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The current study investigated whether degree centrality of the thalamus mediates the effect of sCD14, a marker of monocyte activation, on fatigue and whether those parameters vary as a function of HIV-status. Resting-state functional connectivity MRI data, blood plasma, and self-report data were collected from 16 HIV\u2009+\u2009and 25 HIV- post-menopausal women. Analyses tested whether degree centrality of the thalamus, caudate, and right putamen mediated the relationship between sCD14 and fatigue. HIV-serostatus was then tested as a moderator. Compared to HIV-negative, HIV\u2009+\u2009women had higher levels of sCD14,\n                    <jats:italic>t<\/jats:italic>\n                    (34) = -3.85,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;.001, and lower thalamic degree centrality,\n                    <jats:italic>t<\/jats:italic>\n                    (33)\u2009=\u20092.17,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=.038. SCD14 predicted lower thalamic DC,\n                    <jats:italic>b<\/jats:italic>\n                    = -1.16,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=.035. Degree centrality predicted fatigue,\n                    <jats:italic>b<\/jats:italic>\n                    = -4.50,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=.03. Indirect and moderation effects were not significant. Monocyte activation is feature of chronic HIV-infection that impacts the number of thalamic connections to whole brain. The reduced thalamic degree centrality is associated with greater neurobiological vulnerability for fatigue after menopause.\n                  <\/jats:p>","DOI":"10.1007\/s11682-025-01028-3","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T01:18:49Z","timestamp":1750036729000},"page":"1018-1027","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatigue, monocyte activation, and degree centrality of the thalamus in post-menopausal women living with HIV"],"prefix":"10.1007","volume":"19","author":[{"given":"Kaitlyn","family":"Dillon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Lobo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Pallikkuth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Levin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"McIntosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"issue":"3","key":"1028_CR1","first-page":"101","volume":"20","author":"JA Aberg","year":"2012","unstructured":"Aberg, J. 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