S. K., Novak, J. E., & Agranoff, B. W. (2002). Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. Journal of Neurochemistry, 82(4), 736\u2013754. \n                    https:\/\/doi.org\/10.1046\/j.1471-4159.2002.01041.x\n                    \n                  .","journal-title":"Journal of Neurochemistry"},{"key":"9913_CR5","doi-asserted-by":"publisher","unstructured":"Frederick, B. D., Kyoon, I., Satlin, A., Heup, K., Kim, M. J., Yurgelun-todd, D. A., \u2026, & Renshaw, P. F. (2004). In vivo proton magnetic resonance spectroscopy of the temporal lobe in Alzheimer\u2019s disease, 28, 1313\u20131322. \n                    https:\/\/doi.org\/10.1016\/j.pnpbp.2004.08.013\n                    \n                  .","DOI":"10.1016\/j.pnpbp.2004.08.013"},{"key":"9913_CR6","doi-asserted-by":"publisher","unstructured":"Godbolt, A. K., Waldman, A. D., MacManus, D. G., Schott, J. M., Frost, C., Cipolotti, L., \u2026, & Rossor, M. N. (2006). MRS shows abnormalities before symptoms in familial Alzheimer disease. Neurology, 66, 718\u2013722. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000201237.05869.df\n                    \n                  .","DOI":"10.1212\/01.wnl.0000201237.05869.df"},{"issue":"2","key":"9913_CR7","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ejrad.2008.03.002","volume":"67","author":"M Hajek","year":"2008","unstructured":"Hajek, M., & Dezortova, M. (2008). Introduction to clinical in vivo MR spectroscopy. European Journal of Radiology, 67(2), 185\u2013193. \n                    https:\/\/doi.org\/10.1016\/j.ejrad.2008.03.002\n                    \n                  .","journal-title":"European Journal of Radiology"},{"key":"9913_CR8","doi-asserted-by":"publisher","unstructured":"Huang, D., Liu, D., Yin, J., Qian, T., Shrestha, S., & Ni, H. (2016). Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment. European Radiology, 1\u20137. \n                    https:\/\/doi.org\/10.1007\/s00330-016-4669-8\n                    \n                  .","DOI":"10.1007\/s00330-016-4669-8"},{"key":"9913_CR9","doi-asserted-by":"publisher","unstructured":"Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., \u2026, & Trojanowski, J. Q. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer\u2019s pathological cascade. Lancet Neurology, 9(1), 119\u2013128. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(09)70299-6\n                    \n                  .","DOI":"10.1016\/S1474-4422(09)70299-6"},{"key":"9913_CR10","doi-asserted-by":"publisher","unstructured":"Jack, C. R., Vemuri, P., Wiste, H. J., Weigand, S. D., Aisen, P. S., Trojanowski, J. Q., \u2026, & Alzheimer\u2019s Disease Neuroimaging Initiative. (2011). Evidence for ordering of Alzheimer disease biomarkers. Archives of Neurology, 68(12), 1526\u201335. \n                    https:\/\/doi.org\/10.1001\/archneurol.2011.183\n                    \n                  .","DOI":"10.1001\/archneurol.2011.183"},{"key":"9913_CR11","doi-asserted-by":"publisher","unstructured":"Jack, C. R., Knopman, D. S., Jagust, W. J., Petersen, R. C., Weiner, M. W., Aisen, P. S., \u2026, & Trojanowski, J. Q. (2013). Tracking pathophysiological processes in Alzheimer\u2019s disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurology, 12(2), 207\u2013216. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(12)70291-0\n                    \n                  .","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"9913_CR12","doi-asserted-by":"crossref","unstructured":"Kantarci, K., Jack, C. R. Jr., Xu, Y. C., Campeau, N. G., O\u2019Brien, P. C., Smith, G. E., \u2026, & Petersen R.C.. (2000). Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease, a 1H MRS study. Neurology, 55(2), 210\u2013217.","DOI":"10.1212\/WNL.55.2.210"},{"key":"9913_CR13","doi-asserted-by":"publisher","unstructured":"Kantarci, K., Knopman, D. S., Dickson, D. W., Parisi, J. E., Whitwell, J. L., Weigand, S. D., \u2026, & Jack, C. R. (2008). Alzheimer disease: Postmortem neuropathologic correlates of antemortem 1H MR spectroscopy metabolite measurements. Radiology, 248(1), 210\u201320. \n                    https:\/\/doi.org\/10.1148\/radiol.2481071590\n                    \n                  .","DOI":"10.1148\/radiol.2481071590"},{"key":"9913_CR14","doi-asserted-by":"publisher","unstructured":"Katzman, R., Terry, R., DeTeresa, R., Brown, T., Davies, P., Fuld, P., \u2026, & Peck, A. (1988). Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques. Annals of Neurology, 23(2), 138\u2013144. \n                    https:\/\/doi.org\/10.1002\/ana.410230206\n                    \n                  .","DOI":"10.1002\/ana.410230206"},{"key":"9913_CR15","doi-asserted-by":"publisher","unstructured":"Metastasio, A., Rinaldi, P., Tarducci, R., Mariani, E., Feliziani, F. T., Cherubini, A., \u2026, & Mecocci, P. (2006). Conversion of MCI to dementia: role of proton magnetic resonance spectroscopy. Neurobiology of Aging, 27(7), 926\u2013932. \n                    https:\/\/doi.org\/10.1016\/j.neurobiolaging.2005.05.002\n                    \n                  .","DOI":"10.1016\/j.neurobiolaging.2005.05.002"},{"issue":"1","key":"9913_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/0891988706297089","volume":"20","author":"L Minati","year":"2007","unstructured":"Minati, L., Grisoli, M., & Bruzzone, M. G. (2007). MR spectroscopy, functional MRI, and diffusion-tensor imaging in the aging brain: a conceptual review. Journal of Geriatric Psychiatry and Neurology, 20(1), 3\u201321. \n                    https:\/\/doi.org\/10.1177\/0891988706297089\n                    \n                  .","journal-title":"Journal of Geriatric Psychiatry and Neurology"},{"issue":"4","key":"9913_CR17","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1176\/appi.ajp.162.4.667","volume":"162","author":"PJ Modrego","year":"2005","unstructured":"Modrego, P. J., Fayed, N., & Pina, M. A. (2005). Conversion from mild cognitive impairment to probable Alzheimer\u2019s disease predicted by brain magnetic resonance spectroscopy. The American Journal of Psychiatry, 162(4), 667\u2013675. \n                    https:\/\/doi.org\/10.1176\/appi.ajp.162.4.667\n                    \n                  .","journal-title":"The American Journal of Psychiatry"},{"key":"9913_CR18","doi-asserted-by":"publisher","unstructured":"Modrego, P. J., Fayed, N., & Sarasa, M. (2011). Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: A prospective cohort study. BMJ Open, 1(1). \n                    https:\/\/doi.org\/10.1136\/bmjopen-2010-000007\n                    \n                  .","DOI":"10.1136\/bmjopen-2010-000007"},{"issue":"Supplement S1","key":"9913_CR19","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1017\/S1041610297004870","volume":"9","author":"JC Morris","year":"1997","unstructured":"Morris, J. C. (1997). Clinical dementia rating: A reliable and valid diagnostic and staging measure for dementia of the Alzheimer type. International Psychogeriatrics, 9(Supplement S1), 173\u2013176. \n                    https:\/\/doi.org\/10.1017\/S1041610297004870\n                    \n                  .","journal-title":"International Psychogeriatrics"},{"key":"9913_CR20","doi-asserted-by":"publisher","unstructured":"Murray, M. E., Przybelski, S. A., Lesnick, T. G., Liesinger, A. M., Spychalla, A., Zhang, B., \u2026, & Kantarci, K. (2014). Early Alzheimer\u2019s disease neuropathology detected by proton MR spectroscopy. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience, 34(49), 16247\u201355. \n                    https:\/\/doi.org\/10.1523\/JNEUROSCI.2027-14.2014\n                    \n                  .","DOI":"10.1523\/JNEUROSCI.2027-14.2014"},{"issue":"3","key":"9913_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ijnp\/pyu059","volume":"18","author":"J O\u2019Neill","year":"2015","unstructured":"O\u2019Neill, J., Tobias, M. C., Hudkins, M., & London, E. D. (2015). Glutamatergic neurometabolites during early abstinence from chronic methamphetamine abuse. International Journal of Neuropsychopharmacology, 18(3), 1\u20139. \n                    https:\/\/doi.org\/10.1093\/ijnp\/pyu059\n                    \n                  .","journal-title":"International Journal of Neuropsychopharmacology"},{"issue":"4","key":"9913_CR22","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1002\/nbm.698","volume":"14","author":"SW Provencher","year":"2001","unstructured":"Provencher, S. W. (2001). Automatic quantitation of localized in vivo 1H spectra with LCModel. NMR in Biomedicine, 14(4), 260\u2013264. \n                    https:\/\/doi.org\/10.1002\/nbm.698\n                    \n                  .","journal-title":"NMR in Biomedicine"},{"key":"9913_CR23","doi-asserted-by":"publisher","unstructured":"Ringman, J. M., Younkin, S. G., Pratico, D., Seltzer, W., Cole, G. M., Geschwind, D. H., \u2026, & Cummings, J. L. (2008). Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology, 71(2), 85\u201392. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000303973.71803.81\n                    \n                  .","DOI":"10.1212\/01.wnl.0000303973.71803.81"},{"key":"9913_CR24","doi-asserted-by":"publisher","unstructured":"Ryman, D. C., Acosta-Baena, N., Aisen, P. S., Bird, T., Danek, A., Fox, N. C., \u2026, & Bateman, R. J. (2014). Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology, 83(3), 253\u2013260. \n                    https:\/\/doi.org\/10.1212\/WNL.0000000000000596\n                    \n                  .","DOI":"10.1212\/WNL.0000000000000596"},{"issue":"10043","key":"9913_CR25","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","volume":"388","author":"P Scheltens","year":"2016","unstructured":"Scheltens, P., Blennow, K., Breteler, M. M. B., de Strooper, B., Frisoni, G. B., Salloway, S., Van der Flier, & aria, W. M. (2016). Alzheimer\u2019s disease. Lancet (London, England), 388(10043), 505\u2013517. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(15)01124-1\n                    \n                  .","journal-title":"Lancet (London, England)"},{"key":"9913_CR26","doi-asserted-by":"publisher","unstructured":"Seese, R. R., O\u2019Neill, J., Hudkins, M., Siddarth, P., Levitt, J., Tseng, B., \u2026, & Caplan, R. (2011). Proton magnetic resonance spectroscopy and thought disorder in childhood schizophrenia. Schizophrenia Research, 133(1\u20133), 82\u201390.\n                    https:\/\/doi.org\/10.1016\/j.schres.2011.07.011\n                    \n                  .","DOI":"10.1016\/j.schres.2011.07.011"},{"issue":"5","key":"9913_CR27","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1006\/nimg.2000.0730","volume":"13","author":"DW Shattuck","year":"2001","unstructured":"Shattuck, D. W., Sandor-Leahy, S. R., Schaper, K. A., Rottenberg, D. A., & Leahy, R. M. (2001). Magnetic resonance image tissue classification using a partial volume model. NeuroImage, 13(5), 856\u2013876. \n                    https:\/\/doi.org\/10.1006\/nimg.2000.0730\n                    \n                  .","journal-title":"NeuroImage"},{"issue":"1","key":"9913_CR28","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.crad.2008.07.002","volume":"64","author":"DP Soares","year":"2009","unstructured":"Soares, D. P., & Law, M. (2009). Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications. Clinical Radiology, 64(1), 12\u201321. \n                    https:\/\/doi.org\/10.1016\/j.crad.2008.07.002\n                    \n                  .","journal-title":"Clinical Radiology"},{"issue":"1\u20132","key":"9913_CR29","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.jns.2013.08.023","volume":"335","author":"MG Targosz-gajniak","year":"2013","unstructured":"Targosz-gajniak, M. G., Siuda, J. S., Wicher, M. M., Banasik, T. J., Bujak, M. A., Augusciak-duma, A. M., & Opala, G. (2013). Magnetic resonance spectroscopy as a predictor of conversion of mild cognitive impairment to dementia. Journal of the Neurological Sciences, 335(1\u20132), 58\u201363. \n                    https:\/\/doi.org\/10.1016\/j.jns.2013.08.023\n                    \n                  .","journal-title":"Journal of the Neurological Sciences"},{"key":"9913_CR30","doi-asserted-by":"publisher","unstructured":"Wang, H., Tan, L., Wang, H. F., Liu, Y., Yin, R. H., Wang, W. Y., \u2026, & Yu, J. T. (2015). Magnetic resonance spectroscopy in Alzheimer\u2019s disease: systematic review and meta-analysis. Journal of Alzheimer's Disease, 46(4), 1049\u20131070. \n                    https:\/\/doi.org\/10.3233\/JAD-143225\n                    \n                  .","DOI":"10.3233\/JAD-143225"},{"key":"9913_CR31","doi-asserted-by":"crossref","unstructured":"Zhang, N., Song, X., Bartha, R., Beyea, S., D'Arcy, R., Zhang, Y., & Rockwood, K. (2014). Advances in high-field magnetic resonance spectroscopy in Alzheimer\u2019s disease. Current Alzheimer Research, 2014(11), 367\u2013388.","DOI":"10.2174\/1567205011666140302200312"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-018-9913-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11682-018-9913-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-018-9913-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:18:52Z","timestamp":1589739532000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11682-018-9913-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,16]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["9913"],"URL":"https:\/\/doi.org\/10.1007\/s11682-018-9913-1","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"value":"1931-7557","type":"print"},{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,16]]},"assertion":[{"value":"16 June 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}