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This research was conducted to assess the effect of some Egyptian herbal extracts against <jats:italic>Toxoplasma gondii<\/jats:italic> (<jats:italic>T. gondii)<\/jats:italic> tachyzoites in vitro.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The methanol extracts of <jats:italic>Withania somnifera, Cyper rotundus<\/jats:italic>, <jats:italic>Acacia nilotica<\/jats:italic><jats:bold>,<\/jats:bold><jats:italic>Chrysanthemum cinerariae folium<\/jats:italic>, <jats:italic>Anethum graveolens<\/jats:italic>, <jats:italic>Raphanus sativus<\/jats:italic>, <jats:italic>Ceratonia siliqua<\/jats:italic>, <jats:italic>Elettaria cardamomum<\/jats:italic> and <jats:italic>Cuminum cyminum<\/jats:italic> were tested against <jats:italic>T. gondii<\/jats:italic> tachyzoites.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among the tested plants, the extracts from <jats:italic>Raphanus sativus, Cuminum cyminum,<\/jats:italic> and <jats:italic>Ceratonia siliqua<\/jats:italic> exhibited high <jats:italic>anti-Toxoplasma<\/jats:italic> activities at 50\u00a0\u00b5g\/ml, relative to sulfadiazine. They showed low IC<jats:sub>50<\/jats:sub> values on <jats:italic>T. gondii<\/jats:italic> (7.92, 9.47 and 13.52\u00a0\u00b5g\/ml, respectively) and high selectivity index values (100.79, 59.19, and 29.05, respectively). Scanning electron microscopy (SEM) findings indicated evident morphological changes in tachyzoites treated with these three herbal extracts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p><jats:italic>Raphanus sativus<\/jats:italic>, <jats:italic>Ceratonia siliqua<\/jats:italic>, and <jats:italic>Cuminum cyminum<\/jats:italic> methanol extracts could be promising sources of new medicament for toxoplasmosis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11686-022-00633-2","type":"journal-article","created":{"date-parts":[[2022,10,30]],"date-time":"2022-10-30T13:02:32Z","timestamp":1667134952000},"page":"1800-1806","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Anti-Toxoplasma Activities of Some Egyptian Plant Extracts: An In Vitro Study"],"prefix":"10.1007","volume":"67","author":[{"given":"Sara T.","family":"Elazab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadwa M.","family":"Arafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,30]]},"reference":[{"key":"633_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X","author":"JG Montoya","year":"2004","unstructured":"Montoya JG, Liesenfeld O (2004) The lancet. 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