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Informed consent was obtained from each subject before starting this study. Our research has already been registered on\n                      \n                      , the Clinical Trial Registration Number was ChiCTR-IPR-16009144.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}