{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:11:18Z","timestamp":1785247878028,"version":"3.55.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Front. Med."],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11684-018-0672-6","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T04:50:41Z","timestamp":1550897441000},"page":"427-437","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects"],"prefix":"10.1007","volume":"13","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"issue":"10","key":"672_CR1","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1093\/annonc\/mdx323","volume":"28","author":"B Kasper","year":"2017","unstructured":"Kasper B, Baumgarten C, Garcia J, Bonvalot S, Haas R, Haller F, Hohenberger P, Penel N, Messiou C, van der Graaf WT, Gronchi A; Desmoid Working Group. An update on the management of sporadic desmoid-type fibromatosis: a European Consensus Initiative between Sarcoma PAtients EuroNet(SPAEN) and European Organization for Research and Treatment of Cancer(EORTC)\/Soft Tissue and Bone Sarcoma Group(STBSG). Ann Oncol 2017; 28(10): 2399\u20132408","journal-title":"Ann Oncol"},{"issue":"9","key":"672_CR2","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1016\/j.crad.2015.04.015","volume":"70","author":"S Otero","year":"2015","unstructured":"Otero S, Moskovic EC, Strauss DC, Benson C, Miah AB, Thway K, Messiou C. Desmoid-type fibromatosis. Clin Radiol 2015; 70(9): 1038\u20131045","journal-title":"Clin Radiol"},{"issue":"2","key":"672_CR3","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1002\/1097-0215(20010320)95:2<102::AID-IJC1018>3.0.CO;2-8","volume":"95","author":"L Bertario","year":"2001","unstructured":"Bertario L, Russo A, Sala P, Eboli M, Giarola M, D\u2019amico F, Gismondi V, Varesco L, Pierotti MA, Radice P; Hereditary Colorectal Tumours Registry. Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. Int J Cancer 2001; 95(2): 102\u2013107","journal-title":"Int^J Cancer"},{"issue":"6","key":"672_CR4","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.mayocp.2017.02.012","volume":"92","author":"KM Skubitz","year":"2017","unstructured":"Skubitz KM. Biology and treatment of aggressive fibromatosis or desmoid tumor. Mayo Clin Proc 2017; 92(6): 947\u2013964","journal-title":"Mayo Clin Proc"},{"issue":"5","key":"672_CR5","first-page":"1518","volume":"173","author":"AJ Lazar","year":"2008","unstructured":"Lazar AJ, Tuvin D, Hajibashi S, Habeeb S, Bolshakov S, Mayordomo-Aranda E, Warneke CL, Lopez-Terrada D, Pollock RE, Lev D. Specific mutations in the \u03b2-catenin gene(CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol 2008; 173(5): 1518\u20131527","journal-title":"Am^J Pathol"},{"issue":"2","key":"672_CR6","first-page":"329","volume":"151","author":"BA Alman","year":"1997","unstructured":"Alman BA, Li C, Pajerski ME, Diaz-Cano S,Wolfe HJ. Increased \u03b2-catenin protein and somatic APC mutations in sporadic aggressive fibromatoses(desmoid tumors). Am J Pathol 1997; 151(2): 329\u2013334","journal-title":"Am^J Pathol"},{"issue":"6","key":"672_CR7","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1002\/gcc.20766","volume":"49","author":"S Salas","year":"2010","unstructured":"Salas S, Chibon F, Noguchi T, Terrier P, Ranchere-Vince D, Lagarde P, Benard J, Forget S, Blanchard C, D\u00f4mont J, Bonvalot S, Guillou L, Leroux A, Mechine-Neuville A, Sch\u00f6ffski P, La\u00eb M, Collin F, Verola O, Carbonnelle A, Vescovo L, Bui B, Brouste V, Sobol H, Aurias A, Coindre JM. Molecular characterization by array comparative genomic hybridization and DNA sequencing of 194 desmoid tumors. Genes Chromosomes Cancer 2010; 49(6): 560\u2013568","journal-title":"Genes Chromosomes Cancer"},{"issue":"12","key":"672_CR8","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1038\/modpathol.2012.115","volume":"25","author":"S Guellec Le","year":"2012","unstructured":"Le Guellec S, Soubeyran I, Rochaix P, Filleron T, Neuville A, Hostein I, Coindre JM. CTNNB1 mutation analysis is a useful tool for the diagnosis of desmoid tumors: a study of 260 desmoid tumors and 191 potential morphologic mimics. Mod Pathol 2012; 25(12): 1551\u20131558","journal-title":"Mod Pathol"},{"issue":"20","key":"672_CR9","doi-asserted-by":"publisher","first-page":"3696","DOI":"10.1002\/cncr.28271","volume":"119","author":"C Colombo","year":"2013","unstructured":"Colombo C, Miceli R, Lazar AJ, Perrone F, Pollock RE, Le Cesne A, Hartgrink HH, Cleton-Jansen AM, Domont J, Bov\u00e9e JV, Bonvalot S, Lev D, Gronchi A. CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study. Cancer 2013; 119(20): 3696\u20133702","journal-title":"Cancer"},{"issue":"5","key":"672_CR10","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1245\/s10434-014-4156-x","volume":"22","author":"DL Broekhoven van","year":"2015","unstructured":"van Broekhoven DL, Verhoef C, Gr\u00fcnhagen DJ, van Gorp JM, den Bakker MA, Hinrichs JW, de Voijs CM, van Dalen T. Prognostic value of CTNNB1 gene mutation in primary sporadic aggressive fibromatosis. Ann Surg Oncol 2015; 22(5): 1464\u20131470","journal-title":"Ann Surg Oncol"},{"issue":"11","key":"672_CR11","first-page":"1438","volume":"23","author":"M Lacroix-Triki","year":"2010","unstructured":"Lacroix-Triki M, Geyer FC, Lambros MB, Savage K, Ellis IO, Lee AH, Reis-Filho JS. \u03b2-catenin\/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol 2010; 23(11): 1438\u20131448","journal-title":"\u03b2-catenin\/Wnt signalling pathway in fibromatosis, metaplastic carcinomas and phyllodes tumours of the breast. Mod Pathol"},{"issue":"3","key":"672_CR12","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1034\/j.1399-0004.2000.570306.x","volume":"57","author":"J Couture","year":"2000","unstructured":"Couture J, Mitri A, Lagace R, Smits R, Berk T, Bouchard HL, Fodde R, Alman B, Bapat B. A germline mutation at the extreme 3\u2032 end of the APC gene results in a severe desmoid phenotype and is associated with overexpression of \u03b2-catenin in the desmoid tumor. Clin Genet 2000; 57(3): 205\u2013212","journal-title":"Clin Genet"},{"issue":"4","key":"672_CR13","first-page":"475","volume":"85","author":"JC Harvey","year":"1979","unstructured":"Harvey JC, Quan SH, Fortner JG. Gardner\u2019s syndrome complicated by mesenteric desmoid tumors. Surgery 1979; 85(4): 475\u2013477","journal-title":"Surgery"},{"issue":"2","key":"672_CR14","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ejca.2014.11.019","volume":"51","author":"C Colombo","year":"2015","unstructured":"Colombo C, Miceli R, Le P\u00e9choux C, Palassini E, Honor\u00e9 C, Stacchiotti S, Mir O, Casali PG, D\u00f4mont J, Fiore M, Le Cesne A, Gronchi A, Bonvalot S. Sporadic extra abdominal wall desmoidtype fibromatosis: surgical resection can be safely limited to a minority of patients. Eur J Cancer 2015; 51(2): 186\u2013192","journal-title":"Eur^J Cancer"},{"issue":"2","key":"672_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ejca.2014.11.005","volume":"51","author":"B Kasper","year":"2015","unstructured":"Kasper B, Baumgarten C, Bonvalot S, Haas R, Haller F, Hohenberger P, Moreau G, van der Graaf WT, Gronchi A; Desmoid Working Group. Management of sporadic desmoid-type fibromatosis: a European consensus approach based on patients\u2019 and professionals\u2019 expertise \u2014 a sarcoma patients EuroNet and European Organisation for Research and Treatment of Cancer\/Soft Tissue and Bone Sarcoma Group initiative. Eur J Cancer 2015; 51(2): 127\u2013136","journal-title":"Eur^J Cancer"},{"issue":"4","key":"672_CR16","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.ejso.2007.06.006","volume":"34","author":"S Bonvalot","year":"2008","unstructured":"Bonvalot S, Eldweny H, Haddad V, Rimareix F, Missenard G, Oberlin O, Vanel D, Terrier P, Blay JY, Le Cesne A, Le P\u00e9choux C. Extra-abdominal primary fibromatosis: aggressive management could be avoided in a subgroup of patients. Eur J Surg Oncol 2008; 34(4): 462\u2013468","journal-title":"Eur^J Surg Oncol"},{"issue":"9","key":"672_CR17","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.1245\/s10434-009-0586-2","volume":"16","author":"M Fiore","year":"2009","unstructured":"Fiore M, Rimareix F, Mariani L, Domont J, Collini P, Le P\u00e9choux C, Casali PG, Le Cesne A, Gronchi A, Bonvalot S. Desmoid-type fibromatosis: a front-line conservative approach to select patients for surgical treatment. Ann Surg Oncol 2009; 16(9): 2587\u20132593","journal-title":"Ann Surg Oncol"},{"issue":"8","key":"672_CR18","doi-asserted-by":"publisher","first-page":"631","DOI":"10.2106\/JBJS.M.00988","volume":"96","author":"S Briand","year":"2014","unstructured":"Briand S, Barbier O, Biau D, Bertrand-Vasseur A, Larousserie F, Anract P, Gouin F. Wait-and-see policy as a first-line management for extra-abdominal desmoid tumors. J Bone Joint Surg Am 2014; 96(8): 631\u2013638","journal-title":"J Bone Joint Surg Am"},{"key":"672_CR19","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ejca.2017.02.001","volume":"76","author":"B Kasper","year":"2017","unstructured":"Kasper B, Gruenwald V, Reichardt P, Bauer S, Rauch G, Limprecht R, Sommer M, Dimitrakopoulou-Strauss A, Pilz L, Haller F, Hohenberger P. Imatinib induces sustained progression arrest in RECIST progressive desmoid tumours: final results of a phase II study of the German Interdisciplinary Sarcoma Group(GISG). Eur J Cancer 2017; 76: 60\u201367","journal-title":"Eur^J Cancer"},{"issue":"2","key":"672_CR20","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/annonc\/mdq341","volume":"22","author":"N Penel","year":"2011","unstructured":"Penel N, Le Cesne A, Bui BN, Perol D, Brain EG, Ray-Coquard I, Guillemet C, Chevreau C, Cupissol D, Chabaud S, Jimenez M, Duffaud F, Piperno-Neumann S, Mignot L, Blay JY. Imatinib for progressive and recurrent aggressive fibromatosis(desmoid tumors): an FNCLCC\/French Sarcoma Group phase II trial with a long-term follow-up. Ann Oncol 2011; 22(2): 452\u2013457","journal-title":"Ann Oncol"},{"issue":"14","key":"672_CR21","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1200\/JCO.2016.71.1994","volume":"35","author":"S Kummar","year":"2017","unstructured":"Kummar S, O\u2019Sullivan Coyne G, Do KT, Turkbey B, Meltzer PS, Polley E, Choyke PL, Meehan R, Vilimas R, Horneffer Y, Juwara L, Lih A, Choudhary A, Mitchell SA, Helman LJ, Doroshow JH, Chen AP. Clinical activity of the g-secretase inhibitor PF-03084014 in adults with desmoid tumors(aggressive fibromatosis). J Clin Oncol 2017; 35(14): 1561\u20131569","journal-title":"J Clin Oncol"},{"issue":"4","key":"672_CR22","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1097\/CAD.0000000000000474","volume":"28","author":"Z Szucs","year":"2017","unstructured":"Szucs Z, Messiou C,Wong HH, Hatcher H, Miah A, Zaidi S, van der Graaf WT, Judson I, Jones RL, Benson C. Pazopanib, a promising option for the treatment of aggressive fibromatosis. Anticancer Drugs 2017; 28(4): 421\u2013426","journal-title":"Anticancer Drugs"},{"issue":"7","key":"672_CR23","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1158\/1078-0432.CCR-10-1970","volume":"17","author":"C Brogsitter","year":"2011","unstructured":"Brogsitter C, Faulhaber D, Kotzerke J. Intraarterial treatment of GEP NET:(68)Ga-DOTATOC SUV cannot predict(90)Y-DOTATOC uptake. Clin Cancer Res 2011; 17(7): 2065","journal-title":"Clin Cancer Res"},{"issue":"3","key":"672_CR24","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00280-009-1010-0","volume":"64","author":"KM Skubitz","year":"2009","unstructured":"Skubitz KM, Manivel JC, Clohisy DR, Frolich JW. Response of imatinib-resistant extra-abdominal aggressive fibromatosis to sunitinib: case report and review of the literature on response to tyrosine kinase inhibitors. Cancer Chemother Pharmacol 2009; 64(3): 635\u2013640","journal-title":"Cancer Chemother Pharmacol"},{"issue":"1","key":"672_CR25","first-page":"139","volume":"295","author":"E Buchdunger","year":"2000","unstructured":"Buchdunger E, Cioffi CL, Law N, Stover D, Ohno-Jones S, Druker BJ, Lydon NB. Abl protein-tyrosine kinase inhibitor STI571 inhibits in vitro signal transduction mediated by c-kit and platelet-derived growth factor receptors. J Pharmacol Exp Ther 2000; 295(1): 139\u2013145","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"672_CR26","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1002\/cncr.11029","volume":"95","author":"J Mace","year":"2002","unstructured":"Mace J, Sybil Biermann J, Sondak V, McGinn C, Hayes C, Thomas D, Baker L. Response of extraabdominal desmoid tumors to therapy with imatinib mesylate. Cancer 2002; 95(11): 2373\u20132379","journal-title":"Cancer"},{"issue":"12","key":"672_CR27","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1182\/blood.V90.12.4947","volume":"90","author":"M Carroll","year":"1997","unstructured":"Carroll M, Ohno-Jones S, Tamura S, Buchdunger E, Zimmermann J, Lydon NB, Gilliland DG, Druker BJ. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TELABL, and TEL-PDGFR fusion proteins. Blood 1997; 90(12): 4947\u20134952","journal-title":"Blood"},{"issue":"7","key":"672_CR28","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1200\/JCO.2005.04.0717","volume":"24","author":"MC Heinrich","year":"2006","unstructured":"Heinrich MC, McArthur GA, Demetri GD, Joensuu H, Bono P, Herrmann R, Hirte H, Cresta S, Koslin DB, Corless CL, Dirnhofer S, van Oosterom AT, Nikolova Z, Dimitrijevic S, Fletcher JA. Clinical and molecular studies of the effect of imatinib on advanced aggressive fibromatosis(desmoid tumor). J Clin Oncol 2006; 24(7): 1195\u20131203","journal-title":"J Clin Oncol"},{"issue":"8","key":"672_CR29","first-page":"533","volume":"133","author":"G Wcislo","year":"2007","unstructured":"Wcislo G, Szarlej-Wcislo K, Szczylik C. Control of aggressive fibromatosis by treatment with imatinib mesylate. A case report and review of the literature. J Cancer Res Clin Oncol 2007; 133(8): 533\u2013538","journal-title":"A case report and review of the literature.^J Cancer Res Clin Oncol"},{"issue":"19","key":"672_CR30","doi-asserted-by":"publisher","first-page":"4884","DOI":"10.1158\/1078-0432.CCR-10-1177","volume":"16","author":"R Chugh","year":"2010","unstructured":"Chugh R, Wathen JK, Patel SR, Maki RG, Meyers PA, Schuetze SM, Priebat DA, Thomas DG, Jacobson JA, Samuels BL, Benjamin RS, Baker LH; Sarcoma Alliance for Research through Collaboration(SARC). Efficacy of imatinib in aggressive fibromatosis: results of a phase II multicenter Sarcoma Alliance for Research through Collaboration(SARC) trial. Clin Cancer Res 2010; 16(19): 4884\u20134891","journal-title":"Clin Cancer Res"},{"issue":"9440","key":"672_CR31","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/S0140-6736(04)17098-0","volume":"364","author":"J Verweij","year":"2004","unstructured":"Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY, Issels R, van Oosterom A, Hogendoorn PC, Van Glabbeke M, Bertulli R, Judson I. Progression-free survival in gastrointestinal stromal tumours with high-dose imatinib: randomised trial. Lancet 2004; 364(9440): 1127\u20131134","journal-title":"Lancet"},{"issue":"12","key":"672_CR32","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1016\/j.ejca.2005.04.034","volume":"41","author":"JR Zalcberg","year":"2005","unstructured":"Zalcberg JR, Verweij J, Casali PG, Le Cesne A, Reichardt P, Blay JY, Schlemmer M, Van Glabbeke M, Brown M, Judson IR; EORTC Soft Tissue and Bone Sarcoma Group, the Italian Sarcoma Group; Australasian Gastrointestinal Trials Group. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800 mg after progression on 400 mg. Eur J Cancer 2005; 41(12): 1751\u20131757","journal-title":"Eur^J Cancer"},{"issue":"4","key":"672_CR33","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1200\/JCO.2007.13.4452","volume":"26","author":"CD Blanke","year":"2008","unstructured":"Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, Raymond AK, Bramwell VH, Baker LH, Maki RG, Tanaka M, Hecht JR, Heinrich MC, Fletcher CD, Crowley JJ, Borden EC. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol 2008; 26(4): 626\u2013632","journal-title":"J Clin Oncol"},{"issue":"12","key":"672_CR34","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1038\/sj.bjc.6603170","volume":"94","author":"E Weisberg","year":"2006","unstructured":"Weisberg E, Manley P, Mestan J, Cowan-Jacob S, Ray A, Griffin JD. AMN107(nilotinib): a novel and selective inhibitor of BCRABL. Br J Cancer 2006; 94(12): 1765\u20131769","journal-title":"Br^J Cancer"},{"key":"672_CR35","volume-title":"Semin Oncol","author":"JY Blay","year":"2011","unstructured":"Blay JY, von Mehren M. Nilotinib: a novel, selective tyrosine kinase inhibitor. Semin Oncol 2011; 38(Suppl 1): S3\u2013S9"},{"issue":"19","key":"672_CR36","doi-asserted-by":"publisher","first-page":"6977","DOI":"10.1016\/j.bmc.2010.08.026","volume":"18","author":"PW Manley","year":"2010","unstructured":"Manley PW, Stiefl N, Cowan-Jacob SW, Kaufman S, Mestan J, Wartmann M, Wiesmann M, Woodman R, Gallagher N. Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib. Bioorg Med Chem 2010; 18(19): 6977\u20136986","journal-title":"Bioorg Med Chem"},{"issue":"3","key":"672_CR37","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.bbapap.2009.11.008","volume":"1804","author":"PW Manley","year":"2010","unstructured":"Manley PW, Drueckes P, Fendrich G, Furet P, Liebetanz J, Martiny-Baron G, Mestan J, Trappe J, Wartmann M, Fabbro D. Extended kinase profile and properties of the protein kinase inhibitor nilotinib. Biochim Biophys Acta 2010; 1804(3): 445\u2013453","journal-title":"Biochim Biophys Acta"},{"issue":"9829","key":"672_CR38","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/S0140-6736(12)60651-5","volume":"379","author":"WT Graaf van der","year":"2012","unstructured":"van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Casali PG, Sch\u00f6ffski P, Aglietta M, Staddon AP, Beppu Y, Le Cesne A, Gelderblom H, Judson IR, Araki N, Ouali M, Marreaud S, Hodge R, Dewji MR, Coens C, Demetri GD, Fletcher CD, Dei Tos AP, Hohenberger P; EORTC Soft Tissue and Bone Sarcoma Group; PALETTE Study Group. Pazopanib for metastatic soft-tissue sarcoma(PALETTE): a randomised, double-blind, placebo-con-trolled phase 3 trial. Lancet 2012; 379(9829): 1879\u20131886","journal-title":"Lancet"},{"issue":"1","key":"672_CR39","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2045-3329-3-13","volume":"3","author":"J Martin-Liberal","year":"2013","unstructured":"Martin-Liberal J, Benson C, McCarty H, Thway K, Messiou C, Judson I. Pazopanib is an active treatment in desmoid tumour\/aggressive fibromatosis. Clin Sarcoma Res 2013; 3(1): 13","journal-title":"Clin Sarcoma Res"},{"issue":"12","key":"672_CR40","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1158\/1078-0432.CCR-10-3322","volume":"17","author":"MM Gounder","year":"2011","unstructured":"Gounder MM, Lefkowitz RA, Keohan ML, D\u2019Adamo DR, Hameed M, Antonescu CR, Singer S, Stout K, Ahn L, Maki RG. Activity of sorafenib against desmoid tumor\/deep fibromatosis. Clin Cancer Res 2011; 17(12): 4082\u20134090","journal-title":"Clin Cancer Res"},{"issue":"13","key":"672_CR41","doi-asserted-by":"publisher","first-page":"12876","DOI":"10.1074\/jbc.M311652200","volume":"279","author":"GT Wong","year":"2004","unstructured":"Wong GT, Manfra D, Poulet FM, Zhang Q, Josien H, Bara T, Engstrom L, Pinzon-Ortiz M, Fine JS, Lee HJ, Zhang L, Higgins GA, Parker EM. Chronic treatment with the \u03b3-secretase inhibitor LY-411,575 inhibits \u03b2-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation. J Biol Chem 2004; 279(13): 12876\u201312882","journal-title":"J Biol Chem"},{"issue":"1","key":"672_CR42","first-page":"35","volume":"6","author":"SJ Pollack","year":"2005","unstructured":"Pollack SJ, Lewis H. Secretase inhibitors for Alzheimer\u2019s disease: challenges of a promiscuous protease. Curr Opin Investig Drugs 2005; 6(1): 35\u201347","journal-title":"Curr Opin Investig Drugs"},{"issue":"10","key":"672_CR43","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1185\/03007995.2014.939167","volume":"30","author":"DB Henley","year":"2014","unstructured":"Henley DB, Sundell KL, Sethuraman G, Dowsett SA, May PC. Safety profile of semagacestat, a \u03b3-secretase inhibitor: IDENTITY trial findings. Curr Med Res Opin 2014; 30(10): 2021\u20132032","journal-title":"Curr Med Res Opin"},{"issue":"4","key":"672_CR44","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0092-8674(91)90111-B","volume":"66","author":"LW Ellisen","year":"1991","unstructured":"Ellisen LW, Bird J, West DC, Soreng AL, Reynolds TC, Smith SD, Sklar J. TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 1991; 66(4): 649\u2013661","journal-title":"Cell"},{"issue":"5694","key":"672_CR45","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1126\/science.1102160","volume":"306","author":"AP Weng","year":"2004","unstructured":"Weng AP, Ferrando AA, Lee W, Morris JP 4th, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004; 306(5694): 269\u2013271","journal-title":"Science"},{"issue":"14","key":"672_CR46","doi-asserted-by":"publisher","first-page":"6414","DOI":"10.1073\/pnas.92.14.6414","volume":"92","author":"P Zagouras","year":"1995","unstructured":"Zagouras P, Stifani S, Blaumueller CM, Carcangiu ML, Artavanis-Tsakonas S. Alterations in Notch signaling in neoplastic lesions of the human cervix. Proc Natl Acad Sci USA 1995; 92(14): 6414\u20136418","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"672_CR47","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S1535-6108(03)00140-5","volume":"3","author":"Y Miyamoto","year":"2003","unstructured":"Miyamoto Y, Maitra A, Ghosh B, Zechner U, Argani P, Iacobuzio-Donahue CA, Sriuranpong V, Iso T, Meszoely IM, Wolfe MS, Hruban RH, Ball DW, Schmid RM, Leach SD. Notch mediates TGF \u03b1-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell 2003; 3(6): 565\u2013576","journal-title":"Cancer Cell"},{"issue":"15","key":"672_CR48","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.1073\/pnas.0813221106","volume":"106","author":"V Rodilla","year":"2009","unstructured":"Rodilla V, Villanueva A, Obrador-Hevia A, Robert-Moreno A, Fern\u00e1ndez-Majada V, Grilli A, L\u00f3pez-Bigas N, Bellora N, Alb\u00e0 MM, Torres F, Du\u00f1ach M, Sanjuan X, Gonzalez S, Gridley T, Capella G, Bigas A, Espinosa L. Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer. Proc Natl Acad Sci USA 2009; 106(15): 6315\u20136320","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"672_CR49","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1172\/JCI61216","volume":"122","author":"HA Kim","year":"2012","unstructured":"Kim HA, Koo BK, Cho JH, Kim YY, Seong J, Chang HJ, Oh YM, Stange DE, Park JG, Hwang D, Kong YY. Notch1 counteracts WNT\/\u03b2-catenin signaling through chromatin modification in colorectal cancer. J Clin Invest 2012; 122(9): 3248\u20133259","journal-title":"J Clin Invest"},{"issue":"2","key":"672_CR50","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.cell.2009.03.045","volume":"137","author":"R Kopan","year":"2009","unstructured":"Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137(2): 216\u2013233","journal-title":"Cell"},{"issue":"9","key":"672_CR51","doi-asserted-by":"publisher","first-page":"833","DOI":"10.4161\/cbt.25332","volume":"14","author":"J Yao","year":"2013","unstructured":"Yao J, Qian C, Shu T, Zhang X, Zhao Z, Liang Y. Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT\/\u03b2-catenin. Cancer Biol Ther 2013; 14(9): 833\u2013839","journal-title":"Cancer Biol Ther"},{"issue":"3","key":"672_CR52","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/bjc.2013.361","volume":"109","author":"JJ Arcaroli","year":"2013","unstructured":"Arcaroli JJ, Quackenbush KS, Purkey A, Powell RW, Pitts TM, Bagby S, Tan AC, Cross B, McPhillips K, Song EK, Tai WM,Winn RA, Bikkavilli K, Vanscoyk M, Eckhardt SG, Messersmith WA. Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a g-secretase inhibitor, in a preclinical colorectal explant model. Br J Cancer 2013; 109(3): 667\u2013675","journal-title":"Br^J Cancer"},{"issue":"1","key":"672_CR53","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1158\/1078-0432.CCR-14-0607","volume":"21","author":"WA Messersmith","year":"2015","unstructured":"Messersmith WA, Shapiro GI, Cleary JM, Jimeno A, Dasari A, Huang B, Shaik MN, Cesari R, Zheng X, Reynolds JM, English PA, McLachlan KR, Kern KA, LoRusso PM. A Phase I, dose-finding study in patients with advanced solid malignancies of the oral gsecretase inhibitor PF-03084014. Clin Cancer Res 2015; 21(1): 60\u201367","journal-title":"Clin Cancer Res"},{"issue":"4","key":"672_CR54","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.ejso.2015.01.001","volume":"41","author":"S Roussin","year":"2015","unstructured":"Roussin S, Mazouni C, Rimareix F, Honor\u00e9 C, Terrier P, Mir O, D\u00f4mont J, Le P\u00e9choux C, Le Cesne A, Bonvalot S. Toward a new strategy in desmoid of the breast? Eur J Surg Oncol 2015; 41(4): 571\u2013576","journal-title":"Eur^J Surg Oncol"},{"issue":"6","key":"672_CR55","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s11864-006-0019-4","volume":"7","author":"S Okuno","year":"2006","unstructured":"Okuno S. The enigma of desmoid tumors. Curr Treat Options Oncol 2006; 7(6): 438\u2013443","journal-title":"Curr Treat Options Oncol"},{"issue":"13","key":"672_CR56","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1200\/JCO.2006.10.5015","volume":"25","author":"D Lev","year":"2007","unstructured":"Lev D, Kotilingam D, Wei C, Ballo MT, Zagars GK, Pisters PW, Lazar AA, Patel SR, Benjamin RS, Pollock RE. Optimizing treatment of desmoid tumors. J Clin Oncol 2007; 25(13): 1785\u20131791","journal-title":"J Clin Oncol"},{"issue":"4","key":"672_CR57","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1002\/1097-0142(19940815)74:4<1270::AID-CNCR2820740415>3.0.CO;2-7","volume":"74","author":"MA Rodriguez-Bigas","year":"1994","unstructured":"Rodriguez-Bigas MA, Mahoney MC, Karakousis CP, Petrelli NJ. Desmoid tumors in patients with familial adenomatous polyposis. Cancer 1994; 74(4): 1270\u20131274","journal-title":"Cancer"},{"issue":"1","key":"672_CR58","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1200\/JCO.1999.17.1.158","volume":"17","author":"MT Ballo","year":"1999","unstructured":"Ballo MT, Zagars GK, Pollack A, Pisters PW, Pollack RA. Desmoid tumor: prognostic factors and outcome after surgery, radiation therapy, or combined surgery and radiation therapy. J Clin Oncol 1999; 17(1): 158\u2013167","journal-title":"J Clin Oncol"},{"issue":"7","key":"672_CR59","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1200\/JCO.2003.05.150","volume":"21","author":"A Gronchi","year":"2003","unstructured":"Gronchi A, Casali PG, Mariani L, Lo Vullo S, Colecchia M, Lozza L, Bertulli R, Fiore M, Olmi P, Santinami M, Rosai J. Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol 2003; 21(7): 1390\u20131397","journal-title":"J Clin Oncol"},{"issue":"4","key":"672_CR60","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/jso.2930040406","volume":"4","author":"JG Johnson","year":"1972","unstructured":"Johnson JG, Gilbert E, Zimmermann B, Watne AL. Gardner\u2019s syndrome, colon cancer, and sarcoma. J Surg Oncol 1972; 4(4): 354\u2013362","journal-title":"J Surg Oncol"},{"issue":"8","key":"672_CR61","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/0360-3016(83)90175-X","volume":"9","author":"SA Leibel","year":"1983","unstructured":"Leibel SA, Wara WM, Hill DR, Bovill EG Jr, de Lorimier AA, Beckstead JH, Phillips TL. Desmoid tumors: local control and patterns of relapse following radiation therapy. Int J Radiat Oncol Biol Phys 1983; 9(8): 1167\u20131171","journal-title":"Int^J Radiat Oncol Biol Phys"},{"key":"672_CR62","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/00003086-200006000-00025","volume":"375","author":"G Pignatti","year":"2000","unstructured":"Pignatti G, Barbanti-Br\u00f2dano G, Ferrari D, Gherlinzoni F, Bertoni F, Bacchini P, Barbieri E, Giunti A, Campanacci M. Extraabdominal desmoid tumor. A study of 83 cases. Clin Orthop Relat Res 2000;(375): 207\u2013213","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"672_CR63","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1001\/archsurg.1989.01410020061010","volume":"124","author":"MC Posner","year":"1989","unstructured":"Posner MC, Shiu MH, Newsome JL, Hajdu SI, Gaynor JJ, Brennan MF. The desmoid tumor. Not a benign disease. Arch Surg 1989; 124(2): 191\u2013196","journal-title":"Not a benign disease. Arch Surg"},{"issue":"11","key":"672_CR64","first-page":"1318","volume":"118","author":"JJ Reitamo","year":"1983","unstructured":"Reitamo JJ. The desmoid tumor. IV. Choice of treatment, results, and complications. Arch Surg 1983; 118(11): 1318\u20131322","journal-title":"IV. Choice of treatment, results, and complications. Arch Surg"},{"issue":"2","key":"672_CR65","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/000164702753671830","volume":"73","author":"A S\u00f8rensen","year":"2002","unstructured":"S\u00f8rensen A, Keller J, Nielsen OS, Jensen OM. Treatment of aggressive fibromatosis: a retrospective study of 72 patients followed for 1\u201327 years. Acta Orthop Scand 2002; 73(2): 213\u2013219","journal-title":"Acta Orthop Scand"},{"issue":"2","key":"672_CR66","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1097\/SLA.0b013e31828c8a30","volume":"258","author":"AM Crago","year":"2013","unstructured":"Crago AM, Denton B, Salas S, Dufresne A, Mezhir JJ, Hameed M, Gonen M, Singer S, Brennan MF. A prognostic nomogram for prediction of recurrence in desmoid fibromatosis. Ann Surg 2013; 258(2): 347\u2013353","journal-title":"Ann Surg"},{"issue":"18","key":"672_CR67","doi-asserted-by":"publisher","first-page":"2800","DOI":"10.1016\/j.ejca.2015.08.026","volume":"51","author":"M Fiore","year":"2015","unstructured":"Fiore M, Colombo C, Radaelli S, Callegaro D, Palassini E, Barisella M, Morosi C, Baldi GG, Stacchiotti S, Casali PG, Gronchi A. Hormonal manipulation with toremifene in sporadic desmoid-type fibromatosis. Eur J Cancer 2015; 51(18): 2800\u20132807","journal-title":"Eur^J Cancer"},{"issue":"1","key":"672_CR68","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10689-015-9830-z","volume":"15","author":"DR Quast","year":"2016","unstructured":"Quast DR, Schneider R, Burdzik E, Hoppe S, M\u00f6slein G. Long-term outcome of sporadic and FAP-associated desmoid tumors treated with high-dose selective estrogen receptor modulators and sulindac: a single-center long-term observational study in 134 patients. Fam Cancer 2016; 15(1): 31\u201340","journal-title":"Fam Cancer"},{"issue":"1","key":"672_CR69","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10689-014-9760-1","volume":"14","author":"T Desurmont","year":"2015","unstructured":"Desurmont T, Lef\u00e8vre JH, Shields C, Colas C, Tiret E, Parc Y. Desmoid tumour in familial adenomatous polyposis patients: responses to treatments. Fam Cancer 2015; 14(1): 31\u201339","journal-title":"Fam Cancer"},{"issue":"3","key":"672_CR70","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1002\/cncr.11937","volume":"100","author":"A Hansmann","year":"2004","unstructured":"Hansmann A, Adolph C, Vogel T, Unger A, Moeslein G. High-dose tamoxifen and sulindac as first-line treatment for desmoid tumors. Cancer 2004; 100(3): 612\u2013620","journal-title":"Cancer"},{"issue":"1","key":"672_CR71","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s40487-016-0017-z","volume":"4","author":"JH Howard","year":"2016","unstructured":"Howard JH, Pollock RE. Intra-abdominal and abdominal wall desmoid fibromatosis. Oncol Ther 2016; 4(1): 57\u201372","journal-title":"Oncol Ther"},{"issue":"18","key":"672_CR72","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","volume":"90","author":"B Fisher","year":"1998","unstructured":"Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998; 90(18): 1371\u20131388","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"672_CR73","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1002\/cncr.25089","volume":"116","author":"VP Camargo de","year":"2010","unstructured":"de Camargo VP, Keohan ML, D\u2019Adamo DR, Antonescu CR, Brennan MF, Singer S, Ahn LS, Maki RG. Clinical outcomes of systemic therapy for patients with deep fibromatosis(desmoid tumor). Cancer 2010; 116(9): 2258\u20132265","journal-title":"Cancer"},{"issue":"1","key":"672_CR74","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1200\/JCO.2005.02.1923","volume":"24","author":"M Gega","year":"2006","unstructured":"Gega M, Yanagi H, Yoshikawa R, Noda M, Ikeuchi H, Tsukamoto K, Oshima T, Fujiwara Y, Gondo N, Tamura K, Utsunomiya J, Hashimoto-Tamaoki T, Yamamura T. Successful chemotherapeutic modality of doxorubicin plus dacarbazine for the treatment of desmoid tumors in association with familial adenomatous polyposis. J Clin Oncol 2006; 24(1): 102\u2013105","journal-title":"J Clin Oncol"},{"issue":"17","key":"672_CR75","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.1016\/j.ejca.2009.08.016","volume":"45","author":"A Constantinidou","year":"2009","unstructured":"Constantinidou A, Jones RL, Scurr M, Al-Muderis O, Judson I. Pegylated liposomal doxorubicin, an effective, well-tolerated treatment for refractory aggressive fibromatosis. Eur J Cancer 2009; 45(17): 2930\u20132934","journal-title":"Eur^J Cancer"},{"issue":"1","key":"672_CR76","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/annonc\/mdr051","volume":"23","author":"D Garbay","year":"2012","unstructured":"Garbay D, Le Cesne A, Penel N, Chevreau C, Marec-Berard P, Blay JY, Debled M, Isambert N, Thyss A, Bompas E, Collard O, Salas S, Coindre JM, Bui B, Italiano A. Chemotherapy in patients with desmoid tumors: a study from the French Sarcoma Group(FSG). Ann Oncol 2012; 23(1): 182\u2013186","journal-title":"Ann Oncol"},{"issue":"2","key":"672_CR77","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/00000421-199904000-00020","volume":"22","author":"AJ Weiss","year":"1999","unstructured":"Weiss AJ, Horowitz S, Lackman RD. Therapy of desmoid tumors and fibromatosis using vinorelbine. Am J Clin Oncol 1999; 22(2): 193\u2013195","journal-title":"Am^J Clin Oncol"},{"issue":"5","key":"672_CR78","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/1097-0142(20010901)92:5<1259::AID-CNCR1446>3.0.CO;2-Y","volume":"92","author":"A Azzarelli","year":"2001","unstructured":"Azzarelli A, Gronchi A, Bertulli R, Tesoro JD, Baratti D, Pennacchioli E, Dileo P, Rasponi A, Ferrari A, Pilotti S, Casali PG. Low-dose chemotherapy with methotrexate and vinblastine for patients with advanced aggressive fibromatosis. Cancer 2001; 92(5): 1259\u20131264","journal-title":"Cancer"},{"issue":"16","key":"672_CR79","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1016\/j.ejca.2008.06.038","volume":"44","author":"MM Bertagnolli","year":"2008","unstructured":"Bertagnolli MM, Morgan JA, Fletcher CD, Raut CP, Dileo P, Gill RR, Demetri GD, George S. Multimodality treatment of mesenteric desmoid tumours. Eur J Cancer 2008; 44(16): 2404\u20132410","journal-title":"Eur^J Cancer"},{"issue":"1","key":"672_CR80","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1477-7819-6-17","volume":"6","author":"K Tanaka","year":"2008","unstructured":"Tanaka K, Yoshikawa R, Yanagi H, Gega M, Fujiwara Y, Hashimoto-Tamaoki T, Hirota S, Tsujimura T, Tomita N. Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug. World J Surg Oncol 2008; 6(1): 17","journal-title":"World^J Surg Oncol"},{"key":"672_CR81","volume-title":"Colorectal Dis","author":"D Bocale","year":"2011","unstructured":"Bocale D, Rotelli MT, Cavallini A, Altomare DF. Anti-oestrogen therapy in the treatment of desmoid tumours: a systematic review. Colorectal Dis 2011; 13(12): e388\u2013e395"},{"issue":"5","key":"672_CR82","doi-asserted-by":"publisher","first-page":"455","DOI":"10.21147\/j.issn.1000-9604.2017.05.10","volume":"29","author":"S Li","year":"2017","unstructured":"Li S, Fan Z, Fang Z, Liu J, Bai C, Xue R, Zhang L, Gao T. Efficacy of vinorelbine combined with low-dose methotrexate for treatment of inoperable desmoid tumor and prognostic factor analysis. Chin J Cancer Res 2017; 29(5): 455\u2013462","journal-title":"Chin^J Cancer Res"}],"container-title":["Frontiers of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11684-018-0672-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-018-0672-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-018-0672-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T02:07:30Z","timestamp":1721009250000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11684-018-0672-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,22]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["672"],"URL":"https:\/\/doi.org\/10.1007\/s11684-018-0672-6","relation":{},"ISSN":["2095-0217","2095-0225"],"issn-type":[{"value":"2095-0217","type":"print"},{"value":"2095-0225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,22]]},"assertion":[{"value":"19 March 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}