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Baofeng Yang is one of Honorary Editors-in-Chief of Frontiers of Medicine. Yong Zhang is a member of the Editorial Board of Frontiers of Medicine. Baofeng Yang and Yong Zhang were excluded from the peer-review process and all editorial decisions related to the acceptance and publication of this article. Peer-review was handled independently by the other editors to minimise bias.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"The use of animals has been approved by the Ethics Committee of Harbin Medical University (No. IRB3052724) and the protocols conformed to the Guidelines for the Care and Use of Laboratory Animals published by the National Institutes of Health (NIH Publication No.85-23, revised in 1996).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}