{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:19:35Z","timestamp":1790399975403,"version":"4.1.0"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Front. Med."],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1007\/s11684-023-0985-y","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:01:59Z","timestamp":1683072119000},"page":"207-219","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Progress and challenges in RET-targeted cancer therapy"],"prefix":"10.1007","volume":"17","author":[{"given":"Xueqing","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujjwol","family":"Khatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"issue":"3","key":"985_CR1","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/nrc3680","volume":"14","author":"LM Mulligan","year":"2014","unstructured":"Mulligan LM. RET revisited: expanding the oncogenic portfolio. Nat Rev Cancer 2014; 14(3): 173\u2013186","journal-title":"Nat Rev Cancer"},{"issue":"12","key":"985_CR2","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1016\/j.trecan.2021.07.003","volume":"7","author":"KZ Thein","year":"2021","unstructured":"Thein KZ, Velcheti V, Mooers BHM, Wu J, Subbiah V. Precision therapy for RET-altered cancers with RET inhibitors. Trends Cancer 2021; 7(12): 1074\u20131088","journal-title":"Trends Cancer"},{"issue":"3","key":"985_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/nrclinonc.2017.175","volume":"15","author":"A Drilon","year":"2018","unstructured":"Drilon A, Hu ZI, Lai GGY, Tan DSW. Targeting RET-driven cancers: lessons from evolving preclinical and clinical landscapes. Nat Rev Clin Oncol 2018; 15(3): 151\u2013167","journal-title":"Nat Rev Clin Oncol"},{"issue":"3","key":"985_CR4","first-page":"472","volume":"3","author":"X Liu","year":"2020","unstructured":"Liu X, Hu X, Shen T, Li Q, Mooers BHM, Wu J. RET kinase alterations in targeted cancer therapy. Cancer Drug Resist 2020; 3(3): 472\u2013481","journal-title":"Cancer Drug Resist"},{"issue":"11","key":"985_CR5","doi-asserted-by":"publisher","first-page":"1209","DOI":"10.1200\/JCO.19.02551","volume":"38","author":"V Subbiah","year":"2020","unstructured":"Subbiah V, Yang D, Velcheti V, Drilon A, Meric-Bernstam F. State-of-the-art strategies for targeting RET-dependent cancers. J Clin Oncol 2020; 38(11): 1209\u20131221","journal-title":"J Clin Oncol"},{"issue":"12","key":"985_CR6","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1158\/2159-8290.CD-18-1022","volume":"8","author":"Z Piotrowska","year":"2018","unstructured":"Piotrowska Z, Isozaki H, Lennerz JK, Gainor JF, Lennes IT, Zhu VW, Marcoux N, Banwait MK, Digumarthy SR, Su W, Yoda S, Riley AK, Nangia V, Lin JJ, Nagy RJ, Lanman RB, Dias-Santagata D, Mino-Kenudson M, Iafrate AJ, Heist RS, Shaw AT, Evans EK, Clifford C, Ou SI, Wolf B, Hata AN, Sequist LV. Landscape of acquired resistance to osimertinib in EGFR-mutant NSCLC and clinical validation of combined EGFR and RET inhibition with osimertinib and BLU-667 for acquired RET fusion. Cancer Discov 2018; 8(12): 1529\u20131539","journal-title":"Cancer Discov"},{"issue":"6","key":"985_CR7","first-page":"100343","volume":"3","author":"Z Zhao","year":"2022","unstructured":"Zhao Z, Su C, Xiu W, Wang W, Zeng S, Huang M, Gong Y, Lu Y, Zhang Y. Response to pralsetinib observed in meningeal-metastatic EGFR-mutant NSCLC with acquired RET fusion: a brief report. JTO Clin Res Rep 2022; 3(6): 100343","journal-title":"JTO Clin Res Rep"},{"issue":"1","key":"985_CR8","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12967-022-03593-3","volume":"20","author":"C Wang","year":"2022","unstructured":"Wang C, Zhang Z, Sun Y, Wang S, Wu M, Ou Q, Xu Y, Chen Z, Shao Y, Liu H, Hou P. RET fusions as primary oncogenic drivers and secondary acquired resistance to EGFR tyrosine kinase inhibitors in patients with non-small-cell lung cancer. J Transl Med 2022; 20(1): 390","journal-title":"J Transl Med"},{"issue":"25","key":"985_CR9","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1056\/NEJMoa2105281","volume":"384","author":"MM Awad","year":"2021","unstructured":"Awad MM, Liu S, Rybkin II, Arbour KC, Dilly J, Zhu VW, Johnson ML, Heist RS, Patil T, Riely GJ, Jacobson JO, Yang X, Persky NS, Root DE, Lowder KE, Feng H, Zhang SS, Haigis KM, Hung YP, Sholl LM, Wolpin BM, Wiese J, Christiansen J, Lee J, Schrock AB, Lim LP, Garg K, Li M, Engstrom LD, Waters L, Lawson JD, Olson P, Lito P, Ou SI, Christensen JG, J\u00e4nne PA, Aguirre AJ. Acquired resistance to KRASG12C inhibition in cancer. N Engl J Med 2021; 384(25): 2382\u20132393","journal-title":"N Engl J Med"},{"issue":"10","key":"985_CR10","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1158\/1535-7163.MCT-21-0329","volume":"20","author":"JJ Adashek","year":"2021","unstructured":"Adashek JJ, Desai AP, Andreev-Drakhlin AY, Roszik J, Cote GJ, Subbiah V. Hallmarks of RET and co-occuring genomic alterations in RET-aberrant cancers. Mol Cancer Ther 2021; 20(10): 1769\u20131776","journal-title":"Mol Cancer Ther"},{"issue":"5","key":"985_CR11","doi-asserted-by":"publisher","first-page":"e000799","DOI":"10.1136\/esmoopen-2020-000799","volume":"5","author":"A Hegde","year":"2020","unstructured":"Hegde A, Andreev-Drakhlin AY, Roszik J, Huang L, Liu S, Hess K, Cabanillas M, Hu MI, Busaidy NL, Sherman SI, Dadu R, Grubbs EG, Ali SM, Lee J, Elamin YY, Simon GR, Blumenschein GRJr, Papadimitrakopoulou VA, Hong D, Meric-Bernstam F, Heymach J, Subbiah V. Responsiveness to immune checkpoint inhibitors versus other systemic therapies in RET-aberrant malignancies. ESMO Open 2020; 5(5): e000799","journal-title":"ESMO Open"},{"issue":"6","key":"985_CR12","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/cas.12941","volume":"107","author":"M Saito","year":"2016","unstructured":"Saito M, Shiraishi K, Kunitoh H, Takenoshita S, Yokota J, Kohno T. Gene aberrations for precision medicine against lung adenocarcinoma. Cancer Sci 2016; 107(6): 713\u2013720","journal-title":"Cancer Sci"},{"issue":"8","key":"985_CR13","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1093\/annonc\/mdz167","volume":"30","author":"J Mazieres","year":"2019","unstructured":"Mazieres J, Drilon A, Lusque A, Mhanna L, Cortot AB, Mezquita L, Thai AA, Mascaux C, Couraud S, Veillon R, Van den Heuvel M, Neal J, Peled N, Fr\u00fch M, Ng TL, Gounant V, Popat S, Diebold J, Sabari J, Zhu VW, Rothschild SI, Bironzo P, Martinez-Marti A, Curioni-Fontecedro A, Rosell R, Lattuca-Truc M, Wiesweg M, Besse B, Solomon B, Barlesi F, Schouten RD, Wakelee H, Camidge DR, Zalcman G, Novello S, Ou SI, Milia J, Gautschi O. Immune checkpoint inhibitors for patients with advanced lung cancer and oncogenic driver alterations: results from the IMMUNOTARGET registry. Ann Oncol 2019; 30(8): 1321\u20131328","journal-title":"Ann Oncol"},{"issue":"13","key":"985_CR14","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1200\/JCO.2016.70.9352","volume":"35","author":"O Gautschi","year":"2017","unstructured":"Gautschi O, Milia J, Filleron T, Wolf J, Carbone DP, Owen D, Camidge R, Narayanan V, Doebele RC, Besse B, Remon-Masip J, Janne PA, Awad MM, Peled N, Byoung CC, Karp DD, Van Den Heuvel M, Wakelee HA, Neal JW, Mok TSK, Yang JCH, Ou SI, Pall G, Froesch P, Zalcman G, Gandara DR, Riess JW, Velcheti V, Zeidler K, Diebold J, Fr\u00fch M, Michels S, Monnet I, Popat S, Rosell R, Karachaliou N, Rothschild SI, Shih JY, Warth A, Muley T, Cabillic F, Mazi\u00e8res J, Drilon A. Targeting RET in patients with RET-rearranged lung cancers: results from the global, multicenter RET registry. J Clin Oncol 2017; 35(13): 1403\u20131410","journal-title":"J Clin Oncol"},{"issue":"7","key":"985_CR15","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1158\/2159-8290.CD-18-0338","volume":"8","author":"V Subbiah","year":"2018","unstructured":"Subbiah V, Gainor JF, Rahal R, Brubaker JD, Kim JL, Maynard M, Hu W, Cao Q, Sheets MP, Wilson D, Wilson KJ, DiPietro L, Fleming P, Palmer M, Hu MI, Wirth L, Brose MS, Ou SI, Taylor M, Garralda E, Miller S, Wolf B, Lengauer C, Guzi T, Evans EK. Precision targeted therapy with BLU-667 for RET-driven cancers. Cancer Discov 2018; 8(7): 836\u2013849","journal-title":"Cancer Discov"},{"issue":"8","key":"985_CR16","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1093\/annonc\/mdy137","volume":"29","author":"V Subbiah","year":"2018","unstructured":"Subbiah V, Velcheti V, Tuch BB, Ebata K, Busaidy NL, Cabanillas ME, Wirth LJ, Stock S, Smith S, Lauriault V, Corsi-Travali S, Henry D, Burkard M, Hamor R, Bouhana K, Winski S, Wallace RD, Hartley D, Rhodes S, Reddy M, Brandhuber BJ, Andrews S, Rothenberg SM, Drilon A. Selective RET kinase inhibition for patients with RET-altered cancers. Ann Oncol 2018; 29(8): 1869\u20131876","journal-title":"Ann Oncol"},{"issue":"7","key":"985_CR17","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/S1470-2045(21)00247-3","volume":"22","author":"JF Gainor","year":"2021","unstructured":"Gainor JF, Curigliano G, Kim DW, Lee DH, Besse B, Baik CS, Doebele RC, Cassier PA, Lopes G, Tan DSW, Garralda E, Paz-Ares LG, Cho BC, Gadgeel SM, Thomas M, Liu SV, Taylor MH, Mansfield AS, Zhu VW, Clifford C, Zhang H, Palmer M, Green J, Turner CD, Subbiah V. Pralsetinib for RET fusion-positive non-small-cell lung cancer (ARROW): a multi-cohort, open-label, phase 1\/2 study. Lancet Oncol 2021; 22(7): 959\u2013969","journal-title":"Lancet Oncol"},{"issue":"9","key":"985_CR18","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1056\/NEJMoa2005653","volume":"383","author":"A Drilon","year":"2020","unstructured":"Drilon A, Oxnard GR, Tan DSW, Loong HHF, Johnson M, Gainor J, McCoach CE, Gautschi O, Besse B, Cho BC, Peled N, Weiss J, Kim YJ, Ohe Y, Nishio M, Park K, Patel J, Seto T, Sakamoto T, Rosen E, Shah MH, Barlesi F, Cassier PA, Bazhenova L, De Braud F, Garralda E, Velcheti V, Satouchi M, Ohashi K, Pennell NA, Reckamp KL, Dy GK, Wolf J, Solomon B, Falchook G, Ebata K, Nguyen M, Nair B, Zhu EY, Yang L, Huang X, Olek E, Rothenberg SM, Goto K, Subbiah V. Efficacy of selpercatinib in RET fusion-positive non-small-cell lung cancer. N Engl J Med 2020; 383(9): 813\u2013824","journal-title":"N Engl J Med"},{"issue":"8","key":"985_CR19","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S2213-8587(21)00120-0","volume":"9","author":"V Subbiah","year":"2021","unstructured":"Subbiah V, Hu MI, Wirth LJ, Schuler M, Mansfield AS, Curigliano G, Brose MS, Zhu VW, Leboulleux S, Bowles DW, Baik CS, Adkins D, Keam B, Matos I, Garralda E, Gainor JF, Lopes G, Lin CC, Godbert Y, Sarker D, Miller SG, Clifford C, Zhang H, Turner CD, Taylor MH. Pralsetinib for patients with advanced or metastatic RET-altered thyroid cancer (ARROW): a multi-cohort, open-label, registrational, phase 1\/2 study. Lancet Diabetes Endocrinol 2021; 9(8): 491\u2013501","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"9","key":"985_CR20","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1056\/NEJMoa2005651","volume":"383","author":"LJ Wirth","year":"2020","unstructured":"Wirth LJ, Sherman E, Robinson B, Solomon B, Kang H, Lorch J, Worden F, Brose M, Patel J, Leboulleux S, Godbert Y, Barlesi F, Morris JC, Owonikoko TK, Tan DSW, Gautschi O, Weiss J, de la Fouchardi\u00e8re C, Burkard ME, Laskin J, Taylor MH, Kroiss M, Medioni J, Goldman JW, Bauer TM, Levy B, Zhu VW, Lakhani N, Moreno V, Ebata K, Nguyen M, Heirich D, Zhu EY, Huang X, Yang L, Kherani J, Rothenberg SM, Drilon A, Subbiah V, Shah MH, Cabanillas ME. Efficacy of selpercatinib in RET-altered thyroid cancers. N Engl J Med 2020; 383(9): 825\u2013835","journal-title":"N Engl J Med"},{"issue":"11","key":"985_CR21","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1016\/j.annonc.2022.08.002","volume":"33","author":"F Griesinger","year":"2022","unstructured":"Griesinger F, Curigliano G, Thomas M, Subbiah V, Baik CS, Tan DSW, Lee DH, Misch D, Garralda E, Kim DW, van der Wekken AJ, Gainor JF, Paz-Ares L, Liu SV, Kalemkerian GP, Houvras Y, Bowles DW, Mansfield AS, Lin JJ, Smoljanovic V, Rahman A, Kong S, Zalutskaya A, Louie-Gao M, Boral AL, Mazi\u00e8res J. Safety and efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer including as first-line therapy: update from the ARROW trial. Ann Oncol 2022; 33(11): 1168\u20131178","journal-title":"Ann Oncol"},{"issue":"2","key":"985_CR22","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1200\/JCO.22.00393","volume":"41","author":"A Drilon","year":"2023","unstructured":"Drilon A, Subbiah V, Gautschi O, Tomasini P, de Braud F, Solomon BJ, Shao-Weng Tan D, Alonso G, Wolf J, Park K, Goto K, Soldatenkova V, Szymczak S, Barker SS, Puri T, Bence Lin A, Loong H, Besse B. Selpercatinib in patients with RET fusionpositive non-small-cell lung cancer: updated safety and efficacy from the registrational LIBRETTO-001 phase I\/II trial. J Clin Oncol 2023; 41(2): 385\u2013394","journal-title":"J Clin Oncol"},{"issue":"8","key":"985_CR23","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1038\/s41591-022-01931-y","volume":"28","author":"V Subbiah","year":"2022","unstructured":"Subbiah V, Cassier PA, Siena S, Garralda E, Paz-Ares L, Garrido P, Nadal E, Vuky J, Lopes G, Kalemkerian GP, Bowles DW, Seetharam M, Chang J, Zhang H, Green J, Zalutskaya A, Schuler M, Fan Y, Curigliano G. Pan-cancer efficacy of pralsetinib in patients with RET fusion-positive solid tumors from the phase 1\/2 ARROW trial. Nat Med 2022; 28(8): 1640\u20131645","journal-title":"Nat Med"},{"issue":"10","key":"985_CR24","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/S1470-2045(22)00541-1","volume":"23","author":"V Subbiah","year":"2022","unstructured":"Subbiah V, Wolf J, Konda B, Kang H, Spira A, Weiss J, Takeda M, Ohe Y, Khan S, Ohashi K, Soldatenkova V, Szymczak S, Sullivan L, Wright J, Drilon A. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1\/2, open-label, basket trial. Lancet Oncol 2022; 23(10): 1261\u20131273","journal-title":"Lancet Oncol"},{"issue":"4","key":"985_CR25","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.jtho.2020.01.006","volume":"15","author":"BJ Solomon","year":"2020","unstructured":"Solomon BJ, Tan L, Lin JJ, Wong SQ, Hollizeck S, Ebata K, Tuch BB, Yoda S, Gainor JF, Sequist LV, Oxnard GR, Gautschi O, Drilon A, Subbiah V, Khoo C, Zhu EY, Nguyen M, Henry D, Condroski KR, Kolakowski GR, Gomez E, Ballard J, Metcalf AT, Blake JF, Dawson SJ, Blosser W, Stancato LF, Brandhuber BJ, Andrews S, Robinson BG, Rothenberg SM. RET solvent front mutations mediate acquired resistance to selective RET inhibition in RET-driven malignancies. J Thorac Oncol 2020; 15(4): 541\u2013549","journal-title":"J Thorac Oncol"},{"issue":"12","key":"985_CR26","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1016\/j.annonc.2020.09.015","volume":"31","author":"JJ Lin","year":"2020","unstructured":"Lin JJ, Liu SV, McCoach CE, Zhu VW, Tan AC, Yoda S, Peterson J, Do A, Prutisto-Chang K, Dagogo-Jack I, Sequist LV, Wirth LJ, Lennerz JK, Hata AN, Mino-Kenudson M, Nardi V, Ou SI, Tan DSW, Gainor JF. Mechanisms of resistance to selective RET tyrosine kinase inhibitors in RET fusion-positive non-small-cell lung cancer. Ann Oncol 2020; 31(12): 1725\u20131733","journal-title":"Ann Oncol"},{"issue":"2","key":"985_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.annonc.2020.10.599","volume":"32","author":"V Subbiah","year":"2021","unstructured":"Subbiah V, Shen T, Terzyan SS, Liu X, Hu X, Patel KP, Hu M, Cabanillas M, Behrang A, Meric-Bernstam F, Vo PTT, Mooers BHM, Wu J. Structural basis of acquired resistance to selpercatinib and pralsetinib mediated by non-gatekeeper RET mutations. Ann Oncol 2021; 32(2): 261\u2013268","journal-title":"Ann Oncol"},{"issue":"1","key":"985_CR28","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1158\/1078-0432.CCR-20-2278","volume":"27","author":"EY Rosen","year":"2021","unstructured":"Rosen EY, Johnson ML, Clifford SE, Somwar R, Kherani JF, Son J, Bertram AA, Davare MA, Gladstone E, Ivanova EV, Henry DN, Kelley EM, Lin M, Milan MSD, Nair BC, Olek EA, Scanlon JE, Vojnic M, Ebata K, Hechtman JF, Li BT, Sholl LM, Taylor BS, Ladanyi M, J\u00e4nne PA, Rothenberg SM, Drilon A, Oxnard GR. Overcoming MET-dependent resistance to selective RET inhibition in patients with RET fusion-positive lung cancer by combining selpercatinib with crizotinib. Clin Cancer Res 2021; 27(1): 34\u201342","journal-title":"Clin Cancer Res"},{"issue":"1","key":"985_CR29","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1038\/s41467-022-28848-x","volume":"13","author":"EY Rosen","year":"2022","unstructured":"Rosen EY, Won HH, Zheng Y, Cocco E, Selcuklu D, Gong Y, Friedman ND, de Bruijn I, Sumer O, Bielski CM, Savin C, Bourque C, Falcon C, Clarke N, Jing X, Meng F, Zimel C, Shifman S, Kittane S, Wu F, Ladanyi M, Ebata K, Kherani J, Brandhuber BJ, Fagin J, Sherman EJ, Rekhtman N, Berger MF, Scaltriti M, Hyman DM, Taylor BS, Drilon A. The evolution of RET inhibitor resistance in RET-driven lung and thyroid cancers. Nat Commun 2022; 13(1): 1450","journal-title":"Nat Commun"},{"issue":"1","key":"985_CR30","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1530\/ERC-16-0393","volume":"24","author":"EY Lian","year":"2017","unstructured":"Lian EY, Maritan SM, Cockburn JG, Kasaian K, Crupi MJ, Hurlbut D, Jones SJ, Wiseman SM, Mulligan LM. Differential roles of RET isoforms in medullary and papillary thyroid carcinomas. Endocr Relat Cancer 2017; 24(1): 53\u201369","journal-title":"Endocr Relat Cancer"},{"issue":"3","key":"985_CR31","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nm.2658","volume":"18","author":"K Takeuchi","year":"2012","unstructured":"Takeuchi K, Soda M, Togashi Y, Suzuki R, Sakata S, Hatano S, Asaka R, Hamanaka W, Ninomiya H, Uehara H, Lim Choi Y, Satoh Y, Okumura S, Nakagawa K, Mano H, Ishikawa Y. RET, ROS1 and ALK fusions in lung cancer. Nat Med 2012; 18(3): 378\u2013381","journal-title":"Nat Med"},{"issue":"6","key":"985_CR32","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1089\/thy.2014.0335","volume":"25","author":"SA Wells Jr","year":"2015","unstructured":"Wells SAJr, Asa SL, Dralle H, Elisei R, Evans DB, Gagel RF, Lee N, Machens A, Moley JF, Pacini F, Raue F, Frank-Raue K, Robinson B, Rosenthal MS, Santoro M, Schlumberger M, Shah M, Waguespack SG; American Thyroid Association Guidelines Task Force on Medullary Thyroid Carcinoma. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid 2015; 25(6): 567\u2013610","journal-title":"Thyroid"},{"issue":"13","key":"985_CR33","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1002\/cncr.28661","volume":"120","author":"GW Krampitz","year":"2014","unstructured":"Krampitz GW, Norton JA. RET gene mutations (genotype and phenotype) of multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma. Cancer 2014; 120(13): 1920\u20131931","journal-title":"Cancer"},{"issue":"8","key":"985_CR34","doi-asserted-by":"publisher","first-page":"2195","DOI":"10.1210\/clinem\/dgac325","volume":"107","author":"R Elisei","year":"2022","unstructured":"Elisei R, Ciampi R, Matrone A, Prete A, Gambale C, Ramone T, Simeakis G, Materazzi G, Torregrossa L, Ugolini C, Romei C. Somatic RET indels in sporadic medullary thyroid cancer: prevalence and response to selpercatinib. J Clin Endocrinol Metab 2022; 107(8): 2195\u20132202","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"985_CR35","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1128\/MCB.15.3.1613","volume":"15","author":"N Asai","year":"1995","unstructured":"Asai N, Iwashita T, Matsuyama M, Takahashi M. Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 1995; 15(3): 1613\u20131619","journal-title":"Mol Cell Biol"},{"issue":"5","key":"985_CR36","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.molcel.2014.01.015","volume":"53","author":"I Plaza-Menacho","year":"2014","unstructured":"Plaza-Menacho I, Barnouin K, Goodman K, Mart\u00ednez-Torres RJ, Borg A, Murray-Rust J, Mouilleron S, Knowles P, McDonald NQ. Oncogenic RET kinase domain mutations perturb the autophosphorylation trajectory by enhancing substrate presentation in trans. Mol Cell 2014; 53(5): 738\u2013751","journal-title":"Mol Cell"},{"issue":"4","key":"985_CR37","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1002\/humu.20928","volume":"30","author":"RL Margraf","year":"2009","unstructured":"Margraf RL, Crockett DK, Krautscheid PM, Seamons R, Calderon FR, Wittwer CT, Mao R. Multiple endocrine neoplasia type 2 RET protooncogene database: repository of MEN2-associated RET sequence variation and reference for genotype\/phenotype correlations. Hum Mutat 2009; 30(4): 548\u2013556","journal-title":"Hum Mutat"},{"issue":"269","key":"985_CR38","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, Cerami E, Sander C, Schultz N. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal 2013; 6(269): pl1","journal-title":"Sci Signal"},{"issue":"6126","key":"985_CR39","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1038\/328170a0","volume":"328","author":"A Fusco","year":"1987","unstructured":"Fusco A, Grieco M, Santoro M, Berlingieri MT, Pilotti S, Pierotti MA, Della Porta G, Vecchio G. A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases. Nature 1987; 328(6126): 170\u2013172","journal-title":"Nature"},{"issue":"4","key":"985_CR40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/nrendo.2016.11","volume":"12","author":"C Romei","year":"2016","unstructured":"Romei C, Ciampi R, Elisei R. A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma. Nat Rev Endocrinol 2016; 12(4): 192\u2013202","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"985_CR41","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1101\/gr.133645.111","volume":"22","author":"YS Ju","year":"2012","unstructured":"Ju YS, Lee WC, Shin JY, Lee S, Bleazard T, Won JK, Kim YT, Kim JI, Kang JH, Seo JS. A transforming KIF5B and RET gene fusion in lung adenocarcinoma revealed from whole-genome and transcriptome sequencing. Genome Res 2012; 22(3): 436\u2013445","journal-title":"Genome Res"},{"issue":"3","key":"985_CR42","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/nm.2644","volume":"18","author":"T Kohno","year":"2012","unstructured":"Kohno T, Ichikawa H, Totoki Y, Yasuda K, Hiramoto M, Nammo T, Sakamoto H, Tsuta K, Furuta K, Shimada Y, Iwakawa R, Ogiwara H, Oike T, Enari M, Schetter AJ, Okayama H, Haugen A, Skaug V, Chiku S, Yamanaka I, Arai Y, Watanabe S, Sekine I, Ogawa S, Harris CC, Tsuda H, Yoshida T, Yokota J, Shibata T. KIF5B-RET fusions in lung adenocarcinoma. Nat Med 2012; 18(3): 375\u2013377","journal-title":"Nat Med"},{"issue":"3","key":"985_CR43","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/nm.2673","volume":"18","author":"D Lipson","year":"2012","unstructured":"Lipson D, Capelletti M, Yelensky R, Otto G, Parker A, Jarosz M, Curran JA, Balasubramanian S, Bloom T, Brennan KW, Donahue A, Downing SR, Frampton GM, Garcia L, Juhn F, Mitchell KC, White E, White J, Zwirko Z, Peretz T, Nechushtan H, Soussan-Gutman L, Kim J, Sasaki H, Kim HR, Park SI, Ercan D, Sheehan CE, Ross JS, Cronin MT, J\u00e4nne PA, Stephens PJ. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Nat Med 2012; 18(3): 382\u2013384","journal-title":"Nat Med"},{"issue":"5","key":"985_CR44","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/cr.2012.27","volume":"22","author":"F Li","year":"2012","unstructured":"Li F, Feng Y, Fang R, Fang Z, Xia J, Han X, Liu XY, Chen H, Liu H, Ji H. Identification of RET gene fusion by exon array analyses in \u201cpan-negative\u201d lung cancer from never smokers. Cell Res 2012; 22(5): 928\u2013931","journal-title":"Cell Res"},{"issue":"1","key":"985_CR45","doi-asserted-by":"publisher","first-page":"4821","DOI":"10.1038\/s41467-018-07341-4","volume":"9","author":"BS Paratala","year":"2018","unstructured":"Paratala BS, Chung JH, Williams CB, Yilmazel B, Petrosky W, Williams K, Schrock AB, Gay LM, Lee E, Dolfi SC, Pham K, Lin S, Yao M, Kulkarni A, DiClemente F, Liu C, Rodriguez-Rodriguez L, Ganesan S, Ross JS, Ali SM, Leyland-Jones B, Hirshfield KM. RET rearrangements are actionable alterations in breast cancer. Nat Commun 2018; 9(1): 4821","journal-title":"Nat Commun"},{"issue":"7","key":"985_CR46","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1634\/theoncologist.2013-0095","volume":"18","author":"JF Gainor","year":"2013","unstructured":"Gainor JF, Shaw AT. Novel targets in non-small cell lung cancer: ROS1 and RET fusions. Oncologist 2013; 18(7): 865\u2013875","journal-title":"Oncologist"},{"issue":"11","key":"985_CR47","doi-asserted-by":"publisher","first-page":"4861","DOI":"10.1158\/0008-5472.CAN-08-4425","volume":"69","author":"DS Richardson","year":"2009","unstructured":"Richardson DS, Gujral TS, Peng S, Asa SL, Mulligan LM. Transcript level modulates the inherent oncogenicity of RET\/PTC oncoproteins. Cancer Res 2009; 69(11): 4861\u20134869","journal-title":"Cancer Res"},{"issue":"4","key":"985_CR48","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1158\/1535-7163.MCT-11-0645","volume":"11","author":"J James","year":"2012","unstructured":"James J, Ruggeri B, Armstrong RC, Rowbottom MW, Jones-Bolin S, Gunawardane RN, Dobrzanski P, Gardner MF, Zhao H, Cramer MD, Hunter K, Nepomuceno RR, Cheng M, Gitnick D, Yazdanian M, Insko DE, Ator MA, Apuy JL, Faraoni R, Dorsey BD, Williams M, Bhagwat SS, Holladay MW. CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity. Mol Cancer Ther 2012; 11(4): 930\u2013941","journal-title":"Mol Cancer Ther"},{"issue":"12","key":"985_CR49","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1158\/1078-0432.CCR-16-1887","volume":"23","author":"GG Li","year":"2017","unstructured":"Li GG, Somwar R, Joseph J, Smith RS, Hayashi T, Martin L, Franovic A, Schairer A, Martin E, Riely GJ, Harris J, Yan S, Wei G, Oliver JW, Patel R, Multani P, Ladanyi M, Drilon A. Antitumor activity of RXDX-105 in multiple cancer types with RET rearrangements or mutations. Clin Cancer Res 2017; 23(12): 2981\u20132990","journal-title":"Clin Cancer Res"},{"issue":"3","key":"985_CR50","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1158\/2159-8290.CD-18-0839","volume":"9","author":"A Drilon","year":"2019","unstructured":"Drilon A, Fu S, Patel MR, Fakih M, Wang D, Olszanski AJ, Morgensztern D, Liu SV, Cho BC, Bazhenova L, Rodriguez CP, Doebele RC, Wozniak A, Reckamp KL, Seery T, Nikolinakos P, Hu Z, Oliver JW, Trone D, McArthur K, Patel R, Multani PS, Ahn MJ. A phase I\/Ib trial of the VEGFR-sparing multikinase RET inhibitor RXDX-105. Cancer Discov 2019; 9(3): 384\u2013395","journal-title":"Cancer Discov"},{"issue":"10","key":"985_CR51","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.celrep.2017.08.037","volume":"20","author":"TK Das","year":"2017","unstructured":"Das TK, Cagan RL. KIF5B-RET oncoprotein signals through a multi-kinase signaling hub. Cell Rep 2017; 20(10): 2368\u20132383","journal-title":"Cell Rep"},{"issue":"10","key":"985_CR52","doi-asserted-by":"publisher","first-page":"2649","DOI":"10.1016\/j.cell.2021.03.031","volume":"184","author":"A Tulpule","year":"2021","unstructured":"Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell 2021; 184(10): 2649\u20132664.e18","journal-title":"Cell"},{"issue":"11","key":"985_CR53","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1016\/j.celrep.2016.08.019","volume":"16","author":"S Levinson","year":"2016","unstructured":"Levinson S, Cagan RL. Drosophila cancer models identify functional differences between RET fusions. Cell Rep 2016; 16(11): 3052\u20133061","journal-title":"Cell Rep"},{"issue":"3","key":"985_CR54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.annonc.2020.11.021","volume":"32","author":"C Belli","year":"2021","unstructured":"Belli C, Penault-Llorca F, Ladanyi M, Normanno N, Scoazec JY, Lacroix L, Reis-Filho JS, Subbiah V, Gainor JF, Endris V, Repetto M, Drilon A, Scarpa A, Andr\u00e9 F, Douillard JY, Curigliano G. ESMO recommendations on the standard methods to detect RET fusions and mutations in daily practice and clinical research. Ann Oncol 2021; 32(3): 337\u2013350","journal-title":"Ann Oncol"},{"issue":"17","key":"985_CR55","doi-asserted-by":"publisher","first-page":"3504","DOI":"10.1111\/bph.14395","volume":"175","author":"X Liu","year":"2018","unstructured":"Liu X, Shen T, Mooers BHM, Hilberg F, Wu J. Drug resistance profiles of mutations in the RET kinase domain. Br J Pharmacol 2018; 175(17): 3504\u20133515","journal-title":"Br J Pharmacol"},{"issue":"11","key":"985_CR56","doi-asserted-by":"publisher","first-page":"e226","DOI":"10.1016\/j.jtho.2018.06.021","volume":"13","author":"I Dagogo-Jack","year":"2018","unstructured":"Dagogo-Jack I, Stevens SE, Lin JJ, Nagy R, Ferris L, Shaw AT, Gainor JF. Emergence of a RET V804M gatekeeper mutation during treatment with vandetanib in RET-rearranged NSCLC. J Thorac Oncol 2018; 13(11): e226\u2013e227","journal-title":"J Thorac Oncol"},{"issue":"44","key":"985_CR57","doi-asserted-by":"publisher","first-page":"33577","DOI":"10.1074\/jbc.M605604200","volume":"281","author":"PP Knowles","year":"2006","unstructured":"Knowles PP, Murray-Rust J, Kjaer S, Scott RP, Hanrahan S, Santoro M, Ib\u00e1\u00f1ez CF, McDonald NQ. Structure and chemical inhibition of the RET tyrosine kinase domain. J Biol Chem 2006; 281(44): 33577\u201333587","journal-title":"J Biol Chem"},{"issue":"27","key":"985_CR58","doi-asserted-by":"publisher","first-page":"10428","DOI":"10.1074\/jbc.RA119.007682","volume":"294","author":"SS Terzyan","year":"2019","unstructured":"Terzyan SS, Shen T, Liu X, Huang Q, Teng P, Zhou M, Hilberg F, Cai J, Mooers BHM, Wu J. Structural basis of resistance of mutant RET protein-tyrosine kinase to its inhibitors nintedanib and vandetanib. J Biol Chem 2019; 294(27): 10428\u201310437","journal-title":"J Biol Chem"},{"issue":"18","key":"985_CR59","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1056\/NEJMoa1411817","volume":"372","author":"PA J\u00e4nne","year":"2015","unstructured":"J\u00e4nne PA, Yang JC, Kim DW, Planchard D, Ohe Y, Ramalingam SS, Ahn MJ, Kim SW, Su WC, Horn L, Haggstrom D, Felip E, Kim JH, Frewer P, Cantarini M, Brown KH, Dickinson PA, Ghiorghiu S, Ranson M. AZD9291 in EGFR inhibitor-resistant non-small-cell lung cancer. N Engl J Med 2015; 372(18): 1689\u20131699","journal-title":"N Engl J Med"},{"issue":"1","key":"985_CR60","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1056\/NEJMoa1913662","volume":"382","author":"SS Ramalingam","year":"2020","unstructured":"Ramalingam SS, Vansteenkiste J, Planchard D, Cho BC, Gray JE, Ohe Y, Zhou C, Reungwetwattana T, Cheng Y, Chewaskulyong B, Shah R, Cobo M, Lee KH, Cheema P, Tiseo M, John T, Lin MC, Imamura F, Kurata T, Todd A, Hodge R, Saggese M, Rukazenkov Y, Soria JC; FLAURA Investigators. Overall survival with osimertinib in untreated, EGFR-mutated advanced NSCLC. N Engl J Med 2020; 382(1): 41\u201350","journal-title":"N Engl J Med"},{"issue":"1","key":"985_CR61","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jtho.2018.09.004","volume":"14","author":"BC Cho","year":"2019","unstructured":"Cho BC, Chewaskulyong B, Lee KH, Dechaphunkul A, Sriuranpong V, Imamura F, Nogami N, Kurata T, Okamoto I, Zhou C, Cheng Y, Cho EK, Voon PJ, Lee JS, Mann H, Saggese M, Reungwetwattana T, Ramalingam SS, Ohe Y. Osimertinib versus standard of care EGFR TKI as first-line treatment in patients with EGFRm advanced NSCLC: FLAURA Asian Subset. J Thorac Oncol 2019; 14(1): 99\u2013106","journal-title":"J Thorac Oncol"},{"issue":"15","key":"985_CR62","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.1158\/1078-0432.CCR-21-0800","volume":"27","author":"V Subbiah","year":"2021","unstructured":"Subbiah V, Gainor JF, Oxnard GR, Tan DSW, Owen DH, Cho BC, Loong HH, McCoach CE, Weiss J, Kim YJ, Bazhenova L, Park K, Daga H, Besse B, Gautschi O, Rolfo C, Zhu EY, Kherani JF, Huang X, Kang S, Drilon A. Intracranial efficacy of selpercatinib in RET fusion-positive non-small cell lung cancers on the LIBRETTO-001 trial. Clin Cancer Res 2021; 27(15): 4160\u20134167","journal-title":"Clin Cancer Res"},{"issue":"10","key":"985_CR63","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1016\/j.jtho.2018.07.004","volume":"13","author":"A Drilon","year":"2018","unstructured":"Drilon A, Lin JJ, Filleron T, Ni A, Milia J, Bergagnini I, Hatzoglou V, Velcheti V, Offin M, Li B, Carbone DP, Besse B, Mok T, Awad MM, Wolf J, Owen D, Camidge DR, Riely GJ, Peled N, Kris MG, Mazieres J, Gainor JF, Gautschi O. Frequency of brain metastases and multikinase inhibitor outcomes in patients with RET-rearranged lung cancers. J Thorac Oncol 2018; 13(10): 1595\u20131601","journal-title":"J Thorac Oncol"},{"issue":"6","key":"985_CR64","doi-asserted-by":"publisher","first-page":"e2200040","DOI":"10.1200\/PO.22.00040","volume":"6","author":"EM Urbanska","year":"2022","unstructured":"Urbanska EM, S\u00f8rensen JB, Melchior LC, Costa JC, Santoni-Rugiu E. Durable response to combined osimertinib and pralsetinib treatment for osimertinib resistance due to novel intergenic ANK3-RET fusion in EGFR-mutated non-small-cell lung cancer. JCO Precis Oncol 2022; 6(6): e2200040","journal-title":"JCO Precis Oncol"},{"issue":"10","key":"985_CR65","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1158\/1535-7163.MCT-16-0258","volume":"15","author":"Q Huang","year":"2016","unstructured":"Huang Q, Schneeberger VE, Luetteke N, Jin C, Afzal R, Budzevich MM, Makanji RJ, Martinez GV, Shen T, Zhao L, Fung KM, Haura EB, Coppola D, Wu J. Preclinical modeling of KIF5B-RET fusion lung adenocarcinoma. Mol Cancer Ther 2016; 15(10): 2521\u20132529","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"985_CR66","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/s41698-021-00188-x","volume":"5","author":"T Shen","year":"2021","unstructured":"Shen T, Hu X, Liu X, Subbiah V, Mooers BHM, Wu J. The L730V\/I RET roof mutations display different activities toward pralsetinib and selpercatinib. NPJ Precis Oncol 2021; 5(1): 48","journal-title":"NPJ Precis Oncol"},{"issue":"11","key":"985_CR67","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/s41416-021-01344-7","volume":"124","author":"JJ Lin","year":"2021","unstructured":"Lin JJ, Gainor JF. An early look at selective RET inhibitor resistance: new challenges and opportunities. Br J Cancer 2021; 124(11): 1757\u20131758","journal-title":"Br J Cancer"},{"issue":"6","key":"985_CR68","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.annonc.2021.02.010","volume":"32","author":"V Subbiah","year":"2021","unstructured":"Subbiah V, Shen T, Tetzlaff M, Weissferdt A, Byers LA, Cascone T, Behrang A, Meric-Bernstam F, Mooers BHM, Rothenberg SM, Ebata K, Wu J. Patient-driven discovery and post-clinical validation of NTRK3 fusion as an acquired resistance mechanism to selpercatinib in RET fusion-positive lung cancer. Ann Oncol 2021; 32(6): 817\u2013819","journal-title":"Ann Oncol"},{"issue":"7","key":"985_CR69","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/j.jtho.2020.03.020","volume":"15","author":"VW Zhu","year":"2020","unstructured":"Zhu VW, Madison R, Schrock AB, Ou SI. Emergence of High Level of MET Amplification as off-target resistance to selpercatinib treatment in KIF5B-RET NSCLC. J Thorac Oncol 2020; 15(7): e124\u2013e127","journal-title":"J Thorac Oncol"},{"key":"985_CR70","doi-asserted-by":"publisher","first-page":"506P","DOI":"10.1093\/annonc\/mdz244.068","volume":"30","author":"A Drilon","year":"2019","unstructured":"Drilon A, Rogers E, Zhai D, Deng W, Zhang X, Lee D, Ung J, Whitten J, Zhang H, Liu J, Hu T, Zhuang H, Lu Y, Huang Z, Braber A, Zimmerman Z, Xin R, Cui J, Subbiah V. TPX-0046 is novel and potent RET\/SRC inhibitor for RET-driven cancers. Ann Oncol 2019; 30(ESMO abstract): 506P","journal-title":"Ann Oncol"},{"key":"985_CR71","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1200\/JCO.2020.38.15_suppl.3616","volume":"38","author":"AE Drilon","year":"2020","unstructured":"Drilon AE, Zhai D, Rogers E, Deng W, Zhang X, Ung J, Lee D, Rodon L, Graber A, Zimmerman ZF, Murray BW, Subbiah V. The next-generation RET inhibitor TPX-0046 is active in drug-resistant and na\u00efve RET-driven cancer models. J Clin Oncol 2020; 38(15 suppl): 3616","journal-title":"J Clin Oncol"},{"issue":"5","key":"985_CR72","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s10637-022-01259-x","volume":"40","author":"M Repetto","year":"2022","unstructured":"Repetto M, Crimini E, Ascione L, Boscolo Bielo L, Belli C, Curigliano G. The return of RET GateKeeper mutations? An insilico exploratory analysis of potential resistance mechanisms to novel RET macrocyclic inhibitor TPX-0046 Invest New Drugs 2022; 40(5): 1133\u20131136","journal-title":"Invest New Drugs"},{"issue":"suppl 16","key":"985_CR73","doi-asserted-by":"publisher","first-page":"TPS8595","DOI":"10.1200\/JCO.2022.40.16_suppl.TPS8595","volume":"40","author":"NA Pennell","year":"2022","unstructured":"Pennell NA, Wirth LJ, Gainor JF, Rotow JK, Johnson ML, Bauer TM, Kroiss M, Sukrithan V, Kang H, Worden FP, Bestvina CM, Hadoux J, Cassier PA, Italiano A, Wolf J, Brose MS, Avsar E, Axelson MD, Subbiah V, Drilon AE. A first-in-human phase 1 study of the next-generation RET inhibitor, LOXO-260, in RET inhibitor refractory patients with RET-altered cancers (trial in progress). J Clin Oncol 2022; 40(suppl 16): TPS8595","journal-title":"J Clin Oncol"},{"key":"985_CR74","doi-asserted-by":"crossref","unstructured":"Miyazaki I, Ishida K, Kato M, Suzuki T, Fujita H, Ohkubo S, Iwasawa Y. Discovery of TAS0953\/HM06, a novel next generation RET-specific inhibitor capable of inhibiting RET solvent front mutations. AACR-NCI-EORTC Virtual International Conference 2021; October 7\u201310","DOI":"10.1158\/1535-7163.TARG-21-P06-02"},{"key":"985_CR75","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1200\/JCO.2021.39.15_suppl.3008","volume":"39","author":"P Schoffski","year":"2021","unstructured":"Schoffski P, Cho BC, Italiano A, Loong HHF, Massard C, Rodriguez LM, Shih JY, Subbiah V, Verlingue L, Andreas K, Basson CT, Clawson A, Ho PTC, Knight S, Scheuber A, Keegan M. BOS172738, a highly potent and selective RET inhibitor, for the treatment of RET-altered tumors including RET-fusion+ NSCLC and RET-mutant MTC: phase 1 study results. J Clin Oncol 2021; 39(15 suppl): 3008","journal-title":"J Clin Oncol"},{"key":"985_CR76","doi-asserted-by":"publisher","first-page":"e15107","DOI":"10.1200\/JCO.2022.40.16_suppl.e15107","volume":"40","author":"V Subbiah","year":"2022","unstructured":"Subbiah V, Zhong J, Lu Y, Liu Y, Chen M, Chen X, Wang H, Zhu J, Lu S, Drilon AE. The development of APS03118, a potent next-generation RET inhibitor for treating RET-inhibitor-resistant patients. J Clin Oncol 2022; 40(16 suppl): e15107","journal-title":"J Clin Oncol"}],"container-title":["Frontiers of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-023-0985-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11684-023-0985-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-023-0985-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T02:17:36Z","timestamp":1685413056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11684-023-0985-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["985"],"URL":"https:\/\/doi.org\/10.1007\/s11684-023-0985-y","relation":{},"ISSN":["2095-0217","2095-0225"],"issn-type":[{"value":"2095-0217","type":"print"},{"value":"2095-0225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"12 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 May 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Xueqing Hu, Ujjwol Khatri, Tao Shen, and Jie Wu declare that they have no conflicts of interest. This manuscript is a review article and does not involve a research protocol that requires the approval of relevant institutional review board or ethics committee.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}