{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:17:51Z","timestamp":1790691471122,"version":"4.1.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T00:00:00Z","timestamp":1534723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS082386"],"award-info":[{"award-number":["R01NS082386"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R01NR01481"],"award-info":[{"award-number":["R01NR01481"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s11682-018-9938-5","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T04:53:58Z","timestamp":1534740838000},"page":"1246-1254","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Regional leukoaraiosis and cognition in non-demented older adults"],"prefix":"10.1007","volume":"13","author":[{"given":"Margaret E.","family":"Wiggins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared","family":"Tanner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel J.","family":"Crowley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Schmalfuss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette","family":"Brumback","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Libon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine C.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"9938_CR1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013","unstructured":"American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.","edition":"5"},{"issue":"4","key":"9938_CR2","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/WNN.0b013e31815e6265","volume":"20","author":"S Amici","year":"2007","unstructured":"Amici, S., Ogar, J., Brambati, S. M., Miller, B. L., Neuhaus, J., Dronkers, N. L., & Gorno-Tempini, M. L. (2007). Performance in specific language tasks correlates with regional volume changes in progressive aphasia. Cognitive and Behavioral Neurology, 20(4), 203\u2013211. \n                    https:\/\/doi.org\/10.1097\/WNN.0b013e31815e6265\n                    \n                  .","journal-title":"Cognitive and Behavioral Neurology"},{"key":"9938_CR3","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1111\/ene.12511","volume":"21","author":"C Annweiler","year":"2014","unstructured":"Annweiler, C., Annweiler, T., Bartha, R., Hermann, F. R., Camicioli, R., & Beauchet, O. (2014). Vitamin d and white matter abnormalities in older adults: A cross-sectional neuroimaging study. Medical Biophysics Publications, 21, 1436\u20131442. \n                    https:\/\/doi.org\/10.1111\/ene.12511\n                    \n                  .","journal-title":"Medical Biophysics Publications"},{"key":"9938_CR4","volume-title":"Hopkins verbal learning test\u2014Revised. Professional manual","author":"J Brandt","year":"2001","unstructured":"Brandt, J., & Benedict, R. H. B. (2001). Hopkins verbal learning test\u2014Revised. Professional manual. Lutz, FL: Psychological Assessment Resources, Inc.."},{"issue":"2","key":"9938_CR5","first-page":"111","volume":"1","author":"J Brandt","year":"1988","unstructured":"Brandt, J., Spencer, M., & Folstein, M. (1988). The telephone interview for cognitive status. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 1(2), 111\u2013117.","journal-title":"Neuropsychiatry, Neuropsychology, and Behavioral Neurology"},{"issue":"7","key":"9938_CR6","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","volume":"44","author":"MM Breteler","year":"1994","unstructured":"Breteler, M. M., van Swieten, J. C., Bots, M. L., Grobbee, D. E., Claus, J. J., van den Hout, J. H., et al. (1994). Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: The Rotterdam study. Neurology, 44(7), 1246\u20131252.","journal-title":"Neurology"},{"issue":"12","key":"9938_CR7","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1001\/archneurol.2012.1527","volume":"69","author":"AM Brickman","year":"2012","unstructured":"Brickman, A. M., Provenzano, F. A., Muraskin, J., Manly, J. J., Blum, S., Apa, Z., et al. (2012). Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer disease in the community. Archives of Neurology, 69(12), 1621\u20131627. \n                    https:\/\/doi.org\/10.1001\/archneurol.2012.1527\n                    \n                  .","journal-title":"Archives of Neurology"},{"issue":"11","key":"9938_CR8","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/0895-4356(94)90129-5","volume":"47","author":"M Charlson","year":"1994","unstructured":"Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994). Validation of a combined comorbidity index. Journal of Clinical Epidemiology, 47(11), 1245\u20131251.","journal-title":"Journal of Clinical Epidemiology"},{"key":"9938_CR9","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1002\/1097-4679(198705)43:3<368::AID-JCLP2270430309>3.0.CO;2-F","volume":"43","author":"JD Corrigan","year":"1987","unstructured":"Corrigan, J. D., Agresti, A. A., & Hinkeldey, N. S. (1987). Psychometric characteristics of the category test: Replication and extension. Journal of Clinical Psychology, 43, 368\u2013376.","journal-title":"Journal of Clinical Psychology"},{"issue":"3","key":"9938_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/ane.12398","volume":"132","author":"A Del Bene","year":"2015","unstructured":"Del Bene, A., Ciolli, L., Borgheresi, L., Poggesi, A., Inzitari, D., & Pantoni, L. (2015). Is type 2 diabetes related to leukoaraiosis? An updated review. Acta Neurologica Scandinavica, 132(3), 147\u2013155.","journal-title":"Acta Neurologica Scandinavica"},{"issue":"11","key":"9938_CR11","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1212\/01.wnl.0000256697.20968.d7","volume":"68","author":"DP Devanand","year":"2007","unstructured":"Devanand, D. P., Pradhaban, G., Lui, X., Khandji, A., De Santi, S., Segal, S., et al. (2007). Hippocampal and entorhinal atrophy in mild cognitive impairment prediction of Alzheimer disease. Neurology, 68(11), 828\u2013836. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000256697.20968.d7\n                    \n                  .","journal-title":"Neurology"},{"key":"9938_CR12","first-page":"23","volume":"59","author":"T Erkinjuntti","year":"2000","unstructured":"Erkinjuntti, T., Inzitari, D., Pantoni, L., Wallin, A., Scheltens, P., Rockwood, K., Roman, G. C., Chui, H., & Desmond, D. W. (2000). Research criteria for subcortical vascular dementia in clinical trials. Journal of Neural Transmission, 59, 23\u201330.","journal-title":"Journal of Neural Transmission"},{"issue":"5433","key":"9938_CR13","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1126\/science.285.5433.1582","volume":"285","author":"G Fern\u00e1ndez","year":"1999","unstructured":"Fern\u00e1ndez, G., Effern, A., Grunwald, T., Pezer, N., Lehnertz, K., D\u00fcmpelmann, M., et al. (1999). Real-time tracking of memory formation in the human rhinal cortex and hippocampus. Science, 285(5433), 1582\u20131585.","journal-title":"Science"},{"key":"9938_CR14","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","volume":"62","author":"B Fischl","year":"2012","unstructured":"Fischl, B. (2012). Freesurfer. Neuroimage, 62, 774\u2013781.","journal-title":"Neuroimage"},{"issue":"3","key":"9938_CR15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., & Haselgrove, C. (2002). Whole brain segmentation: Automated labeling of neuroanatomical structures in the human brain. Neuron, 33(3), 341\u2013355.","journal-title":"Neuron"},{"issue":"5","key":"9938_CR16","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1159\/000117055","volume":"34","author":"T Fukui","year":"1994","unstructured":"Fukui, T., Sugita, K., Sato, Y., Takeuchi, T., & Tsukagoshi, H. (1994). Cognitive functions in subjects with incidental cerebral hyperintensities. European Neurology, 34(5), 272\u2013276.","journal-title":"European Neurology"},{"issue":"3","key":"9938_CR17","first-page":"169","volume":"4","author":"JM Fuster","year":"1985","unstructured":"Fuster, J. M. (1985). The prefrontal cortex, mediator of cross-temporal contingencies. Human Neurobiology, 4(3), 169\u2013179.","journal-title":"Human Neurobiology"},{"key":"9938_CR18","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/1531-8249(200002)47:2<145::AID-ANA3>3.0.CO;2-P","volume":"47","author":"JC de Groot","year":"2000","unstructured":"de Groot, J. C., de Leeuw, F. E., Oudkerk, M., van Gijn, J., Hofman, A., Jolles, J., & Breteler, M. M. (2000). Cerebral white matter lesions and cognitive function: The Rotterdam scan study. Annals of Neurology, 47, 145\u2013151.","journal-title":"Annals of Neurology"},{"key":"9938_CR19","first-page":"533","volume":"13","author":"VC Hachinski","year":"1986","unstructured":"Hachinski, V. C., Potter, P., & Merskey, H. (1986). Leuko-araiosis: An ancient term for a new problem. Le Journal Canadien des Sciences Neurologiques, 13, 533\u2013534.","journal-title":"Le Journal Canadien des Sciences Neurologiques"},{"key":"9938_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1001\/archneur.1987.00520130013009","volume":"44","author":"VC Hachinski","year":"1987","unstructured":"Hachinski, V. C., Potter, P., & Merskey, H. (1987). Leuko-araiosis. Archives of Neurology, 44, 21\u201323.","journal-title":"Archives of Neurology"},{"key":"9938_CR21","volume-title":"Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults","author":"R Heaton","year":"2004","unstructured":"Heaton, R., Miller, W., Taylor, M., & Grant, I. (2004). Revised comprehensive norms for an expanded Halstead-Reitan battery: Demographically adjusted neuropsychological norms for African American and Caucasian adults. Lutz, FL: Psychological Assessment Resources, Inc.."},{"issue":"5","key":"9938_CR22","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1001\/archneur.59.5.787","volume":"59","author":"E Hogervorst","year":"2002","unstructured":"Hogervorst, E., Ribiero, H. M., Molyneux, A., Budge, M., & Smith, A. D. (2002). Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer disease. Archives of Neurology, 59(5), 788\u2013793.","journal-title":"Archives of Neurology"},{"issue":"5","key":"9938_CR23","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1097\/JGP.0b013e31819431d5","volume":"17","author":"AJ Jak","year":"2009","unstructured":"Jak, A. J., Bondi, M. W., Delano-Wood, L., Wierenga, C., Corey-Bloom, J., Salmon, D. P., & Delis, D. C. (2009). Quantification of five neuropsychological approaches to defining mild cognitive impairment. The American Journal of Geriatric Psychiatry, 17(5), 368\u2013375.","journal-title":"The American Journal of Geriatric Psychiatry"},{"key":"9938_CR24","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","volume":"62","author":"M Jenkinson","year":"2012","unstructured":"Jenkinson, M., Beckmann, C. F., Behrens, T. E., Woolrich, M. W., & Smith, S. M. (2012). FSL. Neuroimage, 62, 782\u2013790.","journal-title":"Neuroimage"},{"key":"9938_CR25","doi-asserted-by":"crossref","unstructured":"Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage, 17, 825\u2013841.","DOI":"10.1006\/nimg.2002.1132"},{"issue":"2","key":"9938_CR26","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1001\/archneur.1990.00530020047013","volume":"47","author":"C Junqu\u00e9","year":"1990","unstructured":"Junqu\u00e9, C., Jes\u00fas, P., Vandrell, P., Bruna, O., J\u00f3dar, M., Ribas, J., et al. (1990). Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Archives of Neurology, 47(2), 151\u2013156. \n                    https:\/\/doi.org\/10.1001\/archneur.1990.00530020047013\n                    \n                  .","journal-title":"Archives of Neurology"},{"key":"9938_CR27","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1155\/2010\/505979","volume":"22","author":"M Lamar","year":"2009","unstructured":"Lamar, M., Price, C. C., Giovannetti, T., Swenson, R., & Libon, D. J. (2009\/2010). The dysexecutive syndrome associated with ischaemic vascular disease and related subcortical neuropathology: A Boston process approach. Behavioral Neurology, 22, 53\u201362. \n                    https:\/\/doi.org\/10.3233\/BEN-2009-0237\n                    \n                  .","journal-title":"Behavioral Neurology"},{"issue":"3","key":"9938_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","volume":"9","author":"MP Lawton","year":"1969","unstructured":"Lawton, M. P., & Brody, E. M. (1969). Assessment of older people: Self-maintaining and instrumental activities of daily living. The Gerontologist, 9(3), 179\u2013186.","journal-title":"The Gerontologist"},{"issue":"6","key":"9938_CR29","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1046\/j.1468-1331.1999.660653.x","volume":"6","author":"M Leskel\u00e4","year":"1999","unstructured":"Leskel\u00e4, M., Hietanen, M., Kalska, H., Ylikoski, R., Pohjasvaara, T., M\u00e4ntyl\u00e4, R., & Erkinjuntti, T. (1999). Executive functions and speed of mental processing in elderly patients with frontal or nonfrontal ischemic stroke. European Journal of Neurology, 6(6), 653\u2013661.","journal-title":"European Journal of Neurology"},{"key":"9938_CR30","volume-title":"Neuropsychological Assessment (5th Ed.)","author":"MD Lezak","year":"2012","unstructured":"Lezak, M. D., Howieson, D., Bigler, E., & Tranel, D. (2012). Neuropsychological Assessment (5th Ed.). New York: Oxford University press."},{"key":"9938_CR31","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1161\/01.STR.27.12.2262","volume":"27","author":"D Liao","year":"1996","unstructured":"Liao, D., Cooper, L., Cai, J., Toole, J. F., Bryan, N. R., Hutchinson, R. G., & Tyroler, H. A. (1996). Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC Study. Stroke, 27, 2262\u20132270. \n                    https:\/\/doi.org\/10.1161\/01.STR.27.12.2262\n                    \n                  .","journal-title":"Stroke"},{"key":"9938_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/13854040490507181","volume":"18","author":"DJ Libon","year":"2004","unstructured":"Libon, D. J., Price, C. C., Garrett, K. D., & Giovannetti, T. (2004). From Binswanger\u2019s disease to leukoaraiosis: What we have learned about subcortical vascular dementia. The Clinical Neuropsychologist, 18, 83\u2013100. \n                    https:\/\/doi.org\/10.1080\/13854040490507181\n                    \n                  .","journal-title":"The Clinical Neuropsychologist"},{"key":"9938_CR33","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1161\/STROKEAHA.107.489997","volume":"39","author":"D Libon","year":"2008","unstructured":"Libon, D., Price, C. C., Giovannetti, T., Swenson, R., Bettcher, B. M., Heilman, K., & Pennisi, A. (2008). Linking MRI hyperintensities with patterns of neuropsychological impairment: Evidence for a threshold effect. Stroke, 39, 806\u2013813. \n                    https:\/\/doi.org\/10.1161\/STROKEAHA.107.489997\n                    \n                  .","journal-title":"Stroke"},{"key":"9938_CR34","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.nicl.2017.01.022","volume":"14","author":"ER Lindemer","year":"2017","unstructured":"Lindemer, E. R., Greve, D. N., Fischl, B. R., Augustinack, J. C., & Salat, D. H. (2017). Regional staging of white matter signal abnormalities in aging and Alzheimer\u2019s disease. Neuroimage: Clinical, 14, 156\u2013165. \n                    https:\/\/doi.org\/10.1016\/j.nicl.2017.01.022\n                    \n                  .","journal-title":"Neuroimage: Clinical"},{"issue":"5","key":"9938_CR35","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/01.STR.25.5.929","volume":"25","author":"A Lindgren","year":"1994","unstructured":"Lindgren, A., Roijer, A., Rudling, O., Norrving, B., Larson, E. M., Eskilsson, J., et al. (1994). Cerebral lesions on magnetic resonance imaging, heart disease, and vascular risk factors in subjects without stroke. A population-based study. Stroke, 25(5), 929\u2013934.","journal-title":"Stroke"},{"issue":"4","key":"9938_CR36","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.neuroimage.2010.05.019","volume":"52","author":"S Michielse","year":"2010","unstructured":"Michielse, S., Coupland, N., Camicioli, R., Carter, R., Seres, P., Sabino, J., & Malykhin, N. (2010). Selective effects of aging on brain white matter microstructure: A diffusion tensor imaging tractography study. NeuroImage, 52(4), 1190\u20131201.","journal-title":"NeuroImage"},{"issue":"3","key":"9938_CR37","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1212\/01.WNL.0000168877.06011.15","volume":"65","author":"CC Price","year":"2005","unstructured":"Price, C. C., Jefferson, A. L., Merino, J. G., Heilman, K. M., & Libon, D. J. (2005). Subcortical vascular dementia: Integrating neuropsychological and neuroradiologic data. Neurology, 65(3), 376\u2013382. \n                    https:\/\/doi.org\/10.1212\/01.wnl.0000168877.06011.15\n                    \n                  .","journal-title":"Neurology"},{"key":"9938_CR38","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1212\/WNL.0b013e3182661ef6","volume":"79","author":"CC Price","year":"2012","unstructured":"Price, C. C., Mitchell, S. M., Brumback, B., Tanner, J. J., Schmalfuss, I., Lamar, M., et al. (2012). MRI-leukoaraiosis thresholds and the phenotypic expression of dementia. Neurology, 79, 734\u2013740.","journal-title":"Neurology"},{"issue":"3","key":"9938_CR39","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3233\/JAD-150407","volume":"48","author":"CC Price","year":"2015","unstructured":"Price, C. C., Tanner, J. J., Schmalfuss, I. M., Brumback, B., Heilman, K. M., & Libon, D. J. (2015). Dissociating statistically-determined Alzheimer\u2019s disease\/vascular dementia neuropsychological syndromes using white and gray Neuroradiological parameters. Journal of Alzheimer\u2019s Disease, 48(3), 833\u2013847.","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"9938_CR40","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","volume":"8","author":"RM Reitan","year":"1958","unstructured":"Reitan, R. M. (1958). Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271\u2013276.","journal-title":"Perceptual and Motor Skills"},{"issue":"12","key":"9938_CR41","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1212\/WNL.43.12.2490","volume":"43","author":"R Schmidt","year":"1993","unstructured":"Schmidt, R., Fazekas, F., Offenbacher, H., Dusek, T., Zach, E., Reinhard, B., et al. (1993). Neuropsychologic correlates of MRI white matter hyperintensities: A study of 150 normal volunteers. Neurology, 43(12), 2490\u20132494.","journal-title":"Neurology"},{"issue":"1","key":"9938_CR42","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1212\/WNL.53.1.132","volume":"53","author":"R Schmidt","year":"1999","unstructured":"Schmidt, R., Fazekas, F., Kapeller, P., Schmidt, H., & Hartung, H. P. (1999). MRI white matter hyperintensities: Three-year follow-up of the Austrian stroke prevention study. Neurology, 53(1), 132\u2013139.","journal-title":"Neurology"},{"issue":"9","key":"9938_CR43","first-page":"1964","volume":"27","author":"A Spilt","year":"2006","unstructured":"Spilt, A., Goekoop, R., Westendorp, R. G., Blauw, G. J., de Craen, A. J., & van Buchem, M. A. (2006). Not all age-related white matter hyperintensities are the same: A magnetization transfer imaging study. American Journal of Neuroradiology, 27(9), 1964\u20131968.","journal-title":"American Journal of Neuroradiology"},{"issue":"8","key":"9938_CR44","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1001\/archneur.1996.00550080056013","volume":"53","author":"JC Stout","year":"1996","unstructured":"Stout, J. C., Jernigan, T. L., Archibald, S. L., & Salmon, D. P. (1996). Association of dementia severity with cortical gray matter and abnormal white matter volumes in dementia of the Alzheimer type. Archives of Neurology, 53(8), 742\u2013749.","journal-title":"Archives of Neurology"},{"issue":"5","key":"9938_CR45","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1017\/S1355617711000695","volume":"17","author":"DT Stuss","year":"2011","unstructured":"Stuss, D. T. (2011). Functions of the frontal lobes: Relation to executive functions. Journal of the International Neuropsychological Society, 17(5), 759\u2013765.","journal-title":"Journal of the International Neuropsychological Society"},{"issue":"8","key":"9938_CR46","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1001\/archpsyc.63.8.916","volume":"63","author":"MH Tabert","year":"2006","unstructured":"Tabert, M. H., Manly, J. J., Lui, X., Pelton, G. H., Rosenblum, S., Jacobs, M., et al. (2006). Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry, 63(8), 916\u2013924. \n                    https:\/\/doi.org\/10.1001\/archpsyc.63.8.916\n                    \n                  .","journal-title":"Archives of General Psychiatry"},{"issue":"3","key":"9938_CR47","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000090677","volume":"21","author":"H Tomimoto","year":"2006","unstructured":"Tomimoto, H., Ohtani, R., Wakita, H., Lin, J. X., Ihara, M., Miki, Y., et al. (2006). Small artery dementia in Japan: Radiological differences between CADASIL, leukoaraiosis and Binswanger's disease. Dementia and Geriatric Cognitive Disorders, 21(3), 169\u2013169. \n                    https:\/\/doi.org\/10.1159\/000090677\n                    \n                  .","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"7","key":"9938_CR48","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1001\/jamaneurol.2014.667","volume":"71","author":"G Tosto","year":"2014","unstructured":"Tosto, G., Zimmerman, M. E., Carmichael, O. T., & Brickman, A. M. (2014). Predicting aggressive decline in mild cognitive impairment: The importance of white matter hyperintensities. JAMA Neurology, 71(7), 872\u2013877. \n                    https:\/\/doi.org\/10.1001\/jamaneurol.2014.667\n                    \n                  .","journal-title":"JAMA Neurology"},{"issue":"12","key":"9938_CR49","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1016\/j.jalz.2015.05.014","volume":"11","author":"G Tosto","year":"2015","unstructured":"Tosto, G., Zimmerman, M. E., Hamilton, J. L., Carmichael, O. T., & Brickman, A. M. (2015). The effect of white matter hyperintensities on neurodegeneration in mild cognitive impairment. Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association, 11(12), 1510\u20131519. \n                    https:\/\/doi.org\/10.1016\/j.jalz.2015.05.014\n                    \n                  .","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"10","key":"9938_CR50","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/S0028-3932(03)00059-9","volume":"41","author":"YD Van der Werf","year":"2003","unstructured":"Van der Werf, Y. D., Scheltens, P., Lindeboom, J., Witter, M. P., Uylings, H. B., & Jolles, J. (2003). Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localized lesions. Neuropsychologia, 41(10), 1330\u20131344.","journal-title":"Neuropsychologia"},{"key":"9938_CR51","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpsychires.2014.05.005","volume":"56","author":"L Wang","year":"2014","unstructured":"Wang, L., Leonards, C. O., Sterzer, P., & Ebinger, M. (2014). White matter lesions and depression: A systematic review and meta-analysis. Journal of Psychiatric Research, 56, 56\u201364.","journal-title":"Journal of Psychiatric Research"},{"key":"9938_CR52","volume-title":"Wechsler memory scale (WMS-III)","author":"D Wechsler","year":"1997","unstructured":"Wechsler, D. (1997). Wechsler memory scale (WMS-III) (Vol. 14). San Antonio, TX: Psychological corporation."},{"key":"9938_CR53","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1016\/j.neuroimage.2010.09.005","volume":"54","author":"DA Wolk","year":"2011","unstructured":"Wolk, D. A., & Dickerson, B. C. (2011). Fractionating verbal episodic memory in Alzheimer\u2019s disease. Neuroimage, 54, 1530\u20131539.","journal-title":"Neuroimage"},{"issue":"1","key":"9938_CR54","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0022-3956(82)90033-4","volume":"17","author":"JA Yesavage","year":"1982","unstructured":"Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17(1), 37\u201349.","journal-title":"Journal of Psychiatric Research"},{"issue":"8","key":"9938_CR55","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1001\/archneur.1993.00540080029009","volume":"50","author":"R Ylikoski","year":"1993","unstructured":"Ylikoski, R., Ylikoski, A., Erkinjuntti, T., Sulkava, R., Raininko, R., & Tilvis, R. (1993). White matter changes in healthy elderly persons correlate with attention and speed of mental processing. Archives of Neurology, 50(8), 818\u2013824.","journal-title":"Archives of Neurology"},{"issue":"3","key":"9938_CR56","doi-asserted-by":"publisher","first-page":"443","DOI":"10.2214\/ajr.146.3.443","volume":"146","author":"RD Zimmerman","year":"1986","unstructured":"Zimmerman, R. D., Fleming, C. A., & Lee, B. C. (1986). Periventricular hyperintensity as seen by magnetic resonance: Prevalence and significance. American Journal of Roentgenology, 146(3), 443\u2013450.","journal-title":"American Journal of Roentgenology"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-018-9938-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11682-018-9938-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-018-9938-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T18:19:41Z","timestamp":1589739581000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11682-018-9938-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["9938"],"URL":"https:\/\/doi.org\/10.1007\/s11682-018-9938-5","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"value":"1931-7557","type":"print"},{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,20]]},"assertion":[{"value":"20 August 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, and the applicable revisions at the time of the investigation. Informed consent was obtained from all patients for being included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}