{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T04:03:10Z","timestamp":1750910590413,"version":"3.41.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"crossref","award":["2023AFB213"],"award-info":[{"award-number":["2023AFB213"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"crossref","award":["2042023kf0014"],"award-info":[{"award-number":["2042023kf0014"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["U21A20364"],"award-info":[{"award-number":["U21A20364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1314600"],"award-info":[{"award-number":["2018YFC1314600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"DOI":"10.1007\/s11682-025-00983-1","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T05:54:54Z","timestamp":1743746094000},"page":"713-720","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of polygenic risk for major depressive disorder and childhood emotional neglect on cortical blood flow complexity in young depression patients"],"prefix":"10.1007","volume":"19","author":[{"given":"Lijun","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaowen","family":"Nie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaohua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Bu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongchun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,4,2]]},"reference":[{"issue":"1","key":"983_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/cercor\/bhu214","volume":"26","author":"IK Amlien","year":"2016","unstructured":"Amlien, I. K., Fjell, A. M., Tamnes, C. K., Grydeland, H., Krogsrud, S. K., Chaplin, T. A., Rosa, M., & Walhovd, K. B. (2016). Organizing principles of human cortical development\u2013thickness and area from 4 to 30 years: Insights from comparative Primate Neuroanatomy. Cerebral Cortex, 26(1), 257\u2013267.","journal-title":"Cerebral Cortex"},{"issue":"1","key":"983_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/S0924-9338(97)86748-X","volume":"13","author":"P Amorim","year":"1998","unstructured":"Amorim, P., Lecrubier, Y., Weiller, E., Hergueta, T., & Sheehan, D. (1998). DSM-IH-R Psychotic disorders: Procedural validity of the mini international neuropsychiatric interview (MINI). Concordance and causes for discordance with the CIDI. European Psychiatry: The Journal of the Association of European Psychiatrists, 13(1), 26\u201334.","journal-title":"European Psychiatry: The Journal of the Association of European Psychiatrists"},{"key":"983_CR3","unstructured":"Arbanas, G. (2015). Diagnostic and statistical manual of mental disorders (DSM-5)."},{"issue":"7571","key":"983_CR4","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","volume":"526","author":"A Auton","year":"2015","unstructured":"Auton, A., Brooks, L. D., Durbin, R. M., Garrison, E. P., Kang, H. M., Korbel, J. O., Marchini, J. L., McCarthy, S., McVean, G. A., & Abecasis, G. R. (2015). A global reference for human genetic variation. Nature, 526(7571), 68\u201374.","journal-title":"Nature"},{"issue":"8","key":"983_CR5","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","volume":"151","author":"DP Bernstein","year":"1994","unstructured":"Bernstein, D. P., Fink, L., Handelsman, L., Foote, J., Lovejoy, M., Wenzel, K., Sapareto, E., & Ruggiero, J. (1994). Initial reliability and validity of a new retrospective measure of child abuse and neglect. American Journal of Psychiatry, 151(8), 1132\u20131136.","journal-title":"American Journal of Psychiatry"},{"key":"983_CR6","doi-asserted-by":"crossref","unstructured":"Bogdan, R., Salmeron, B. J., Carey, C. E., Agrawal, A., Calhoun, V. D., Garavan, H., Hariri, A. R., Heinz, A., Hill, M. N., & Holmes, A. (2017). Imaging genetics and genomics in psychiatry: a critical review of progress and potential.  Biological Psychiatry 82(3):165\u2013175.","DOI":"10.1016\/j.biopsych.2016.12.030"},{"key":"983_CR7","doi-asserted-by":"crossref","unstructured":"Bureau, A., Berthelot, N., Ricard, J., Lafrance, C., Jomphe, V., Dioni, A., Fortin-Fabbro, E., Boisvert, M. C., & Maziade, M. (2023). Heterogeneity in the longitudinal courses of global functioning in children at familial risk of major psychiatric disorders: Association with trauma and familial characteristics. Bipolar Disord.","DOI":"10.1111\/bdi.13386"},{"key":"983_CR8","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.jad.2022.05.007","volume":"310","author":"G Cattarinussi","year":"2022","unstructured":"Cattarinussi, G., Delvecchio, G., Sambataro, F., & Brambilla, P. (2022). The effect of polygenic risk scores for major depressive disorder, bipolar disorder and schizophrenia on morphological brain measures: A systematic review of the evidence. Journal of Affective Disorders, 310, 213\u2013222.","journal-title":"Journal of Affective Disorders"},{"key":"983_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13742-015-0047-8","volume":"4","author":"CC Chang","year":"2015","unstructured":"Chang, C. C., Chow, C. C., Tellier, L. C., Vattikuti, S., Purcell, S. M., & Lee, J. J. (2015). Second-generation PLINK: Rising to the challenge of larger and richer datasets. Gigascience, 4, 7.","journal-title":"Gigascience"},{"key":"983_CR10","doi-asserted-by":"publisher","first-page":"111729","DOI":"10.1016\/j.pscychresns.2023.111729","volume":"336","author":"S Chen","year":"2023","unstructured":"Chen, S., Yin, Y., Zhang, Y., Yue, Y., Jiang, W., Hou, Z., & Yuan, Y. (2023). Abnormal spontaneous activity of regions related to mood regulation mediates the effect of childhood emotional neglect on major depressive disorder. Psychiatry Res Neuroimaging, 336, 111729.","journal-title":"Psychiatry Res Neuroimaging"},{"key":"983_CR12","doi-asserted-by":"crossref","unstructured":"Choi, S. W., & O\u2019Reilly, P. F. (2019). PRSice-2: Polygenic risk score software for biobank-scale data. Gigascience8(7).","DOI":"10.1093\/gigascience\/giz082"},{"issue":"9","key":"983_CR11","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1038\/s41596-020-0353-1","volume":"15","author":"SW Choi","year":"2020","unstructured":"Choi, S. W., Mak, T. S., & O\u2019Reilly, P. F. (2020). Tutorial: A guide to performing polygenic risk score analyses. Nature Protocols, 15(9), 2759\u20132772.","journal-title":"Nature Protocols"},{"issue":"11","key":"983_CR13","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1001\/jamapsychiatry.2022.2983","volume":"79","author":"M Chuong","year":"2022","unstructured":"Chuong, M., Adams, M. J., Kwong, A., Haley, C. S., Amador, C., & McIntosh, A. M. (2022). Genome-by-trauma exposure interactions in adults with Depression in the UK Biobank. JAMA Psychiatry, 79(11), 1110\u20131117.","journal-title":"JAMA Psychiatry"},{"key":"983_CR14","unstructured":"Coleman, J., Peyrot, W. J., Purves, K. L., Davis, K., Rayner, C., Choi, S. W., Hubel, C., Gaspar, H. A., Kan, C., & Van der Auwera, S. (2020). and others. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Mol Psychiatry25(7):1430\u20131446."},{"key":"983_CR15","doi-asserted-by":"crossref","unstructured":"Cooper, C. M., Chin, F. C., Liu, P., Grannemann, B. D., Carmody, T., Almeida, J., Deckersbach, T., Fava, M., Kurian, B. T., & Malchow, A. L. (2020). Discovery and replication of cerebral blood flow differences in major depressive disorder. Molecular Psychiatry25(7):1500\u20131510.","DOI":"10.1038\/s41380-019-0464-7"},{"key":"983_CR16","doi-asserted-by":"crossref","unstructured":"Das, S., Forer, L., Schonherr, S., Sidore, C., Locke, A. E., Kwong, A., Vrieze, S. I., Chew, E. Y., Levy, S., & McGue, M. (2016). and others. Next-generation genotype imputation service and methods. Nat Genet48(10):1284\u20131287.","DOI":"10.1038\/ng.3656"},{"issue":"4","key":"983_CR17","doi-asserted-by":"publisher","first-page":"e1004219","DOI":"10.1371\/journal.pcbi.1004219","volume":"11","author":"CA de Leeuw","year":"2015","unstructured":"de Leeuw, C. A., Mooij, J. M., Heskes, T., & Posthuma, D. (2015). MAGMA: Generalized gene-set analysis of GWAS data. Plos Computational Biology, 11(4), e1004219.","journal-title":"Plos Computational Biology"},{"issue":"11","key":"983_CR20","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1001\/jamapsychiatry.2021.2099","volume":"78","author":"O Giannakopoulou","year":"2021","unstructured":"Giannakopoulou, O., Lin, K., Meng, X., Su, M. H., Kuo, P. H., Peterson, R. E., Awasthi, S., Moscati, A., Coleman, J., Bass, N., & others. (2021). The genetic architecture of depression in individuals of east Asian ancestry: A genome-wide association study. JAMA Psychiatry, 78(11), 1258\u20131269.","journal-title":"JAMA Psychiatry"},{"key":"983_CR22","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1136\/jnnp.23.1.56","volume":"23","author":"HAMILTON M","year":"1960","unstructured":"Hamilton M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56\u201362.","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"1","key":"983_CR23","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/s41398-022-01829-w","volume":"12","author":"C He","year":"2022","unstructured":"He, C., Fan, D., Liu, X., Wang, Q., Zhang, H., Zhang, H., Zhang, Z., & Xie, C. (2022). Insula network connectivity mediates the association between childhood maltreatment and depressive symptoms in major depressive disorder patients. Transl Psychiatry, 12(1), 89.","journal-title":"Transl Psychiatry"},{"key":"983_CR24","unstructured":"Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivieres, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., & Andersson, M. (2015). Common genetic variants influence human subcortical brain structures. Nature 520(7546):224-9."},{"issue":"50","key":"983_CR25","doi-asserted-by":"publisher","first-page":"18087","DOI":"10.1523\/JNEUROSCI.2531-12.2012","volume":"32","author":"AJ Holmes","year":"2012","unstructured":"Holmes, A. J., Lee, P. H., Hollinshead, M. O., Bakst, L., Roffman, J. L., Smoller, J. W., & Buckner, R. L. (2012). Individual differences in amygdala-medial prefrontal anatomy link negative affect, impaired social functioning, and polygenic depression risk. Journal of Neuroscience, 32(50), 18087\u201318100.","journal-title":"Journal of Neuroscience"},{"key":"983_CR26","unstructured":"Howard, D. M., Adams, M. J., Clarke, T. K., Hafferty, J. D., Gibson, J., Shirali, M., Coleman, J., Hagenaars, S. P., Ward, J., & Wigmore, E. M. (2019). Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions. Nature Neuroscience22(3):343\u2013352."},{"issue":"1","key":"983_CR27","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41398-022-01892-3","volume":"12","author":"B Hu","year":"2022","unstructured":"Hu, B., Cha, J., Fullerton, J. M., Hesam-Shariati, S., Nakamura, K., Nurnberger, J. I., & Anand, A. (2022). Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: A novel molecular approach. Transl Psychiatry, 12(1), 137.","journal-title":"Transl Psychiatry"},{"key":"983_CR28","doi-asserted-by":"crossref","unstructured":"Kang, L., Li, R., Liu, H., Ma, S., Sun, S., Zhang, N., Yao, L., Wang, Y., Zong, X., & Ai, C. (2021). and others. Nonsuicidal self-injury in undergraduate students with major depressive disorder: The role of psychosocial factors. Journal of Affective Disorders290:102\u2013108.","DOI":"10.1016\/j.jad.2021.04.083"},{"key":"983_CR29","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","volume":"34","author":"RC Kessler","year":"2013","unstructured":"Kessler, R. C., & Bromet, E. J. (2013). The epidemiology of depression across cultures. Annual Review of Public Health, 34, 119\u2013138.","journal-title":"Annual Review of Public Health"},{"key":"983_CR30","doi-asserted-by":"crossref","unstructured":"Koch, E., Nyberg, L., Lundquist, A., & Kauppi, K. (2022). Polygenic risk for Schizophrenia has sex-specific effects on Brain Activity during Memory Processing in healthy individuals. Genes (Basel) 13(3).","DOI":"10.3390\/genes13030412"},{"key":"983_CR31","doi-asserted-by":"crossref","unstructured":"Kochunov, P., Jahanshad, N., Marcus, D., Winkler, A., Sprooten, E., Nichols, T. E., Wright, S. N., Hong, L. E., Patel, B., & Behrens, T. (2015). Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. NeuroImage, 111:300\u2013\u200911.","DOI":"10.1016\/j.neuroimage.2015.02.050"},{"issue":"1","key":"983_CR32","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12916-023-02783-0","volume":"21","author":"D Li","year":"2023","unstructured":"Li, D., Xie, J., Wang, L., Sun, Y., Hu, Y., & Tian, Y. (2023a). Genetic susceptibility and lifestyle modify the association of long-term air pollution exposure on major depressive disorder: A prospective study in UK Biobank. Bmc Medicine, 21(1), 67.","journal-title":"Bmc Medicine"},{"key":"983_CR33","doi-asserted-by":"crossref","unstructured":"Li, X., Huang, Y., Liu, M., Zhang, M., Liu, Y., Teng, T., Liu, X., Yu, Y., Jiang, Y., & Ouyang, X. (2023b). and others. Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder. Int J Clin Health Psychol23(4):100401.","DOI":"10.1016\/j.ijchp.2023.100401"},{"issue":"12","key":"983_CR34","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","volume":"27","author":"A Liberzon","year":"2011","unstructured":"Liberzon, A., Subramanian, A., Pinchback, R., Thorvaldsdottir, H., Tamayo, P., & Mesirov, J. P. (2011). Molecular signatures database (MSigDB) 3.0. Bioinformatics, 27(12), 1739\u20131740.","journal-title":"Bioinformatics"},{"issue":"9","key":"983_CR35","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1017\/S0033291719001442","volume":"50","author":"S Liu","year":"2020","unstructured":"Liu, S., Li, A., Liu, Y., Li, J., Wang, M., Sun, Y., Qin, W., Yu, C., Jiang, T., & Liu, B. (2020). MIR137 polygenic risk is associated with schizophrenia and affects functional connectivity of the dorsolateral prefrontal cortex. Psychological Medicine, 50(9), 1510\u20131518.","journal-title":"Psychological Medicine"},{"key":"983_CR36","doi-asserted-by":"crossref","unstructured":"Loh, P. R., Danecek, P., Palamara, P. F., Fuchsberger, C., A RY, K. F. H., Schoenherr, S., Forer, L., McCarthy, S., & Abecasis, G. R. (2016). and others. Reference-based phasing using the Haplotype Reference Consortium panel. Nat Genet48(11):1443\u20131448.","DOI":"10.1038\/ng.3679"},{"issue":"10","key":"983_CR38","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1111\/jcpp.13657","volume":"63","author":"S Machlitt-Northen","year":"2022","unstructured":"Machlitt-Northen, S., Keers, R., Munroe, P. B., Howard, D. M., Trubetskoy, V., & Pluess, M. (2022). Polygenic scores for schizophrenia and major depression are associated with psychosocial risk factors in children: Evidence of gene-environment correlation. Journal of Child Psychology and Psychiatry, 63(10), 1140\u20131152.","journal-title":"Journal of Child Psychology and Psychiatry"},{"issue":"10161","key":"983_CR39","doi-asserted-by":"publisher","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","volume":"392","author":"GS Malhi","year":"2018","unstructured":"Malhi, G. S., & Mann, J. J. (2018). Depression Lancet392(10161):2299\u20132312.","journal-title":"Depression Lancet"},{"issue":"4","key":"983_CR40","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1093\/schbul\/sbx140","volume":"44","author":"JA Miller","year":"2018","unstructured":"Miller, J. A., Scult, M. A., Conley, E. D., Chen, Q., Weinberger, D. R., & Hariri, A. R. (2018). Effects of schizophrenia polygenic risk scores on brain activity and performance during working memory subprocesses in healthy young adults. Schizophrenia Bulletin, 44(4), 844\u2013853.","journal-title":"Schizophrenia Bulletin"},{"key":"983_CR41","doi-asserted-by":"crossref","unstructured":"Mutsaerts, H., Petr, J., Groot, P., Vandemaele, P., Ingala, S., Robertson, A. D., Vaclavu, L., Groote, I., Kuijf, H., & Zelaya, F. (2020).. ExploreASL: An image processing pipeline for multi-center ASL perfusion MRI studies. NeuroImage219:117031.","DOI":"10.1016\/j.neuroimage.2020.117031"},{"key":"983_CR42","doi-asserted-by":"publisher","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","volume":"2","author":"C Otte","year":"2016","unstructured":"Otte, C., Gold, S. M., Penninx, B. W., Pariante, C. M., Etkin, A., Fava, M., Mohr, D. C., & Schatzberg, A. F. (2016). Major depressive disorder. Nat Rev Dis Primers, 2, 16065.","journal-title":"Nat Rev Dis Primers"},{"key":"983_CR43","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.jad.2021.06.016","volume":"293","author":"H Park","year":"2021","unstructured":"Park, H., Forthman, K. L., Kuplicki, R., Victor, T. A., Yeh, H. W., Thompson, W. K., & Paulus, M. P. (2021). Polygenic risk for neuroticism moderates response to gains and losses in amygdala and caudate: Evidence from a clinical cohort. Journal of Affective Disorders, 293, 124\u2013132.","journal-title":"Journal of Affective Disorders"},{"issue":"12","key":"983_CR45","doi-asserted-by":"publisher","first-page":"e190","DOI":"10.1371\/journal.pgen.0020190","volume":"2","author":"N Patterson","year":"2006","unstructured":"Patterson, N., Price, A. L., & Reich, D. (2006). Population structure and eigenanalysis. Plos Genetics, 2(12), e190.","journal-title":"Plos Genetics"},{"issue":"8","key":"983_CR46","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/ng1847","volume":"38","author":"AL Price","year":"2006","unstructured":"Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006). Principal components analysis corrects for stratification in genome-wide association studies. Nature Genetics, 38(8), 904\u2013909.","journal-title":"Nature Genetics"},{"key":"983_CR47","doi-asserted-by":"crossref","unstructured":"Qin, X., Wang, M., Lu, X., Sun, J., Dong, Q., Zhang, L., Liu, J., Ju, Y., Wan, P., & Guo, H. (2021a). and others. Childhood emotional neglect is associated with low social support in chinese patients with major depressive disorder. Frontiers in Psychiatry12:781738.","DOI":"10.3389\/fpsyt.2021.781738"},{"key":"983_CR48","doi-asserted-by":"crossref","unstructured":"Qin, Y., Wu, J., Chen, T., Li, J., Zhang, G., Wu, D., Zhou, Y., Zheng, N., Cai, A., & Ning, Q. (2021b). and others. Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations. J Clin Invest131(8).","DOI":"10.1172\/JCI147329"},{"key":"983_CR49","doi-asserted-by":"crossref","unstructured":"Reus, L. M., Shen, X., Gibson, J., Wigmore, E., Ligthart, L., Adams, M. J., Davies, G., Cox, S. R., Hagenaars, S. P., & Bastin, M. E. (2017). Association of polygenic risk for major psychiatric illness with subcortical volumes and white matter integrity in UK Biobank. Scientific Reports7:42140.","DOI":"10.1038\/srep42140"},{"issue":"6","key":"983_CR51","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.biopsych.2018.09.032","volume":"85","author":"D Voineskos","year":"2019","unstructured":"Voineskos, D., Blumberger, D. M., Zomorrodi, R., Rogasch, N. C., Farzan, F., Foussias, G., Rajji, T. K., & Daskalakis, Z. J. (2019). Altered transcranial magnetic stimulation-electroencephalographic markers of inhibition and excitation in the Dorsolateral Prefrontal Cortex in Major Depressive Disorder. Biological Psychiatry, 85(6), 477\u2013486.","journal-title":"Biological Psychiatry"},{"issue":"1","key":"983_CR52","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe, K., Taskesen, E., van Bochoven, A., & Posthuma, D. (2017). Functional mapping and annotation of genetic associations with FUMA. Nature Communications, 8(1), 1826.","journal-title":"Nature Communications"},{"key":"983_CR53","doi-asserted-by":"crossref","unstructured":"Winter, N. R., Leenings, R., Ernsting, J., Sarink, K., Fisch, L., Emden, D., Blanke, J., Goltermann, J., Opel, N., & Barkhau, C. (2022). Quantifying deviations of brain structure and function in major depressive disorder across neuroimaging modalities. JAMA Psychiatry79(9):879\u2013888.","DOI":"10.1001\/jamapsychiatry.2022.1780"},{"key":"983_CR54","unstructured":"Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., & Andlauer, T. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50(5):668\u2013681."},{"key":"983_CR55","doi-asserted-by":"crossref","unstructured":"Zhang, C., Li, X., Zhao, L., Guo, W., Deng, W., Wang, Q., Hu, X., Du, X., Sham, P. C., & Luo, X. (2023). and others. Brain transcriptome-wide association study implicates novel risk genes underlying schizophrenia risk. Psychological Medicine, 1\u201311.","DOI":"10.1017\/S0033291723000417"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-025-00983-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-025-00983-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-025-00983-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T06:51:40Z","timestamp":1750834300000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11682-025-00983-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,2]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,6]]}},"alternative-id":["983"],"URL":"https:\/\/doi.org\/10.1007\/s11682-025-00983-1","relation":{},"ISSN":["1931-7565"],"issn-type":[{"type":"electronic","value":"1931-7565"}],"subject":[],"published":{"date-parts":[[2025,4,2]]},"assertion":[{"value":"11 February 2025","order":1,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2025","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This experiment was examined and approved by the ethics committee of the Renmin Hospital of Wuhan University, and all the participants were informed and agreed to participate in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}