{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:51:17Z","timestamp":1762660277958,"version":"3.37.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T00:00:00Z","timestamp":1667347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["91717306","016.VICI.170.200","91211021"],"award-info":[{"award-number":["91717306","016.VICI.170.200","91211021"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008358","name":"Hersenstichting","doi-asserted-by":"publisher","award":["HA-2017-00227"],"award-info":[{"award-number":["HA-2017-00227"]}],"id":[{"id":"10.13039\/501100008358","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>While functional brain characteristics of obsessive-compulsive disorder have been extensively studied, literature on network topology and subnetwork connectivity related to obsessive-compulsive symptoms (OCS) is sparse. Here we investigated the functional brain characteristics of OCS in children from the general population using a multiscale approach. Since we previously observed OCS-related differences in thalamus morphology, we also focused on the network participation of thalamic subregions. The study included 1701 participants (9\u201312 years) from the population-based Generation R study. OCS were measured using the Short Obsessive-Compulsive Disorder Screener. We studied the brain network at multiple scales: global network topology, subnetwork connectivity and network participation of thalamic nodes (pre-registration:<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/osf.io\/azr9c\">https:\/\/osf.io\/azr9c<\/jats:ext-link>). Modularity, small-worldness and average participation coefficient were calculated on the global scale. We used a data-driven consensus community approach to extract a partition of five subnetworks involving thalamic subregions and calculate the within- and between-subnetwork functional connectivity and topology. Multiple linear regression models were fitted to model the relationship between OCS and functional brain measures. No significant associations were found when using our preregistered definition of probable OCS. However, post-hoc analyses showed that children endorsing at least one OCS (compared with controls) had higher modularity, lower connectivity between frontoparietal, limbic and visual networks as well as altered participation of the lateral prefrontal thalamus node. Our results suggest that network characteristics of OCS in children from the general population are partly symptom-specific and severity-dependent. Thorough assessment of symptom dimensions can deepen our understanding of OCS-related brain networks.<\/jats:p>","DOI":"10.1007\/s11682-022-00732-8","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T02:02:31Z","timestamp":1667354551000},"page":"2715-2724","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Obsessive-compulsive symptoms and resting-state functional characteristics in pre-adolescent children from the general population"],"prefix":"10.1007","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1238-3769","authenticated-orcid":false,"given":"Cees J.","family":"Weeland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odile A.","family":"van den Heuvel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Tiemeier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Vriend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,2]]},"reference":[{"key":"732_CR1","doi-asserted-by":"crossref","unstructured":"Achenbach, T. M., & Rescorla, L. A. (2001). Manual for the ASEBA school-age forms & profiles: child behavior checklist for ages 6\u201318, teacher\u2019s report form, youth self-report: an integrated system of multi-informant assessment. University of Vermont, research center for children youth & families","DOI":"10.1037\/t47452-000"},{"key":"732_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpsc.2021.07.014","author":"AF Alexander-Bloch","year":"2021","unstructured":"Alexander-Bloch, A. F., Sood, R., Shinohara, R. T., Moore, T. M., Calkins, M. E., Chertavian, C., Wolf, D. H., Gur, R. C., Satterthwaite, T. D., Gur, R. E., & Barzilay, R. (2021). Connectome-wide functional connectivity abnormalities in youth with obsessive compulsive symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. https:\/\/doi.org\/10.1016\/j.bpsc.2021.07.014","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"732_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.jad.2015.12.071","volume":"193","author":"CC Armstrong","year":"2016","unstructured":"Armstrong, C. C., Moody, T. D., Feusner, J. D., McCracken, J. T., Chang, S., Levitt, J. G., Piacentini, J. C., & O\u2019Neill, J. (2016). Graph-theoretical analysis of resting-state fMRI in pediatric obsessive-compulsive disorder. Journal of affective disorders, 193, 175\u2013184. https:\/\/doi.org\/10.1016\/j.jad.2015.12.071","journal-title":"Journal of affective disorders"},{"issue":"1","key":"732_CR4","doi-asserted-by":"publisher","first-page":"013142","DOI":"10.1063\/1.4790830","volume":"23","author":"DS Bassett","year":"2013","unstructured":"Bassett, D. S., Porter, M. A., Wymbs, N. F., Grafton, S. T., Carlson, J. M., & Mucha, P. J. (2013). Robust detection of dynamic community structure in networks. Chaos (Woodbury, N.Y.), 23(1), 013142","journal-title":"Chaos (Woodbury, N.Y.)"},{"issue":"5","key":"732_CR5","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1038\/nrn3214","volume":"13","author":"E Bullmore","year":"2012","unstructured":"Bullmore, E., & Sporns, O. (2012). The economy of brain network organization. Nature Reviews Neuroscience, 13(5), 336\u2013349. https:\/\/doi.org\/10.1038\/nrn3214","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"732_CR6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","volume":"16","author":"O Esteban","year":"2019","unstructured":"Esteban, O., Markiewicz, C. J., Blair, R. W., Moodie, C. A., Isik, A. I., Erramuzpe, A., Kent, J. D., Goncalves, M., DuPre, E., Snyder, M., Oya, H., Ghosh, S. S., Wright, J., Durnez, J., Poldrack, R. A., & Gorgolewski, K. J. (2019). fMRIPrep: a robust preprocessing pipeline for functional MRI. Nature Methods, 16(1), 111\u2013116. https:\/\/doi.org\/10.1038\/s41592-018-0235-4","journal-title":"Nature Methods"},{"issue":"8","key":"732_CR7","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1093\/cercor\/bhw157","volume":"26","author":"L Fan","year":"2016","unstructured":"Fan, L., Li, H., Zhuo, J., Zhang, Y., Wang, J., Chen, L., Yang, Z., Chu, C., Xie, S., Laird, A. R., Fox, P. T., Eickhoff, S. B., Yu, C., & Jiang, T. (2016). The Human Brainnetome Atlas: A New Brain Atlas Based on Connectional Architecture. Cerebral Cortex, 26(8), 3508\u20133526","journal-title":"Cerebral Cortex"},{"issue":"9","key":"732_CR8","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1016\/j.jaac.2011.06.011","volume":"50","author":"KD Fitzgerald","year":"2011","unstructured":"Fitzgerald, K. D., Welsh, R. C., Stern, E. R., Angstadt, M., Hanna, G. L., Abelson, J. L., & Taylor, S. F. (2011). Developmental alterations of frontal-striatal-thalamic connectivity in obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 50(9), 938\u2013948. e933","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"issue":"3","key":"732_CR9","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1176\/appi.ajp.2008.08071006","volume":"166","author":"MA Fullana","year":"2009","unstructured":"Fullana, M. A., Mataix-Cols, D., Caspi, A., Harrington, H., Grisham, J. R., Moffitt, T. E., & Poulton, R. (2009). Obsessions and compulsions in the community: prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. American Journal of Psychiatry, 166(3), 329\u2013336","journal-title":"American Journal of Psychiatry"},{"issue":"6","key":"732_CR10","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1002\/hbm.23593","volume":"38","author":"C Garcia-Ramos","year":"2017","unstructured":"Garcia-Ramos, C., Bobholz, S., Dabbs, K., Hermann, B., Joutsa, J., Rinne, J. O., Karrasch, M., Prabhakaran, V., Shinnar, S., Sillanp\u00e4\u00e4, M., & Group, T. S. (2017). Brain structure and organization five decades after childhood onset epilepsy. Human Brain Mapping, 38(6), 3289\u20133299. https:\/\/doi.org\/10.1002\/hbm.23593","journal-title":"Human Brain Mapping"},{"key":"732_CR11","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neubiorev.2018.01.016","volume":"87","author":"DA G\u00fcrsel","year":"2018","unstructured":"G\u00fcrsel, D. A., Avram, M., Sorg, C., Brandl, F., & Koch, K. (2018). Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity. Neuroscience & Biobehavioral Reviews, 87, 151\u2013160","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"16","key":"732_CR12","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1056\/NEJMc1710724","volume":"377","author":"PR Jansen","year":"2017","unstructured":"Jansen, P. R., Dremmen, M., Van Den Berg, A., Dekkers, I. A., Blanken, L. M. E., Muetzel, R. L., Bolhuis, K., Mulder, R. M., Kocevska, D., & Jansen, T. A. (2017). Incidental Findings on Brain Imaging in the General Pediatric Population. The New England journal of medicine, 377(16), 1593","journal-title":"The New England journal of medicine"},{"issue":"12","key":"732_CR13","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1007\/s10654-016-0224-9","volume":"31","author":"MN Kooijman","year":"2016","unstructured":"Kooijman, M. N., Kruithof, C. J., van Duijn, C. M., Duijts, L., van Franco, O. H., de Jongste, I. M. H., Klaver, J. C., van der Lugt, C. C., Mackenbach, A., Moll, J. P., Peeters, H. A., Raat, R. P., Rings, H., Rivadeneira, E. H., van der Schroeff, F., Steegers, M. P., Tiemeier, E. A., Uitterlinden, H., & Jaddoe, A. G., V. W (2016). The Generation R Study: design and cohort update 2017. European Journal Of Epidemiology, 31(12), 1243\u20131264. https:\/\/doi.org\/10.1007\/s10654-016-0224-9. 10.1007\/s10654-016-0224-9 [pii]","journal-title":"European Journal Of Epidemiology"},{"issue":"4","key":"732_CR15","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/ane.13198","volume":"141","author":"HJ Lee","year":"2020","unstructured":"Lee, H. J., Seo, S. A., Lee, B. I., Kim, S. E., & Park, K. M. (2020). Thalamic nuclei volumes and network in juvenile myoclonic epilepsy. Acta Neurologica Scandinavica, 141(4), 271\u2013278","journal-title":"Acta Neurologica Scandinavica"},{"key":"732_CR16","doi-asserted-by":"publisher","first-page":"111982","DOI":"10.1016\/j.bbr.2019.111982","volume":"371","author":"K Li","year":"2019","unstructured":"Li, K., Zhang, H., Yang, Y., Zhu, J., Wang, B., Shi, Y., Li, X., Meng, Z., Lv, L., & Zhang, H. (2019). Abnormal functional network of the thalamic subregions in adult patients with obsessive-compulsive disorder. Behavioural brain research, 371, 111982","journal-title":"Behavioural brain research"},{"issue":"2","key":"732_CR17","doi-asserted-by":"publisher","first-page":"133","DOI":"10.31887\/DCNS.2018.20.2\/smarek","volume":"20","author":"S Marek","year":"2018","unstructured":"Marek, S., & Dosenbach, N. U. F. (2018). The frontoparietal network: function, electrophysiology, and importance of individual precision mapping. Dialogues in clinical neuroscience, 20(2), 133\u2013140. https:\/\/doi.org\/10.31887\/DCNS.2018.20.2\/smarek","journal-title":"Dialogues in clinical neuroscience"},{"issue":"18","key":"732_CR18","doi-asserted-by":"publisher","first-page":"8117","DOI":"10.1523\/JNEUROSCI.22-18-08117.2002","volume":"22","author":"NR McFarland","year":"2002","unstructured":"McFarland, N. R., & Haber, S. N. (2002). Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas. Journal of Neuroscience, 22(18), 8117\u20138132","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"732_CR19","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.1542\/peds.108.1.e14","volume":"108","author":"EC Nelson","year":"2001","unstructured":"Nelson, E. C., Hanna, G. L., Hudziak, J. J., Botteron, K. N., Heath, A. C., & Todd, R. D. (2001). Obsessive-compulsive scale of the child behavior checklist: specificity, sensitivity, and predictive power. Pediatrics, 108(1), e14\u2013e14","journal-title":"Pediatrics"},{"issue":"4","key":"732_CR20","first-page":"399","volume":"6","author":"D Pagliaccio","year":"2021","unstructured":"Pagliaccio, D., Durham, K., Fitzgerald, K. D., & Marsh, R. (2021). Obsessive-Compulsive Symptoms Among Children in the Adolescent Brain and Cognitive Development Study: Clinical, Cognitive, and Brain Connectivity Correlates. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 6(4), 399\u2013409","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"732_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuroimage.2015.02.064","volume":"112","author":"RHR Pruim","year":"2015","unstructured":"Pruim, R. H. R., Mennes, M., van Rooij, D., Llera, A., Buitelaar, J. K., & Beckmann, C. F. (2015). ICA-AROMA: A robust ICA-based strategy for removing motion artifacts from fMRI data. Neuroimage, 112, 267\u2013277","journal-title":"Neuroimage"},{"key":"732_CR22","unstructured":"R Core Team (2020). R: A language and environment for statistical computing. In R Foundation for Statistical Computing. https:\/\/www.R-project.org\/"},{"issue":"9","key":"732_CR23","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1093\/cercor\/bhu036","volume":"25","author":"TD Satterthwaite","year":"2015","unstructured":"Satterthwaite, T. D., Wolf, D. H., Roalf, D. R., Ruparel, K., Erus, G., Vandekar, S., Gennatas, E. D., Elliott, M. A., Smith, A., Hakonarson, H., Verma, R., Davatzikos, C., Gur, R. E., & Gur, R. C. (2015). Linked Sex Differences in Cognition and Functional Connectivity in Youth. Cerebral Cortex, 25(9), 2383\u20132394. https:\/\/doi.org\/10.1093\/cercor\/bhu036","journal-title":"Cerebral Cortex"},{"issue":"4","key":"732_CR24","first-page":"438","volume":"5","author":"Z Sha","year":"2020","unstructured":"Sha, Z., Edmiston, E. K., Versace, A., Fournier, J. C., Graur, S., Greenberg, T., Lima Santos, J. P., Chase, H. W., Stiffler, R. S., Bonar, L., Hudak, R., Yendiki, A., Greenberg, B. D., Rasmussen, S., Liu, H., Quirk, G., Haber, S., & Phillips, M. L. (2020). Functional Disruption of Cerebello-thalamo-cortical Networks in Obsessive-Compulsive Disorder. Biol Psychiatry Cogn Neurosci Neuroimaging, 5(4), 438\u2013447","journal-title":"Biol Psychiatry Cogn Neurosci Neuroimaging"},{"key":"732_CR25","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-020-01007-8","author":"E Shephard","year":"2021","unstructured":"Shephard, E., Stern, E. R., van den Heuvel, O. A., Costa, D. L. C., Batistuzzo, M. C., Godoy, P. B. G., Lopes, A. C., Brunoni, A. R., Hoexter, M. Q., Shavitt, R. G., Reddy, Y. C. J., Lochner, C., Stein, D. J., Simpson, H. B., & Miguel, E. C. (2021). Toward a neurocircuit-based taxonomy to guide treatment of obsessive\u2013compulsive disorder. Molecular Psychiatry. https:\/\/doi.org\/10.1038\/s41380-020-01007-8","journal-title":"Molecular Psychiatry"},{"issue":"8","key":"732_CR26","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.biopsych.2013.09.002","volume":"75","author":"DJ Shin","year":"2014","unstructured":"Shin, D. J., Jung, W. H., He, Y., Wang, J., Shim, G., Byun, M. S., Jang, J. H., Kim, S. N., Lee, T. Y., Park, H. Y., & Kwon, J. S. (2014). The Effects of Pharmacological Treatment on Functional Brain Connectome in Obsessive-Compulsive Disorder. Biological Psychiatry, 75(8), 606\u2013614. https:\/\/doi.org\/10.1016\/j.biopsych.2013.09.002","journal-title":"Biological Psychiatry"},{"key":"732_CR27","doi-asserted-by":"crossref","unstructured":"Stern, E. R., Fitzgerald, K. D., Welsh, R. C., Abelson, J. L., & Taylor, S. F. (2012). Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder.PloS one, 7(5), e36356","DOI":"10.1371\/journal.pone.0036356"},{"issue":"4","key":"732_CR28","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.tics.2020.01.008","volume":"24","author":"LE Su\u00e1rez","year":"2020","unstructured":"Su\u00e1rez, L. E., Markello, R. D., Betzel, R. F., & Misic, B. (2020). Linking Structure and Function in Macroscale Brain Networks [doi: 10.1016\/j.tics.2020.01.008]. Trends in Cognitive Sciences, 24(4), 302\u2013315. https:\/\/doi.org\/10.1016\/j.tics.2020.01.008","journal-title":"Trends in Cognitive Sciences"},{"issue":"6","key":"732_CR29","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.jaac.2020.08.435","volume":"60","author":"M Su\u00f1ol","year":"2021","unstructured":"Su\u00f1ol, M., Saiz-Masvidal, C., Contreras-Rodr\u00edguez, O., Maci\u00e0, D., Mart\u00ednez-Vilavella, G., Mart\u00ednez-Zalaca\u00edn, I., Mench\u00f3n, J. M., Pujol, J., Sunyer, J., & Soriano-Mas, C. (2021). Brain Functional Connectivity Correlates of Subclinical Obsessive-Compulsive Symptoms in Healthy Children. Journal of the American Academy of Child & Adolescent Psychiatry, 60(6), 757\u2013767. https:\/\/doi.org\/10.1016\/j.jaac.2020.08.435","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"key":"732_CR30","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.jpsychires.2020.06.021","volume":"129","author":"S Tikoo","year":"2020","unstructured":"Tikoo, S., Cardona, F., Tommasin, S., Giann\u00ec, C., Conte, G., Upadhyay, N., Mirabella, G., Suppa, A., & Pantano, P. (2020). Resting-state functional connectivity in drug-naive pediatric patients with Tourette syndrome and obsessive-compulsive disorder. Journal Of Psychiatric Research, 129, 129\u2013140","journal-title":"Journal Of Psychiatric Research"},{"key":"732_CR31","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.nicl.2017.05.014","volume":"15","author":"YS Tyan","year":"2017","unstructured":"Tyan, Y. S., Liao, J. R., Shen, C. Y., Lin, Y. C., & Weng, J. C. (2017). Gender differences in the structural connectome of the teenage brain revealed by generalized q-sampling MRI. NeuroImage: Clinical, 15, 376\u2013382. https:\/\/doi.org\/10.1016\/j.nicl.2017.05.014","journal-title":"NeuroImage: Clinical"},{"key":"732_CR32","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1192\/bjp.bp.106.034967","volume":"191","author":"R Uher","year":"2007","unstructured":"Uher, R., Heyman, I., Mortimore, C., Frampton, I., & Goodman, R. (2007). Screening young people for obsessive compulsive disorder. British Journal Of Psychiatry, 191, 353\u2013354. https:\/\/doi.org\/10.1192\/bjp.bp.106.034967","journal-title":"British Journal Of Psychiatry"},{"key":"732_CR33","doi-asserted-by":"publisher","unstructured":"van Buuren, S., & Groothuis-Oudshoorn, K. (2011). mice: Multivariate Imputation by Chained Equations in R. 2011, 45(3), 67. https:\/\/doi.org\/10.18637\/jss.v045.i03","DOI":"10.18637\/jss.v045.i03"},{"key":"732_CR34","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neuroimage.2017.02.005","volume":"152","author":"MP van den Heuvel","year":"2017","unstructured":"van den Heuvel, M. P., de Lange, S. C., Zalesky, A., Seguin, C., Yeo, B. T. T., & Schmidt, R. (2017). Proportional thresholding in resting-state fMRI functional connectivity networks and consequences for patient-control connectome studies: Issues and recommendations. Neuroimage, 152, 437\u2013449. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.02.005","journal-title":"Neuroimage"},{"issue":"44","key":"732_CR35","doi-asserted-by":"publisher","first-page":"15775","DOI":"10.1523\/JNEUROSCI.3539-11.2011","volume":"31","author":"MP van den Heuvel","year":"2011","unstructured":"van den Heuvel, M. P., & Sporns, O. (2011). Rich-club organization of the human connectome. Journal Of Neuroscience, 31(44), 15775\u201315786","journal-title":"Journal Of Neuroscience"},{"issue":"5","key":"732_CR36","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.euroneuro.2015.12.005","volume":"26","author":"OA van den Heuvel","year":"2016","unstructured":"van den Heuvel, O. A., van Wingen, G., Soriano-Mas, C., Alonso, P., Chamberlain, S. R., Nakamae, T., Denys, D., Goudriaan, A. E., & Veltman, D. J. (2016). Brain circuitry of compulsivity. European Neuropsychopharmacology, 26(5), 810\u2013827. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.12.005","journal-title":"European Neuropsychopharmacology"},{"issue":"1","key":"732_CR37","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41398-022-01823-2","volume":"12","author":"CJ Weeland","year":"2022","unstructured":"Weeland, C. J., Kasprzak, S., de Joode, N. T., Abe, Y., Alonso, P., Ameis, S. H., Anticevic, A., Arnold, P. D., Balachander, S., Banaj, N., Bargallo, N., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Brecke, V., Brem, S., Cappi, C., Cheng, Y., & Group, E. O. W. (2022). The thalamus and its subnuclei\u2014a gateway to obsessive-compulsive disorder. Translational Psychiatry, 12(1), 70. https:\/\/doi.org\/10.1038\/s41398-022-01823-2","journal-title":"Translational Psychiatry"},{"issue":"2","key":"732_CR38","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.jaac.2021.05.024","volume":"61","author":"CJ Weeland","year":"2022","unstructured":"Weeland, C. J., Vriend, C., van der Werf, Y., Huyser, C., Hillegers, M., Tiemeier, H., White, T., & van den Heuvel, O. A. (2022). Thalamic Subregions and Obsessive-Compulsive Symptoms in 2,500 Children From the General Population [doi: 10.1016\/j.jaac.2021.05.024]. Journal of the American Academy of Child & Adolescent Psychiatry, 61(2), 321\u2013330. https:\/\/doi.org\/10.1016\/j.jaac.2021.05.024","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"issue":"4","key":"732_CR39","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.jaac.2020.03.012","volume":"60","author":"CJ Weeland","year":"2021","unstructured":"Weeland, C. J., White, T., Vriend, C., Muetzel, R. L., Starreveld, J., Hillegers, M. H. J., Tiemeier, H., & van den Heuvel, O. A. (2021). Brain Morphology Associated With Obsessive-Compulsive Symptoms in 2,551 Children From the General Population [doi: 10.1016\/j.jaac.2020.03.012]. Journal of the American Academy of Child & Adolescent Psychiatry, 60(4), 470\u2013478. https:\/\/doi.org\/10.1016\/j.jaac.2020.03.012","journal-title":"Journal of the American Academy of Child & Adolescent Psychiatry"},{"issue":"1","key":"732_CR40","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10654-017-0319-y","volume":"33","author":"T White","year":"2018","unstructured":"White, T., Muetzel, R. L., Marroun, E., Blanken, H., Jansen, L. M. E., Bolhuis, P., Kocevska, K., Mous, D., Mulder, S. E., Jaddoe, R., van der Lugt, V. W. V., Verhulst, A., F. C., & Tiemeier, H. (2018). Paediatric population neuroimaging and the Generation R Study: the second wave. European Journal Of Epidemiology, 33(1), 99\u2013125. https:\/\/doi.org\/10.1007\/s10654-017-0319-y. 10.1007\/s10654-017-0319-y [pii]","journal-title":"European Journal Of Epidemiology"},{"issue":"2","key":"732_CR42","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1093\/brain\/awaa001","volume":"143","author":"JY Yun","year":"2020","unstructured":"Yun, J. Y., Boedhoe, P. S. W., Vriend, C., Jahanshad, N., Abe, Y., Ameis, S. H., Anticevic, A., Arnold, P. D., Batistuzzo, M. C., Benedetti, F., Beucke, J. C., Bollettini, I., Bose, A., Brem, S., Calvo, A., Cheng, Y., Cho, K. I. K., Ciullo, V., Dallaspezia, S., & Kwon, J. S. (2020). Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium. Brain, 143(2), 684\u2013700. https:\/\/doi.org\/10.1093\/brain\/awaa001","journal-title":"Brain"},{"issue":"1","key":"732_CR43","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1503\/jpn.100006","volume":"36","author":"T Zhang","year":"2011","unstructured":"Zhang, T., Wang, J., Yang, Y., Wu, Q., Li, B., Chen, L., Yue, Q., Tang, H., Yan, C., Lui, S., Huang, X., Chan, R. C., Zang, Y., He, Y., & Gong, Q. (2011). Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder. Journal Of Psychiatry And Neuroscience, 36(1), 23\u201331","journal-title":"Journal Of Psychiatry And Neuroscience"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-022-00732-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-022-00732-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-022-00732-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T22:46:29Z","timestamp":1701297989000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11682-022-00732-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,2]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["732"],"URL":"https:\/\/doi.org\/10.1007\/s11682-022-00732-8","relation":{},"ISSN":["1931-7557","1931-7565"],"issn-type":[{"type":"print","value":"1931-7557"},{"type":"electronic","value":"1931-7565"}],"subject":[],"published":{"date-parts":[[2022,11,2]]},"assertion":[{"value":"29 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Medical Ethical Committee of the Erasmus Medical Centre in Rotterdam and was conducted according to the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent and assent was obtained from the participants and\/or parents or legal guardians of the participants as required by law.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent and assent was obtained from the participants and\/or parents or legal guardians of the participants as required by law.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"<i>Author contributions<\/i>.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"Author contributions included conception and study design (All authors), data collection or acquisition (CW), statistical analysis (CV, CW), interpretation of results (CW, CV, OH, TW), drafting the manuscript work or revising it critically for important intellectual content (CW, CV, OH) and approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (All authors).","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to publish"}},{"value":"O.A. van den Heuvel received consultancy fee from Lundbeck. C. Vriend is listed as an inventor on a patent licensed to General Electric (WO2018115148A1). C. Weeland has no financial relationships with commercial interests to report. T. White has no financial relationships with commercial interests to report. H. Tiemeier has no financial relationships with commercial interests to report.","order":7,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}