{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T06:00:05Z","timestamp":1772776805963,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"projects of leading talents in pearl river talent plan of guangdong province","award":["No. 81000-42020004"],"award-info":[{"award-number":["No. 81000-42020004"]}]},{"name":"guangzhou science, technology and innovation commission","award":["No. 202102080580"],"award-info":[{"award-number":["No. 202102080580"]}]},{"DOI":"10.13039\/501100003453","name":"natural science foundation of guangdong province","doi-asserted-by":"publisher","award":["No. 2021A1515011433"],"award-info":[{"award-number":["No. 2021A1515011433"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s11682-021-00500-0","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T23:13:20Z","timestamp":1626995600000},"page":"270-280","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Quantitative magnetic resonance imaging assessment of brain injury after successful cardiopulmonary resuscitation in a rat model of asphyxia cardiac arrest"],"prefix":"10.1007","volume":"16","author":[{"given":"Zhifeng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhui","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gongfa","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanchun","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,23]]},"reference":[{"key":"500_CR1","doi-asserted-by":"publisher","first-page":"e000161","DOI":"10.1161\/JAHA.113.000161","volume":"2","author":"D Aksoy","year":"2013","unstructured":"Aksoy, D., Bammer, R., Mlynash, M., et al. (2013). Magnetic resonance imaging profile of blood-brain barrier injury in patients with acute intracerebral hemorrhage. J Am Heart Assoc, 2, e000161.","journal-title":"J Am Heart Assoc"},{"key":"500_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jns.2011.12.007","volume":"315","author":"A Chalkias","year":"2012","unstructured":"Chalkias, A., & Xanthos, T. (2012). Post-cardiac arrest brain injury: Pathophysiology and treatment. Journal of the Neurological Sciences, 315, 1\u20138.","journal-title":"Journal of the Neurological Sciences"},{"key":"500_CR3","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.resuscitation.2014.03.314","volume":"85","author":"T Drabek","year":"2014","unstructured":"Drabek, T., Foley, L. M., Janata, A., et al. (2014). Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using asl-mri. Resuscitation, 85, 964\u2013971.","journal-title":"Resuscitation"},{"key":"500_CR4","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s12028-012-9706-0","volume":"19","author":"EL Fink","year":"2013","unstructured":"Fink, E. L., Panigrahy, A., Clark, R. S., et al. (2013). Regional brain injury on conventional and diffusion weighted mri is associated with outcome after pediatric cardiac arrest. Neurocritical Care, 19, 31\u201340.","journal-title":"Neurocritical Care"},{"key":"500_CR5","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.resuscitation.2015.10.003","volume":"97","author":"P Gong","year":"2015","unstructured":"Gong, P., Zhao, S., Wang, J., et al. (2015). Mild hypothermia preserves cerebral cortex microcirculation after resuscitation in a rat model of cardiac arrest. Resuscitation, 97, 109\u2013114.","journal-title":"Resuscitation"},{"key":"500_CR6","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/0300-9572(84)90062-5","volume":"12","author":"HH Hendrickx","year":"1984","unstructured":"Hendrickx, H. H., Rao, G. R., Safar, P., et al. (1984). Asphyxia, cardiac arrest and resuscitation in rats. I. Short term recovery. Resuscitation, 12, 97\u2013116.","journal-title":"Resuscitation"},{"key":"500_CR7","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1002\/mrm.22339","volume":"63","author":"TN Nagaraja","year":"2010","unstructured":"Nagaraja, T. N., Karki, K., Ewing, J. R., et al. (2010). The MRI-measured arterial input function resulting from a bolus injection of Gd-DTPA in a rat model of stroke slightly underestimates that of Gd-[14C]DTPA and marginally overestimates the blood-to-brain influx rate constant determined by Patlak plots. Magnetic Resonance in Medicine, 63, 1502\u20131509.","journal-title":"Magnetic Resonance in Medicine"},{"key":"500_CR8","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.neuroimage.2015.10.018","volume":"125","author":"AK Heye","year":"2016","unstructured":"Heye, A. K., Thrippleton, M. J., Armitage, P. A., et al. (2016). Tracer kinetic modelling for dce-mri quantification of subtle blood-brain barrier permeability. NeuroImage, 125, 446\u2013455.","journal-title":"NeuroImage"},{"key":"500_CR9","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/jon.12143","volume":"25","author":"KG Hirsch","year":"2015","unstructured":"Hirsch, K. G., Mlynash, M., Jansen, S., et al. (2015). Prognostic value of a qualitative brain mri scoring system after cardiac arrest. Journal of Neuroimaging, 25, 430\u2013437.","journal-title":"Journal of Neuroimaging"},{"key":"500_CR10","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1161\/STROKEAHA.107.483008","volume":"38","author":"M Iwai","year":"2007","unstructured":"Iwai, M., Cao, G., Chen, J., et al. (2007). Erythropoietin promotes neuronal replacement through revascularization and neurogenesis after neonatal hypoxia\/ischemia in rats. Stroke, 38, 2795\u20132803.","journal-title":"Stroke"},{"key":"500_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.resuscitation.2009.01.004","volume":"80","author":"H Jarnum","year":"2009","unstructured":"Jarnum, H., Knutsson, L., Rundgren, M., et al. (2009). Diffusion and perfusion mri of the brain in comatose patients treated with mild hypothermia after cardiac arrest: A prospective observational study. Resuscitation, 80, 425\u2013430.","journal-title":"Resuscitation"},{"key":"500_CR12","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1007\/s00134-004-2425-z","volume":"30","author":"S Laver","year":"2004","unstructured":"Laver, S., Farrow, C., Turner, D., et al. (2004). Mode of death after admission to an intensive care unit following cardiac arrest. Intensive Care Medicine, 30, 2126\u20132128.","journal-title":"Intensive Care Medicine"},{"key":"500_CR13","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1097\/ALN.0b013e318275148c","volume":"117","author":"CE Luyt","year":"2012","unstructured":"Luyt, C. E., Galanaud, D., Perlbarg, V., et al. (2012). Diffusion tensor imaging to predict long-term outcome after cardiac arrest: A bicentric pilot study. Anesthesiology, 117, 1311\u20131321.","journal-title":"Anesthesiology"},{"key":"500_CR14","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/labinvest.2015.70","volume":"95","author":"MA McMillin","year":"2015","unstructured":"McMillin, M. A., Frampton, G. A., Seiwell, A. P., et al. (2015). Tgfbeta1 exacerbates blood-brain barrier permeability in a mouse model of hepatic encephalopathy via upregulation of mmp9 and downregulation of claudin-5. Laboratory Investigation, 95, 903\u2013913.","journal-title":"Laboratory Investigation"},{"key":"500_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.resuscitation.2018.01.003","volume":"124","author":"M Memar","year":"2018","unstructured":"Memar, M., Geara, S. J., Hjalmarsson, P., et al. (2018). Long-term mortality and morbidity among 30-day survivors after in-hospital cardiac arrests - a swedish cohort study. Resuscitation, 124, 76\u201379.","journal-title":"Resuscitation"},{"key":"500_CR16","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1056\/NEJMoa1610493","volume":"376","author":"FW Moler","year":"2017","unstructured":"Moler, F. W., Silverstein, F. S., Holubkov, R., et al. (2017). Therapeutic hypothermia after in-hospital cardiac arrest in children. New England Journal of Medicine, 376, 318\u2013329.","journal-title":"New England Journal of Medicine"},{"key":"500_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.resuscitation.2018.02.020","volume":"126","author":"HK Moon","year":"2018","unstructured":"Moon, H. K., Jang, J., Park, K. N., et al. (2018). Quantitative analysis of relative volume of low apparent diffusion coefficient value can predict neurologic outcome after cardiac arrest. Resuscitation, 126, 36\u201342.","journal-title":"Resuscitation"},{"key":"500_CR18","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.resuscitation.2008.09.017","volume":"79","author":"JP Nolan","year":"2008","unstructured":"Nolan, J. P., Neumar, R. W., Adrie, C., et al. (2008). Post-cardiac arrest syndrome: Epidemiology, pathophysiology, treatment, and prognostication. A scientific statement from the international liaison committee on resuscitation; the american heart association emergency cardiovascular care committee; the council on cardiovascular surgery and anesthesia; the council on cardiopulmonary, perioperative, and critical care; the council on clinical cardiology; the council on stroke. Resuscitation, 79, 350\u2013379.","journal-title":"Resuscitation"},{"key":"500_CR19","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.cardfail.2012.12.001","volume":"19","author":"A Pan","year":"2013","unstructured":"Pan, A., Kumar, R., Macey, P. M., et al. (2013). Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. Journal of Cardiac Failure, 19, 94\u2013100.","journal-title":"Journal of Cardiac Failure"},{"key":"500_CR20","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1038\/jcbfm.2009.106","volume":"29","author":"DR Pillai","year":"2009","unstructured":"Pillai, D. R., Dittmar, M. S., Baldaranov, D., et al. (2009). Cerebral ischemia-reperfusion injury in rats\u2013a 3 t mri study on biphasic blood-brain barrier opening and the dynamics of edema formation. Journal of Cerebral Blood Flow and Metabolism, 29, 1846\u20131855.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"500_CR21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/0006-8993(94)91520-2","volume":"633","author":"R Pluta","year":"1994","unstructured":"Pluta, R., Lossinsky, A. S., Wisniewski, H. M., et al. (1994). Early blood-brain barrier changes in the rat following transient complete cerebral ischemia induced by cardiac arrest. Brain Research, 633, 41\u201352.","journal-title":"Brain Research"},{"key":"500_CR22","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1515\/CCLM.2005.210","volume":"43","author":"L Ramont","year":"2005","unstructured":"Ramont, L., Thoannes, H., Volondat, A., et al. (2005). Effects of hemolysis and storage condition on neuron-specific enolase (nse) in cerebrospinal fluid and serum: Implications in clinical practice. Clinical Chemistry and Laboratory Medicine, 43, 1215\u20131217.","journal-title":"Clinical Chemistry and Laboratory Medicine"},{"key":"500_CR23","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/S1474-4422(16)00015-6","volume":"15","author":"AO Rossetti","year":"2016","unstructured":"Rossetti, A. O., Rabinstein, A. A., & Oddo, M. (2016). Neurological prognostication of outcome in patients in coma after cardiac arrest. Lancet Neurology, 15, 597\u2013609.","journal-title":"Lancet Neurology"},{"key":"500_CR24","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1097\/CCM.0000000000001263","volume":"43","author":"SM Ryoo","year":"2015","unstructured":"Ryoo, S. M., Jeon, S. B., Sohn, C. H., et al. (2015). Predicting outcome with diffusion-weighted imaging in cardiac arrest patients receiving hypothermia therapy: Multicenter retrospective cohort study. Critical Care Medicine, 43, 2370\u20132377.","journal-title":"Critical Care Medicine"},{"key":"500_CR25","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s12028-010-9412-8","volume":"15","author":"EA Samaniego","year":"2011","unstructured":"Samaniego, E. A., Mlynash, M., Caulfield, A. F., et al. (2011). Sedation confounds outcome prediction in cardiac arrest survivors treated with hypothermia. Neurocritical Care, 15, 113\u2013119.","journal-title":"Neurocritical Care"},{"key":"500_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/s00702-010-0486-4","volume":"118","author":"HS Sharma","year":"2011","unstructured":"Sharma, H. S., Miclescu, A., & Wiklund, L. (2011). Cardiac arrest-induced regional blood-brain barrier breakdown, edema formation and brain pathology: A light and electron microscopic study on a new model for neurodegeneration and neuroprotection in porcine brain. Journal of Neural Transmission (Vienna), 118, 87\u2013114.","journal-title":"Journal of Neural Transmission (Vienna)"},{"key":"500_CR27","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3390\/ijms19010275","volume":"19","author":"JW Shim","year":"2018","unstructured":"Shim, J. W., & Madsen, J. R. (2018). Vegf signaling in neurological disorders. International Journalof Molecular Sciences, 19, 275.","journal-title":"International Journalof Molecular Sciences"},{"key":"500_CR28","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B","volume":"89","author":"RA Soslow","year":"2000","unstructured":"Soslow, R. A., Dannenberg, A. J., Rush, D., et al. (2000). Cox-2 is expressed in human pulmonary, colonic, and mammary tumors. Cancer, 89, 2637\u20132645.","journal-title":"Cancer"},{"key":"500_CR29","doi-asserted-by":"publisher","first-page":"2104","DOI":"10.1016\/j.jacc.2015.03.538","volume":"65","author":"P Stammet","year":"2015","unstructured":"Stammet, P., Collignon, O., Hassager, C., et al. (2015). Neuron-specific enolase as a predictor of death or poor neurological outcome after out-of-hospital cardiac arrest and targeted temperature management at 33 degrees c and 36 degrees c. Journal of the American College of Cardiology, 65, 2104\u20132114.","journal-title":"Journal of the American College of Cardiology"},{"key":"500_CR30","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.ajem.2012.06.008","volume":"31","author":"ZR Tang","year":"2013","unstructured":"Tang, Z. R., Li, C. S., Zhao, H., et al. (2013). Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest. American Journal of Emergency Medicine, 31, 86\u201393.","journal-title":"American Journal of Emergency Medicine"},{"key":"500_CR31","doi-asserted-by":"publisher","first-page":"e789","DOI":"10.1097\/CCM.0000000000002412","volume":"45","author":"MC Tjepkema-Cloostermans","year":"2017","unstructured":"Tjepkema-Cloostermans, M. C., Hofmeijer, J., Beishuizen, A., et al. (2017). Cerebral recovery index: Reliable help for prediction of neurologic outcome after cardiac arrest. Critical Care Medicine, 45, e789\u2013e797.","journal-title":"Critical Care Medicine"},{"key":"500_CR32","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neulet.2014.06.020","volume":"578","author":"EE Tress","year":"2014","unstructured":"Tress, E. E., Clark, R. S., Foley, L. M., et al. (2014). Blood brain barrier is impermeable to solutes and permeable to water after experimental pediatric cardiac arrest. Neuroscience Letters, 578, 17\u201321.","journal-title":"Neuroscience Letters"},{"key":"500_CR33","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1002\/mrm.22848","volume":"66","author":"F Vlachos","year":"2011","unstructured":"Vlachos, F., Tung, Y. S., & Konofagou, E. (2011). Permeability dependence study of the focused ultrasound-induced blood-brain barrier opening at distinct pressures and microbubble diameters using dce-mri. Magnetic Resonance in Medicine, 66, 821\u2013830.","journal-title":"Magnetic Resonance in Medicine"},{"key":"500_CR34","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/aas.13074","volume":"62","author":"E Wallin","year":"2018","unstructured":"Wallin, E., Larsson, I. M., Kristofferzon, M. L., et al. (2018). Acute brain lesions on magnetic resonance imaging in relation to neurological outcome after cardiac arrest. Acta Anaesthesiologica Scandinavica, 62, 635\u2013647.","journal-title":"Acta Anaesthesiologica Scandinavica"},{"key":"500_CR35","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.trsl.2018.01.002","volume":"194","author":"P Wang","year":"2018","unstructured":"Wang, P., Li, Y., Yang, Z., et al. (2018). Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest. Translational Research, 194, 68\u201378.","journal-title":"Translational Research"},{"key":"500_CR36","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1002\/ana.21632","volume":"65","author":"CA Wijman","year":"2009","unstructured":"Wijman, C. A., Mlynash, M., Caulfield, A. F., et al. (2009). Prognostic value of brain diffusion-weighted imaging after cardiac arrest. Annals of Neurology, 65, 394\u2013402.","journal-title":"Annals of Neurology"},{"key":"500_CR37","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1001\/jama.2013.278483","volume":"310","author":"M Wissenberg","year":"2013","unstructured":"Wissenberg, M., Lippert, F. K., Folke, F., et al. (2013). Association of national initiatives to improve cardiac arrest management with rates of bystander intervention and patient survival after out-of-hospital cardiac arrest. JAMA, 310, 1377\u20131384.","journal-title":"JAMA"},{"key":"500_CR38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.resuscitation.2016.12.010","volume":"112","author":"A Wormsbecker","year":"2017","unstructured":"Wormsbecker, A., Sekhon, M. S., Griesdale, D. E., et al. (2017). The association between anemia and neurological outcome in hypoxic ischemic brain injury after cardiac arrest. Resuscitation, 112, 11\u201316.","journal-title":"Resuscitation"},{"key":"500_CR39","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1148\/radiol.2521081232","volume":"252","author":"O Wu","year":"2009","unstructured":"Wu, O., Sorensen, A. G., Benner, T., et al. (2009). Comatose patients with cardiac arrest: Predicting clinical outcome with diffusion-weighted mr imaging. Radiology, 252, 173\u2013181.","journal-title":"Radiology"},{"key":"500_CR40","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1177\/0271678X17726062","volume":"38","author":"J Zhu","year":"2018","unstructured":"Zhu, J., Li, X., Yin, J., et al. (2018). Glycocalyx degradation leads to blood-brain barrier dysfunction and brain edema after asphyxia cardiac arrest in rats. Journal of Cerebral Blood Flow and Metabolism, 38, 1979\u20131992.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-021-00500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-021-00500-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-021-00500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T12:21:02Z","timestamp":1644322862000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11682-021-00500-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,23]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["500"],"URL":"https:\/\/doi.org\/10.1007\/s11682-021-00500-0","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"value":"1931-7557","type":"print"},{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,23]]},"assertion":[{"value":"5 July 2021","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 July 2021","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiments were approved by the Institutional Animal Care and Use Committee of the Tang Wanchun Laboratories of Emergency & Critical Care Medicine at Sun Yat-sen Memorial Hospital, Sun Yat-sen University (IACUC-SYSU -R17010).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"The authors declare that they have no conflict of interest.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}