{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:40:37Z","timestamp":1792525237541,"version":"4.5.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82270696"],"award-info":[{"award-number":["82270696"]}]},{"name":"Lingang Laboratory","award":["LGLG-TKN-202205-01"],"award-info":[{"award-number":["LGLG-TKN-202205-01"]}]},{"name":"Open Fund Project of Shaanxi Key Laboratory of Acupuncture and Medicine","award":["KF2019"],"award-info":[{"award-number":["KF2019"]}]},{"name":"Xidian University Specially Funded Project for Interdisciplinary Exploration","award":["TZJHF202521"],"award-info":[{"award-number":["TZJHF202521"]}]},{"name":"Shaanxi Provincial Key Laboratory of Integrated Acupuncture and Medication","award":["KF2219"],"award-info":[{"award-number":["KF2219"]}]},{"name":"National Key R&D Program of China","award":["2022YFC3500701 and 2018YFC1704606"],"award-info":[{"award-number":["2022YFC3500701 and 2018YFC1704606"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Brain Imaging and Behavior"],"DOI":"10.1007\/s11682-026-01171-5","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T02:27:35Z","timestamp":1792463255000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Altered brain function and its spatial correlations with neurotransmitter maps in anterior shoulder pain patients"],"prefix":"10.1007","volume":"20","author":[{"given":"Zhijun","family":"Diao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingdong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yintao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"1171_CR1","doi-asserted-by":"publisher","first-page":"116794","DOI":"10.1016\/j.neuroimage.2020.116794","volume":"215","author":"J Archibald","year":"2020","unstructured":"Archibald, J., MacMillan, E. L., Enzler, A., Jutzeler, C. R., Schweinhardt, P., & Kramer, J. L. K. (2020). Excitatory and inhibitory responses in the brain to experimental pain: A systematic review of MR spectroscopy studies. Neuroimage, 215, 116794.","journal-title":"Neuroimage"},{"key":"1171_CR2","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/j.pain.0000000000001745","volume":"161","author":"M Azqueta-Gavaldon","year":"2020","unstructured":"Azqueta-Gavaldon, M., Youssef, A. M., Storz, C., Lemme, J., Schulte-G\u00f6cking, H., Becerra, L., Azad, S. C., Reiners, A., Ertl-Wagner, B., Borsook, D., Upadhyay, J., & Kraft, E. (2020). Implications of the putamen in pain and motor deficits in complex regional pain syndrome. Pain, 161, 595\u2013608.","journal-title":"Pain"},{"key":"1171_CR3","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/j.pain.0000000000002022","volume":"162","author":"T Bell","year":"2021","unstructured":"Bell, T., Stokoe, M., Khaira, A., Webb, M., Noel, M., Amoozegar, F., & Harris, A. D. (2021). GABA and glutamate in pediatric migraine. Pain, 162, 300\u2013308.","journal-title":"Pain"},{"key":"1171_CR4","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s10020-023-00647-0","volume":"29","author":"U Breitinger","year":"2023","unstructured":"Breitinger, U., & Breitinger, H. G. (2023). Excitatory and inhibitory neuronal signaling in inflammatory and diabetic neuropathic pain. Molecular Medicine, 29, 53.","journal-title":"Molecular Medicine"},{"key":"1171_CR5","doi-asserted-by":"publisher","first-page":"E557","DOI":"10.36076\/ppj.2024.7.E557","volume":"27","author":"S Cheng","year":"2024","unstructured":"Cheng, S., Dong, X., Lai, P., Chen, X., Zhou, J., Li, Z., & Wu, X. (2024). A multimodal meta-analysis of structural and functional alterations in the brain of knee osteoarthritis systematic review. Pain Physician, 27, E557\u2013E566.","journal-title":"Pain Physician"},{"key":"1171_CR6","doi-asserted-by":"publisher","first-page":"104544","DOI":"10.1016\/j.neuint.2019.104544","volume":"131","author":"N Chuhma","year":"2019","unstructured":"Chuhma, N., Tanaka, K. F., & Nagai, T. (2019). The physiology and pathophysiology of basal ganglia: from signal transduction to circuits. Neurochemistry International, 131, 104544.","journal-title":"Neurochemistry International"},{"key":"1171_CR7","doi-asserted-by":"publisher","first-page":"102638","DOI":"10.1016\/j.nicl.2021.102638","volume":"30","author":"I Coppieters","year":"2021","unstructured":"Coppieters, I., Cagnie, B., De Pauw, R., Meeus, M., & Timmers, I. (2021). Enhanced amygdala-frontal operculum functional connectivity during rest in women with chronic neck pain: Associations with impaired conditioned pain modulation. Neuroimage Clin, 30, 102638.","journal-title":"Neuroimage Clin"},{"key":"1171_CR8","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.1249\/MSS.0000000000000726","volume":"47","author":"G Cunningham","year":"2015","unstructured":"Cunningham, G., Zanchi, D., Emmert, K., Kopel, R., Van De Ville, D., L\u00e4dermann, A., Haller, S., & Hoffmeyer, P. (2015). Neural Correlates of Clinical Scores in Patients with Anterior Shoulder Apprehension. Medicine And Science In Sports And Exercise, 47, 2612\u20132620.","journal-title":"Medicine And Science In Sports And Exercise"},{"key":"1171_CR9","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/j.pain.0000000000001762","volume":"161","author":"R De Pauw","year":"2020","unstructured":"De Pauw, R., Aerts, H., Siugzdaite, R., Meeus, M., Coppieters, I., Caeyenberghs, K., & Cagnie, B. (2020). Hub disruption in patients with chronic neck pain: a graph analytical approach. Pain, 161, 729\u2013741.","journal-title":"Pain"},{"key":"1171_CR10","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/hbm.25244","volume":"42","author":"J Dukart","year":"2021","unstructured":"Dukart, J., Holiga, S., Rullmann, M., Lanzenberger, R., Hawkins, P. C. T., Mehta, M. A., Hesse, S., Barthel, H., Sabri, O., Jech, R., & Eickhoff, S. B. (2021). JuSpace: a tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps. Human Brain Mapping, 42, 555\u2013566.","journal-title":"Human Brain Mapping"},{"key":"1171_CR11","doi-asserted-by":"publisher","first-page":"aac9698","DOI":"10.1126\/science.aac9698","volume":"351","author":"EA Ferenczi","year":"2016","unstructured":"Ferenczi, E. A., Zalocusky, K. A., Liston, C., Grosenick, L., Warden, M. R., Amatya, D., Katovich, K., Mehta, H., Patenaude, B., Ramakrishnan, C., Kalanithi, P., Etkin, A., Knutson, B., Glover, G. H., & Deisseroth, K. (2016). Prefrontal cortical regulation of brainwide circuit dynamics and reward-related behavior. Science, 351, aac9698.","journal-title":"Science"},{"key":"1171_CR12","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jpain.2015.10.003","volume":"17","author":"HC Fritz","year":"2016","unstructured":"Fritz, H. C., McAuley, J. H., Wittfeld, K., Hegenscheid, K., Schmidt, C. O., Langner, S., & Lotze, M. (2016). Chronic back pain is associated with decreased prefrontal and anterior insular gray matter: results from a population-based cohort study. The Journal Of Pain : Official Journal Of The American Pain Society, 17, 111\u2013118.","journal-title":"The Journal Of Pain : Official Journal Of The American Pain Society"},{"key":"1171_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s10194-023-01544-x","volume":"24","author":"X Ge","year":"2023","unstructured":"Ge, X., Wang, L., Pan, L., Ye, H., Zhu, X., Fan, S., Feng, Q., Du, Q., Yu, W., & Ding, Z. (2023). Alteration of the cortical morphology in classical trigeminal neuralgia: voxel-, deformation-, and surface-based analysis. The Journal Of Headache And Pain, 24, 17.","journal-title":"The Journal Of Headache And Pain"},{"key":"1171_CR14","doi-asserted-by":"publisher","first-page":"783355","DOI":"10.3389\/fnhum.2021.783355","volume":"15","author":"H Guo","year":"2021","unstructured":"Guo, H., Wang, Y., Qiu, L., Huang, X., He, C., Zhang, J., & Gong, Q. (2021). Structural and functional abnormalities in knee osteoarthritis pain revealed with multimodal magnetic resonance imaging. Frontiers In Human Neuroscience, 15, 783355.","journal-title":"Frontiers In Human Neuroscience"},{"key":"1171_CR15","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1002\/art.23223","volume":"58","author":"RE Harris","year":"2008","unstructured":"Harris, R. E., Sundgren, P. C., Pang, Y., Hsu, M., Petrou, M., Kim, S. H., McLean, S. A., Gracely, R. H., & Clauw, D. J. (2008). Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis And Rheumatism, 58, 903\u2013907.","journal-title":"Arthritis And Rheumatism"},{"key":"1171_CR16","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neulet.2014.08.027","volume":"581","author":"T Hiramatsu","year":"2014","unstructured":"Hiramatsu, T., Nakanishi, K., Yoshimura, S., Yoshino, A., Adachi, N., Okamoto, Y., Yamawaki, S., & Ochi, M. (2014). The dorsolateral prefrontal network is involved in pain perception in knee osteoarthritis patients. Neuroscience Letters, 581, 109\u2013114.","journal-title":"Neuroscience Letters"},{"key":"1171_CR17","doi-asserted-by":"publisher","first-page":"R154","DOI":"10.1016\/j.cub.2005.02.037","volume":"15","author":"SE Hyman","year":"2005","unstructured":"Hyman, S. E. (2005). Neurotransmitters Curr Biol 15, R154\u2013158.","journal-title":"Neurotransmitters Curr Biol"},{"key":"1171_CR18","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.apmr.2020.07.006","volume":"102","author":"JJ Im","year":"2021","unstructured":"Im, J. J., Kim, J., Jeong, H., Oh, J. K., Lee, S., Lyoo, I. K., Chung, Y. A., & Yoon, S. (2021). Prefrontal white matter abnormalities associated with pain catastrophizing in patients with complex regional pain syndrome. Archives Of Physical Medicine And Rehabilitation, 102, 216\u2013224.","journal-title":"Archives Of Physical Medicine And Rehabilitation"},{"key":"1171_CR19","doi-asserted-by":"publisher","first-page":"102326","DOI":"10.1016\/j.nicl.2020.102326","volume":"27","author":"SA Jones","year":"2020","unstructured":"Jones, S. A., Morales, A. M., Holley, A. L., Wilson, A. C., & Nagel, B. J. (2020). Default mode network connectivity is related to pain frequency and intensity in adolescents. Neuroimage Clin, 27, 102326.","journal-title":"Neuroimage Clin"},{"key":"1171_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.bj.2022.01.003","volume":"46","author":"JT Kao","year":"2023","unstructured":"Kao, J. T., Chiu, C. H., Hsu, K. Y., Chang, S. S., Chan, Y. S., & Chen, A. C. (2023). Arthroscopic diagnosis of long head of biceps tendon instability in refractory anterior shoulder pain: A comparison study between pulley tear and non-tear lesions. Biomed J, 46, 163\u2013169.","journal-title":"Biomed J"},{"key":"1171_CR21","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1186\/s12883-021-02374-7","volume":"21","author":"YE Kim","year":"2021","unstructured":"Kim, Y. E., Kim, M. K., Suh, S. I., & Kim, J. H. (2021). Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study. Bmc Neurology, 21, 342.","journal-title":"Bmc Neurology"},{"key":"1171_CR22","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.jpain.2019.01.330","volume":"20","author":"M Kohler","year":"2019","unstructured":"Kohler, M., Strauss, S., Horn, U., Langner, I., Usichenko, T., Neumann, N., & Lotze, M. (2019). Differences in neuronal representation of mental rotation in patients with complex regional pain syndrome and healthy controls. The Journal of Pain : Official Journal of The American Pain Society, 20, 898\u2013907.","journal-title":"The Journal Of Pain : Official Journal Of The American Pain Society"},{"key":"1171_CR23","doi-asserted-by":"publisher","first-page":"103414","DOI":"10.1016\/j.nicl.2023.103414","volume":"38","author":"JL Kowalski","year":"2023","unstructured":"Kowalski, J. L., Morse, L. R., Troy, K., Nguyen, N., Battaglino, R. A., Falci, S. P., & Linnman, C. (2023). Resting state functional connectivity differentiation of neuropathic and nociceptive pain in individuals with chronic spinal cord injury. Neuroimage Clin, 38, 103414.","journal-title":"Neuroimage Clin"},{"key":"1171_CR24","doi-asserted-by":"crossref","unstructured":"Labrakakis, C. (2023). The role of the insular cortex in pain. International Journal Of Molecular Sciences, 24, 5736.","DOI":"10.3390\/ijms24065736"},{"key":"1171_CR25","doi-asserted-by":"publisher","first-page":"117186","DOI":"10.1016\/j.neuroimage.2020.117186","volume":"221","author":"H Li","year":"2020","unstructured":"Li, H., Li, X., Feng, Y., Gao, F., Kong, Y., & Hu, L. (2020a). Deficits in ascending and descending pain modulation pathways in patients with postherpetic neuralgia. Neuroimage, 221, 117186.","journal-title":"Neuroimage"},{"key":"1171_CR26","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2147\/JPR.S220370","volume":"13","author":"J-L Li","year":"2020","unstructured":"Li, J-L., Yan, C-Q., Wang, X., Zhang, S., Zhang, N., Hu, S-Q., Wang, L-Q., & Liu, C-Z. (2020b). Brain functional alternations of the pain-related emotional and cognitive regions in patients with chronic shoulder pain. Journal of Pain Research Volume, 13, 575\u2013583.","journal-title":"Journal of Pain Research Volume"},{"key":"1171_CR27","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s10194-020-01203-5","volume":"21","author":"Z Li","year":"2020","unstructured":"Li, Z., Zhou, J., Lan, L., Cheng, S., Sun, R., Gong, Q., Wintermark, M., Zeng, F., & Liang, F. (2020c). Concurrent brain structural and functional alterations in patients with migraine without aura: an fMRI study. The Journal Of Headache And Pain, 21, 141.","journal-title":"The Journal Of Headache And Pain"},{"key":"1171_CR28","doi-asserted-by":"publisher","first-page":"e572","DOI":"10.1097\/j.pain.0000000000002409","volume":"163","author":"HY Liu","year":"2022","unstructured":"Liu, H. Y., Chou, K. H., Lee, P. L., Wang, Y. F., Chen, S. P., Lai, K. L., Lin, C. P., Wang, S. J., & Chen, W. T. (2022). Right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain, 163, e572\u2013e579.","journal-title":"Pain"},{"key":"1171_CR29","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.pain.2004.06.010","volume":"111","author":"A L\u00f3pez-Avila","year":"2004","unstructured":"L\u00f3pez-Avila, A., Coffeen, U., Ortega-Legaspi, J. M., del Angel, R., & Pellicer, F. (2004). Dopamine and NMDA systems modulate long-term nociception in the rat anterior cingulate cortex. Pain, 111, 136\u2013143.","journal-title":"Pain"},{"key":"1171_CR30","first-page":"1390","volume":"39","author":"H Lv","year":"2018","unstructured":"Lv, H., Wang, Z., Tong, E., Williams, L. M., Zaharchuk, G., Zeineh, M., Goldstein-Piekarski, A. N., Ball, T. M., Liao, C., & Wintermark, M. (2018). Resting-state functional MRI: everything that nonexperts have always wanted to know. Ajnr. American Journal Of Neuroradiology, 39, 1390\u20131399.","journal-title":"Ajnr. American Journal Of Neuroradiology"},{"key":"1171_CR31","doi-asserted-by":"crossref","unstructured":"Mancini, F., Mahajan, P., Guttesen, A. \u00c1. V., Onysk, J., Scholtes, I., Shenker, N., Lee, M., & Seymour, B. (2024). Enhanced behavioural and neural sensitivity to punishments in chronic pain and fatigue. Brain, 148, 2151-2162.","DOI":"10.1093\/brain\/awae408"},{"key":"1171_CR32","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1002\/art.41620","volume":"73","author":"I Mawla","year":"2021","unstructured":"Mawla, I., Ichesco, E., Z\u00f6llner, H. J., Edden, R. A. E., Chenevert, T., Buchtel, H., Bretz, M. D., Sloan, H., Kaplan, C. M., Harte, S. E., Mashour, G. A., Clauw, D. J., Napadow, V., & Harris, R. E. (2021). Greater somatosensory afference with acupuncture increases primary somatosensory connectivity and alleviates fibromyalgia pain via insular \u03b3-aminobutyric acid: a randomized neuroimaging trial. Arthritis Rheumatol, 73, 1318\u20131328.","journal-title":"Arthritis Rheumatol"},{"key":"1171_CR33","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s10194-020-01201-7","volume":"21","author":"X Niu","year":"2020","unstructured":"Niu, X., Bai, L., Sun, Y., Wang, Y., Bai, G., Yin, B., Wang, S., Gan, S., Jia, X., & Liu, H. (2020). Mild traumatic brain injury is associated with effect of inflammation on structural changes of default mode network in those developing chronic pain. The Journal Of Headache And Pain, 21, 135.","journal-title":"The Journal Of Headache And Pain"},{"key":"1171_CR34","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1007\/s12035-018-1130-9","volume":"56","author":"WY Ong","year":"2019","unstructured":"Ong, W. Y., Stohler, C. S., & Herr, D. R. (2019). Role of the prefrontal cortex in pain processing. Molecular Neurobiology, 56, 1137\u20131166.","journal-title":"Molecular Neurobiology"},{"key":"1171_CR35","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1016\/j.neuron.2023.04.032","volume":"111","author":"Q Pan","year":"2023","unstructured":"Pan, Q., Guo, S. S., Chen, M., Su, X. Y., Gao, Z. L., Wang, Q., Xu, T. L., Liu, M. G., & Hu, J. (2023). Representation and control of pain and itch by distinct prefrontal neural ensembles. Neuron, 111, 2414\u20132431e2417.","journal-title":"Neuron"},{"key":"1171_CR36","doi-asserted-by":"publisher","first-page":"115800","DOI":"10.1016\/j.biopha.2023.115800","volume":"168","author":"X Qian","year":"2023","unstructured":"Qian, X., Zhao, X., Yu, L., Yin, Y., Zhang, X. D., Wang, L., Li, J. X., Zhu, Q., & Luo, J. L. (2023). Current status of GABA receptor subtypes in analgesia. Biomedicine & Pharmacotherapy, 168, 115800.","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"1171_CR37","first-page":"2668","volume":"9","author":"EB Raney","year":"2017","unstructured":"Raney, E. B., Thankam, F. G., Dilisio, M. F., & Agrawal, D. K. (2017). Pain and the pathogenesis of biceps tendinopathy. Am J Transl Res, 9, 2668\u20132683.","journal-title":"Am J Transl Res"},{"key":"1171_CR38","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1002\/ejp.2172","volume":"28","author":"K Rukavina","year":"2024","unstructured":"Rukavina, K., Mulholland, N., Corcoran, B., Skoric, M. K., Staunton, J., Rota, S., Zinzalias, P., Wu, K., Fieldwalker, A., Bannister, K., Rizos, A., & Chaudhuri, K. R. (2024). Musculoskeletal pain in Parkinson\u2019s disease: association with dopaminergic deficiency in the caudate nucleus. European Journal Of Pain, 28, 244\u2013251.","journal-title":"European Journal Of Pain"},{"key":"1171_CR39","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1016\/j.apmr.2017.03.010","volume":"98","author":"CH Seo","year":"2017","unstructured":"Seo, C. H., Park, C. H., Jung, M. H., Jang, S., Joo, S. Y., Kang, Y., & Ohn, S. H. (2017). Preliminary investigation of pain-related changes in cerebral blood volume in patients with phantom limb pain. Archives Of Physical Medicine And Rehabilitation, 98, 2206\u20132212.","journal-title":"Archives Of Physical Medicine And Rehabilitation"},{"key":"1171_CR40","doi-asserted-by":"publisher","first-page":"835538","DOI":"10.3389\/fnins.2022.835538","volume":"16","author":"Y Shen","year":"2022","unstructured":"Shen, Y., Wang, W., Wang, Y., Yang, L., Yuan, C., Yang, Y., Wu, F., Wang, J., Deng, Y., Wang, X., & Liu, H. (2022). Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability-A Resting-State fMRI Study. Front Neurosci, 16, 835538.","journal-title":"Front Neurosci"},{"key":"1171_CR41","doi-asserted-by":"publisher","first-page":"1856","DOI":"10.1097\/j.pain.0000000000001282","volume":"159","author":"SJ Thompson","year":"2018","unstructured":"Thompson, S. J., Pitcher, M. H., Stone, L. S., Tarum, F., Niu, G., Chen, X., Kiesewetter, D. O., Schweinhardt, P., & Bushnell, M. C. (2018). Chronic neuropathic pain reduces opioid receptor availability with associated anhedonia in rat. Pain, 159, 1856\u20131866.","journal-title":"Pain"},{"key":"1171_CR42","doi-asserted-by":"publisher","first-page":"5235","DOI":"10.1002\/hbm.25999","volume":"43","author":"A Vamvakas","year":"2022","unstructured":"Vamvakas, A., Lawn, T., Veronese, M., Williams, S. C., Tsougos, R., & Howard, I. M A (2022). Neurotransmitter receptor densities are associated with changes in regional Cerebral blood flow during clinical ongoing pain. Human Brain Mapping, 43, 5235\u20135249.","journal-title":"Human Brain Mapping"},{"key":"1171_CR43","doi-asserted-by":"publisher","first-page":"22945","DOI":"10.1038\/s41598-021-02474-x","volume":"11","author":"D Ver\u00e9b","year":"2021","unstructured":"Ver\u00e9b, D., Kincses, B., Spis\u00e1k, T., Schlitt, F., Szab\u00f3, N., Farag\u00f3, P., Kocsis, K., Bozsik, B., T\u00f3th, E., Kir\u00e1ly, A., Zunhammer, M., Schmidt-Wilcke, T., Bingel, U., & Kincses, Z. T. (2021). Resting-state functional heterogeneity of the right insula contributes to pain sensitivity. Scientific Reports, 11, 22945.","journal-title":"Scientific Reports"},{"key":"1171_CR44","doi-asserted-by":"publisher","first-page":"5357","DOI":"10.1002\/hbm.26439","volume":"44","author":"J Wang","year":"2023","unstructured":"Wang, J., Liu, G., Xu, K., Ai, K., Huang, W., & Zhang, J. (2023). The role of neurotransmitters in mediating the relationship between brain alterations and depressive symptoms in patients with inflammatory bowel disease. Human Brain Mapping, 44, 5357\u20135371.","journal-title":"Human Brain Mapping"},{"key":"1171_CR45","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/aps.2008.14","volume":"30","author":"YF Xie","year":"2009","unstructured":"Xie, Y. F., Huo, F. Q., & Tang, J. S. (2009). Cerebral cortex modulation of pain. Acta Pharmacologica Sinica, 30, 31\u201341.","journal-title":"Acta Pharmacologica Sinica"},{"key":"1171_CR48","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1097\/PHM.0000000000000597","volume":"96","author":"SS Zhang","year":"2017","unstructured":"Zhang, S. S., Wu, W., Yang, J. M., & Wang, C. H. (2017). Abnormal spontaneous brain activity in acute low-back pain revealed by resting-state functional MRI. American Journal Of Physical Medicine And Rehabilitation, 96, 253\u2013259.","journal-title":"American Journal Of Physical Medicine And Rehabilitation"},{"key":"1171_CR46","doi-asserted-by":"crossref","unstructured":"Zhang, J., Wang, H., & Guo, L. (2024a). Investigating the brain functional abnormalities underlying pain hypervigilance in chronic neck and shoulder pain: a resting-state fMRI study. Neuroradiology, 66, 1353\u20131361.","DOI":"10.1007\/s00234-024-03286-2"},{"key":"1171_CR47","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1016\/j.apmr.2024.06.012","volume":"105","author":"S Zhang","year":"2024","unstructured":"Zhang, S., Wang, Y., Li, T., Ma, J., He, R., Han, X., Wu, W., & Wang, C. (2024b). Relation between abnormal spontaneous brain activity and altered neuromuscular activation of lumbar paraspinal muscles in chronic low back pain. Archives Of Physical Medicine And Rehabilitation, 105, 2107\u20132117.","journal-title":"Archives Of Physical Medicine And Rehabilitation"},{"key":"1171_CR49","doi-asserted-by":"publisher","first-page":"114516","DOI":"10.1016\/j.biopha.2023.114516","volume":"161","author":"M Zhou","year":"2023","unstructured":"Zhou, M., Zhang, Q., Huo, M., Song, H., Chang, H., Cao, J., Fang, Y., & Zhang, D. (2023). The mechanistic basis for the effects of electroacupuncture on neuropathic pain within the central nervous system. Biomedicine & Pharmacotherapy, 161, 114516.","journal-title":"Biomedicine & Pharmacotherapy"}],"container-title":["Brain Imaging and Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-026-01171-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-026-01171-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11682-026-01171-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:02:40Z","timestamp":1792522960000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11682-026-01171-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,20]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1171"],"URL":"https:\/\/doi.org\/10.1007\/s11682-026-01171-5","relation":{},"ISSN":["1931-7565"],"issn-type":[{"value":"1931-7565","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,20]]},"assertion":[{"value":"27 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 October 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Ethics Committee of the Affiliated Hospital of Shaanxi University of Chinese Medicine, in accordance with the principles outlined in the Declaration of Helsinki.","order":1,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent was obtained from all participants included in the study.","order":2,"name":"Ethics","label":"Consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent for publication was obtained from all participants included in the study.","order":3,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"143"}}