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The unexpected observation of this parasite in an otherwise healthy young lady who had undergone upper endoscopy and biopsy sampling of the gastro-duodenal mucosa, prompted us to review the literature to ascertain the conditions favouring gastric colonization by<jats:italic>SS.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pathology files of gastroduodenal biopsies received at St. Mary\u2019s hospital, Northern Uganda, between 2007 and 2017 were reviewed. Pubmed search was performed under the headings \u201c<jats:italic>Strongyloides stercoralis<\/jats:italic>\u201d, \u201cGastric parasitosis\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histology of the only gastroduodenal biopsy with SS infection showed parasite eggs, immature rhabditiform larvae, and numerous adult worms in gastric pits and rhabditiform larvae in interepithelial parasitic tunnels, causing reactive changes of the glandular epithelium. There was no significant acute inflammatory cell infiltrate surrounding the parasites. Literature review showed that gastric<jats:italic>SS<\/jats:italic>infection appears to be very uncommon and was, as expected, largely prevalent in immunodeficient individuals (84.2% of published cases). The rare gastric<jats:italic>SS<\/jats:italic>infection is a complication of systemic strongyloidiasis, either hyperinfective, or disseminated form. It is also commonly associated with duodenal infection at microscopical examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Involvement of gastric mucosa in the absence of duodenal strongyloidiasis appears to be quite rare and false-negative histopathological exams are reported if only the stomach is biopsied.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s11686-021-00438-9","type":"journal-article","created":{"date-parts":[[2021,6,18]],"date-time":"2021-06-18T12:02:32Z","timestamp":1624017752000},"page":"94-101","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Is Gastric Involvement by Strongyloides stercoralis in an Immunocompetent Patient a Common Finding? 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