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All patients consented to participate after being informed of the study\u2019s purpose. All procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. Participants received a monetary compensation for completing the entire study. This study was registered on the ClinicalTrials.gov website (NCT01405495).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"WEH has received speaker honoraria from CHUGAI, EISAI, Janssen, Lundbeck, Otsuka, and UCB, unrelated to the content of this manuscript. The other authors declare they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}