{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:11:35Z","timestamp":1785787895247,"version":"3.56.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T00:00:00Z","timestamp":1698451200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["\u201cBando per la Ricerca Finalizzata 2018\u201d SG-2018-12368019"],"award-info":[{"award-number":["\u201cBando per la Ricerca Finalizzata 2018\u201d SG-2018-12368019"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["\u201cRicerca Corrente RC n. 2773803\u201d"],"award-info":[{"award-number":["\u201cRicerca Corrente RC n. 2773803\u201d"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["\u201cRicerca Corrente RC n. 2773803\u201d"],"award-info":[{"award-number":["\u201cRicerca Corrente RC n. 2773803\u201d"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 degli Studi di Catania","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a parasomnia characterized by loss of physiological atonia of skeletal muscles with abnormal behaviors arising during REM sleep. RBD is often the early manifestation of neurodegenerative diseases, particularly alpha-synucleinopathies, such as Parkinson\u2019s disease (PD). Both structural and functional neuroimaging studies suggest that iRBD might share, or even precede, some of the features commonly found in PD, although without a definitive conclusion. Aim of the study is to evaluate the presence of structural abnormalities involving cortical and subcortical areas in PD patients with RBD and iRBD. Patients with video-polysomnographic (VPSG)-confirmed iRBD, and patients with a diagnosis of PD were recruited. In all PD patients, the presence of probable RBD was assessed during the follow-up visits (PD\/pRBD). A group of healthy controls (HC) subjects was also recruited. Each subject underwent a structural brain MRI using a 3-D T1-weighted spoiled gradient echo sequence. Twenty-three patients with iRBD, 24 PD\/pRBD, and 26 HC were enrolled. Voxel-based morphometry-AnCOVA analysis revealed clusters of grey matter changes in iRBD and PD\/pRBD compared to HC in several regions, involving mainly the frontal and temporal regions. The involvement of cortical brain structures associated to the control of sleep cycle and REM stage both in PD\/pRBD and iRBD might suggest the presence of a common structural platform linking iRBD and PD, although this pattern may not underlie exclusively RBD-related features. Further longitudinal studies are needed to clarify the patterns of changes occurring at different time points of RBD-related neurodegeneration.<\/jats:p>","DOI":"10.1007\/s11682-023-00815-0","type":"journal-article","created":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T09:01:39Z","timestamp":1698483699000},"page":"83-91","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson\u2019s disease: a Voxel-based morphometry study"],"prefix":"10.1007","volume":"18","author":[{"given":"Giulia","family":"Donzuso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calogero E.","family":"Cicero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loretta","family":"Giuliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Squillaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonina","family":"Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Palmucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonello","family":"Basile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Lanza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Ferri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Zappia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Nicoletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,28]]},"reference":[{"key":"815_CR1","volume-title":"International Classification of Sleep Disorders","author":"American Academy of Sleep Medicine","year":"2014","unstructured":"American Academy of Sleep Medicine. (2014). International Classification of Sleep Disorders (3rd ed.). American Academy of Sleep Medicine.","edition":"3"},{"key":"815_CR2","doi-asserted-by":"publisher","first-page":"839e51","DOI":"10.1016\/j.neuroimage.2005.02.018","volume":"26","author":"J Ashburner","year":"2005","unstructured":"Ashburner, J., & Friston, K. J. (2005). Unified segmentation. Neuroimage, 26, 839e51.","journal-title":"Neuroimage"},{"key":"815_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29172","author":"M Banwinkler","year":"2022","unstructured":"Banwinkler, M., Dzialas, V., Parkinson\u2019s Progression Markers Initiative, Hoenig, M. C., & van Eimeren, T. (2022). Gray matter volume loss in proposed brain-first and body-first Parkinson\u2019s disease subtypes. Movement Disorders. https:\/\/doi.org\/10.1002\/mds.29172","journal-title":"Movement Disorders"},{"key":"815_CR4","doi-asserted-by":"publisher","first-page":"1600","DOI":"10.1002\/mds.26431","volume":"30","author":"D Berg","year":"2015","unstructured":"Berg, D., Postuma, R. B., Adler, C. H., et al. (2015). MDS research criteria for prodromal Parkinson\u2019s disease. Movement Disorders, 30, 1600\u20131611.","journal-title":"Movement Disorders"},{"issue":"3","key":"815_CR5","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/S1071-9164(98)80009-2","volume":"4","author":"M Bj\u00f8rn","year":"1998","unstructured":"Bj\u00f8rn, M., Brendstrup, C., Karlsen, S., & Carlsen, J. E. (1998). Consecutive screening and enrollment in clinical trials: The way to representa-tive patient samples? Journal of Cardiac Failure, 4(3), 225\u2013230.","journal-title":"Journal of Cardiac Failure"},{"key":"815_CR6","doi-asserted-by":"publisher","first-page":"26782","DOI":"10.1038\/srep26782","volume":"6","author":"S Boucetta","year":"2016","unstructured":"Boucetta, S., Salimi, A., Dadar, M., Jones, B. E., Collins, D. L., & Dang-Vu, T. T. (2016). Structural brain alterations associated with rapid eye movement sleep behavior disorder in Parkinson\u2019s disease. Science and Reports, 6, 26782. https:\/\/doi.org\/10.1038\/srep26782","journal-title":"Science and Reports"},{"key":"815_CR7","doi-asserted-by":"publisher","first-page":"1e9","DOI":"10.3389\/fneur.2019.00312","volume":"10","author":"A Campabadal","year":"2019","unstructured":"Campabadal, A., Segura, B., Junque, C., Serradell, M., Abos, A., Uribe, C., et al. (2019). Cortical gray matter and hippocampal atrophy in idiopathic rapid eye movement sleep behavior disorder. Frontiers in Neurology, 10, 1e9.","journal-title":"Frontiers in Neurology"},{"issue":"1","key":"815_CR8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.neurad.2020.04.007","volume":"49","author":"M Chen","year":"2022","unstructured":"Chen, M., Li, Y., Chen, J., Gao, L., Sun, J., Gu, Z., Wu, T., & Chan, P. (2022). Structural and functional brain alterations in patients with idiopathic rapid eye movement sleep behavior disorder. Journal of Neuroradiology. Journal De Neuroradiologie, 49(1), 66\u201372.","journal-title":"Journal of Neuroradiology. Journal De Neuroradiologie"},{"key":"815_CR9","doi-asserted-by":"publisher","first-page":"zsaa294","DOI":"10.1093\/sleep\/zsaa294","volume":"3","author":"CE Cicero","year":"2021","unstructured":"Cicero, C. E., Giuliano, L., Luna, J., Zappia, M., Preux, P. M., & Nicoletti, A. (2021a). Prevalence of idiopathic REM behavior disorder: a systematic review and meta-analysis. Sleep, 3, zsaa294. https:\/\/doi.org\/10.1093\/sleep\/zsaa294","journal-title":"Sleep"},{"issue":"11","key":"815_CR10","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.5664\/jcsm.9416","volume":"17","author":"CE Cicero","year":"2021","unstructured":"Cicero, C. E., Giuliano, L., Sgroi, R., Squillaci, R., Terravecchia, C., Vancheri, E., Italian Society of General Medicine of Catania Study Group, et al. (2021b). Prevalence of isolated RBD in the city of Catania, Italy: a population-based study. Journal of Clinical Sleep Medicine, 17(11), 2241\u20132248.","journal-title":"Journal of Clinical Sleep Medicine"},{"issue":"1","key":"815_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/s41572-018-0016-5","volume":"4","author":"Y Dauvilliers","year":"2018","unstructured":"Dauvilliers, Y., Schenck, C. H., Postuma, R. B., Iranzo, A., Luppi, P. H., Plazzi, G., Montplaisir, J., & Boeve, B. (2018). REM sleep behaviour disorder. Nature Reviews. Disease Primers, 4(1), 19. https:\/\/doi.org\/10.1038\/s41572-018-0016-5","journal-title":"Nature Reviews. Disease Primers"},{"issue":"6","key":"815_CR12","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1002\/ana.24646","volume":"79","author":"R De Marzi","year":"2016","unstructured":"De Marzi, R., Seppi, K., H\u00f6gl, B., M\u00fcller, C., Scherfler, C., Stefani, A., Iranzo, A., Tolosa, E., Santamar\u00eca, J., Gizewski, E., Schocke, M., Skalla, E., Kremser, C., & Poewe, W. (2016). Loss of dorsolateral nigral hyperintensity on 3.0 tesla susceptibility-weighted imaging in idiopathic rapid eye movement sleep behavior disorder. Annals of Neurology, 79(6), 1026\u201330.","journal-title":"Annals of Neurology"},{"issue":"12","key":"815_CR13","doi-asserted-by":"publisher","first-page":"1885","DOI":"10.5665\/sleep.3222","volume":"36","author":"TM Ellmore","year":"2013","unstructured":"Ellmore, T. M., Castriotta, R. J., Hendley, K. L., et al. (2013). Altered nigrostriatal and nigrocortical functional connectivity in rapid eye movement sleep behavior disorder. Sleep, 36(12), 1885\u20131892.","journal-title":"Sleep"},{"key":"815_CR14","first-page":"153","volume-title":"Recent developments in Parkinson\u2019s disease","author":"S Fahn","year":"1987","unstructured":"Fahn, S., Elton, R., Members of the UPDRS Development Committee. (1987). The Unified Parkinson\u2019s disease rating scale. In S. Fahn, C. D. Marsden, D. B. Calne, & M. Goldstein (Eds.), Recent developments in Parkinson\u2019s disease (Vol. 2, pp. 153\u2013163). McMellam Health Care Information."},{"issue":"1","key":"815_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bandc.2007.10.002","volume":"67","author":"ER Foster","year":"2008","unstructured":"Foster, E. R., Black, K. J., Antenor-Dorsey, J. A., Perlmutter, J. S., & Hershey, T. (2008). Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease. Brain and Cognition, 67(1), 1\u201310.","journal-title":"Brain and Cognition"},{"key":"815_CR16","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1038\/jcbfm.2015.173","volume":"35","author":"J Ge","year":"2015","unstructured":"Ge, J., Wu, P., Peng, S., Yu, H., et al. (2015). Assessing cerebral glucose metabolism in patients with idiopathic rapid eye movement sleep behavior disorder. Journal of Cerebral Blood Flow and Metabolism, 35, 2062\u20132069.","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"815_CR17","first-page":"77","volume":"13","author":"S Ghaderi","year":"2023","unstructured":"Ghaderi, S., Karami, A., Ghalyanchi-Langeroudi, A., Abdi, N., Sharif Jalali, S. S., Rezaei, M., Kordestani-Moghadam, P., Banisharif, S., Jalali, M., Mohammadi, S., & Mohammadi, M. (2023). MRI findings in movement disorders and associated sleep disturbances. American Journal of Nuclear Medicine and Molecular Imaging, 13(3), 77\u201394.","journal-title":"American Journal of Nuclear Medicine and Molecular Imaging"},{"issue":"9","key":"815_CR18","doi-asserted-by":"publisher","first-page":"334","DOI":"10.3389\/fneur.2018.00334","volume":"11","author":"T Guo","year":"2018","unstructured":"Guo, T., Guan, X., Zeng, Q., Xuan, M., Gu, Q., Huang, P., Xu, X., & Zhang, M. (2018). Alterations of brain structural network in Parkinson\u2019s disease with and without rapid eye movement sleep behavior disorder. Frontiers in Neurology, 11(9), 334.","journal-title":"Frontiers in Neurology"},{"key":"815_CR19","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.parkreldis.2011.08.023","volume":"18","author":"H Hanyu","year":"2012","unstructured":"Hanyu, H., Inoue, Y., Sakurai, H., Kanetaka, H., Nakamura, M., Miyamoto, T., Sasai, T., & Iwamoto, T. (2012). Voxel-based magnetic resonance imaging study of structural brain changes in patients with idiopathic REM sleep behavior disorder. Parkinsonism and Related Disorders, 18, 136\u2013139.","journal-title":"Parkinsonism and Related Disorders"},{"issue":"5","key":"815_CR20","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1212\/WNL.17.5.427","volume":"17","author":"MM Hoehn","year":"1967","unstructured":"Hoehn, M. M., & Yahr, M. D. (1967). Parkinsonism: Onset, progression and mortality. Neurology, 17(5), 427\u2013442.","journal-title":"Neurology"},{"issue":"3","key":"815_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1093\/sleep\/zsaa199","volume":"44","author":"F Holtbernd","year":"2021","unstructured":"Holtbernd, F., Romanzetti, S., Oertel, W. H., Knake, S., Sittig, E., Heidbreder, A., Maier, A., Krahe, J., Wojtala, J., Dogan, I., Schulz, J. B., Schiefer, J., Janzen, A., & Reetz, K. (2021). Convergent patterns of structural brain changes in rapid eye movement sleep behavior disorder and Parkinson\u2019s disease on behalf of the German rapid eye movement sleep behavior disorder study group. Sleep, 44(3), 199. https:\/\/doi.org\/10.1093\/sleep\/zsaa199","journal-title":"Sleep"},{"key":"815_CR22","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S1474-4422(16)00057-0","volume":"4","author":"A Iranzo","year":"2016","unstructured":"Iranzo, A., Santamaria, J., & Tolosa, E. (2016). Idiopathic rapid eye movement sleep behaviour disorder: Diagnosis, management, and the need for neuroprotective interventions. Lancet Neurology, 4, 405\u2013419. https:\/\/doi.org\/10.1016\/S1474-4422(16)00057-0","journal-title":"Lancet Neurology"},{"key":"815_CR23","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.neulet.2015.09.004","volume":"606","author":"SH Jang","year":"2015","unstructured":"Jang, S. H., & Kwon, H. G. (2015). The direct pathway from the brainstem reticular formation to the cerebral cortex in the ascending reticular activating system: A diffusion tensor imaging study. Neuroscience Letters, 606, 200\u2013203.","journal-title":"Neuroscience Letters"},{"key":"815_CR24","doi-asserted-by":"publisher","first-page":"750767","DOI":"10.3389\/fnagi.2021.750767","volume":"13","author":"X Jia","year":"2022","unstructured":"Jia, X., Fan, W., Wang, Z., Liu, Y., Li, Y., Li, H., Li, H., Ma, T., Wang, J., & Yang, Q. (2022). Progressive prefrontal cortex dysfunction in Parkinson\u2019s disease with probable REM sleep behavior disorder: A 3-year longitudinal study. Frontiers in Aging Neuroscience, 13, 750767.","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"8","key":"815_CR25","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1002\/mds.28592","volume":"36","author":"R Kim","year":"2021","unstructured":"Kim, R., Lee, J. Y., Kim, Y. K., Kim, H., Yoon, E. J., Shin, J. H., Yoo, D., Nam, H., & Jeon, B. (2021). Longitudinal changes in isolated rapid eye movement sleep behavior disorder-related metabolic pattern expression. Movement Disorders, 36(8), 1889\u20131898.","journal-title":"Movement Disorders"},{"issue":"3","key":"815_CR26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/jmri.25571","volume":"46","author":"D Li","year":"2017","unstructured":"Li, D., Huang, P., Zang, Y., et al. (2017). Abnormal baseline brain activity in Parkinson\u2019s disease with and without REM sleep behavior disorder: A resting-state functional MRI study. Journal of Magnetic Resonance Imaging, 46(3), 697\u2013703.","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"815_CR27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.parkreldis.2015.11.027","volume":"23","author":"JS Lim","year":"2016","unstructured":"Lim, J. S., Shin, S. A., Lee, J. Y., Nam, H., Lee, J. Y., & Kim, Y. K. (2016). Neural substrates of rapid eye movement sleep behavior disorder in Parkinson\u2019s disease. Parkinsonism & Related Disorders, 23, 31\u201336.","journal-title":"Parkinsonism & Related Disorders"},{"key":"815_CR28","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.sleep.2021.03.041","volume":"82","author":"J Liu","year":"2021","unstructured":"Liu, J., Shuai, G., Fang, W., Zhu, Y., Chen, H., Wang, Y., Li, Q., Han, Y., Zou, D., & Cheng, O. (2021). Altered regional homogeneity and connectivity in cerebellum and visual-motor relevant cortex in Parkinson\u2019s disease with rapid eye movement sleep behavior disorder. Sleep Medicine, 82, 125\u2013133.","journal-title":"Sleep Medicine"},{"key":"815_CR29","doi-asserted-by":"publisher","first-page":"2470","DOI":"10.1007\/s00415-016-8285-y","volume":"263","author":"S Marelli","year":"2016","unstructured":"Marelli, S., Rancoita, P. M. V., Giarusso, F., et al. (2016). National validation and proposed revision of REM sleep behavior disorder screening questionnaire. Journal of Neurology, 263, 2470\u20132475.","journal-title":"Journal of Neurology"},{"issue":"1","key":"815_CR30","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3233\/JPD-212571","volume":"12","author":"R Matzaras","year":"2022","unstructured":"Matzaras, R., Shi, K., Artemiadis, A., Zis, P., Hadjigeorgiou, G., Rominger, A., Bassetti, C. L. A., & Bargiotas, P. (2022). Brain neuroimaging of rapid eye movement sleep behavior disorder in Parkinson\u2019s disease: A systematic review. Journal of Parkinson\u2019s Disease, 12(1), 69\u201383.","journal-title":"Journal of Parkinson's Disease"},{"key":"815_CR31","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1212\/01.wnl.0000242879.39415.49","volume":"67","author":"S Mazza","year":"2006","unstructured":"Mazza, S., Soucy, J. P., Gravel, P., Michaud, M., Postuma, R., Massicotte-Marquez, J., et al. (2006). Assessing whole brain perfusion changes in patients with REM sleep behavior disorder. Neurology, 67, 1618\u20131622.","journal-title":"Neurology"},{"key":"815_CR32","doi-asserted-by":"publisher","first-page":"88e10","DOI":"10.1016\/j.tics.2009.12.001","volume":"14","author":"Y Nir","year":"2010","unstructured":"Nir, Y., & Tononi, G. (2010). Dreaming and the brain: from phenomenology to neurophysiology. Trends in Cognitive Sciences, 14, 88e10.","journal-title":"Trends in Cognitive Sciences"},{"issue":"7","key":"815_CR33","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.sleep.2011.01.015","volume":"12","author":"T Nomura","year":"2011","unstructured":"Nomura, T., Inoue, Y., Kagimura, T., Uemura, Y., & Nakashima, K. (2011). Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson\u2019s disease patients. Sleep Medicine, 12(7), 711\u2013713.","journal-title":"Sleep Medicine"},{"key":"815_CR34","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s11325-018-1737-0","volume":"23","author":"KM Park","year":"2019","unstructured":"Park, K. M., Lee, H. J., Lee, B. I., & Kim, S. E. (2019). Alterations of the brain network in idiopathic rapid eye movement sleep behavior disorder: Structural connectivity analysis. Sleep Breath, 23, 587\u2013593.","journal-title":"Sleep Breath"},{"issue":"5","key":"815_CR35","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41531-019-0079-3","volume":"3","author":"JB Pereira","year":"2019","unstructured":"Pereira, J. B., Weintraub, D., Chahine, L., Aarsland, D., Hansson, O., & Westman, E. (2019). Cortical thinning in patients with REM sleep behavior disorder is associated with clinical progression. Npj Parkinson\u2019s Disease, 3(5), 7.","journal-title":"Npj Parkinson\u2019s Disease"},{"key":"815_CR36","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.sleep.2012.09.001","volume":"14","author":"RB Postuma","year":"2013","unstructured":"Postuma, R. B., Gagnon, J. F., & Montplaisir, J. (2013). Rapid eye movement sleep behavior disorder as a biomarker for neurodegeneration: The past 10 years. Sleep Medicine, 14, 763\u2013767.","journal-title":"Sleep Medicine"},{"issue":"12","key":"815_CR37","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma, R. B., Berg, D., Stern, M., et al. (2015). MDS clinical diagnostic criteria for Parkinson\u2019s disease. Movement Disorders, 30(12), 1591\u20131601.","journal-title":"Movement Disorders"},{"issue":"3","key":"815_CR38","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/brain\/awz030","volume":"142","author":"RB Postuma","year":"2019","unstructured":"Postuma, R. B., Iranzo, A., Hu, M., H\u00f6gl, B., Boeve, B. F., Manni, R., et al. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: A multicentre study. Brain, 142(3), 744\u2013759.","journal-title":"Brain"},{"issue":"5","key":"815_CR39","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/mds.25820","volume":"30","author":"S Rahayel","year":"2015","unstructured":"Rahayel, S., Montplaisir, J., Monchi, O., Bedetti, C., Postuma, R. B., Brambati, S., Carrier, J., Joubert, S., Latreille, V., Jubault, T., & Gagnon, J. F. (2015). Patterns of cortical thinning in idiopathic rapid eye movement sleep behavior disorder. Movement Disorders, 30(5), 680\u2013687. https:\/\/doi.org\/10.1002\/mds.25820","journal-title":"Movement Disorders"},{"issue":"20","key":"815_CR40","doi-asserted-by":"publisher","first-page":"e1759","DOI":"10.1212\/WNL.0000000000005523","volume":"90","author":"S Rahayel","year":"2018","unstructured":"Rahayel, S., Postuma, R. B., Montplaisir, J., G\u00e9nierMarchand, D., Escudier, F., Gaubert, M., Bourgouin, P. A., Carrier, J., Monchi, O., Joubert, S., Blanc, F., & Gagnon, J. F. (2018a). Cortical and subcortical gray matter bases of cognitive deficits in REM sleep behavior disorder. Neurology, 90(20), e1759\u2013e1770.","journal-title":"Neurology"},{"issue":"2","key":"815_CR41","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1093\/cercor\/bhx137","volume":"28","author":"S Rahayel","year":"2018","unstructured":"Rahayel, S., Postuma, R. B., Montplaisir, J., Bedetti, C., Brambati, S., Carrier, J., Monchi, O., Bourgouin, P. A., Gaubert, M., & Gagnon, J. F. (2018b). Abnormal gray matter shape, thickness, and volume in the motor Cortico-subcortical loop in idiopathic rapid eye movement sleep behavior disorder: Association with clinical and motor features. Cerebral Cortex, 28(2), 658\u2013671. https:\/\/doi.org\/10.1093\/cercor\/bhx137","journal-title":"Cerebral Cortex"},{"issue":"6","key":"815_CR42","doi-asserted-by":"publisher","first-page":"zsz062","DOI":"10.1093\/sleep\/zsz062","volume":"42","author":"S Rahayel","year":"2019","unstructured":"Rahayel, S., Gaubert, M., Postuma, R. B., Montplaisir, J., Carrier, J., Monchi, O., R\u00e9millard-Pelchat, D., Bourgouin, P. A., Panisset, M., Chouinard, S., Joubert, S., & Gagnon, J. F. (2019). Brain atrophy in Parkinson\u2019s disease with polysomnography-confirmed REM sleep behavior disorder. Sleep, 42(6), zsz062. https:\/\/doi.org\/10.1093\/sleep\/zsz062","journal-title":"Sleep"},{"issue":"Pt 8","key":"815_CR43","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1093\/brain\/aww124","volume":"139","author":"M Rolinski","year":"2016","unstructured":"Rolinski, M., Griffanti, L., Piccini, P., et al. (2016). Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson\u2019s disease. Brain, 139(Pt 8), 2224\u20132234.","journal-title":"Brain"},{"issue":"9","key":"815_CR44","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/j.parkreldis.2014.06.012","volume":"20","author":"M Salsone","year":"2014","unstructured":"Salsone, M., Cerasa, A., Arabia, G., et al. (2014). Reduced thalamic volume in Parkinson disease with REM sleep behavior disorder: Volumetric study. Parkinsonism & Related Disorders, 20(9), 1004\u20131008. https:\/\/doi.org\/10.1016\/j.parkreldis.2014.06.012","journal-title":"Parkinsonism & Related Disorders"},{"key":"815_CR45","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/j.sleep.2012.10.009","volume":"14","author":"C Schenck","year":"2013","unstructured":"Schenck, C., Boeve, B., & Mahowald, M. (2013). Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behaviour disorder: A 16-year update on a previously reported series. Sleep Medicine, 14, 744\u2013748.","journal-title":"Sleep Medicine"},{"issue":"2","key":"815_CR46","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1002\/ana.22245","volume":"69","author":"C Scherfler","year":"2011","unstructured":"Scherfler, C., Frauscher, B., Schocke, M., Iranzo, A., Gschliesser, V., Seppi, K., Santamaria, J., Tolosa, E., H\u00f6gl, B., Poewe, W., SINBAR (Sleep Innsbruck Barcelona) Group. (2011). White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: a diffusion-tensor imaging and voxel-based morphometry study. Annals of Neurology, 69(2), 400\u20137.","journal-title":"Annals of Neurology"},{"issue":"4","key":"815_CR47","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.parkreldis.2014.01.005","volume":"20","author":"M Sommerauer","year":"2014","unstructured":"Sommerauer, M., Valko, P. O., Werth, E., Poryazova, R., Hauser, S., & Baumann, C. R. (2014). Revisiting the impact of REM sleep behavior disorder on motor progression in Parkinson\u2019s disease. Parkinsonism & Related Disorders, 20(4), 460\u2013462.","journal-title":"Parkinsonism & Related Disorders"},{"issue":"6","key":"815_CR48","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1093\/sleep\/33.6.767","volume":"33","author":"MM Unger","year":"2010","unstructured":"Unger, M. M., Belke, M., Menzler, K., et al. (2010). Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regions. Sleep, 33(6), 767\u2013773.","journal-title":"Sleep"},{"issue":"10","key":"815_CR49","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1002\/jnr.25099","volume":"100","author":"M Valli","year":"2022","unstructured":"Valli, M., Uribe, C., Mihaescu, A., & Strafella, A. P. (2022). Neuroimaging of rapid eye movement sleep behavior disorder and its relation to Parkinson\u2019s disease. Journal of Neuroscience Research, 100(10), 1815\u20131833. https:\/\/doi.org\/10.1002\/jnr.25099","journal-title":"Journal of Neuroscience Research"},{"key":"815_CR50","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1002\/mds.23721","volume":"26","author":"M Vendette","year":"2011","unstructured":"Vendette, M., Gagnon, J. F., Soucy, J. P., Gosselin, N., Postuma, R. B., Tuineag, M., et al. (2011). Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder. Movement Disorders, 26, 1717\u20131724.","journal-title":"Movement Disorders"},{"key":"815_CR51","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.parkreldis.2021.03.005","volume":"85","author":"N Wakasugi","year":"2021","unstructured":"Wakasugi, N., Togo, H., Mukai, Y., Nishikawa, N., Sakamoto, T., Murata, M., Takahashi, Y., Matsuda, H., & Hanakawa, T. (2021). Prefrontal network dysfunctions in rapid eye movement sleep behavior disorder. Parkinsonism & Related Disorders, 85, 72\u201377.","journal-title":"Parkinsonism & Related Disorders"},{"issue":"12","key":"815_CR52","doi-asserted-by":"publisher","first-page":"213","DOI":"10.3389\/fnagi.2020.00213","volume":"12","author":"C Yang","year":"2020","unstructured":"Yang, C., Chang, J., Liang, X., Bao, X., & Wang, R. (2020). Gray matter alterations in Parkinson\u2019s disease with rapid eye movement sleep behavior disorder: A meta-analysis of voxel-based morphometry studies. Frontiers in Aging Neuroscience, 12(12), 213. https:\/\/doi.org\/10.3389\/fnagi.2020.00213","journal-title":"Frontiers in Aging Neuroscience"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-023-00815-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-023-00815-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-023-00815-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T12:23:01Z","timestamp":1707394981000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11682-023-00815-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,28]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2]]}},"alternative-id":["815"],"URL":"https:\/\/doi.org\/10.1007\/s11682-023-00815-0","relation":{},"ISSN":["1931-7565"],"issn-type":[{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,28]]},"assertion":[{"value":"15 October 2023","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2023","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was carried out in accordance with the Declaration of Helsinki and approval from the local ethical committee (Ethical Committee Catania 1) was obtained. All the participants were asked to sign an informed consent prior to be included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare that there are no competing interests to report.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}