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Informed consent was obtained from all individual participants included in the study. Participants were provided with detailed information about the study objectives and procedures prior to their voluntary consent.","order":1,"name":"Ethics","label":"Human ethics and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The funding source had no involvement in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.","order":2,"name":"Ethics","label":"Disclosure","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In this experiment, due to the high cost of magnetic sensitivity quantitative imaging, it is difficult to include the sample size for scientific research, so a total of 60 cases have been completed in the experimental group and the control group after three years. The small sample size limited subgroup analyses. Our future studies will explore iron deposition in PD subtypes or across disease stages. On this basis, we further validated the interaction between iron metabolism and neuroinflammation and iron deposition in the substantia nigra of Parkinson\u2019s disease at the animal and cellular levels.","order":4,"name":"Ethics","label":"Limitations and strengths of the study","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":5,"name":"Ethics","label":"Clinical trial number","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"88"}}