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Fonseca declares research funding and honoraria from UCB Pharma, Esteve laboratorios, Eisai Inc, GW Pharmaceuticals, Angelini Pharma and Sanofi Genzyme. E. Santamarina declares research funding and speaking fees from UCB Pharma, BIAL Pharmaceutical, EISAI Inc. and Esteve laboratorios. L. Abraira declares research funding and speaking fees from UCB Pharma, BIAL Pharmaceutical, EISAI Inc., Sanofi Genzyme and Esteve laboratorios. I. Seijo declares research funding from UCB Pharma, Neuraxpharm and GW pharmaceuticals. M. Toledo declares research funding and speaking fees from UCB Pharma, BIAL Pharmaceutical, EISAI Inc., GW Pharmaceuticals, Arvelle Therapeutics, Angelini Pharma and Esteve laboratorios. S. Sarria, D. Pareto, M. Turon, M. Quintana, C. Tortajada and A. Rovira have no conflicts of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"We confirm that we have read the journal\u2019s position on issues concerning ethical publication and that this report is consistent with those guidelines. The study protocol was approved by the Vall d\u2019Hebron Research Institute Ethics Committee [PR(AG)391\/2017], following the Ethics of the World Medical Association for experiments involving humans. The study conforms with the STROBE guidelines for observational studies.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All patients provided signed written informed consent prior to inclusion in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}