{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T05:38:03Z","timestamp":1776749883774,"version":"3.51.2"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:00:00Z","timestamp":1701907200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002386","name":"Cairo University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background and Objective<\/jats:title>\n                <jats:p><jats:italic>Giardia<\/jats:italic> is a parasitic hard protozoan that causes a variety of parasitological and pathological changes in gastrointestinal epithelial cells and is resistant to a variety of disinfectants and treatments. This study used experimental animals infected with <jats:italic>Giardia Lamblia<\/jats:italic> to assess the potential therapeutic effect of <jats:italic>Lactobacillus casei<\/jats:italic>, <jats:italic>Lactobacillus bulgaricus<\/jats:italic> (Lactobacillus in yoghurt) and curcumin in comparison to one of the commonly used drugs (metronidazole).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The study included 54 Syrian hamsters (<jats:italic>Mesocricetus auratus<\/jats:italic>) that ranged in weight from 80 to 100\u00a0g and were divided into six groups: The effect of the used preparations was assessed in terms of parasitological and histopathological aspects in Group I non-infected healthy control, Group II infected non-treated, Group III infected treated with metronidazole MTZ, Group IV infected treated with <jats:italic>Lactobacillus casei<\/jats:italic>, Group V infected treated with curcumin, and Group VI infected treated with, <jats:italic>Lactobacillus bulgaricus<\/jats:italic> (Lactobacillus in yoghurt). The number of <jats:italic>G. lamblia<\/jats:italic> cysts per gram of stool was counted during the parasitological examination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The difference between the infected non-treated group and all the treated groups was statistically significant (P0.05). When compared to the infected untreated group, <jats:italic>Lactobacillus casei<\/jats:italic> and,<jats:italic> Lactobacillus bulgaricus<\/jats:italic> (Lactobacillus in yoghurt) produced a 100% reduction in <jats:italic>G. lamblia<\/jats:italic> cyst shedding, curcumin produced an 87.80% reduction in number of cysts, and metronidazole produced a 78.4% reduction in number of cysts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our results highlight the potentially effective therapeutic effect of different preparations of probiotics and curcumin against Giardiasis.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11686-023-00744-4","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T16:02:04Z","timestamp":1701964924000},"page":"302-308","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluating the Effect of Lactobacillus casei FEGY 9973 and Curcumin on Experimental Giardiasis"],"prefix":"10.1007","volume":"69","author":[{"given":"Omima M. 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