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Here, we investigate the relationship between the fronto-striatal D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability and response inhibition in a selected population of healthy OPRM1 G-allele carriers. Twenty-two participants successively underwent blood-oxygen level dependent functional magnetic resonance imaging (fMRI) while performing a stop-signal task and a separate positron emission tomography (PET) scan. Striatal and extrastriatal D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability was measured using the radiotracer [<jats:sup>18<\/jats:sup>F]fallypride. Caudate D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability positively correlated with stopping-related fronto-striatal fMRI activation. In addition, right prefrontal D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability correlated positively with stopping-related striatal fMRI BOLD signal. Our study partially replicates previous findings on correlations between striatal D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability and response inhibition in a population selected for its genetic determination of dopamine response to alcohol and as a modulator of impulse control via the endogenous opioid system. We confirm the important role of D<jats:sub>2<\/jats:sub>\/D<jats:sub>3<\/jats:sub> dopamine receptor availability in the fronto-striatal neural circuit for response inhibition. Moreover, we extend previous findings suggesting that dopamine receptor availability in the right inferior frontal cortex, a crucial region of the stopping network, is also strongly associated with stopping-related striatal fMRI activity in healthy OPRM1 G-allele carriers.<\/jats:p>","DOI":"10.1007\/s11682-021-00491-y","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T05:03:02Z","timestamp":1629176582000},"page":"186-198","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prefrontal and striatal dopamine D2\/D3 receptors correlate with fMRI BOLD activation during stopping"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8241-3682","authenticated-orcid":false,"given":"Philippe","family":"Pfeifer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Georg","family":"Buchholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph P.","family":"Kaller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Gr\u00fcnder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Fehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Schreckenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"T\u00fcscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"491_CR1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1037\/a0022112","volume":"23","author":"ZW Adams","year":"2011","unstructured":"Adams, Z. 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