{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:57:16Z","timestamp":1774267036375,"version":"3.50.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T00:00:00Z","timestamp":1407283200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Front. Med."],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s11684-014-0347-x","type":"journal-article","created":{"date-parts":[[2014,8,6]],"date-time":"2014-08-06T12:22:55Z","timestamp":1407327775000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis"],"prefix":"10.1007","volume":"9","author":[{"given":"Namita","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. D.","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Bansal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,6]]},"reference":[{"issue":"1","key":"347_CR1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.0906-6713.2002.03202.x","volume":"32","author":"ME Nunn","year":"2000","unstructured":"Nunn ME. Understanding the etiology of periodontitis: an overview of periodontal risk factors. Periodontol 2000 2003; 32(1): 11\u201323","journal-title":"Periodontol"},{"issue":"1","key":"347_CR2","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","volume":"1","author":"S Offenbacher","year":"1996","unstructured":"Offenbacher S. Periodontal diseases: pathogenesis. Ann Periodontol 1996; 1(1): 821\u2013878","journal-title":"Ann Periodontol"},{"issue":"19","key":"347_CR3","doi-asserted-by":"crossref","first-page":"6246","DOI":"10.1158\/1078-0432.CCR-07-5037","volume":"14","author":"S Hu","year":"2008","unstructured":"Hu S, Arellano M, Boontheung P, Wang J, Zhou H, Jiang, Elashoff D, Wei R, Loo JA, Wong DT. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res 2008; 14(19): 6246\u20136252","journal-title":"Clin Cancer Res"},{"issue":"24","key":"347_CR4","doi-asserted-by":"crossref","first-page":"8442","DOI":"10.1158\/1078-0432.CCR-04-1167","volume":"10","author":"Y Li","year":"2004","unstructured":"Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res 2004; 10(24): 8442\u20138450","journal-title":"Clin Cancer Res"},{"issue":"11","key":"347_CR5","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1002\/art.22954","volume":"56","author":"S Hu","year":"2007","unstructured":"Hu S, Wang J, Meijer J, Ieong S, Xie Y, Yu T, Zhou H, Henry S, Vissink A, Pijpe J, Kallenberg C, Elashoff D, Loo JA, Wong DT. Salivary proteomic and genomic biomarkers for primary Sj\u00f6gren\u2019s syndrome. Arthritis Rheum 2007; 56(11): 3588\u20133600","journal-title":"Arthritis Rheum"},{"issue":"1","key":"347_CR6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.0906-6713.2002.003421.x","volume":"34","author":"GC Armitage","year":"2000","unstructured":"Armitage GC. Periodontal diagnoses and classification of periodontal diseases. Periodontol 2000 2004; 34(1): 9\u201321","journal-title":"Periodontol"},{"issue":"1","key":"347_CR7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-0757.2008.00288.x","volume":"50","author":"WV Giannobile","year":"2000","unstructured":"Giannobile WV, Beikler T, Kinney JS, Ramseier CA, Morelli T, Wong DT. Saliva as a diagnostic tool for periodontal disease: current state and future directions. Periodontol 2000 2009; 50(1): 52\u201364","journal-title":"Periodontol"},{"issue":"1","key":"347_CR8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0765.2011.01416.x","volume":"47","author":"M Kraft-Neum\u00e4rker","year":"2012","unstructured":"Kraft-Neum\u00e4rker M, Lorenz K, Koch R, Hoffmann T, M\u00e4ntyl\u00e4 P, Sorsa T, Netuschil L. Full-mouth profile of active MMP-8 in periodontitis patients. J Periodontal Res 2012; 47(1): 121\u2013128","journal-title":"J Periodontal Res"},{"issue":"5","key":"347_CR9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890600800103","volume":"38","author":"T Sorsa","year":"2006","unstructured":"Sorsa T, Tj\u00e4derhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, Golub LM, Brown DL, M\u00e4ntyl\u00e4 P. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med 2006; 38(5): 306\u2013321","journal-title":"Ann Med"},{"issue":"13","key":"347_CR10","doi-asserted-by":"crossref","first-page":"5268","DOI":"10.1073\/pnas.0607254104","volume":"104","author":"AE Herr","year":"2007","unstructured":"Herr AE, Hatch AV, Throckmorton DJ, Tran HM, Brennan JS, Giannobile WV, Singh AK. Microfluidic immunoassays as rapid saliva-based clinical diagnostics. Proc Natl Acad Sci USA 2007; 104(13): 5268\u20135273","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"347_CR11","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/j.1600-051X.1996.tb01814.x","volume":"23","author":"T Ingman","year":"1996","unstructured":"Ingman T, Tervahartiala T, Ding Y, Tschesche H, Haerian A, Kinane DF, Konttinen YT, Sorsa T. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 1996; 23(12): 1127\u20131132","journal-title":"J Clin Periodontol"},{"issue":"9","key":"347_CR12","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1902\/jop.2010.090608","volume":"81","author":"AM Heikkinen","year":"2010","unstructured":"Heikkinen AM, Sorsa T, Pitk\u00e4niemi J, Tervahartiala T, Kari K, Broms U, Koskenvuo M, Meurman JH. Smoking affects diagnostic salivary periodontal disease biomarker levels in adolescents. J Periodontol 2010; 81(9): 1299\u20131307","journal-title":"J Periodontol"},{"issue":"6","key":"347_CR13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","volume":"10","author":"T Sorsa","year":"2004","unstructured":"Sorsa T, Tj\u00e4derhane L, Salo T. Matrix metalloproteinases (MMPs) in oral diseases. Oral Dis 2004; 10(6): 311\u2013318","journal-title":"Oral Dis"},{"issue":"1","key":"347_CR14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","volume":"141","author":"K Kessenbrock","year":"2010","unstructured":"Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 2010; 141(1): 52\u201367","journal-title":"Cell"},{"issue":"6","key":"347_CR15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1902\/jop.1967.38.6.610","volume":"38","author":"H L\u00f6e","year":"1967","unstructured":"L\u00f6e H. The Gingival Index, the Plaque Index and the Retention Index Systems. J Periodontol 1967; 38(6): 610\u2013616","journal-title":"J Periodontol"},{"issue":"6","key":"347_CR16","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3109\/00016356309011240","volume":"21","author":"H L\u00f6e","year":"1963","unstructured":"L\u00f6e H, Silness J. Periodontal disease in pregnancy. Prevelance and severity. Acta Odontol Scand 1963; 21(6): 533\u2013551","journal-title":"Prevelance and severity. Acta Odontol Scand"},{"key":"347_CR17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1749-6632.1993.tb18343.x","volume":"694","author":"M Navazesh","year":"1993","unstructured":"Navazesh M. Methods for collecting saliva. Ann N Y Acad Sci 1993; 694: 72\u201377","journal-title":"Ann N Y Acad Sci"},{"key":"347_CR18","unstructured":"Quantikine Human Total MMP-8 Immunnoassay; Catalog Number DMP800: R&D Systems, Inc. 614 McKinley Place NE, Minneapolis, MN55413, USA"},{"issue":"3","key":"347_CR19","doi-asserted-by":"crossref","first-page":"322","DOI":"10.14219\/jada.archive.2006.0181","volume":"137","author":"CS Miller","year":"2006","unstructured":"Miller CS, King CP Jr, Langub MC, Kryscio RJ, Thomas MV. Salivary biomarkers of existing periodontal disease: a crosssectional study. J Am Dent Assoc 2006; 137(3): 322\u2013329","journal-title":"J Am Dent Assoc"},{"issue":"3","key":"347_CR20","first-page":"G231","volume":"242","author":"SG Oberg","year":"1982","unstructured":"Oberg SG, Izutsu KT, Truelove EL. Human parotid saliva protein composition: dependence on physiological factors. Am J Physiol 1982; 242(3): G231\u2013G236","journal-title":"Am J Physiol"},{"issue":"1","key":"347_CR21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1601-0825.2009.01603.x","volume":"16","author":"T Sorsa","year":"2010","unstructured":"Sorsa T, Hern\u00e1ndez M, Leppilahti J, Munjal S, Netuschil L, M\u00e4ntyl\u00e4 P. Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods. Oral Dis 2010; 16(1): 39\u201345","journal-title":"Oral Dis"},{"issue":"2","key":"347_CR22","first-page":"108","volume":"63","author":"T Sorsa","year":"2011","unstructured":"Sorsa T, Tervahartiala T, Leppilahti J, Hernandez M, Gamonal J, Tuomainen AM, Lauhio A, Pussinen PJ, M\u00e4ntyl\u00e4 P. Collagenase-2 (MMP-8) as a point-of-care biomarker in periodontitis and cardiovascular diseases. Therapeutic response to non-antimicrobial properties of tetracyclines. Pharmacol Res 2011; 63(2): 108\u2013113","journal-title":"Therapeutic response to non-antimicrobial properties of tetracyclines. Pharmacol Res"},{"issue":"5","key":"347_CR23","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/jcpe.12234","volume":"41","author":"A Salminen","year":"2014","unstructured":"Salminen A, Gursoy UK, Paju S, Hyv\u00e4rinen K, M\u00e4ntyl\u00e4 P, Buhlin K, K\u00f6n\u00f6nen E, Nieminen MS, Sorsa T, Sinisalo J, Pussinen PJ. Salivary biomarkers of bacterial burden, inflammatory response, and tissue destruction in periodontitis. J Clin Periodontol 2014; 41(5): 442\u2013450","journal-title":"J Clin Periodontol"},{"issue":"6","key":"347_CR24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1600-0765.1993.tb02114.x","volume":"28","author":"MS Tonetti","year":"1993","unstructured":"Tonetti MS, Freiburghaus K, Lang NP, Bickel M. Detection of interleukin-8 and matrix metalloproteinases transcripts in healthy and diseased gingival biopsies by RNA\/PCR. J Periodontal Res 1993; 28(6): 511\u2013513","journal-title":"J Periodontal Res"},{"issue":"2","key":"347_CR25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/IAI.00873-08","volume":"77","author":"H Kuula","year":"2009","unstructured":"Kuula H, Salo T, Piril\u00e4 E, Tuomainen AM, Jauhiainen M, Uitto VJ, Tj\u00e4derhane L, Pussinen PJ, Sorsa T. Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis. Infect Immun 2009; 77(2): 850\u2013859","journal-title":"Infect Immun"},{"issue":"2","key":"347_CR26","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/jcpe.12038","volume":"40","author":"N Rathnayake","year":"2013","unstructured":"Rathnayake N, Akerman S, Klinge B, Lundegren N, Jansson H, Tryselius Y, Sorsa T, Gustafsson A. Salivary biomarkers of oral health: a cross-sectional study. J Clin Periodontol 2013; 40(2): 140\u2013147","journal-title":"J Clin Periodontol"},{"issue":"1","key":"347_CR27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/jcpe.12020","volume":"40","author":"UK Gursoy","year":"2013","unstructured":"Gursoy UK, K\u00f6n\u00f6nen E, Huumonen S, Tervahartiala T, Pussinen PJ, Suominen AL, Sorsa T. Salivary type I collagen degradation end-products and related matrix metalloproteinases in periodontitis. J Clin Periodontol 2013; 40(1): 18\u201325","journal-title":"J Clin Periodontol"},{"issue":"5","key":"347_CR28","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1902\/jop.2013.130514","volume":"85","author":"F Javed","year":"2014","unstructured":"Javed F, Ahmed HB, Saeed A, Mehmood A, Bain C. Whole salivary interleukin-6 and matrix metalloproteinase-8 levels in patients with chronic periodontitis with and without prediabetes. J Periodontol 2014; 85(5): e130\u2013e135","journal-title":"J Periodontol"}],"container-title":["Frontiers of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-014-0347-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11684-014-0347-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-014-0347-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T20:44:53Z","timestamp":1559421893000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11684-014-0347-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,6]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["347"],"URL":"https:\/\/doi.org\/10.1007\/s11684-014-0347-x","relation":{},"ISSN":["2095-0217","2095-0225"],"issn-type":[{"value":"2095-0217","type":"print"},{"value":"2095-0225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,6]]}}}