{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T12:03:09Z","timestamp":1768737789369,"version":"3.49.0"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s11686-021-00513-1","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:05:27Z","timestamp":1642982727000},"page":"773-783","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dandelion (Taraxacum officinale) Improves the Therapeutic Efficiency of Praziquantel in Experimental Schistosomiasis"],"prefix":"10.1007","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6262-2855","authenticated-orcid":false,"given":"Marwa Th. M.","family":"Atwa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0995-1983","authenticated-orcid":false,"given":"Areeg M.","family":"Abd-Elrazek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha I. S.","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"key":"513_CR1","doi-asserted-by":"publisher","first-page":"902","DOI":"10.4269\/ajtmh.1974.23.902","volume":"23","author":"KS Warren","year":"1974","unstructured":"Warren KS, Mahmoud AAF, Cummings P, Murphy DJ, Houser HB (1974) Schistosomiasis mansoni in Yemeni in California: duration of infection, presence of disease, therapeutic management. Am J Trop Med Hyg 23:902\u2013909. https:\/\/doi.org\/10.4269\/ajtmh.1974.23.902","journal-title":"Am J Trop Med Hyg"},{"key":"513_CR2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-018-0013-8","author":"DP McManus","year":"2018","unstructured":"McManus DP, Dunne DW, Sacko M, Utzinger J, Vennervald BJ, Zhou XN (2018) Schistosomiasis. Nat Rev Dis Prim. https:\/\/doi.org\/10.1038\/s41572-018-0013-8","journal-title":"Nat Rev Dis Prim"},{"key":"513_CR3","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/0169-4758(96)10029-6","volume":"12","author":"PG Fallon","year":"1996","unstructured":"Fallon PG, Tao LF, Ismail MM, Bennett JL (1996) Schistosome resistance to praziquantel: Fact or artifact? Parasitol Today 12:316\u2013320. https:\/\/doi.org\/10.1016\/0169-4758(96)10029-6","journal-title":"Parasitol Today"},{"key":"513_CR4","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1371\/journal.pmed.0030102","volume":"3","author":"PJ Hotez","year":"2006","unstructured":"Hotez PJ, Molyneux DH, Fenwick A, Ottesen E, Sachs SE, Sachs JD (2006) Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV\/AIDS, tuberculosis, and malaria: a comprehensive pro-poor health policy and strategy for the developing world. PLoS Med 3:576\u2013584. https:\/\/doi.org\/10.1371\/journal.pmed.0030102","journal-title":"PLoS Med"},{"issue":"3","key":"513_CR5","doi-asserted-by":"publisher","first-page":"629","DOI":"10.21608\/jesp.2018.76578","volume":"48","author":"GS Sadek","year":"2018","unstructured":"Sadek GS, Harba NM, El-Refai A, Ahmed S, El-Deen S, Saleh MM (2018) efficacy of praziquantel loaded chitosan nanoparticles against both adult and schistosomula stages of Schistosoma mansoni. J Egypt Soc Parasitol 48(3):629\u2013638","journal-title":"J Egypt Soc Parasitol"},{"key":"513_CR6","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.exppara.2014.02.010","volume":"139","author":"RN De Oliveira","year":"2014","unstructured":"De Oliveira RN, Rehder VLG, Oliveira ASS, Jeraldo VLS, Linhares AX, Allegretti SM (2014) Anthelmintic activity  in vitro and in vivo of Baccharis trimera (Less) DC against immature and adult worms of Schistosoma mansoni. Exp Parasitol 139:63\u201372. https:\/\/doi.org\/10.1016\/j.exppara.2014.02.010","journal-title":"Exp Parasitol"},{"key":"513_CR7","doi-asserted-by":"publisher","first-page":"0130","DOI":"10.1371\/journal.pmed.0040014","volume":"4","author":"MH Abdulla","year":"2007","unstructured":"Abdulla MH, Lim KC, Sajid M, McKerrow JH, Caffrey CR (2007) Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor. PLoS Med 4:0130\u20130138. https:\/\/doi.org\/10.1371\/journal.pmed.0040014","journal-title":"PLoS Med"},{"key":"513_CR8","doi-asserted-by":"crossref","unstructured":"Abebe F (2008) Botanical medicine in clinical practice. In: Walson R, Preedly V (eds) CABI. Cambridge, pp 175\u2013183","DOI":"10.1079\/9781845934132.0175"},{"key":"513_CR9","doi-asserted-by":"publisher","first-page":"4513","DOI":"10.1007\/s00436-014-4141-0","volume":"113","author":"TY Mahmoud","year":"2014","unstructured":"Mahmoud TY, Rizk SM, Maghraby AS, Shaheen AA (2014) Propolis enhances the effectiveness of praziquantel in experimental schistosomiasis: biochemical and histopathological study. Parasitol Res 113:4513\u20134523. https:\/\/doi.org\/10.1007\/s00436-014-4141-0","journal-title":"Parasitol Res"},{"key":"513_CR10","unstructured":"WHO (2002) Traditional medicine strategy"},{"key":"513_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jnutbio.2017.11.003","volume":"55","author":"M Bae","year":"2018","unstructured":"Bae M, Park YK, Lee JY (2018) Food components with antifibrotic activity and implications in prevention of liver disease. J Nutr Biochem 55:1\u201311. https:\/\/doi.org\/10.1016\/j.jnutbio.2017.11.003","journal-title":"J Nutr Biochem"},{"key":"513_CR12","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.scitotenv.2007.03.026","volume":"381","author":"P Kalny","year":"2007","unstructured":"Kalny P, Fija\u0142ek Z, Daszczuk A, Ostapczuk P (2007) Determination of selected microelements in polish herbs and their infusions. Sci Total Environ 381:99\u2013104. https:\/\/doi.org\/10.1016\/j.scitotenv.2007.03.026","journal-title":"Sci Total Environ"},{"key":"513_CR13","doi-asserted-by":"publisher","first-page":"12771","DOI":"10.3390\/molecules171112771","volume":"17","author":"M Wink","year":"2012","unstructured":"Wink M (2012) Medicinal plants: a source of anti-parasitic secondary metabolites. Molecules 17:12771\u201312791. https:\/\/doi.org\/10.3390\/molecules171112771","journal-title":"Molecules"},{"key":"513_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jep.2006.07.021","volume":"107","author":"K Sch\u00fctz","year":"2006","unstructured":"Sch\u00fctz K, Carle R, Schieber A (2006) Taraxacum\u2014a review on its phytochemical and pharmacological profile. J Ethnopharmacol 107:313\u2013323. https:\/\/doi.org\/10.1016\/j.jep.2006.07.021","journal-title":"J Ethnopharmacol"},{"key":"513_CR15","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1900\/RDS.2016.13.113","volume":"13","author":"FE Wirngo","year":"2016","unstructured":"Wirngo FE, Lambert MN, Jeppesen PB (2016) The physiological effects of dandelion (Taraxacum officinale) in type 2 diabetes. Rev Diabet Stud 13:113\u2013131. https:\/\/doi.org\/10.1900\/RDS.2016.13.113","journal-title":"Rev Diabet Stud"},{"key":"513_CR16","doi-asserted-by":"publisher","first-page":"202","DOI":"10.7324\/JAPS.2016.60429","volume":"6","author":"E Devaraj","year":"2016","unstructured":"Devaraj E (2016) Hepatoprotective properties of dandelion: recent update. J Appl Pharm Sci 6:202\u2013205. https:\/\/doi.org\/10.7324\/JAPS.2016.60429","journal-title":"J Appl Pharm Sci"},{"key":"513_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00875","author":"G Rehman","year":"2017","unstructured":"Rehman G, Hamayun M, Iqbal A, Khan SA, Khan H, Shehzad A et al (2017) Effect of methanolic extract of dandelion roots on cancer cell lines and AMP-activated protein kinase pathway. Front Pharmacol. https:\/\/doi.org\/10.3389\/fphar.2017.00875","journal-title":"Front Pharmacol"},{"key":"513_CR18","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.7.1398s","author":"MB Roberfroid","year":"1999","unstructured":"Roberfroid MB (1999) Concepts in functional foods: the case of inulin and oligofructose. J Nutr. https:\/\/doi.org\/10.1093\/jn\/129.7.1398s","journal-title":"J Nutr"},{"key":"513_CR19","doi-asserted-by":"publisher","first-page":"2871","DOI":"10.1016\/j.fct.2008.05.027","volume":"46","author":"S Arpadjan","year":"2008","unstructured":"Arpadjan S, \u00c7elik G, Ta\u015fkesen S, G\u00fc\u00e7er \u015e (2008) Arsenic, cadmium and lead in medicinal herbs and their fractionation. Food Chem Toxicol 46:2871\u20132875. https:\/\/doi.org\/10.1016\/j.fct.2008.05.027","journal-title":"Food Chem Toxicol"},{"key":"513_CR20","first-page":"540","volume":"6","author":"K Sharma","year":"2014","unstructured":"Sharma K, Zafar R (2014) Simultaneous estimation of taraxerol and taraxasterol in root callus cultures of Taraxacum officinale Weber. Int J Pharmacogn Phytochem Res 6:540\u2013546","journal-title":"Int J Pharmacogn Phytochem Res"},{"key":"513_CR21","doi-asserted-by":"publisher","first-page":"558","DOI":"10.2307\/3277297","volume":"55","author":"PA Peters","year":"1969","unstructured":"Peters PA, Warren KS (1969) A rapid method of infecting mice and other laboratory animals with Schistosoma mansoni: subcutaneous injection. J Parasitol 55:558. https:\/\/doi.org\/10.2307\/3277297","journal-title":"J Parasitol"},{"key":"513_CR22","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1111\/j.1365-3024.1990.tb00975.x","volume":"12","author":"KP Piper","year":"1990","unstructured":"Piper KP, Mott RF, McLaren DJ (1990) Schistosoma mansoni: histological analysis of the synergistic interaction between vaccine immunity and praziquantel therapy in the lungs of mice. Parasite Immunol 12:367\u2013387. https:\/\/doi.org\/10.1111\/j.1365-3024.1990.tb00975.x","journal-title":"Parasite Immunol"},{"key":"513_CR23","first-page":"94","volume":"44","author":"AA Shaheen","year":"1994","unstructured":"Shaheen AA, Abd El-Fattah AA, Ebeid FA (1994) Effect of praziquantel treatment of lipid peroxide levels and superoxide dismutase activity in tissues of healthy and Schistosoma mansoni infected mice. Arzneimittel-Forschung\/Drug Res 44:94\u201396","journal-title":"Arzneimittel-Forschung\/Drug Res"},{"key":"513_CR24","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1017\/S0031182000086248","volume":"55","author":"SR Smithers","year":"1965","unstructured":"Smithers SR, Terry RJ (1965) The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms. Parasitology 55:695\u2013700. https:\/\/doi.org\/10.1017\/S0031182000086248","journal-title":"Parasitology"},{"key":"513_CR25","first-page":"328","volume":"39","author":"AW Cheever","year":"1968","unstructured":"Cheever AW (1968) Conditions affecting the accuracy of potassium hydroxide digestion techniques for counting Schistosoma mansoni eggs in tissues. Bull World Health Organ 39:328\u2013331","journal-title":"Bull World Health Organ"},{"key":"513_CR26","doi-asserted-by":"publisher","first-page":"363","DOI":"10.4269\/ajtmh.1965.14.363","volume":"14","author":"J Pellegrino","year":"1965","unstructured":"Pellegrino J, Faria J (1965) The oogram method for the screening of drugs in Schistosomiasis mansoni. Am J Trop Med Hyg 14:363\u2013369. https:\/\/doi.org\/10.4269\/ajtmh.1965.14.363","journal-title":"Am J Trop Med Hyg"},{"key":"513_CR27","volume-title":"Wallington: Carleton\u2019s histological technique","author":"R Druray","year":"1980","unstructured":"Druray R, Wallington EA (1980) Wallington: Carleton\u2019s histological technique, 5th edn. Oxford University Press, Oxford","edition":"5"},{"key":"513_CR28","first-page":"2033","volume":"150","author":"W Jacobs","year":"1997","unstructured":"Jacobs W, Bogers J, Deelder A, W\u00e9ry M, Van Marck E (1997) Adult Schistosoma mansoni worms positively modulate soluble egg antigen-induced inflammatory hepatic granuloma formation in vivo: stereological analysis and immunophenotyping of extracellular matrix proteins, adhesion molecules, and chemokines. Am J Pathol 150:2033\u20132045","journal-title":"Am J Pathol"},{"key":"513_CR29","doi-asserted-by":"publisher","first-page":"724","DOI":"10.3923\/jms.2007.724.731","volume":"7","author":"SA Maghraby","year":"2007","unstructured":"Maghraby SA, Shker KH, Zahran HG, El-Sherbiny M (2007) in vivo the immunological effects of Fasciola gigantica worms homogenate mixed with saponin on mice infected with Schistosoma mansoni. J Med Sci 7:724\u2013731. https:\/\/doi.org\/10.3923\/jms.2007.724.731","journal-title":"J Med Sci"},{"key":"513_CR30","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2280(2000)35:3","author":"RRR Tice","year":"2000","unstructured":"Tice RRR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H et al (2000) Single cell gel\/comet assay: guidelines for  in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen. https:\/\/doi.org\/10.1002\/(SICI)1098-2280(2000)35:3","journal-title":"Environ Mol Mutagen"},{"key":"513_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/biom10030426","author":"M Liu","year":"2020","unstructured":"Liu M, Panda SK, Luyten W (2020) Plant-based natural products for the discovery and development of novel anthelmintics against nematodes. Biomolecules. https:\/\/doi.org\/10.3390\/biom10030426","journal-title":"Biomolecules"},{"key":"513_CR32","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2018008","author":"SK Panda","year":"2018","unstructured":"Panda SK, Luyten W (2018) Antiparasitic activity in Asteraceae with special attention to ethnobotanical use by the tribes of Odisha. India Parasite. https:\/\/doi.org\/10.1051\/parasite\/2018008","journal-title":"India. Parasite"},{"key":"513_CR33","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/BF00389899","volume":"52","author":"R G\u00f6nnert","year":"1977","unstructured":"G\u00f6nnert R, Andrews P (1977) Praziquantel, a new broad-spectrum antischistosomal agent. Zeitschrift F\u00fcr Parasitenkd 52:129\u2013150. https:\/\/doi.org\/10.1007\/BF00389899","journal-title":"Zeitschrift F\u00fcr Parasitenkd"},{"key":"513_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/S40249-018-0448-X","author":"M Kabuyaya","year":"2018","unstructured":"Kabuyaya M, Chimbari MJ, Mukaratirwa S (2018) Efficacy of praziquantel treatment regimens in pre-school and school aged children infected with schistosomiasis in sub-Saharan Africa: a systematic review. Infect Dis Poverty. https:\/\/doi.org\/10.1186\/S40249-018-0448-X","journal-title":"Infect Dis Poverty"},{"key":"513_CR35","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/0035-9203(86)90126-4","volume":"80","author":"MJ Doenhoff","year":"1986","unstructured":"Doenhoff MJ, Hassounah O, Murare H, Bain J, Murare H (1986) The schistosome egg granuloma: immunopathology in the cause of host protection or parasite survival? Trans R Soc Trop Med Hyg 80:503\u2013514. https:\/\/doi.org\/10.1016\/0035-9203(86)90126-4","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"513_CR36","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/j.jep.2010.05.046","volume":"130","author":"R Domitrovi\u0107","year":"2010","unstructured":"Domitrovi\u0107 R, Jakovac H, Romi\u0107 \u017d, Raheli\u0107 D, Tadi\u0107 \u017d (2010) Antifibrotic activity of Taraxacum officinale root in carbon tetrachloride-induced liver damage in mice. J Ethnopharmacol 130:569\u2013577. https:\/\/doi.org\/10.1016\/j.jep.2010.05.046","journal-title":"J Ethnopharmacol"},{"key":"513_CR37","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1016\/j.fct.2010.03.037","volume":"48","author":"Y You","year":"2010","unstructured":"You Y, Yoo S, Yoon HG, Park J, Lee YH, Kim S et al (2010)  In vitro and in vivo hepatoprotective effects of the aqueous extract from Taraxacum officinale (dandelion) root against alcohol-induced oxidative stress. Food Chem Toxicol 48:1632\u20131637. https:\/\/doi.org\/10.1016\/j.fct.2010.03.037","journal-title":"Food Chem Toxicol"},{"key":"513_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41936-020-00177-9","volume":"81","author":"AA Hamza","year":"2020","unstructured":"Hamza AA, Mohamed MG, Lashin FM, Amin A (2020) Dandelion prevents liver fibrosis, inflammatory response, and oxidative stress in rats. J Basic Appl Zool 81:1\u201313. https:\/\/doi.org\/10.1186\/s41936-020-00177-9","journal-title":"J Basic Appl Zool"},{"key":"513_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4103\/2221-1691.273081","volume":"1","author":"M Mahboubi","year":"2020","unstructured":"Mahboubi M, Mahboubi M (2020) Hepatoprotection by dandelion (Taraxacum officinale) and mechanisms. Asian Pac J Trop Biomed 1:1\u201310. https:\/\/doi.org\/10.4103\/2221-1691.273081","journal-title":"Asian Pac J Trop Biomed"},{"key":"513_CR40","doi-asserted-by":"publisher","first-page":"20459","DOI":"10.1073\/pnas.1010337107","volume":"107","author":"M Ritter","year":"2010","unstructured":"Ritter M, Gross O, Kays S, Ruland J, Nimmerjahn F, Saijo S et al (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proc Natl Acad Sci USA 107:20459\u201320464. https:\/\/doi.org\/10.1073\/pnas.1010337107","journal-title":"Proc Natl Acad Sci USA"},{"key":"513_CR41","doi-asserted-by":"publisher","first-page":"17001","DOI":"10.1074\/jbc.M512601200","volume":"281","author":"AA Sayed","year":"2006","unstructured":"Sayed AA, Cook SK, Williams DL (2006) Redox balance mechanisms in Schistosoma mansoni rely on peroxiredoxins and albumin and implicate peroxiredoxins as novel drug targets. J Biol Chem 281:17001\u201317010. https:\/\/doi.org\/10.1074\/jbc.M512601200","journal-title":"J Biol Chem"},{"key":"513_CR42","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1194\/jlr.M800415-JLR200","volume":"50","author":"VM Rimkunas","year":"2009","unstructured":"Rimkunas VM, Graham MJ, Crooke RM, Liscum L (2009) TNF-\u03b1 plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease. J Lipid Res 50:327\u2013333. https:\/\/doi.org\/10.1194\/jlr.M800415-JLR200","journal-title":"J Lipid Res"},{"key":"513_CR43","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1128\/IAI.69.1.271-280.2001","volume":"69","author":"SK Lundy","year":"2001","unstructured":"Lundy SK, Lerman SP, Boros DL (2001) Soluble egg antigen-stimulated T helper lymphocyte apoptosis and evidence for cell death mediated by FasL+ T and B cells during murine Schistosoma mansoni infection. Infect Immun 69:271\u2013280. https:\/\/doi.org\/10.1128\/IAI.69.1.271-280.2001","journal-title":"Infect Immun"},{"key":"513_CR44","doi-asserted-by":"publisher","first-page":"945","DOI":"10.4269\/ajtmh.14-0444","volume":"92","author":"AL Bustinduy","year":"2015","unstructured":"Bustinduy AL, Sutherland LJ, Chang-Cojulun A, Malhotra I, DuVall AS, Fairley JK et al (2015) Age-stratified profiles of serum IL-6, IL-10, and TNF-\u03b1 cytokines among kenyan children with Schistosoma haematobium, Plasmodium falciparum, and other chronic parasitic co-infections. Am J Trop Med Hyg 92:945\u2013951","journal-title":"Am J Trop Med Hyg"},{"key":"513_CR45","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1194\/jlr.M800415-JLR200","volume":"50","author":"VM Rimkunas","year":"2009","unstructured":"Rimkunas VM, Graham MJ, Crooke RM, Liscum L (2009) TNF-a plays a role in hepatocyte apoptosis in Niemann-Pick type C liver disease. J Lipid Res 50:327\u2013333","journal-title":"J Lipid Res"},{"key":"513_CR46","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/356604a0","volume":"356","author":"P Amiri","year":"1992","unstructured":"Amiri P, Locksley RM, Parslow TG, Sadiek M, Rector E et al (1992) Tumour necrosis factor alpha restores granulomas and jnduces parasite egg-laying in schistosome-infected SCID mice. Nature 356:604\u2013607","journal-title":"Nature"},{"key":"513_CR47","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1111\/j.1753-4887.2012.00509.x","volume":"70","author":"M Gonz\u00e1lez-Castej\u00f3n","year":"2012","unstructured":"Gonz\u00e1lez-Castej\u00f3n M, Visioli F, Rodriguez-Casado A (2012) Diverse biological activities of dandelion. Nutr Rev 70:534\u2013547. https:\/\/doi.org\/10.1111\/j.1753-4887.2012.00509.x","journal-title":"Nutr Rev"},{"key":"513_CR48","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/S0893-133X(00)00147-0","volume":"23","author":"ZA Martinez","year":"2000","unstructured":"Martinez ZA, Oostwegel J, Geyer MA, Ellison GD, Swerdlow NR (2000) \u201cEarly\u201d and \u201clate\u201d effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits. Neuropsychopharmacology 23:517\u2013527. https:\/\/doi.org\/10.1016\/S0893-133X(00)00147-0","journal-title":"Neuropsychopharmacology"},{"key":"513_CR49","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jep.2012.02.020","volume":"141","author":"X Zhang","year":"2012","unstructured":"Zhang X, Xiong H, Liu L (2012) Effects of taraxasterol on inflammatory responses in lipopolysaccharide-induced RAW 264.7 macrophages. J Ethnopharmacol 141:206\u2013211. https:\/\/doi.org\/10.1016\/j.jep.2012.02.020","journal-title":"J Ethnopharmacol"},{"key":"513_CR50","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1016\/j.freeradbiomed.2011.02.021","volume":"50","author":"P Mukhopadhyay","year":"2011","unstructured":"Mukhopadhyay P, Rajesh M, Horv\u00e1th B, B\u00e1tkai S, Park O, Tanchian G et al (2011) Cannabidiol protects against hepatic ischemia\/reperfusion injury by attenuating inflammatory signaling and response, oxidative\/nitrative stress, and cell death. Free Radic Biol Med 50:1368\u20131381. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.02.021","journal-title":"Free Radic Biol Med"},{"key":"513_CR51","first-page":"63","volume":"3","author":"R Mostafa","year":"1984","unstructured":"Mostafa R (1984) Detecion of mutagenicity in Urothelial cells of bilharzial patients by \u201cthe micronucleus test\u201d | Virtual Health Sciences Library. J Egypt Natl Canc Inst 3:63\u201373","journal-title":"J Egypt Natl Canc Inst"},{"key":"513_CR52","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1182\/blood.v76.4.655.655","volume":"76","author":"SA Weitzman","year":"1990","unstructured":"Weitzman SA, Gordon LI (1990) Inflammation and cancer: role of phagocyte-generated oxidants in carcinogenesis. Blood 76:655\u2013663. https:\/\/doi.org\/10.1182\/blood.v76.4.655.655","journal-title":"Blood"},{"key":"513_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4172\/2168-9431.1000117","volume":"4","author":"R Tripathi","year":"2015","unstructured":"Tripathi R, Jaiswal N, Sharma B, Malhotra SK (2015) Helminth infections mediated DNA damage: mechanisms and consequences. Single Cell Biol 4:3. https:\/\/doi.org\/10.4172\/2168-9431.1000117","journal-title":"Single Cell Biol"},{"key":"513_CR54","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7324\/JAPS.2014.40505","volume":"4","author":"JI Eid","year":"2014","unstructured":"Eid JI, Mohammed AR, Hussien NA, El-Shennawy AM, Noshy MM, Abbas M (2014) in vivo antioxidant and antigenotoxic evaluation of an enaminone derivative BDHQ combined with praziquantel in uninfected and Schistosoma mansoni infected mice. J Appl Pharm Sci 4:25\u201333. https:\/\/doi.org\/10.7324\/JAPS.2014.40505","journal-title":"J Appl Pharm Sci"},{"key":"513_CR55","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1089\/jmf.2013.0179","volume":"18","author":"S Clichici","year":"2015","unstructured":"Clichici S, Olteanu D, Nagy AL, Oros A, Filip A, Mircea PA (2015) Silymarin inhibits the progression of fibrosis in the early stages of liver injury in CCl4-treated rats. J Med Food 18:290\u2013298. https:\/\/doi.org\/10.1089\/jmf.2013.0179","journal-title":"J Med Food"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-021-00513-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-021-00513-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-021-00513-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T16:28:23Z","timestamp":1653323303000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-021-00513-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":55,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["513"],"URL":"https:\/\/doi.org\/10.1007\/s11686-021-00513-1","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"20 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2022","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In this article the ORCiD http:\/\/orcid.org\/0000-0002-0995-1983 for  Areeg M. Abd-Elrazek was inadvertently omitted.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no financial support and there is no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}