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Infections caused by <jats:italic>Schistosoma mansoni<\/jats:italic> (<jats:italic>S. mansoni<\/jats:italic>) can be treated with gold nanoparticles (AuNPs). This study aims to determine the most effective route of AuNPs administration and the magnitude of its anti-fibrotic effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In the five groups' <jats:italic>in vivo<\/jats:italic> assay design, AuNPs were administered intraperitoneally (1\u00a0mg\/kg) and orally (1\u00a0mg\/100\u00a0g) to <jats:italic>S. mansoni<\/jats:italic>-infected mice. Biochemical parameters (serum levels of albumin and liver enzymes alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured. The histological changes of the liver in distinct groups were evaluated using Hematoxylin and Eosin, Masson's trichrome, and immunohistochemical stains.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Infection with <jats:italic>S. mansoni<\/jats:italic> was associated with substantial changes in the histological architecture of liver tissue and abnormal levels of hepatic function tests (albumin, AST, and ALT). <jats:italic>Schistosoma<\/jats:italic> infected hepatocytes exhibited an abnormal microscopic morphology, granuloma formation and aggressive fibrosis. AuNPs restored the liver histological architecture with a highly significant anti-fibrotic effect and significantly corrected hepatic function test levels. Intraperitoneal administration of AuNPs resulted in the most significant anti-fibrotic effect against hepatic <jats:italic>S. mansoni<\/jats:italic> infection as observed in all histological sections with Masson's trichrome being the best stain to represent this fact.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>For treating <jats:italic>S. mansoni<\/jats:italic>-induced chronic liver fibrosis, intraperitoneal administration of AuNPs is a successful and effective route of administration that can be recommended.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11686-023-00730-w","type":"journal-article","created":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T04:35:14Z","timestamp":1700022914000},"page":"190-202","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-fibrotic Effect of Oral Versus Intraperitoneal Administration of Gold Nanoparticles in Hepatic Schistosoma mansoni-Infected Mice"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0310-8725","authenticated-orcid":false,"given":"Shahira Abdelaziz Ali","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samer Eid Mohamed","family":"Gad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omima Mohamed","family":"Eida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Mohamed","family":"Makhlouf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,15]]},"reference":[{"key":"730_CR1","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PNTD.0009706","volume":"15","author":"P Chienwichai","year":"2021","unstructured":"Chienwichai P, Tipthara P, Tarning J et al (2021) Metabolomics reveal alterations in arachidonic acid metabolism in Schistosoma mekongi after exposure to praziquantel. 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