{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:57:11Z","timestamp":1780487831539,"version":"3.54.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Thai Government Fund","award":["GRB_APS_07_57_30_05"],"award-info":[{"award-number":["GRB_APS_07_57_30_05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s11682-019-00182-9","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T20:05:33Z","timestamp":1566331533000},"page":"1665-1673","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Early prediction of donepezil cognitive response in Alzheimer\u2019s disease by brain perfusion single photon emission tomography"],"prefix":"10.1007","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6092-0488","authenticated-orcid":false,"given":"Supatporn","family":"Tepmongkol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solaphat","family":"Hemrungrojn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavit","family":"Tunvirachaisakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daruj","family":"Aniwattanapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuttachai","family":"Likitjareon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thitiporn","family":"Supasitthumrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itthipol","family":"Tawankanjanachot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natakorn","family":"Siritranon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phenphichcha","family":"Chuchuen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buntipa","family":"Natsawang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sookjaroen","family":"Tangwongchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"182_CR1","unstructured":"Alzheimer's association (2016). Current Alzheimer's treatment. www.alz.org. Accessed December 12 2016."},{"key":"182_CR2","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.dadm.2017.03.007","volume":"8","author":"A Badhwar","year":"2017","unstructured":"Badhwar, A., Tam, A., Dansereau, C., Orban, P., Hoffstaedter, F., & Bellec, P. (2017). Resting-state network dysfunction in Alzheimer's disease: A systematic review and meta-analysis. Alzheimers Dement (Amst), 8, 73\u201385. \nhttps:\/\/doi.org\/10.1016\/j.dadm.2017.03.007\n\n.","journal-title":"Alzheimers Dement (Amst)"},{"issue":"4","key":"182_CR3","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/00002093-200210000-00001","volume":"16","author":"WW Barker","year":"2002","unstructured":"Barker, W. W., Luis, C. A., Kashuba, A., Luis, M., Harwood, D. G., Loewenstein, D., et al. (2002). Relative frequencies of Alzheimer disease, Lewy body, vascular and frontotemporal dementia, and hippocampal sclerosis in the State of Florida Brain Bank. Alzheimer Disease and Associated Disorders, 16(4), 203\u2013212.","journal-title":"Alzheimer Disease and Associated Disorders"},{"issue":"11","key":"182_CR4","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1185\/030079905X65655","volume":"21","author":"L Bartorelli","year":"2005","unstructured":"Bartorelli, L., Giraldi, C., Saccardo, M., Cammarata, S., Bottini, G., Fasanaro, A. M., et al. (2005). Effects of switching from an AChE inhibitor to a dual AChE-BuChE inhibitor in patients with Alzheimer's disease. Current Medical Research and Opinion, 21(11), 1809\u20131817. \nhttps:\/\/doi.org\/10.1185\/030079905X65655\n\n.","journal-title":"Current Medical Research and Opinion"},{"issue":"1","key":"182_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2165\/00002512-200421010-00004","volume":"21","author":"M Boada-Rovira","year":"2004","unstructured":"Boada-Rovira, M., Brodaty, H., Cras, P., Baloyannis, S., Emre, M., Zhang, R., et al. (2004). Efficacy and safety of donepezil in patients with Alzheimer's disease: results of a global, multinational, clinical experience study. Drugs & Aging, 21(1), 43\u201353.","journal-title":"Drugs & Aging"},{"issue":"3","key":"182_CR6","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0304-3940(01)01586-5","volume":"300","author":"P Davidsson","year":"2001","unstructured":"Davidsson, P., Blennow, K., Andreasen, N., Eriksson, B., Minthon, L., & Hesse, C. (2001). Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease. Neuroscience Letters, 300(3), 157\u2013160. \nhttps:\/\/doi.org\/10.1016\/S0304-3940(01)01586-5\n\n.","journal-title":"Neuroscience Letters"},{"issue":"4","key":"182_CR7","doi-asserted-by":"publisher","first-page":"969","DOI":"10.3233\/jad-150747","volume":"50","author":"M Gallucci","year":"2016","unstructured":"Gallucci, M., Spagnolo, P., Arico, M., & Grossi, E. (2016). Predictors of Response to Cholinesterase Inhibitors Treatment of Alzheimer's Disease: Date Mining from the TREDEM Registry. Journal of Alzheimer's Disease, 50(4), 969\u2013979. \nhttps:\/\/doi.org\/10.3233\/jad-150747\n\n.","journal-title":"Journal of Alzheimer's Disease"},{"issue":"6","key":"182_CR8","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1159\/000181148","volume":"26","author":"J Hongo","year":"2008","unstructured":"Hongo, J., Nakaaki, S., Shinagawa, Y., Murata, Y., Sato, J., Tatsumi, H., et al. (2008). SPECT-identified neuroanatomical predictor of the cognitive effects of donepezil treatment in patients with Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 26(6), 556\u2013566. \nhttps:\/\/doi.org\/10.1159\/000181148\n\n.","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"9","key":"182_CR9","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1016\/j.neurobiolaging.2014.04.006","volume":"35","author":"V Kljajevic","year":"2014","unstructured":"Kljajevic, V., Grothe, M. J., Ewers, M., & Teipel, S. (2014). Distinct pattern of hypometabolism and atrophy in preclinical and predementia Alzheimer's disease. Neurobiology of Aging, 35(9), 1973\u20131981. \nhttps:\/\/doi.org\/10.1016\/j.neurobiolaging.2014.04.006\n\n.","journal-title":"Neurobiology of Aging"},{"key":"182_CR10","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neuroimage.2013.04.011","volume":"78","author":"W Li","year":"2013","unstructured":"Li, W., Qin, W., Liu, H., Fan, L., Wang, J., Jiang, T., et al. (2013). Subregions of the human superior frontal gyrus and their connections. Neuroimage, 78, 46\u201358. \nhttps:\/\/doi.org\/10.1016\/j.neuroimage.2013.04.011\n\n.","journal-title":"Neuroimage"},{"issue":"11","key":"182_CR11","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1007\/s00259-016-3417-2","volume":"43","author":"C Liguori","year":"2016","unstructured":"Liguori, C., Chiaravalloti, A., Sancesario, G., Stefani, A., Sancesario, G. M., Mercuri, N. B., et al. (2016). Cerebrospinal fluid lactate levels and brain [18F] FDG PET hypometabolism within the default mode network in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 43(11), 2040\u20132049. \nhttps:\/\/doi.org\/10.1007\/s00259-016-3417-2\n\n.","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"issue":"1","key":"182_CR12","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/brain.2016.0438","volume":"7","author":"LE Mak","year":"2017","unstructured":"Mak, L. E., Minuzzi, L., MacQueen, G., Hall, G., Kennedy, S. H., & Milev, R. (2017). The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis. Brain Connectivity, 7(1), 25\u201333. \nhttps:\/\/doi.org\/10.1089\/brain.2016.0438\n\n.","journal-title":"Brain Connectivity"},{"issue":"4","key":"182_CR13","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.neuroimage.2007.05.042","volume":"37","author":"N Makris","year":"2007","unstructured":"Makris, N., Papadimitriou, G. M., Sorg, S., Kennedy, D. N., Caviness, V. S., & Pandya, D. N. (2007). The occipitofrontal fascicle in humans: a quantitative, in vivo, DT-MRI study. Neuroimage, 37(4), 1100\u20131111. \nhttps:\/\/doi.org\/10.1016\/j.neuroimage.2007.05.042\n\n.","journal-title":"Neuroimage"},{"issue":"3","key":"182_CR14","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","volume":"7","author":"GM McKhann","year":"2011","unstructured":"McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Jr., Kawas, C. H., et al. (2011). The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement, 7(3), 263\u2013269. \nhttps:\/\/doi.org\/10.1016\/j.jalz.2011.03.005\n\n.","journal-title":"Alzheimers Dement"},{"issue":"2","key":"182_CR15","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1176\/jnp.12.2.209","volume":"12","author":"MS Mega","year":"2000","unstructured":"Mega, M. S., Dinov, I. D., Lee, L., O'Connor, S. M., Masterman, D. M., Wilen, B., et al. (2000). Orbital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 12(2), 209\u2013218. \nhttps:\/\/doi.org\/10.1176\/jnp.12.2.209\n\n.","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"issue":"2","key":"182_CR16","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3233\/jad-142148","volume":"45","author":"LF Miranda","year":"2015","unstructured":"Miranda, L. F., Gomes, K. B., Silveira, J. N., Pianetti, G. A., Byrro, R. M., Peles, P. R., et al. (2015). Predictive factors of clinical response to cholinesterase inhibitors in mild and moderate Alzheimer's disease and mixed dementia: a one-year naturalistic study. Journal of Alzheimer's Disease, 45(2), 609\u2013620. \nhttps:\/\/doi.org\/10.3233\/jad-142148\n\n.","journal-title":"Journal of Alzheimer's Disease"},{"issue":"8","key":"182_CR17","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/S1388-2457(02)00110-4","volume":"113","author":"Flavio Nobili","year":"2002","unstructured":"Nobili, F., Vitali, P., Canfora, M., Girtler, N., De Leo, C., Mariani, G., et al. (2002). Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients. Clinical Neurophysiology, 113(8), 1241\u20131248.","journal-title":"Clinical Neurophysiology"},{"issue":"5\u20136","key":"182_CR18","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00228-005-0946-1","volume":"61","author":"R Raschetti","year":"2005","unstructured":"Raschetti, R., Maggini, M., Sorrentino, G. C., Martini, N., Caffari, B., & Vanacore, N. (2005). A cohort study of effectiveness of acetylcholinesterase inhibitors in Alzheimer's disease. European Journal of Clinical Pharmacology, 61(5\u20136), 361\u2013368. \nhttps:\/\/doi.org\/10.1007\/s00228-005-0946-1\n\n.","journal-title":"European Journal of Clinical Pharmacology"},{"issue":"3","key":"182_CR19","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1517\/17425255.1.3.527","volume":"1","author":"B Seltzer","year":"2005","unstructured":"Seltzer, B. (2005). Donepezil: a review. Expert Opinion on Drug Metabolism & Toxicology, 1(3), 527\u2013536. \nhttps:\/\/doi.org\/10.1517\/17425255.1.3.527\n\n.","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"issue":"8","key":"182_CR20","doi-asserted-by":"publisher","first-page":"6449","DOI":"10.1007\/s12035-017-0848-0","volume":"55","author":"S Tangwongchai","year":"2018","unstructured":"Tangwongchai, S., Supasitthumrong, T., Hemrunroj, S., Tunvirachaisakul, C., Chuchuen, P., Houngngam, N., et al. (2018). In Thai nationals, the ApoE4 allele affects multiple domains of neuropsychological, biobehavioral, and social functioning thereby contributing to Alzheimer's disorder, while the ApoE3 allele protects against neuropsychiatric symptoms and psychosocial deficits. Molecular Neurobiology, 55(8), 6449\u20136462. \nhttps:\/\/doi.org\/10.1007\/s12035-017-0848-0\n\n.","journal-title":"Molecular Neurobiology"},{"issue":"8","key":"182_CR21","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1007\/s00234-008-0401-y","volume":"50","author":"M Tateno","year":"2008","unstructured":"Tateno, M., Kobayashi, S., Utsumi, K., Morii, H., & Fujii, K. (2008). Quantitative analysis of the effects of donepezil on regional cerebral blood flow in Alzheimer's disease by using an automated program, 3DSRT. Neuroradiology, 50(8), 723\u2013727. \nhttps:\/\/doi.org\/10.1007\/s00234-008-0401-y\n\n.","journal-title":"Neuroradiology"},{"issue":"2","key":"182_CR22","first-page":"110","volume":"12","author":"C Tranfaglia","year":"2009","unstructured":"Tranfaglia, C., Palumbo, B., Siepi, D., Sinzinger, H., & Parnetti, L. (2009). Semi-quantitative analysis of perfusion of Brodmann areas in the differential diagnosis of cognitive impairment in Alzheimer's disease, fronto-temporal dementia and mild cognitive impairment. Hellenic Journal of Nuclear Medicine, 12(2), 110\u2013114.","journal-title":"Hellenic Journal of Nuclear Medicine"},{"issue":"1\u20132","key":"182_CR23","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000487232","volume":"45","author":"C Tunvirachaisakul","year":"2018","unstructured":"Tunvirachaisakul, C., Supasitthumrong, T., Tangwongchai, S., Hemrunroj, S., Chuchuen, P., Tawankanjanachot, I., et al. (2018). Characteristics of mild cognitive impairment using the Thai version of the consortium to establish a registry for Alzheimer's disease tests: a multivariate and machine learning study. Dementia and Geriatric Cognitive Disorders, 45(1\u20132), 38\u201348. \nhttps:\/\/doi.org\/10.1159\/000487232\n\n.","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"issue":"11","key":"182_CR24","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1007\/s00259-002-0883-5","volume":"29","author":"A Varrone","year":"2002","unstructured":"Varrone, A., Pappata, S., Caraco, C., Soricelli, A., Milan, G., Quarantelli, M., et al. (2002). Voxel-based comparison of rCBF SPET images in frontotemporal dementia and Alzheimer's disease highlights the involvement of different cortical networks. European Journal of Nuclear Medicine and Molecular Imaging, 29(11), 1447\u20131454. \nhttps:\/\/doi.org\/10.1007\/s00259-002-0883-5\n\n.","journal-title":"European Journal of Nuclear Medicine and Molecular Imaging"},{"issue":"1","key":"182_CR25","doi-asserted-by":"publisher","first-page":"137","DOI":"10.3233\/jad-142589","volume":"47","author":"JF Waring","year":"2015","unstructured":"Waring, J. F., Tang, Q., Robieson, W. Z., King, D. P., Das, U., Dubow, J., et al. (2015). APOE-varepsilon4 carrier status and donepezil response in patients with Alzheimer's disease. Journal of Alzheimer's Disease, 47(1), 137\u2013148. \nhttps:\/\/doi.org\/10.3233\/jad-142589\n\n.","journal-title":"Journal of Alzheimer's Disease"},{"key":"182_CR26","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.cortex.2017.08.018","volume":"96","author":"M Wegrzyn","year":"2017","unstructured":"Wegrzyn, M., Herbert, C., Ethofer, T., Flaisch, T., & Kissler, J. (2017). Auditory attention enhances processing of positive and negative words in inferior and superior prefrontal cortex. Cortex, 96, 31\u201345. \nhttps:\/\/doi.org\/10.1016\/j.cortex.2017.08.018\n\n.","journal-title":"Cortex"},{"issue":"1","key":"182_CR27","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0028-3932(98)00044-X","volume":"37","author":"CL Wiggs","year":"1999","unstructured":"Wiggs, C. L., Weisberg, J., & Martin, A. (1999). Neural correlates of semantic and episodic memory retrieval. Neuropsychologia, 37(1), 103\u2013118.","journal-title":"Neuropsychologia"},{"issue":"10","key":"182_CR28","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s40263-016-0356-1","volume":"30","author":"T Xiao","year":"2016","unstructured":"Xiao, T., Jiao, B., Zhang, W., Tang, B., & Shen, L. (2016). Effect of the CYP2D6 and APOE polymorphisms on the efficacy of donepezil in patients with Alzheimer\u2019s disease: a systematic review and meta-analysis. CNS Drugs, 30(10), 899\u2013907. \nhttps:\/\/doi.org\/10.1007\/s40263-016-0356-1\n\n.","journal-title":"CNS Drugs"},{"issue":"5","key":"182_CR29","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s12149-007-0022-2","volume":"21","author":"T Yoshida","year":"2007","unstructured":"Yoshida, T., Ha-Kawa, S., Yoshimura, M., Nobuhara, K., Kinoshita, T., & Sawada, S. (2007). Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's disease. Annals of Nuclear Medicine, 21(5), 257\u2013265. \nhttps:\/\/doi.org\/10.1007\/s12149-007-0022-2\n\n.","journal-title":"Annals of Nuclear Medicine"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-019-00182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11682-019-00182-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-019-00182-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:10:47Z","timestamp":1597795847000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11682-019-00182-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["182"],"URL":"https:\/\/doi.org\/10.1007\/s11682-019-00182-9","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"value":"1931-7557","type":"print"},{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"assertion":[{"value":"20 August 2019","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and with the 1964 Helsinki declaration and its later amendments.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that they have no conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}