{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T10:51:11Z","timestamp":1780915871892,"version":"3.54.1"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Front. Med."],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11684-024-1111-5","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T03:51:21Z","timestamp":1735185081000},"page":"79-89","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Gallstones, cholecystectomy, and cancer risk: an observational and Mendelian randomization study"],"prefix":"10.1007","volume":"19","author":[{"given":"Yuanyue","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linhui","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guijun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xulei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiange","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengnan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feixia","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuojie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youmin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengli","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huacong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lulu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieli","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"issue":"2","key":"1111_CR1","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1159\/000323885","volume":"29","author":"CS Stokes","year":"2011","unstructured":"Stokes CS, Krawczyk M, Lammert F. Gallstones: environment, lifestyle and genes. Dig Dis 2011; 29(2): 191\u2013201","journal-title":"Dig Dis"},{"issue":"13","key":"1111_CR2","doi-asserted-by":"publisher","first-page":"735","DOI":"10.21037\/atm-21-6186","volume":"10","author":"Y Song","year":"2022","unstructured":"Song Y, Ma Y, Xie FC, Jin C, Yang XB, Yang X, Long JY, Wang DX, Sang XT, Li LM, Zhao HT, Ning Y. Age, gender, geographic and clinical differences for gallstones in China: a nationwide study. Ann Transl Med 2022; 10(13): 735","journal-title":"Ann Transl Med"},{"issue":"4","key":"1111_CR3","doi-asserted-by":"publisher","first-page":"e69","DOI":"10.1016\/j.clinre.2020.04.015","volume":"44","author":"Z Su","year":"2020","unstructured":"Su Z, Gong Y, Liang Z. Prevalence of gallstone in the Chinese mainland: a meta-analysis of cross-sectional studies. Clin Res Hepatol Gastroenterol 2020; 44(4): e69\u2013e71","journal-title":"Clin Res Hepatol Gastroenterol"},{"issue":"9","key":"1111_CR4","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1007\/s00535-023-02014-6","volume":"58","author":"N Fujita","year":"2023","unstructured":"Fujita N, Yasuda I, Endo I, Isayama H, Iwashita T, Ueki T, Uemura K, Umezawa A, Katanuma A, Katayose Y, Suzuki Y, Shoda J, Tsuyuguchi T, Wakai T, Inui K, Unno M, Takeyama Y, Itoi T, Koike K, Mochida S. Evidence-based clinical practice guidelines for cholelithiasis 2021. J Gastroenterol 2023; 58(9): 801\u2013833","journal-title":"J Gastroenterol"},{"issue":"1","key":"1111_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.jhep.2016.03.005","volume":"65","author":"European Association for the Study of the Liver (EASL)","year":"2016","unstructured":"European Association for the Study of the Liver (EASL). EASL clinical practice guidelines on the prevention. diagnosis and treatment of gallstones. J Hepatol 2016; 65(1): 146\u2013181","journal-title":"J Hepatol"},{"issue":"5","key":"1111_CR6","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1111\/jgh.15234","volume":"36","author":"CC Wang","year":"2021","unstructured":"Wang CC, Tseng MH, Wu SW, Yang TW, Chen HY, Sung WW, Su CC, Wang YT, Chen WL, Lai HC, Lin CC, Tsai MC. Symptomatic cholelithiasis patients have an increased risk of pancreatic cancer: a population-based study. J Gastroenterol Hepatol 2021; 36(5): 1187\u20131196","journal-title":"J Gastroenterol Hepatol"},{"issue":"6","key":"1111_CR7","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1093\/annonc\/mdl080","volume":"17","author":"F Bravi","year":"2006","unstructured":"Bravi F, Scotti L, Bosetti C, Talamini R, Negri E, Montella M, Franceschi S, La Vecchia C. Self-reported history of hypercholesterolaemia and gallstones and the risk of prostate cancer. Ann Oncol 2006; 17(6): 1014\u20131017","journal-title":"Ann Oncol"},{"issue":"6","key":"1111_CR8","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1093\/aje\/kwt322","volume":"179","author":"L Nogueira","year":"2014","unstructured":"Nogueira L, Freedman ND, Engels EA, Warren JL, Castro F, Koshiol J. Gallstones, cholecystectomy, and risk of digestive system cancers. Am J Epidemiol 2014; 179(6): 731\u2013739","journal-title":"Am J Epidemiol"},{"issue":"3","key":"1111_CR9","doi-asserted-by":"publisher","first-page":"465","DOI":"10.5009\/gnl210009","volume":"16","author":"YJ Choi","year":"2022","unstructured":"Choi YJ, Jin EH, Lim JH, Shin CM, Kim N, Han K, Lee DH. Increased risk of cancer after cholecystectomy: a nationwide cohort study in the Republic of Korea including 123 295 patients. Gut Liver 2022; 16(3): 465\u2013473","journal-title":"Gut Liver"},{"issue":"4","key":"1111_CR10","first-page":"503","volume":"55","author":"Y Fan","year":"0016","unstructured":"Fan Y, Hu J, Feng B, Wang W, Yao G, Zhai J, Li X. Increased risk of pancreatic cancer related to gallstones and cholecystectomy: a systematic review and meta-analysis. ancreaas 0016; 55(4): 503\u2013509","journal-title":"ancreaas"},{"issue":"1","key":"1111_CR11","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1053\/j.gastro.2023.03.227","volume":"165","author":"E Kharazmi","year":"2023","unstructured":"Kharazmi E, Scherer D, Boekstegers F, Liang Q, Sundquist K, Sundquist J, Fallah M, Lorenzo Bermejo J. Gallstones, cholecystectomy, and kidney cancer: observational and Mendelian randomization results based on large cohorts. Gastroenterology 2023; 165(1): 218\u201327.e8","journal-title":"Gastroenterology"},{"issue":"12","key":"1111_CR12","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.3109\/00365521.2012.719928","volume":"47","author":"M Schmidt","year":"2012","unstructured":"Schmidt M, Sm\u00e5stuen MC, Sondenaa K. Increased cancer incidence in some gallstone diseases, and equivocal effect of cholecystectomy: a long-term analysis of cancer and mortality. Scand J Gastroenterol 2012; 47(12): 1467\u20131474","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"1111_CR13","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1111\/jgh.15759","volume":"37","author":"HS Ahn","year":"2022","unstructured":"Ahn HS, Kim HJ, Kang TU, Park SM. Cholecystectomy reduces the risk of cholangiocarcinoma in patients with complicated gallstones, but has negligible effect on hepatocellular carcinoma. J Gastroenterol Hepatol 2022; 37(4): 669\u2013677","journal-title":"J Gastroenterol Hepatol"},{"issue":"11","key":"1111_CR14","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1038\/s41416-021-01325-w","volume":"124","author":"Y Pang","year":"2021","unstructured":"Pang Y, Lv J, Kartsonaki C, Guo Y, Yu C, Chen Y, Yang L, Bian Z, Millwood IY, Walters RG, Li X, Zou J, Holmes MV, Chen J, Chen Z, Li L. Causal effects of gallstone disease on risk of gastrointestinal cancer in Chinese. Br J Cancer 2021; 124(11): 1864\u20131872","journal-title":"Br J Cancer"},{"issue":"7","key":"1111_CR15","doi-asserted-by":"publisher","first-page":"1744","DOI":"10.1111\/liv.14456","volume":"40","author":"X Zhao","year":"2020","unstructured":"Zhao X, Wang N, Sun Y, Zhu G, Wang Y, Wang Z, Zhang Y, Cheng K, Wang G, Wu S, Wang L. Screen-detected gallstone disease and risk of liver and pancreatic cancer: The Kailuan Cohort Study. Liver Int 2020; 40(7): 1744\u20131755","journal-title":"Liver Int"},{"key":"1111_CR16","doi-asserted-by":"publisher","first-page":"1008394","DOI":"10.3389\/fonc.2022.1008394","volume":"12","author":"Q Qin","year":"0222","unstructured":"Qin Q, Li W, Ren A, Luo R, Luo S. Benign gallbladder disease is a risk factor for colorectal cancer, but cholecystectomy is not: a propensity score matching analysis. Front Oncol 0222; 12: 1008394","journal-title":"Front Oncol"},{"issue":"3","key":"1111_CR17","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1053\/j.gastro.2012.07.009","volume":"143","author":"T Chiba","year":"2012","unstructured":"Chiba T, Marusawa H, Ushijima T. Inflammation-associated cancer development in digestive organs: mechanisms and roles for genetic and epigenetic modulation. Gastroenterology 2012; 143(3): 550\u2013563","journal-title":"Gastroenterology"},{"issue":"2","key":"1111_CR18","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/1753-0407.12108","volume":"6","author":"Y Bi","year":"2014","unstructured":"Bi Y, Lu J, Wang W, Mu Y, Zhao J, Liu C, Chen L, Shi L, Li Q, Wan Q, Wu S, Yang T, Yan L, Liu Y, Wang G, Luo Z, Tang X, Chen G, Huo Y, Gao Z, Su Q, Ye Z, Wang Y, Qin G, Deng H, Yu X, Shen F, Chen L, Zhao L, Zhang J, Sun J, Dai M, Xu M, Xu Y, Chen Y, Lai S, Bloomgarden ZT, Li D, Ning G. Cohort profile: risk evaluation of cancers in chinese diabetic individuals: a longitudinal (REACTION) study. J Diabetes 2014; 6(2): 147\u2013157","journal-title":"J Diabetes"},{"issue":"19","key":"1111_CR19","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CA Emdin","year":"2017","unstructured":"Emdin CA, Khera AV, Kathiresan S. Mendelian randomization. JAMA 2017; 318(19): 1925\u20131926","journal-title":"JAMA"},{"issue":"16","key":"1111_CR20","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.1001\/jama.2021.18236","volume":"326","author":"VW Skrivankova","year":"2021","unstructured":"Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, Langenberg C, Golub RM, Loder EW, Gallo V, Tybjaerg-Hansen A, Davey Smith G, Egger M, Richards JB. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA 2021; 326(16): 1614\u20131621","journal-title":"JAMA"},{"issue":"8","key":"1111_CR21","doi-asserted-by":"publisher","first-page":"101656","DOI":"10.1016\/j.xcrm.2024.101656","volume":"5","author":"J Lu","year":"2024","unstructured":"Lu J, Li M, He J, Xu Y, Zheng R, Zheng J, Qin G, Qin Y, Chen Y, Tang X, Ye Z, Xu M, Wang T, Shi L, Su Q, Yu X, Yan L, Zhao Z, Wan Q, Chen G, Gao Z, Wang G, Shen F, Gu X, Luo Z, Chen L, Hou X, Huo Y, Li Q, Qiao H, Zhang Y, Zeng T, Hu C, Cao Q, Jia X, Liu C, Wang Y, Wu S, Yang T, Deng H, Qi H, Wu X, Zhang D, Dai M, Li D, Lai S, Chen L, Zhao J, Mu Y, Hu W, Ning G, Hu R, Bi Y, Wang W. Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: a nationwide 10-year prospective cohort study. Cell Rep Med 2024; 5(8): 101656","journal-title":"Cell Rep Med"},{"key":"1111_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0895-3988(11)60014-7","volume":"23","author":"WH Zhao","year":"2010","unstructured":"Zhao WH, Huang ZP, Zhang X, He L, Willett W, Wang JL, Hasegawa K, Chen JS. Reproducibility and validity of a Chinese food frequency questionnaire. Biomed Environ Sci 2010; 23: 1\u201338","journal-title":"Biomed Environ Sci"},{"issue":"8","key":"1111_CR23","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","volume":"35","author":"CL Craig","year":"2003","unstructured":"Craig CL, Marshall AL, Sj\u00f6str\u00f6m M, Bauman AE, Booth ML, Ainsworth B, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc 2003; 35(8): 1381\u20131395","journal-title":"Med Sci Sports Exerc"},{"issue":"4","key":"1111_CR24","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1161\/CIRCULATIONAHA.109.192703","volume":"121","author":"DM Lloyd-Jones","year":"2010","unstructured":"Lloyd-Jones DM, Hong Y, Labarthe D, Mozaffarian D, Appel LJ, Van Horn L, Greenlund K, Daniels S, Nichol G, Tomaselli GF, Arnett DK, Fonarow GC, Ho PM, Lauer MS, Masoudi FA, Robertson RM, Roger V, Schwamm LH, Sorlie P, Yancy CW, Rosamond WD. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association\u2019s strategic impact goal through 2020 and beyond. Circulation 2010; 121(4): 586\u2013613","journal-title":"Circulation"},{"issue":"11","key":"1111_CR25","doi-asserted-by":"publisher","first-page":"e005263","DOI":"10.1161\/CIRCOUTCOMES.118.005263","volume":"11","author":"KL Piercy","year":"2018","unstructured":"Piercy KL, Troiano RP. Physical activity guidelines for Americans from the US department of health and human services. Circ Cardiovasc Qual Outcomes 2018; 11(11): e005263","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"1111_CR26","doi-asserted-by":"publisher","first-page":"1444426","DOI":"10.3389\/fimmu.2024.1444426","volume":"15","author":"Y Yan","year":"2024","unstructured":"Yan Y, Su L, Huang S, He Q, Lu J, Luo H, Xu K, Yang G, Huang S, Chi H. Circadian rhythms and breast cancer: unraveling the biological clock\u2019s role in tumor microenvironment and ageing. Front Immunol 2024; 15: 1444426","journal-title":"Front Immunol"},{"issue":"3","key":"1111_CR27","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1017\/S0029665118002884","volume":"78","author":"Y Dunneram","year":"2019","unstructured":"Dunneram Y, Greenwood DC, Cade JE. Diet, menopause and the risk of ovarian, endometrial and breast cancer. Proc Nutr Soc 2019; 78(3): 438\u2013448","journal-title":"Proc Nutr Soc"},{"key":"1111_CR28","doi-asserted-by":"crossref","unstructured":"Karczewski KJ, Gupta R, Kanai M, Lu W, Tsuo K, Wang Y, Walters RK, Turley P, Callier S, Shah NN, Baya N, Palmer DS, Goldstein JI, Sarma G, Solomonson M, Cheng N, Bryant S, Churchhouse C, Cusick CM, Poterba T, Compitello J, King D, Zhou W, Seed C, Finucane HK, Daly MJ, Neale BM, Atkinson EG, Martin AR. Pan- UK Biobank GWAS improves discovery, analysis of genetic architecture, and resolution into ancestry-enriched effects. medRxiv 2024: 2024.03.13.24303864","DOI":"10.1101\/2024.03.13.24303864"},{"key":"1111_CR29","doi-asserted-by":"publisher","first-page":"e34408","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D, Laurin C, Burgess S, Bowden J, Langdon R, Tan VY, Yarmolinsky J, Shihab HA, Timpson NJ, Evans DM, Relton C, Martin RM, Davey Smith G, Gaunt TR, Haycock PC. The MR-base platform supports systematic causal inference across the human phenome. eLife 2018; 7: e34408","journal-title":"eLife"},{"issue":"10","key":"1111_CR30","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","volume":"53","author":"S Sakaue","year":"2021","unstructured":"Sakaue S, Kanai M, Tanigawa Y, Karjalainen J, Kurki M, Koshiba S, Narita A, Konuma T, Yamamoto K, Akiyama M, Ishigaki K, Suzuki A, Suzuki K, Obara W, Yamaji K, Takahashi K, Asai S, Takahashi Y, Suzuki T, Shinozaki N, Yamaguchi H, Minami S, Murayama S, Yoshimori K, Nagayama S, Obata D, Higashiyama M, Masumoto A, Koretsune Y, Ito K, Terao C, Yamauchi T, Komuro I, Kadowaki T, Tamiya G, Yamamoto M, Nakamura Y, Kubo M, Murakami Y, Yamamoto K, Kamatani Y, Palotie A, Rivas MA, Daly MJ, Matsuda K, Okada Y. A cross-population atlas of genetic associations for 220 human phenotypes. Nat Genet 2021; 53(10): 1415\u20131424","journal-title":"Nat Genet"},{"issue":"7","key":"1111_CR31","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1038\/s41588-018-0142-8","volume":"50","author":"FR Schumacher","year":"2018","unstructured":"Schumacher FR, Al Olama AA, Berndt SI, Benlloch S, Ahmed M, Saunders EJ, Dadaev T, Leongamornlert D, Anokian E, Cieza-Borrella C, Goh C, Brook MN, Sheng X, Fachal L, Dennis J, Tyrer J, Muir K, Lophatananon A, Stevens VL, Gapstur SM, Carter BD, Tangen CM, Goodman PJ, Thompson IM Jr, Batra J, Chambers S, Moya L, Clements J, Horvath L, Tilley W, Risbridger GP, Gronberg H, Aly M, Nordstr\u00f6m T, Pharoah P, Pashayan N, Schleutker J, Tammela TLJ, Sipeky C, Auvinen A, Albanes D, Weinstein S, Wolk A, H\u00e5kansson N, West CML, Dunning AM, Burnet N, Mucci LA, Giovannucci E, Andriole GL, Cussenot O, Cancel-Tassin G, Koutros S, Beane Freeman LE, Sorensen KD, Orntoft TF, Borre M, Maehle L, Grindedal EM, Neal DE, Donovan JL, Hamdy FC, Martin RM, Travis RC, Key TJ, Hamilton RJ, Fleshner NE, Finelli A, Ingles SA, Stern MC, Rosenstein BS, Kerns SL, Ostrer H, Lu YJ, Zhang HW, Feng N, Mao X, Guo X, Wang G, Sun Z, Giles GG, Southey MC, MacInnis RJ, FitzGerald LM, Kibel AS, Drake BF, Vega A, G\u00f3mez-Caamano A, Szulkin R, Eklund M, Kogevinas M, Llorca J, Casta\u00f1o-Vinyals G, Penney KL, Stampfer M, Park JY, Sellers TA, Lin HY, Stanford JL, Cybulski C, Wokolorczyk D, Lubinski J, Ostrander EA, Geybels MS, Nordestgaard BG, Nielsen SF, Weischer M, Bisbjerg R, R\u00f8der MA, Iversen P, Brenner H, Cuk K, Holleczek B, Maier C, Luedeke M, Schnoeller T, Kim J, Logothetis CJ, John EM, Teixeira MR, Paulo P, Cardoso M, Neuhausen SL, Steele L, Ding YC, De Ruyck K, De Meerleer G, Ost P, Razack A, Lim J, Teo SH, Lin DW, Newcomb LF, Lessel D, Gamulin M, Kulis T, Kaneva R, Usmani N, Singhal S, Slavov C, Mitev V, Parliament M, Claessens F, Joniau S, Van den Broeck T, Larkin S, Townsend PA, Aukim-Hastie C, Gago-Dominguez M, Castelao JE, Martinez ME, Roobol MJ, Jenster G, van Schaik RHN, Menegaux F, Truong T, Koudou YA, Xu J, Khaw KT, Cannon-Albright L, Pandha H, Michael A, Thibodeau SN, McDonnell SK, Schaid DJ, Lindstrom S, Turman C, Ma J, Hunter DJ, Riboli E, Siddiq A, Canzian F, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Cui Z, Kraft P, Amos CI, Conti DV, Easton DF, Wiklund F, Chanock SJ, Henderson BE, Kote-Jarai Z, Haiman CA, Eeles RA. Association analyses of more than 140 000 men identify 63 new prostate cancer susceptibility loci. Nat Genet 2018; 50(7): 928\u2013936","journal-title":"Nat Genet"},{"key":"1111_CR32","doi-asserted-by":"publisher","unstructured":"Burrows K, Haycock P. Genome- wide Association Study of Cancer Risk in UK Biobank. doi:https:\/\/doi.org\/10.5523\/bris.aed0u12w0ede20olb0m77p4b9.2021","DOI":"10.5523\/bris.aed0u12w0ede20olb0m77p4b9.2021"},{"issue":"5","key":"1111_CR33","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck M, Chen CY, Neale B, Do R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 2018; 50(5): 693\u2013698","journal-title":"Nat Genet"},{"issue":"10","key":"1111_CR34","doi-asserted-by":"publisher","first-page":"3002","DOI":"10.2337\/db16-0418","volume":"65","author":"LJ Corbin","year":"2016","unstructured":"Corbin LJ, Richmond RC, Wade KH, Burgess S, Bowden J, Smith GD, Timpson NJ. BMI as a modifiable risk factor for type 2 diabetes: refining and understanding causal estimates using Mendelian randomization. Diabetes 2016; 65(10): 3002\u20133007","journal-title":"Diabetes"},{"issue":"11","key":"1111_CR35","doi-asserted-by":"publisher","first-page":"e1007081","DOI":"10.1371\/journal.pgen.1007081","volume":"13","author":"G Hemani","year":"2017","unstructured":"Hemani G, Tilling K, Davey Smith G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet 2017; 13(11): e1007081","journal-title":"PLoS Genet"},{"issue":"7","key":"1111_CR36","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/gepi.21998","volume":"40","author":"S Burgess","year":"2016","unstructured":"Burgess S, Davies NM, Thompson SG. Bias due to participant overlap in two-sample Mendelian randomization. Genet Epidemiol 2016; 40(7): 597\u2013608","journal-title":"Genet Epidemiol"},{"issue":"6","key":"1111_CR37","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1002\/ijc.32090","volume":"145","author":"HA Ward","year":"2019","unstructured":"Ward HA, Murphy N, Weiderpass E, Leitzmann MF, Aglago E, Gunter MJ, Freisling H, Jenab M, Boutron-Ruault MC, Severi G, Carbonnel F, K\u00fchn T, Kaaks R, Boeing H, Tjonneland A, Olsen A, Overvad K, Merino S, Zamora-Ros R, Rodriguez-Barranco M, Dorronsoro M, Chirlaque MD, Barricarte A, Perez-Cornago A, Trichopoulou A, Bamia C, Lagiou P, Masala G, Grioni S, Tumino R, Sacerdote C, Mattiello A, Bueno-de-Mesquita B, Vermeulen R, Van Gils C, Nystr\u00f6m H, Ruteg\u00e5rd M, Aune D, Riboli E, Cross AJ. Gallstones and incident colorectal cancer in a large pan-European cohort study. Int J Cancer 2019; 145(6): 1510\u20131516","journal-title":"Int J Cancer"},{"issue":"5","key":"1111_CR38","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00535-013-0846-6","volume":"49","author":"YK Chen","year":"2014","unstructured":"Chen YK, Yeh JH, Lin CL, Peng CL, Sung FC, Hwang IM, Kao CH. Cancer risk in patients with cholelithiasis and after cholecystectomy: a nationwide cohort study. J Gastroenterol 2014; 49(5): 923\u2013931","journal-title":"J Gastroenterol"},{"issue":"10","key":"1111_CR39","doi-asserted-by":"publisher","first-page":"e109733","DOI":"10.1371\/journal.pone.0109733","volume":"9","author":"Y Liu","year":"2014","unstructured":"Liu Y, He Y, Li T, Xie L, Wang J, Qin X, Li S. Risk of primary liver cancer associated with gallstones and cholecystectomy: a meta-analysis. PLoS One 2014; 9(10): e109733","journal-title":"PLoS One"},{"issue":"8","key":"1111_CR40","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1053\/j.gastro.2017.02.013","volume":"152","author":"DM Shabanzadeh","year":"2017","unstructured":"Shabanzadeh DM, Sorensen LT, Jorgensen T. Association between screen-detected gallstone disease and cancer in a cohort study. Gastroenterology 2017; 152(8): 1965\u201374.e1","journal-title":"Gastroenterology"},{"issue":"6","key":"1111_CR41","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s12262-016-1524-8","volume":"79","author":"D Chaudhary","year":"2017","unstructured":"Chaudhary D, Ahluwalia R, Rai A. Synchronous breast cancer and gallbladder diseases-a chromosomal analysis: a pilot study at a tertiary care centre. Indian J Surg 2017; 79(6): 544\u2013548","journal-title":"Indian J Surg"},{"key":"1111_CR42","doi-asserted-by":"publisher","first-page":"1000563","DOI":"10.3389\/fmed.2022.1000563","volume":"9","author":"X Jiang","year":"2022","unstructured":"Jiang X, Jiang Z, Cheng Q, Sun W, Jiang M, Sun Y. Cholecystectomy promotes the development of colorectal cancer by the alternation of bile acid metabolism and the gut microbiota. Front Med (Lausanne) 2022; 9: 1000563","journal-title":"Front Med (Lausanne)"},{"issue":"11","key":"1111_CR43","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1007\/s10552-014-0458-3","volume":"25","author":"Y Gong","year":"2014","unstructured":"Gong Y, Li S, Tang Y, Mai C, Ba M, Jiang P, Tang H. Cholelithiasis and risk of pancreatic cancer: systematic review and meta-analysis of 21 observational studies. Cancer Causes Control 2014; 25(11): 1543\u20131551","journal-title":"Cancer Causes Control"},{"issue":"3","key":"1111_CR44","doi-asserted-by":"publisher","first-page":"164","DOI":"10.15430\/JCP.2020.25.3.164","volume":"25","author":"D Huang","year":"2020","unstructured":"Huang D, Lee J, Song N, Cho S, Choe S, Shin A. Gallstones, cholecystectomy and the risk of hepatobiliary and pancreatic cancer: a nationwide population-based cohort study in Republic of Korea. J Cancer Prev 2020; 25(3): 164\u2013172","journal-title":"J Cancer Prev"},{"issue":"7","key":"1111_CR45","first-page":"840","volume":"136","author":"L Chen","year":"2023","unstructured":"Chen L, Fan Z, Sun X, Qiu W, Mu W, Chai K, Cao Y, Wang G, Lv G. Associations of cholecystectomy with the risk of colorectal cancer: a Mendelian randomization study. Chin Med J (Engl) 2023; 136(7): 840\u2013847","journal-title":"Chin Med J (Engl)"},{"issue":"6","key":"1111_CR46","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1038\/s41416-020-01211-x","volume":"124","author":"R Culliford","year":"2021","unstructured":"Culliford R, Cornish AJ, Law PJ, Farrington SM, Palin K, Jenkins MA, Casey G, Hoffmeister M, Brenner H, Chang-Claude J, Kirac I, Maughan T, Brezina S, Gsur A, Cheadle JP, Aaltonen LA, Dunlop MG, Houlston RS. Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomization analysis. Br J Cancer 2021; 124(6): 1169\u20131174","journal-title":"Br J Cancer"},{"issue":"5","key":"1111_CR47","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1002\/hep.21616","volume":"45","author":"J Castro","year":"2007","unstructured":"Castro J, Amigo L, Miquel JF, G\u00e4lman C, Crovari F, Raddatz A, Zanlungo S, Jalil R, Rudling M, Nervi F. Increased activity of hepatic microsomal triglyceride transfer protein and bile acid synthesis in gallstone disease. Hepatology 2007; 45(5): 1261\u20131266","journal-title":"Hepatology"},{"issue":"3","key":"1111_CR48","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1053\/gast.2000.16495","volume":"119","author":"LA Thomas","year":"2000","unstructured":"Thomas LA, Veysey MJ, Bathgate T, King A, French G, Smeeton NC, Murphy GM, Dowling RH. Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasis. Gastroenterology 2000; 119(3): 806\u2013815","journal-title":"Gastroenterology"}],"container-title":["Frontiers of Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-024-1111-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11684-024-1111-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11684-024-1111-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T03:26:26Z","timestamp":1740540386000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11684-024-1111-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["1111"],"URL":"https:\/\/doi.org\/10.1007\/s11684-024-1111-5","relation":{},"ISSN":["2095-0217","2095-0225"],"issn-type":[{"value":"2095-0217","type":"print"},{"value":"2095-0225","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"12 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Conflicts of interest Yuanyue Zhu, Linhui Shen, Yanan Huo, Qin Wan, Yingfen Qin, Ruying Hu, Lixin Shi, Qing Su, Xuefeng Yu, Li Yan, Guijun Qin, Xulei Tang, Gang Chen, Yu Xu, Tiange Wang, Zhiyun Zhao, Zhengnan Gao, Guixia Wang, Feixia Shen, Xuejiang Gu, Zuojie Luo, Li Chen, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Lulu Chen, Tianshu Zeng, Jiajun Zhao, Yiming Mu, Weiqing Wang, Guang Ning, Jieli Lu, Min Xu, Yufang Bi, and Weiguo Hu declare that they have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}},{"value":"The study was approved by the Ethical Review Committee of Ruijin Hospital (No. RUIJIN-2011-14) and the study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all patients included in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethics guidelines"}}]}}