{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T04:17:17Z","timestamp":1779164237577,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["95007218"],"award-info":[{"award-number":["95007218"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s11686-022-00571-z","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T10:10:44Z","timestamp":1653559844000},"page":"1425-1431","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Testosterone Augments Propagation of Toxoplasma gondii in Glioblastoma Cells In Vitro"],"prefix":"10.1007","volume":"67","author":[{"given":"Amir","family":"Abdoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0891-8214","authenticated-orcid":false,"given":"Fatemeh","family":"Ghaffarifar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohreh","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Zaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"issue":"1","key":"571_CR1","first-page":"1","volume":"7","author":"A Dalimi","year":"2012","unstructured":"Dalimi A, Abdoli A (2012) Latent toxoplasmosis and human. Iran J Parasitol 7(1):1\u201317","journal-title":"Iran J Parasitol"},{"issue":"2","key":"571_CR2","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1128\/cmr.05013-11","volume":"25","author":"F Robert-Gangneux","year":"2012","unstructured":"Robert-Gangneux F, Dard\u00e9 M-L (2012) Epidemiology of and diagnostic strategies for toxoplasmosis. Clin Microbiol Rev 25(2):264\u2013296. https:\/\/doi.org\/10.1128\/cmr.05013-11","journal-title":"Clin Microbiol Rev"},{"key":"571_CR3","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00389","author":"Z-D Wang","year":"2017","unstructured":"Wang Z-D, Liu H-H, Ma Z-X, Ma H-Y, Li Z-Y, Yang Z-B et al (2017) Toxoplasma gondii infection in immunocompromised patients: a systematic review and meta-analysis. Front Microbiol. https:\/\/doi.org\/10.3389\/fmicb.2017.00389","journal-title":"Front Microbiol"},{"issue":"4","key":"571_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/s2352-3018(17)30048-6","volume":"4","author":"A Abdoli","year":"2017","unstructured":"Abdoli A (2017) Neglected risk factors for HIV and Toxoplasma gondii co-infection. Lancet HIV 4(4):e152. https:\/\/doi.org\/10.1016\/s2352-3018(17)30048-6","journal-title":"Lancet HIV"},{"issue":"6","key":"571_CR5","doi-asserted-by":"publisher","first-page":"970","DOI":"10.3109\/0886022X.2016.1172940","volume":"38","author":"S Rasti","year":"2016","unstructured":"Rasti S, Hassanzadeh M, Soliemani A, Hooshyar H, Mousavi SGA, Nikoueinejad H et al (2016) Serological and molecular survey of toxoplasmosis in renal transplant recipients and hemodialysis patients in Kashan and Qom regions, central Iran. Ren Fail 38(6):970\u2013973. https:\/\/doi.org\/10.3109\/0886022X.2016.1172940","journal-title":"Ren Fail"},{"issue":"13","key":"571_CR6","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3109\/14767058.2013.858685","volume":"27","author":"A Abdoli","year":"2014","unstructured":"Abdoli A, Dalimi A, Arbabi M, Ghaffarifar F (2014) Neuropsychiatric manifestations of latent toxoplasmosis on mothers and their offspring. J Matern Fetal Neonatal Med 27(13):1368\u20131374","journal-title":"J Matern Fetal Neonatal Med"},{"key":"571_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00339","author":"A Abdoli","year":"2014","unstructured":"Abdoli A, Dalimi A (2014) Are there any relationships between latent Toxoplasma gondii infection, testosterone elevation, and risk of autism spectrum disorder? Front Behav Neurosci. https:\/\/doi.org\/10.3389\/fnbeh.2014.00339","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"571_CR8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s11515-014-1291-5","volume":"9","author":"A Abdoli","year":"2014","unstructured":"Abdoli A (2014) Toxoplasma, testosterone, and behavior manipulation: the role of parasite strain, host variations, and intensity of infection. Front Biol 9(2):151\u2013160","journal-title":"Front Biol"},{"issue":"7","key":"571_CR9","doi-asserted-by":"publisher","first-page":"e1004935","DOI":"10.1371\/journal.ppat.1004935","volume":"11","author":"A Vyas","year":"2015","unstructured":"Vyas A (2015) Mechanisms of host behavioral change in Toxoplasma gondii rodent association. PLoS Pathog 11(7):e1004935","journal-title":"PLoS Pathog"},{"issue":"12","key":"571_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e05645","volume":"6","author":"A Abdoli","year":"2020","unstructured":"Abdoli A, Taghipour A, Pirestani M, MofazzalJahromi MA, Roustazadeh A, Mir H et al (2020) Infections, inflammation, and risk of neuropsychiatric disorders: the neglected role of \u201cco-infection.\u201d Heliyon 6(12):e05645. https:\/\/doi.org\/10.1016\/j.heliyon.2020.e05645","journal-title":"Heliyon"},{"issue":"4","key":"571_CR11","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1017\/S0031182007004064","volume":"135","author":"J Flegr","year":"2008","unstructured":"Flegr J, Lindov\u00e1 J, Kodym P (2008) Sex-dependent toxoplasmosis-associated differences in testosterone concentration in humans. Parasitology 135(4):427\u2013431","journal-title":"Parasitology"},{"issue":"3","key":"571_CR12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s12639-013-0382-6","volume":"39","author":"KH Zghair","year":"2015","unstructured":"Zghair KH, Al-Qadhi BN, Mahmood SH (2015) The effect of toxoplasmosis on the level of some sex hormones in males blood donors in Baghdad. J Parasitic Dis 39(3):393\u2013400. https:\/\/doi.org\/10.1007\/s12639-013-0382-6","journal-title":"J Parasitic Dis"},{"issue":"1","key":"571_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s40750-020-00160-2","volume":"7","author":"JI Borr\u00e1z-Le\u00f3n","year":"2021","unstructured":"Borr\u00e1z-Le\u00f3n JI, Rantala MJ, Luoto S, Krams I, Contreras-Gardu\u00f1o J, Cerda-Molina AL et al (2021) Toxoplasma gondii and psychopathology: latent infection is associated with interpersonal sensitivity, psychoticism, and higher testosterone levels in men, but not in women. Adapt Hum Behav Physiol 7(1):28\u201342. https:\/\/doi.org\/10.1007\/s40750-020-00160-2","journal-title":"Adapt Hum Behav Physiol"},{"issue":"1","key":"571_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1111\/mec.12042","volume":"22","author":"A Lim","year":"2013","unstructured":"Lim A, Kumar V, Hari Dass SA, Vyas A (2013) Toxoplasma gondii infection enhances testicular steroidogenesis in rats. Mol Ecol 22(1):102\u2013110. https:\/\/doi.org\/10.1111\/mec.12042","journal-title":"Mol Ecol"},{"issue":"s1","key":"571_CR15","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1111\/j.1439-0272.2011.01249.x","volume":"44","author":"A Abdoli","year":"2012","unstructured":"Abdoli A, Dalimi A, Movahedin M (2012) Impaired reproductive function of male rats infected with Toxoplasma gondii. Andrologia 44(s1):679\u2013687. https:\/\/doi.org\/10.1111\/j.1439-0272.2011.01249.x","journal-title":"Andrologia"},{"issue":"4","key":"571_CR16","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.arcmed.2019.08.001","volume":"50","author":"A Gonz\u00e1lez-Arenas","year":"2019","unstructured":"Gonz\u00e1lez-Arenas A, De la Fuente-Granada M, Camacho-Arroyo I, Zamora-S\u00e1nchez CJ, Pi\u00f1a-Medina AG, Segura-Uribe J et al (2019) Tibolone effects on human glioblastoma cell lines. Arch Med Res 50(4):187\u2013196. https:\/\/doi.org\/10.1016\/j.arcmed.2019.08.001","journal-title":"Arch Med Res"},{"issue":"1","key":"571_CR17","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65(1):55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"571_CR18","doi-asserted-by":"publisher","first-page":"387","DOI":"10.3389\/fcimb.2020.00387","volume":"10","author":"L Zaki","year":"2020","unstructured":"Zaki L, Ghaffarifar F, Sharifi Z, Horton J, Sadraei J (2020) Effect of Imiquimod on Tachyzoites of Toxoplasma gondii and Infected Macrophages in vitro and in BALB\/c Mice. Front Cell Infect Microbiol 10:387. https:\/\/doi.org\/10.3389\/fcimb.2020.00387","journal-title":"Front Cell Infect Microbiol"},{"key":"571_CR19","doi-asserted-by":"publisher","first-page":"107721","DOI":"10.1016\/j.exppara.2019.107721","volume":"204","author":"MDLL Galv\u00e1n-Ram\u00edrez","year":"2019","unstructured":"Galv\u00e1n-Ram\u00edrez MDLL, Ram\u00edrez De Arellano A, Rodr\u00edguez-P\u00e9rez LR, Lopez-Pulido EI, Mu\u00f1oz-Valle JF, Pereira-Su\u00e1rez AL (2019) Hormonal modulation of Toxoplasma gondii infection: regulation of hormonal receptors and cytokine production in THP-1 cells. Exp Parasitol 204:107721. https:\/\/doi.org\/10.1016\/j.exppara.2019.107721","journal-title":"Exp Parasitol"},{"issue":"12","key":"571_CR20","doi-asserted-by":"publisher","first-page":"7128","DOI":"10.1128\/AAC.01323-16","volume":"60","author":"M Montazeri","year":"2016","unstructured":"Montazeri M, Ebrahimzadeh MA, Ahmadpour E, Sharif M, Sarvi S, Daryani A (2016) Evaluation of propranolol effect on experimental acute and chronic toxoplasmosis using quantitative PCR. Antimicrob Agents Chemother 60(12):7128\u20137133. https:\/\/doi.org\/10.1128\/AAC.01323-16","journal-title":"Antimicrob Agents Chemother"},{"key":"571_CR21","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00016","author":"DC Rodr\u00edguez-Lozano","year":"2019","unstructured":"Rodr\u00edguez-Lozano DC, Pi\u00f1a-Medina AG, Hansberg-Pastor V, Bello-Alvarez C, Camacho-Arroyo I (2019) Testosterone promotes glioblastoma cell proliferation, migration, and invasion through androgen receptor activation. Front Endocrinol. https:\/\/doi.org\/10.3389\/fendo.2019.00016","journal-title":"Front Endocrinol"},{"key":"571_CR22","doi-asserted-by":"publisher","first-page":"8813","DOI":"10.2147\/OTT.S262359","volume":"13","author":"DC Rodr\u00edguez-Lozano","year":"2020","unstructured":"Rodr\u00edguez-Lozano DC, Vel\u00e1zquez-V\u00e1zquez DE, Del Moral-Morales A, Camacho-Arroyo I (2020) Dihydrotestosterone induces proliferation, migration, and invasion of human glioblastoma cell lines. Onco Targ Ther 13:8813","journal-title":"Onco Targ Ther"},{"issue":"35","key":"571_CR23","doi-asserted-by":"publisher","first-page":"25492","DOI":"10.1074\/jbc.M603193200","volume":"281","author":"M Estrada","year":"2006","unstructured":"Estrada M, Varshney A, Ehrlich BE (2006) Elevated testosterone induces apoptosis in neuronal cells. J Biol Chem 281(35):25492\u201325501. https:\/\/doi.org\/10.1074\/jbc.M603193200","journal-title":"J Biol Chem"},{"issue":"1","key":"571_CR24","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1186\/s13104-018-3468-5","volume":"11","author":"N Zouei","year":"2018","unstructured":"Zouei N, Shojaee S, Mohebali M, Keshavarz H (2018) The association of latent toxoplasmosis and level of serum testosterone in humans. BMC Res Notes 11(1):365. https:\/\/doi.org\/10.1186\/s13104-018-3468-5","journal-title":"BMC Res Notes"},{"issue":"3","key":"571_CR25","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.exppara.2011.03.014","volume":"128","author":"\u0160 Ka\u0148kov\u00e1","year":"2011","unstructured":"Ka\u0148kov\u00e1 \u0160, Kodym P, Flegr J (2011) Direct evidence of Toxoplasma-induced changes in serum testosterone in mice. Exp Parasitol 128(3):181\u2013183","journal-title":"Exp Parasitol"},{"key":"571_CR26","doi-asserted-by":"publisher","first-page":"105938","DOI":"10.1016\/j.actatropica.2021.105938","volume":"220","author":"L Staurengo-Ferrari","year":"2021","unstructured":"Staurengo-Ferrari L, Sanfelice RAdS, de Souza JB, Assolini JP, dos Santos DP, Cataneo AHD et al (2021) Impact of Toxoplasma gondii infection on TM3 leydig cells: alterations in testosterone and cytokines levels. Acta Trop 220:105938. https:\/\/doi.org\/10.1016\/j.actatropica.2021.105938","journal-title":"Acta Trop"},{"issue":"9","key":"571_CR27","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1007\/s10072-012-1264-x","volume":"34","author":"A Abdoli","year":"2013","unstructured":"Abdoli A (2013) Toxoplasma gondii and neuropsychiatric diseases: strain hypothesis. Neurol Sci 34(9):1697\u20131698. https:\/\/doi.org\/10.1007\/s10072-012-1264-x","journal-title":"Neurol Sci"},{"issue":"1","key":"571_CR28","doi-asserted-by":"publisher","first-page":"22","DOI":"10.14737\/journal.jap\/2016\/3.1.22.31","volume":"3","author":"M Galv\u00e1n-Ram\u00edrez","year":"2016","unstructured":"Galv\u00e1n-Ram\u00edrez M, Guti\u00e9rrez-Maldonado A, Due\u00f1as-Jim\u00e9nez J, Rodr\u00edguez-P\u00e9rez L, Troyo-Sanrom\u00e1n R (2016) Effect of 17\u03b2-estradiol and progesterone on astrocytes infected with Toxoplasma. J Adv Parasitol 3(1):22\u201331","journal-title":"J Adv Parasitol"},{"issue":"4","key":"571_CR29","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1046\/j.1365-3024.2002.00451.x","volume":"24","author":"F Gay-Andrieu","year":"2002","unstructured":"Gay-Andrieu F, Cozon GJN, Ferrandiz J, Peyron F (2002) Progesterone fails to modulate Toxoplasma gondii replication in the RAW 264\u00b77 murine macrophage cell line. Parasite Immunol 24(4):173\u2013178. https:\/\/doi.org\/10.1046\/j.1365-3024.2002.00451.x","journal-title":"Parasite Immunol"},{"issue":"2","key":"571_CR30","doi-asserted-by":"publisher","first-page":"e12690","DOI":"10.1111\/pim.12690","volume":"42","author":"C Brito","year":"2020","unstructured":"Brito C, Silva TM, Castro MM, Wyrwas W, Oliveira B, Fonseca BM et al (2020) Toxoplasma gondii infection reduces serum progesterone levels and adverse effects at the maternal-foetal interface. Parasite Immunol 42(2):e12690. https:\/\/doi.org\/10.1111\/pim.12690","journal-title":"Parasite Immunol"},{"issue":"1","key":"571_CR31","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/0165-5728(93)90072-7","volume":"43","author":"W D\u00e4ubener","year":"1993","unstructured":"D\u00e4ubener W, Pilz K, Zennati SS, Bilzer T, Fischer H-G, Hadding U (1993) Induction of toxoplasmostasis in a human glioblastoma by interferon \u03b3. J Neuroimmunol 43(1):31\u201338. https:\/\/doi.org\/10.1016\/0165-5728(93)90072-7","journal-title":"J Neuroimmunol"},{"issue":"3","key":"571_CR32","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1007\/s00401-003-0804-0","volume":"107","author":"M-P Brenier-Pinchart","year":"2004","unstructured":"Brenier-Pinchart M-P, Blanc-Gonnet E, Marche PN, Berger F, Durand F, Ambroise-Thomas P et al (2004) Infection of human astrocytes and glioblastoma cells with Toxoplasma gondii: monocyte chemotactic protein-1 secretion and chemokine expression in vitro. Acta Neuropathol 107(3):245\u2013249. https:\/\/doi.org\/10.1007\/s00401-003-0804-0","journal-title":"Acta Neuropathol"},{"issue":"1","key":"571_CR33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s13071-019-3529-1","volume":"12","author":"L-J Zhou","year":"2019","unstructured":"Zhou L-J, Chen M, Puthiyakunnon S, He C, Xia J, He CY et al (2019) Toxoplasma gondii ROP18 inhibits human glioblastoma cell apoptosis through a mitochondrial pathway by targeting host cell P2X1. Parasit Vectors 12(1):284. https:\/\/doi.org\/10.1186\/s13071-019-3529-1","journal-title":"Parasit Vectors"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-022-00571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-022-00571-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-022-00571-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T14:23:35Z","timestamp":1661264615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-022-00571-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["571"],"URL":"https:\/\/doi.org\/10.1007\/s11686-022-00571-z","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]},"assertion":[{"value":"28 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All the animal experimentations were approved by the Ethics Committee of Tarbiat Modares University, Tehran, Iran.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}