{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:32:53Z","timestamp":1784820773031,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Front. Med."],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s11684-023-1053-3","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T03:40:43Z","timestamp":1719459643000},"page":"721-734","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epigenetic silencing of BEND4, a novel DNA damage repair gene, is a synthetic lethal marker for ATM inhibitor in pancreatic cancer"],"prefix":"10.1007","volume":"18","author":[{"given":"Yuanxin","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghui","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Herman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm V.","family":"Brock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiai","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francois","family":"Fuks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhou","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"issue":"11","key":"1053_CR1","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1158\/0008-5472.CAN-14-0155","volume":"74","author":"L Rahib","year":"2014","unstructured":"Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res 2014; 74(11): 2913\u20132921","journal-title":"Cancer Res"},{"issue":"10242","key":"1053_CR2","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1016\/S0140-6736(20)30974-0","volume":"395","author":"JD Mizrahi","year":"2020","unstructured":"Mizrahi JD, Surana R, Valle JW, Shroff RT. Pancreatic cancer. Lancet 2020; 395(10242): 2008\u20132020","journal-title":"Lancet"},{"issue":"1","key":"1053_CR3","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41571-018-0112-1","volume":"16","author":"O Strobel","year":"2019","unstructured":"Strobel O, Neoptolemos J, J\u00e4ger D, B\u00fcchler MW. Optimizing the outcomes of pancreatic cancer surgery. Nat Rev Clin Oncol 2019; 16(1): 11\u201326","journal-title":"Nat Rev Clin Oncol"},{"issue":"7","key":"1053_CR4","doi-asserted-by":"publisher","first-page":"1638","DOI":"10.1158\/1078-0432.CCR-16-2411","volume":"23","author":"SB Dreyer","year":"2017","unstructured":"Dreyer SB, Chang DK, Bailey P, Biankin AV. Pancreatic cancer genomes: implications for clinical management and therapeutic development. Clin Cancer Res 2017; 23(7): 1638\u20131646","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1053_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41573-019-0046-z","volume":"19","author":"A Huang","year":"2020","unstructured":"Huang A, Garraway LA, Ashworth A, Weber B. Synthetic lethality as an engine for cancer drug target discovery. Nat Rev Drug Discov 2020; 19(1): 23\u201338","journal-title":"Nat Rev Drug Discov"},{"issue":"7035","key":"1053_CR6","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1038\/nature03445","volume":"434","author":"H Farmer","year":"2005","unstructured":"Farmer H, McCabe N, Lord CJ, Tutt AN, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NM, Jackson SP, Smith GC, Ashworth A. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 2005; 434(7035): 917\u2013921","journal-title":"Nature"},{"issue":"7035","key":"1053_CR7","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1038\/nature03443","volume":"434","author":"HE Bryant","year":"2005","unstructured":"Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 2005; 434(7035): 913\u2013917","journal-title":"Nature"},{"issue":"6330","key":"1053_CR8","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1126\/science.aam7344","volume":"355","author":"CJ Lord","year":"2017","unstructured":"Lord CJ, Ashworth A. PARP inhibitors: synthetic lethality in the clinic. Science 2017; 355(6330): 1152\u20131158","journal-title":"Science"},{"issue":"2","key":"1053_CR9","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1038\/nrc.2015.21","volume":"16","author":"CJ Lord","year":"2016","unstructured":"Lord CJ, Ashworth A. BRCAness revisited. Nat Rev Cancer 2016; 16(2): 110\u2013120","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"1053_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s40364-019-0174-y","volume":"7","author":"M Guo","year":"2019","unstructured":"Guo M, Peng Y, Gao A, Du C, Herman JG. Epigenetic heterogeneity in cancer. Biomark Res 2019; 7(1): 23","journal-title":"Biomark Res"},{"key":"1053_CR11","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s40364-020-00224-1","volume":"8","author":"A Gao","year":"2020","unstructured":"Gao A, Guo M. Epigenetic based synthetic lethal strategies in human cancers. Biomark Res 2020; 8: 44","journal-title":"Biomark Res"},{"issue":"10","key":"1053_CR12","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1038\/s41422-020-0333-6","volume":"30","author":"Y Cui","year":"2020","unstructured":"Cui Y, Chen H, Xi R, Cui H, Zhao Y, Xu E, Yan T, Lu X, Huang F, Kong P, Li Y, Zhu X, Wang J, Zhu W, Wang J, Ma Y, Zhou Y, Guo S, Zhang L, Liu Y, Wang B, Xi Y, Sun R, Yu X, Zhai Y, Wang F, Yang J, Yang B, Cheng C, Liu J, Song B, Li H, Wang Y, Zhang Y, Cheng X, Zhan Q, Li Y, Liu Z. Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma. Cell Res 2020; 30(10): 902\u2013913","journal-title":"Cell Res"},{"issue":"4","key":"1053_CR13","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1093\/bioinformatics\/btn007","volume":"24","author":"S Abhiman","year":"2008","unstructured":"Abhiman S, Iyer LM, Aravind L. BEN: a novel domain in chromatin factors and DNA viral proteins. Bioinformatics 2008; 24(4): 458\u2013461","journal-title":"Bioinformatics"},{"issue":"Pt18","key":"1053_CR14","doi-asserted-by":"publisher","first-page":"3149","DOI":"10.1242\/jcs.086603","volume":"124","author":"KM Sathyan","year":"2011","unstructured":"Sathyan KM, Shen Z, Tripathi V, Prasanth KV, Prasanth SG. A BEN-domain-containing protein associates with heterochromatin and represses transcription. J Cell Sci 2011; 124(Pt 18): 3149\u20133163","journal-title":"J Cell Sci"},{"issue":"1\u20133","key":"1053_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1080\/21541264.2022.2105128","volume":"13","author":"F Kurniawan","year":"2022","unstructured":"Kurniawan F, Prasanth SG. A BEN-domain protein and polycomb complex work coordinately to regulate transcription. Transcription 2022; 13(1\u20133): 82\u201387","journal-title":"Transcription"},{"issue":"6584","key":"1053_CR16","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1126\/science.abm0730","volume":"375","author":"J Zhang","year":"2022","unstructured":"Zhang J, Zhang Y, You Q, Huang C, Zhang T, Wang M, Zhang T, Yang X, Xiong J, Li Y, Liu CP, Zhang Z, Xu RM, Zhu B. Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation. Science 2022; 375(6584): 1053\u20131058","journal-title":"Science"},{"key":"1053_CR17","doi-asserted-by":"publisher","first-page":"e74611","DOI":"10.7554\/eLife.74611","volume":"11","author":"S Babu","year":"2022","unstructured":"Babu S, Takeuchi Y, Masai I. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. eLife 2022; 11: e74611","journal-title":"eLife"},{"issue":"21","key":"1053_CR18","doi-asserted-by":"publisher","first-page":"eabn1606","DOI":"10.1126\/sciadv.abn1606","volume":"8","author":"L Ma","year":"2022","unstructured":"Ma L, Xie D, Luo M, Lin X, Nie H, Chen J, Gao C, Duo S, Han C. Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis. Sci Adv 2022; 8(21): eabn1606","journal-title":"Sci Adv"},{"issue":"10","key":"1053_CR19","doi-asserted-by":"publisher","first-page":"4233","DOI":"10.7150\/ijbs.70866","volume":"18","author":"Y Shi","year":"2022","unstructured":"Shi Y, Zhang D, Chen J, Jiang Q, Song S, Mi Y, Wang T, Ye Q. Interaction between BEND5 and RBPJ suppresses breast cancer growth and metastasis via inhibiting Notch signaling. Int J Biol Sci 2022; 18(10): 4233\u20134244","journal-title":"Int J Biol Sci"},{"issue":"10","key":"1053_CR20","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1007\/s13238-021-00884-1","volume":"13","author":"G Shi","year":"2022","unstructured":"Shi G, Bai Y, Zhang X, Su J, Pang J, He Q, Zeng P, Ding J, Xiong Y, Zhang J, Wang J, Liu D, Ma W, Huang J, Songyang Z. Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation. Protein Cell 2022; 13(10): 721\u2013741","journal-title":"Protein Cell"},{"issue":"7","key":"1053_CR21","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1111\/cas.14917","volume":"112","author":"W Du","year":"2021","unstructured":"Du W, Gao A, Herman JG, Wang L, Zhang L, Jiao S, Guo M. Methylation of NRN1 is a novel synthetic lethal marker of PI3K-Akt-mTOR and ATR inhibitors in esophageal cancer. Cancer Sci 2021; 112(7): 2870\u20132883","journal-title":"Cancer Sci"},{"issue":"1","key":"1053_CR22","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s13148-018-0570-4","volume":"10","author":"H Li","year":"2018","unstructured":"Li H, Zhang M, Linghu E, Zhou F, Herman JG, Hu L, Guo M. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma. Clin Epigenetics 2018; 10(1): 137","journal-title":"Clin Epigenetics"},{"issue":"20","key":"1053_CR23","doi-asserted-by":"publisher","first-page":"2633","DOI":"10.1101\/gad.13.20.2633","volume":"13","author":"AJ Pierce","year":"1999","unstructured":"Pierce AJ, Johnson RD, Thompson LH, Jasin M. XRCC3 promotes homology-directed repair of DNA damage in mammalian cells. Genes Dev 1999; 13(20): 2633\u20132638","journal-title":"Genes Dev"},{"issue":"5","key":"1053_CR24","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/j.molcel.2004.05.008","volume":"14","author":"J Guirouilh-Barbat","year":"2004","unstructured":"Guirouilh-Barbat J, Huck S, Bertrand P, Pirzio L, Desmaze C, Sabatier L, Lopez BS. Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. Mol Cell 2004; 14(5): 611\u2013623","journal-title":"Mol Cell"},{"issue":"1","key":"1053_CR25","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/nprot.2006.5","volume":"1","author":"PL Olive","year":"2006","unstructured":"Olive PL, Ban\u00e1th JP. The comet assay: a method to measure DNA damage in individual cells. Nat Protoc 2006; 1(1): 23\u201329","journal-title":"Nat Protoc"},{"issue":"7","key":"1053_CR26","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.molcel.2022.01.020","volume":"82","author":"C Zhang","year":"2022","unstructured":"Zhang C, Zhou B, Gu F, Liu H, Wu H, Yao F, Zheng H, Fu H, Chong W, Cai S, Huang M, Ma X, Guo Z, Li T, Deng W, Zheng M, Ji Q, Zhao Y, Ma Y, Wang QE, Tang TS, Guo C. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. Mol Cell 2022; 82(7): 1297\u20131312.e8","journal-title":"Mol Cell"},{"issue":"12","key":"1053_CR27","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1038\/s41580-020-00297-8","volume":"21","author":"B Zhao","year":"2020","unstructured":"Zhao B, Rothenberg E, Ramsden DA, Lieber MR. The molecular basis and disease relevance of non-homologous DNA end joining. Nat Rev Mol Cell Biol 2020; 21(12): 765\u2013781","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1053_CR28","doi-asserted-by":"publisher","first-page":"607428","DOI":"10.3389\/fgene.2020.607428","volume":"11","author":"X Yue","year":"2020","unstructured":"Yue X, Bai C, Xie D, Ma T, Zhou PK. DNA-PKcs: a multi-faceted player in DNA damage response. Front Genet 2020; 11: 607428","journal-title":"Front Genet"},{"issue":"4","key":"1053_CR29","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/0092-8674(88)90571-5","volume":"53","author":"C Almoguera","year":"1988","unstructured":"Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 1988; 53(4): 549\u2013554","journal-title":"Cell"},{"issue":"5","key":"1053_CR30","first-page":"1534","volume":"142","author":"A Scarpa","year":"1993","unstructured":"Scarpa A, Capelli P, Mukai K, Zamboni G, Oda T, Iacono C, Hirohashi S. Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 1993; 142(5): 1534\u20131543","journal-title":"Am J Pathol"},{"issue":"5897","key":"1053_CR31","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1126\/science.1164368","volume":"321","author":"S Jones","year":"2008","unstructured":"Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321(5897): 1801\u20131806","journal-title":"Science"},{"issue":"7424","key":"1053_CR32","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1038\/nature11547","volume":"491","author":"AV Biankin","year":"2012","unstructured":"Biankin AV, Waddell N, Kassahn KS, Gingras MC, Muthuswamy LB, Johns AL, Miller DK, Wilson PJ, Patch AM, Wu J, Chang DK, Cowley MJ, Gardiner BB, Song S, Harliwong I, Idrisoglu S, Nourse C, Nourbakhsh E, Manning S, Wani S, Gongora M, Pajic M, Scarlett CJ, Gill AJ, Pinho AV, Rooman I, Anderson M, Holmes O, Leonard C, Taylor D, Wood S, Xu Q, Nones K, Fink JL, Christ A, Bruxner T, Cloonan N, Kolle G, Newell F, Pinese M, Mead RS, Humphris JL, Kaplan W, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chou A, Chin VT, Chantrill LA, Mawson A, Samra JS, Kench JG, Lovell JA, Daly RJ, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N; Australian Pancreatic Cancer Genome Initiative; Kakkar N, Zhao F, Wu YQ, Wang M, Muzny DM, Fisher WE, Brunicardi FC, Hodges SE, Reid JG, Drummond J, Chang K, Han Y, Lewis LR, Dinh H, Buhay CJ, Beck T, Timms L, Sam M, Begley K, Brown A, Pai D, Panchal A, Buchner N, De Borja R, Denroche RE, Yung CK, Serra S, Onetto N, Mukhopadhyay D, Tsao MS, Shaw PA, Petersen GM, Gallinger S, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Schulick RD, Wolfgang CL, Morgan RA, Lawlor RT, Capelli P, Corbo V, Scardoni M, Tortora G, Tempero MA, Mann KM, Jenkins NA, Perez-Mancera PA, Adams DJ, Largaespada DA, Wessels LF, Rust AG, Stein LD, Tuveson DA, Copeland NG, Musgrove EA, Scarpa A, Eshleman JR, Hudson TJ, Sutherland RL, Wheeler DA, Pearson JV, McPherson JD, Gibbs RA, Grimmond SM. Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature 2012; 491(7424): 399\u2013405","journal-title":"Nature"},{"issue":"7592","key":"1053_CR33","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/nature16965","volume":"531","author":"P Bailey","year":"2016","unstructured":"Bailey P, Chang DK, Nones K, Johns AL, Patch AM, Gingras MC, Miller DK, Christ AN, Bruxner TJ, Quinn MC, Nourse C, Murtaugh LC, Harliwong I, Idrisoglu S, Manning S, Nourbakhsh E, Wani S, Fink L, Holmes O, Chin V, Anderson MJ, Kazakoff S, Leonard C, Newell F, Waddell N, Wood S, Xu Q, Wilson PJ, Cloonan N, Kassahn KS, Taylor D, Quek K, Robertson A, Pantano L, Mincarelli L, Sanchez LN, Evers L, Wu J, Pinese M, Cowley MJ, Jones MD, Colvin EK, Nagrial AM, Humphrey ES, Chantrill LA, Mawson A, Humphris J, Chou A, Pajic M, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Lovell JA, Merrett ND, Toon CW, Epari K, Nguyen NQ, Barbour A, Zeps N, Moran-Jones K, Jamieson NB, Graham JS, Duthie F, Oien K, Hair J, Gr\u00fctzmann R, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Rusev B, Capelli P, Salvia R, Tortora G, Mukhopadhyay D, Petersen GM; Australian Pancreatic Cancer Genome Initiative; Munzy DM, Fisher WE, Karim SA, Eshleman JR, Hruban RH, Pilarsky C, Morton JP, Sansom OJ, Scarpa A, Musgrove EA, Bailey UM, Hofmann O, Sutherland RL, Wheeler DA, Gill AJ, Gibbs RA, Pearson JV, Waddell N, Biankin AV, Grimmond SM. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 2016; 531(7592): 47\u201352","journal-title":"Nature"},{"issue":"1","key":"1053_CR34","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1053\/j.gastro.2021.09.022","volume":"162","author":"SB Dreyer","year":"2022","unstructured":"Dreyer SB, Upstill-Goddard R, Legrini A, Biankin AV; Glasgow Precision Oncology Laboratory; Jamieson NB, Chang DK; Australian Pancreatic Genome Initiative; Jamieson NB, Chang DK. Genomic and molecular analyses identify molecular subtypes of pancreatic cancer recurrence. Gastroenterology 2022; 162(1): 320\u2013324.e4","journal-title":"Gastroenterology"},{"issue":"7540","key":"1053_CR35","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/nature14169","volume":"518","author":"N Waddell","year":"2015","unstructured":"Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Gr\u00fctzmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA; Australian Pancreatic Cancer Genome Initiative; Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 2015; 518(7540): 495\u2013501","journal-title":"Nature"},{"issue":"2","key":"1053_CR36","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ccell.2017.07.007","volume":"32","author":"Cancer Genome Atlas Research Network","year":"2017","unstructured":"Cancer Genome Atlas Research Network. Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell 2017; 32(2): 185\u2013203.e13","journal-title":"Cancer Cell"},{"issue":"8","key":"1053_CR37","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1053\/j.gastro.2019.02.037","volume":"156","author":"AD Singhi","year":"2019","unstructured":"Singhi AD, George B, Greenbowe JR, Chung J, Suh J, Maitra A, Klempner SJ, Hendifar A, Milind JM, Golan T, Brand RE, Zureikat AH, Roy S, Schrock AB, Miller VA, Ross JS, Ali SM, Bahary N. Real-time targeted genome profile analysis of pancreatic ductal adenocarcinomas identifies genetic alterations that might be targeted with existing drugs or used as biomarkers. Gastroenterology 2019; 156(8): 2242\u20132253.e4","journal-title":"Gastroenterology"},{"issue":"1","key":"1053_CR38","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13045-020-00958-3","volume":"13","author":"Y Qian","year":"2020","unstructured":"Qian Y, Gong Y, Fan Z, Luo G, Huang Q, Deng S, Cheng H, Jin K, Ni Q, Yu X, Liu C. Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma. J Hematol Oncol 2020; 13(1): 130","journal-title":"J Hematol Oncol"},{"issue":"6","key":"1053_CR39","doi-asserted-by":"publisher","first-page":"100638","DOI":"10.1016\/j.esmoop.2022.100638","volume":"7","author":"MS R\u00e9mond","year":"2022","unstructured":"R\u00e9mond MS, Pellat A, Brezault C, Dhooge M, Coriat R. Are targeted therapies or immunotherapies effective in metastatic pancreatic adenocarcinoma? ESMO Open 2022; 7(6): 100638","journal-title":"ESMO Open"},{"issue":"4","key":"1053_CR40","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1056\/NEJMoa1903387","volume":"381","author":"T Golan","year":"2019","unstructured":"Golan T, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Alg\u00fcl H, O\u2019Reilly EM, McGuinness D, Cui KY, Schlienger K, Locker GY, Kindler HL. Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer. N Engl J Med 2019; 381(4): 317\u2013327","journal-title":"N Engl J Med"},{"issue":"3","key":"1053_CR41","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1136\/gutjnl-2019-319984","volume":"70","author":"L Perkhofer","year":"2021","unstructured":"Perkhofer L, Gout J, Roger E, Kude de Almeida F, Baptista Sim\u00f5es C, Wiesm\u00fcller L, Seufferlein T, Kleger A. DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives. Gut 2021; 70(3): 606\u2013617","journal-title":"Gut"},{"issue":"7","key":"1053_CR42","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41575-021-00463-z","volume":"18","author":"A Hayashi","year":"2021","unstructured":"Hayashi A, Hong J, Iacobuzio-Donahue CA. The pancreatic cancer genome revisited. Nat Rev Gastroenterol Hepatol 2021; 18(7): 469\u2013481","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"25","key":"1053_CR43","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1200\/JCO.18.02050","volume":"37","author":"C Gourley","year":"2019","unstructured":"Gourley C, Balmana J, Ledermann JA, Serra V, Dent R, Loibl S, Pujade-Lauraine E, Boulton SJ. Moving from Poly (ADP-ribose) polymerase inhibition to targeting DNA repair and DNA damage response in cancer therapy. J Clin Oncol 2019; 37(25): 2257\u20132269","journal-title":"J Clin Oncol"},{"issue":"17","key":"1053_CR44","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.2217\/epi-2021-0217","volume":"13","author":"H Li","year":"2021","unstructured":"Li H, Yang W, Zhang M, He T, Zhou F, G Herman J, Hu L, Guo M. Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer. Epigenomics 2021; 13(17): 1403\u20131419","journal-title":"Epigenomics"},{"issue":"4","key":"1053_CR45","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3322\/caac.21765","volume":"73","author":"V Davalos","year":"2023","unstructured":"Davalos V, Esteller M. Cancer epigenetics in clinical practice. CA Cancer J Clin 2023; 73(4): 376\u2013424","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"1053_CR46","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41571-019-0266-5","volume":"17","author":"MJ Topper","year":"2020","unstructured":"Topper MJ, Vaz M, Marrone KA, Brahmer JR, Baylin SB. The emerging role of epigenetic therapeutics in immuno-oncology. Nat Rev Clin Oncol 2020; 17(2): 75\u201390","journal-title":"Nat Rev Clin Oncol"},{"issue":"6623","key":"1053_CR47","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1126\/science.add9838","volume":"378","author":"D Wang","year":"2022","unstructured":"Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science 2022; 378(6623): 983\u2013989","journal-title":"Science"},{"issue":"1","key":"1053_CR48","doi-asserted-by":"publisher","first-page":"10806","DOI":"10.1038\/ncomms10806","volume":"7","author":"AR Weber","year":"2016","unstructured":"Weber AR, Krawczyk C, Robertson AB, Ku\u015bnierczyk A, V\u00e5gb0 CB, Schuermann D, Klungland A, Sch\u00e4r P. Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism. Nat Commun 2016; 7(1): 10806","journal-title":"Nat Commun"}],"container-title":["Frontiers of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-023-1053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11684-023-1053-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-023-1053-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T12:24:48Z","timestamp":1725020688000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11684-023-1053-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,27]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["1053"],"URL":"https:\/\/doi.org\/10.1007\/s11684-023-1053-3","relation":{},"ISSN":["2095-0217","2095-0225"],"issn-type":[{"value":"2095-0217","type":"print"},{"value":"2095-0225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,27]]},"assertion":[{"value":"21 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"<b>Conflicts of interest<\/b> Yuanxin Yao, Honghui Lv, Meiying Zhang, Yuan Li, James G. Herman, Malcolm V. Brock, Aiai Gao, Qian Wang, Francois Fuks, Lirong Zhang and Mingzhou Guo declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"All institutional and national guidelines for the care and use of laboratory animals were followed.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}