{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T09:16:41Z","timestamp":1767863801784,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"PAPIIT","award":["IA204822"],"award-info":[{"award-number":["IA204822"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>We analysed the possible synergistic activity among active extracts from <jats:italic>Artemisia cina<\/jats:italic> and <jats:italic>Tagetes lucida<\/jats:italic> combinations on <jats:italic>Haemonchus contortus<\/jats:italic>, a nematode parasitising sheep.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>The work was carried out in vitro on eggs and infective larvae (L3) of <jats:italic>H. contortus<\/jats:italic>. The results were analysed with SAS 9.1, applying the ANOVA and Tukey test, and the lethal concentration (LC) values LC50 and LC90 were determined with regression analysis, employing Proc Probit of SAS 9.1. Additionally, the lethal concentration (LC) was calculated with LC<jats:sub>50<\/jats:sub> and LC<jats:sub>90<\/jats:sub> to determine the synergistic effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results demonstrated a high efficacy of the two plants studied on both nematode eggs and L3 larvae as well as of their combinations. The highest egg hatching inhibition was obtained with a 50\/50 combination, and the best larvae mortality was obtained with 25% <jats:italic>A. cina<\/jats:italic> and 75% <jats:italic>T. lucida<\/jats:italic> at 10\u00a0mg\/mL. Additionally, this combination showed a synergistic effect.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The two plant species studied here can be applied as natural anthelmintic alternatives due to their high bioactive effect and synergistic response.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s11686-024-00839-6","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T12:02:17Z","timestamp":1712145737000},"page":"1132-1140","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synergistic Interaction Effect of Artemisia cina n-hexane Extract and Tagetes lucida Ethyl Acetate Extract on Haemonchus Contortus"],"prefix":"10.1007","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2535-2398","authenticated-orcid":false,"given":"Itzel","family":"Santiago-Figueroa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3693-1670","authenticated-orcid":false,"given":"Manases","family":"Gonz\u00e1lez-Cortazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3376-5128","authenticated-orcid":false,"given":"Julieta Gertrudis","family":"Estrada-Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9231-1556","authenticated-orcid":false,"given":"Jorge Alfredo","family":"Cu\u00e9llar-Ordaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5499-7449","authenticated-orcid":false,"given":"Mar\u00eda Eugenia","family":"L\u00f3pez-Arellano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1429-0331","authenticated-orcid":false,"given":"Francisco Javier","family":"Gonz\u00e1lez-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9872-9112","authenticated-orcid":false,"given":"Agust\u00edn","family":"Olmedo-Ju\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4657-0159","authenticated-orcid":false,"given":"Rosa Isabel","family":"Higuera-Piedrahita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"839_CR1","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.pt.2014.04.009","volume":"30","author":"J Charlier","year":"2014","unstructured":"Charlier J, van der Voort M, Kenyon F et al (2014) Chasing helminths and their economic impact on farmed ruminants. Trends Parasitol 30:361\u2013367. https:\/\/doi.org\/10.1016\/j.pt.2014.04.009","journal-title":"Trends Parasitol"},{"key":"839_CR2","doi-asserted-by":"crossref","unstructured":"Besier RB, Kahn LP, Sargison ND, Van Wyk JA (2016) The Pathophysiology, Ecology and Epidemiology of Haemonchus contortus Infection in Small Ruminants. pp 95\u2013143","DOI":"10.1016\/bs.apar.2016.02.022"},{"key":"839_CR3","doi-asserted-by":"publisher","unstructured":"Bull K, Glover MJ, Rose Vineer H, Morgan ER (2022) Increasing resistance to multiple anthelmintic classes in gastrointestinal nematodes on sheep farms in Southwest England. Vet Rec 190. https:\/\/doi.org\/10.1002\/vetr.1531","DOI":"10.1002\/vetr.1531"},{"key":"839_CR4","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.smallrumres.2011.10.016","volume":"103","author":"JFJ Torres-Acosta","year":"2012","unstructured":"Torres-Acosta JFJ, Sandoval-Castro CA, Hoste H et al (2012) Nutritional manipulation of sheep and goats for the control of gastrointestinal nematodes under hot humid and subhumid tropical conditions. Small Ruminant Res 103:28\u201340. https:\/\/doi.org\/10.1016\/j.smallrumres.2011.10.016","journal-title":"Small Ruminant Res"},{"key":"839_CR5","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s11250-015-0947-8","volume":"48","author":"J Arece-Garc\u00eda","year":"2016","unstructured":"Arece-Garc\u00eda J, L\u00f3pez-Leyva Y, Gonz\u00e1lez-Gardu\u00f1o R et al (2016) Effect of selective anthelmintic treatments on health and production parameters in Pelibuey ewes during lactation. Trop Anim Health Prod 48:283\u2013287. https:\/\/doi.org\/10.1007\/s11250-015-0947-8","journal-title":"Trop Anim Health Prod"},{"key":"839_CR6","doi-asserted-by":"publisher","first-page":"101004","DOI":"10.1016\/j.funeco.2020.101004","volume":"49","author":"AY Ocampo-Guti\u00e9rrez","year":"2021","unstructured":"Ocampo-Guti\u00e9rrez AY, Hern\u00e1ndez-Vel\u00e1zquez VM, Aguilar-Marcelino L et al (2021) Morphological and molecular characterization, predatory behaviour and effect of organic extracts of four nematophagous fungi from Mexico. Fungal Ecol 49:101004. https:\/\/doi.org\/10.1016\/j.funeco.2020.101004","journal-title":"Fungal Ecol"},{"key":"839_CR7","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.3390\/ani11061843","volume":"11","author":"A Nazish","year":"2021","unstructured":"Nazish A, Fozia, Khattak B et al (2021) Antinematode Activity of Abomasum Bacterial Culture Filtrates against Haemonchus contortus in small ruminants. Animals 11:1843. https:\/\/doi.org\/10.3390\/ani11061843","journal-title":"Animals"},{"key":"839_CR8","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2478\/s11686-019-00116-x","volume":"65","author":"T Davuluri","year":"2020","unstructured":"Davuluri T, Chennuru S, Pathipati M et al (2020) In Vitro Anthelmintic activity of three tropical plant extracts on Haemonchus Contortus. Acta Parasitol 65:11\u201318. https:\/\/doi.org\/10.2478\/s11686-019-00116-x","journal-title":"Acta Parasitol"},{"key":"839_CR9","doi-asserted-by":"publisher","first-page":"113664","DOI":"10.1016\/j.jep.2020.113664","volume":"268","author":"O Goni","year":"2021","unstructured":"Goni O, Khan MF, Rahman MM et al (2021) Pharmacological insights on the antidepressant, anxiolytic and aphrodisiac potentials of Aglaonema Hookerianum Schott. J Ethnopharmacol 268:113664. https:\/\/doi.org\/10.1016\/j.jep.2020.113664","journal-title":"J Ethnopharmacol"},{"key":"839_CR10","doi-asserted-by":"publisher","first-page":"10954","DOI":"10.3390\/ijms241310954","volume":"24","author":"D D\u2019Avino","year":"2023","unstructured":"D\u2019Avino D, Cerqua I, Ullah H et al (2023) Beneficial effects of Astragalus membranaceus (Fisch.) Bunge Extract in Controlling Inflammatory Response and preventing asthma features. Int J Mol Sci 24:10954. https:\/\/doi.org\/10.3390\/ijms241310954","journal-title":"Int J Mol Sci"},{"key":"839_CR11","doi-asserted-by":"publisher","first-page":"112241","DOI":"10.1016\/j.biopha.2021.112241","volume":"143","author":"J Fern\u00e1ndez","year":"2021","unstructured":"Fern\u00e1ndez J, Silv\u00e1n B, Entrialgo-Cadierno R et al (2021) Antiproliferative and palliative activity of flavonoids in colorectal cancer. Biomed Pharmacother 143:112241. https:\/\/doi.org\/10.1016\/j.biopha.2021.112241","journal-title":"Biomed Pharmacother"},{"key":"839_CR12","doi-asserted-by":"publisher","unstructured":"Mitra S, Das R, Emran T, Bin et al (2022) Diallyl Disulfide: a bioactive garlic compound with Anticancer potential. Front Pharmacol 13. https:\/\/doi.org\/10.3389\/fphar.2022.943967","DOI":"10.3389\/fphar.2022.943967"},{"key":"839_CR13","doi-asserted-by":"publisher","first-page":"105624","DOI":"10.1016\/j.fitote.2023.105624","volume":"169","author":"PMP Ferreira","year":"2023","unstructured":"Ferreira PMP, de Almeida AAC, Concei\u00e7\u00e3o MLP et al (2023) Cordia oncocalyx and oncocalyxones: from the phytochemistry to the anticancer action and therapeutic benefits against chronic diseases. Fitoterapia 169:105624. https:\/\/doi.org\/10.1016\/j.fitote.2023.105624","journal-title":"Fitoterapia"},{"key":"839_CR14","doi-asserted-by":"publisher","first-page":"113552","DOI":"10.1016\/j.biopha.2022.113552","volume":"154","author":"EG Ferrarini","year":"2022","unstructured":"Ferrarini EG, Paes RS, Baldasso GM et al (2022) Broad-spectrum cannabis oil ameliorates reserpine-induced fibromyalgia model in mice. Biomed Pharmacother 154:113552. https:\/\/doi.org\/10.1016\/j.biopha.2022.113552","journal-title":"Biomed Pharmacother"},{"key":"839_CR15","doi-asserted-by":"publisher","first-page":"4375","DOI":"10.1002\/ptr.7937","volume":"37","author":"T\u00d6 \u015eahin","year":"2023","unstructured":"\u015eahin T\u00d6, Y\u0131lmaz B, Ye\u015filyurt N et al (2023) Recent insights into the nutritional immunomodulation of cancer-related\u2009<\u2009scp\u2009>\u2009microRNAs. Phytother Res 37:4375\u20134397. https:\/\/doi.org\/10.1002\/ptr.7937","journal-title":"Phytother Res"},{"key":"839_CR16","doi-asserted-by":"publisher","first-page":"106250","DOI":"10.1016\/j.phrs.2022.106250","volume":"181","author":"I Cerqua","year":"2022","unstructured":"Cerqua I, Neukirch K, Terlizzi M et al (2022) A vitamin E long-chain metabolite and the inspired drug candidate \u03b1-amplexichromanol relieve asthma features in an experimental model of allergen sensitization. Pharmacol Res 181:106250. https:\/\/doi.org\/10.1016\/j.phrs.2022.106250","journal-title":"Pharmacol Res"},{"key":"839_CR17","doi-asserted-by":"publisher","first-page":"114182","DOI":"10.1016\/j.jep.2021.114182","volume":"276","author":"MN Uddin Chy","year":"2021","unstructured":"Uddin Chy MN, Md A, Chowdhury MdR, et al (2021) Central and peripheral pain intervention by Ophiorrhiza rugosa leaves: potential underlying mechanisms and insight into the role of pain modulators. J Ethnopharmacol 276:114182. https:\/\/doi.org\/10.1016\/j.jep.2021.114182","journal-title":"J Ethnopharmacol"},{"key":"839_CR18","doi-asserted-by":"publisher","first-page":"115788","DOI":"10.1016\/j.biopha.2023.115788","volume":"168","author":"Y A\u00e7ar","year":"2023","unstructured":"A\u00e7ar Y, A\u011fag\u00fcnd\u00fcz D, De Cicco P, Capasso R (2023) Flavonoids: their putative neurologic roles, epigenetic changes, and gut microbiota alterations in Parkinson\u2019s disease. Biomed Pharmacother 168:115788. https:\/\/doi.org\/10.1016\/j.biopha.2023.115788","journal-title":"Biomed Pharmacother"},{"key":"839_CR19","doi-asserted-by":"publisher","first-page":"108401","DOI":"10.1016\/j.exppara.2022.108401","volume":"242","author":"C Garc\u00eda-Hern\u00e1ndez","year":"2022","unstructured":"Garc\u00eda-Hern\u00e1ndez C, Rojo-Rubio R, Gives PM et al (2022) In vitro and in vivo anthelmintic properties of Caesalpinia coriaria fruits against Haemonchus Contortus. Exp Parasitol 242:108401. https:\/\/doi.org\/10.1016\/j.exppara.2022.108401","journal-title":"Exp Parasitol"},{"key":"839_CR20","doi-asserted-by":"publisher","first-page":"3009","DOI":"10.3390\/ijms22063009","volume":"22","author":"A Rolnik","year":"2021","unstructured":"Rolnik A, Olas B (2021) The plants of the Asteraceae Family as agents in the Protection of Human Health. Int J Mol Sci 22:3009. https:\/\/doi.org\/10.3390\/ijms22063009","journal-title":"Int J Mol Sci"},{"key":"839_CR21","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.3390\/biom11101457","volume":"11","author":"KLTD Jayawardene","year":"2021","unstructured":"Jayawardene KLTD, Palombo EA, Boag PR (2021) Natural products are a Promising source for Anthelmintic Drug Discovery. Biomolecules 11:1457. https:\/\/doi.org\/10.3390\/biom11101457","journal-title":"Biomolecules"},{"key":"839_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/6196198","volume":"2017","author":"VP S\u00fclsen","year":"2017","unstructured":"S\u00fclsen VP, Lizarraga E, Mamadalieva NZ, Lago JHG (2017) Potential of Terpenoids and flavonoids from Asteraceae as anti-inflammatory, Antitumor, and Antiparasitic agents. Evidence-Based Complement Altern Med 2017:1\u20132. https:\/\/doi.org\/10.1155\/2017\/6196198","journal-title":"Evidence-Based Complement Altern Med"},{"key":"839_CR23","doi-asserted-by":"publisher","unstructured":"Higuera-Piedrahita RI, Dolores-Hern\u00e1ndez M, Jim\u00e9nez-P\u00e9rez LG et al (2021) In Vitro Nematocidal Effect and Anthelmintic Activity of Artemisia cina against Haemonchus Contortus in Gerbils and relative expression of Hc29 gene in Transitional Larvae (L3\u2013L4). https:\/\/doi.org\/10.1007\/s11686-021-00364-w. Acta Parasitol 66:","DOI":"10.1007\/s11686-021-00364-w"},{"key":"839_CR24","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s11250-022-03103-z","volume":"54","author":"RI Higuera-Piedrahita","year":"2022","unstructured":"Higuera-Piedrahita RI, Dolores-Hern\u00e1ndez M, de la-Cruz-Cruz HA et al (2022) An Artemisia cina n-hexane extract reduces the Haemonchus contortus and Teladorsagia Circumcincta fecal egg count in naturally infected periparturient goats. Trop Anim Health Prod 54:95. https:\/\/doi.org\/10.1007\/s11250-022-03103-z","journal-title":"Trop Anim Health Prod"},{"key":"839_CR25","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jep.2011.04.063","volume":"137","author":"T Eguale","year":"2011","unstructured":"Eguale T, Tadesse D, Giday M (2011) In vitro anthelmintic activity of crude extracts of five medicinal plants against egg-hatching and larval development of Haemonchus Contortus. J Ethnopharmacol 137:108\u2013113. https:\/\/doi.org\/10.1016\/j.jep.2011.04.063","journal-title":"J Ethnopharmacol"},{"key":"839_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1590\/0037-8682-0457-2016","volume":"50","author":"LE Mesa","year":"2017","unstructured":"Mesa LE, Vasquez D, Lutgen P et al (2017) In vitro and in vivo antileishmanial activity of Artemisia annua L. leaf powder and its potential usefulness in the treatment of uncomplicated cutaneous leishmaniasis in humans. Rev Soc Bras Med Trop 50:52\u201360. https:\/\/doi.org\/10.1590\/0037-8682-0457-2016","journal-title":"Rev Soc Bras Med Trop"},{"key":"839_CR27","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/j.jep.2010.04.007","volume":"129","author":"M Lusakibanza","year":"2010","unstructured":"Lusakibanza M, Mesia G, Tona G et al (2010) In vitro and in vivo antimalarial and cytotoxic activity of five plants used in Congolese traditional medicine. J Ethnopharmacol 129:398\u2013402. https:\/\/doi.org\/10.1016\/j.jep.2010.04.007","journal-title":"J Ethnopharmacol"},{"key":"839_CR28","doi-asserted-by":"publisher","first-page":"7521","DOI":"10.3390\/molecules26247521","volume":"26","author":"S Peter","year":"2021","unstructured":"Peter S, Jama S, Alven S, Aderibigbe BA (2021) Artemisinin and derivatives-based hybrid compounds: promising therapeutics for the treatment of Cancer and Malaria. Molecules 26:7521. https:\/\/doi.org\/10.3390\/molecules26247521","journal-title":"Molecules"},{"key":"839_CR29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00436-010-2060-2","volume":"108","author":"A-R Bashtar","year":"2011","unstructured":"Bashtar A-R, Hassanein M, Abdel-Ghaffar F et al (2011) Studies on monieziasis of sheep I. Prevalence and antihelminthic effects of some plant extracts, a light and electron microscopic study. Parasitol Res 108:177\u2013186. https:\/\/doi.org\/10.1007\/s00436-010-2060-2","journal-title":"Parasitol Res"},{"key":"839_CR30","doi-asserted-by":"publisher","first-page":"4745","DOI":"10.1080\/14786419.2021.2005592","volume":"36","author":"P-D Sandra Liliana","year":"2022","unstructured":"Sandra Liliana P-D, Manas\u00e9s G-C, Enrique J-F et al (2022) Isolation, chemical characterization, and anti-inflammatory activity of coumarins, flavonoids, and terpenes from Tagetes lucida. Nat Prod Res 36:4745\u20134750. https:\/\/doi.org\/10.1080\/14786419.2021.2005592","journal-title":"Nat Prod Res"},{"key":"839_CR31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jep.2016.01.040","volume":"181","author":"G P\u00e9rez-Ortega","year":"2016","unstructured":"P\u00e9rez-Ortega G, Gonz\u00e1lez-Trujano ME, \u00c1ngeles-L\u00f3pez GE et al (2016) Tagetes lucida Cav.: Ethnobotany, phytochemistry and pharmacology of its tranquilizing properties. J Ethnopharmacol 181:221\u2013228. https:\/\/doi.org\/10.1016\/j.jep.2016.01.040","journal-title":"J Ethnopharmacol"},{"key":"839_CR32","doi-asserted-by":"publisher","unstructured":"(2019) Actividad antihelm\u00edntica de la vaina de Leucaena leucocephala sobre nematodos gastrointestinales de ovinos (in vitro). Abanico Veterinario 9:. https:\/\/doi.org\/10.21929\/abavet2019.95","DOI":"10.21929\/abavet2019.95"},{"key":"839_CR33","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.3390\/molecules23112847","volume":"23","author":"B Salehi","year":"2018","unstructured":"Salehi B, Valussi M, Morais-Braga M et al (2018) Tagetes spp. Essential oils and other extracts: Chemical characterization and Biological Activity. Molecules 23:2847. https:\/\/doi.org\/10.3390\/molecules23112847","journal-title":"Molecules"},{"key":"839_CR34","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1080\/14786419.2018.1553172","volume":"34","author":"M-B Nayeli","year":"2020","unstructured":"Nayeli M-B, Maribel H-R, Enrique J-F et al (2020) Anti-inflammatory activity of coumarins isolated from Tagetes lucida Cav. Nat Prod Res 34:3244\u20133248. https:\/\/doi.org\/10.1080\/14786419.2018.1553172","journal-title":"Nat Prod Res"},{"key":"839_CR35","doi-asserted-by":"publisher","first-page":"109345","DOI":"10.1016\/j.vetpar.2021.109345","volume":"290","author":"CR Silva","year":"2021","unstructured":"Silva CR, Lifschitz AL, Macedo SRD et al (2021) Combination of synthetic anthelmintics and monoterpenes: Assessment of efficacy, and ultrastructural and biophysical properties of Haemonchus contortus using atomic force microscopy. Vet Parasitol 290:109345. https:\/\/doi.org\/10.1016\/j.vetpar.2021.109345","journal-title":"Vet Parasitol"},{"key":"839_CR36","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.vetpar.2017.06.008","volume":"243","author":"LM Katiki","year":"2017","unstructured":"Katiki LM, Barbieri AME, Araujo RC et al (2017) Synergistic interaction of ten essential oils against Haemonchus contortus in vitro. Vet Parasitol 243:47\u201351. https:\/\/doi.org\/10.1016\/j.vetpar.2017.06.008","journal-title":"Vet Parasitol"},{"key":"839_CR37","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1079\/PNS2004396","volume":"63","author":"S Athanasiadou","year":"2004","unstructured":"Athanasiadou S, Kyriazakis I (2004) Plant secondary metabolites: antiparasitic effects and their role in ruminant production systems. Proc Nutr Soc 63:631\u2013639. https:\/\/doi.org\/10.1079\/PNS2004396","journal-title":"Proc Nutr Soc"},{"key":"839_CR38","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.3390\/pathogens11101160","volume":"11","author":"G Res\u00e9ndiz-Gonz\u00e1lez","year":"2022","unstructured":"Res\u00e9ndiz-Gonz\u00e1lez G, Higuera-Piedrahita RI, Lara-Bueno A et al (2022) In Vitro Anthelmintic activity of a Hydroalcoholic Extract from Guazuma ulmifolia leaves against Haemonchus Contortus. Pathogens 11:1160. https:\/\/doi.org\/10.3390\/pathogens11101160","journal-title":"Pathogens"},{"key":"839_CR39","doi-asserted-by":"publisher","first-page":"PL417","DOI":"10.1016\/S0024-3205(97)01030-8","volume":"61","author":"RJ Tallarida","year":"1997","unstructured":"Tallarida RJ, Stone DJ, Raffa RB (1997) EFFICIENT DESIGNS FOR STUDYING SYNERGISTIC DRUG COMBINATIONS. Life Sci 61:PL417\u2013PL425. https:\/\/doi.org\/10.1016\/S0024-3205(97)01030-8","journal-title":"Life Sci"},{"key":"839_CR40","doi-asserted-by":"publisher","first-page":"820","DOI":"10.3390\/plants12040820","volume":"12","author":"RI Higuera-Piedrahita","year":"2023","unstructured":"Higuera-Piedrahita RI, Dolores-Hern\u00e1ndez M, Cruz-Cruz HA, de la et al (2023) 3\u2032-Demethoxy-6-O-Demethylisoguaiacin and Norisoguaiacin Nematocidal Lignans from Artemisia cina against Haemonchus Contortus Infective Larvae. Plants 12:820. https:\/\/doi.org\/10.3390\/plants12040820","journal-title":"Plants"},{"key":"839_CR41","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/s11250-021-02819-8","volume":"53","author":"LK Diaz-Medina","year":"2021","unstructured":"Diaz-Medina LK, Col\u00edn-Navarro V, Arriaga-Jord\u00e1n CM et al (2021) In vitro nutritional quality and antioxidant activity of three weed species as feed additives for sheep in the Central Highlands of Mexico. Trop Anim Health Prod 53:394. https:\/\/doi.org\/10.1007\/s11250-021-02819-8","journal-title":"Trop Anim Health Prod"},{"key":"839_CR42","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.20546\/ijcmas.2018.710.245","volume":"7","author":"V Khanolkar","year":"2018","unstructured":"Khanolkar V, Panchbhai CG, Bhojne GR et al (2018) Anthelmintic Efficacy of Polyherbal Formulation in Goats naturally infected with Haemonchus Contortus. Int J Curr Microbiol Appl Sci 7:2133\u20132142. https:\/\/doi.org\/10.20546\/ijcmas.2018.710.245","journal-title":"Int J Curr Microbiol Appl Sci"},{"key":"839_CR43","doi-asserted-by":"publisher","first-page":"202","DOI":"10.4103\/0257-7941.107362","volume":"31","author":"U Bhosale","year":"2012","unstructured":"Bhosale U, Pophale P, Somani R, Yegnanarayan R (2012) Effect of aqueous extracts of Achyranthes aspera Linn. On experimental animal model for inflammation. Anc Sci Life 31:202. https:\/\/doi.org\/10.4103\/0257-7941.107362","journal-title":"Anc Sci Life"},{"key":"839_CR44","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s11250-021-02732-0","volume":"53","author":"SZ Ndlela","year":"2021","unstructured":"Ndlela SZ, Mkwanazi MV, Chimonyo M (2021) In vitro efficacy of plant extracts against gastrointestinal nematodes in goats. Trop Anim Health Prod 53:295. https:\/\/doi.org\/10.1007\/s11250-021-02732-0","journal-title":"Trop Anim Health Prod"},{"key":"839_CR45","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00436-010-2218-y","volume":"109","author":"C Kamaraj","year":"2011","unstructured":"Kamaraj C, Rahuman AA, Elango G et al (2011) Anthelmintic activity of botanical extracts against sheep gastrointestinal nematodes, Haemonchus Contortus. Parasitol Res 109:37\u201345. https:\/\/doi.org\/10.1007\/s00436-010-2218-y","journal-title":"Parasitol Res"},{"key":"839_CR46","doi-asserted-by":"publisher","first-page":"100057","DOI":"10.1016\/j.synres.2019.100057","volume":"10","author":"I Messaoudi Moussii","year":"2020","unstructured":"Messaoudi Moussii I, Nayme K, Timinouni M et al (2020) Synergistic antibacterial effects of Moroccan Artemisia herba Alba, Lavandula angustifolia and Rosmarinus officinalis essential oils. Synergy 10:100057. https:\/\/doi.org\/10.1016\/j.synres.2019.100057","journal-title":"Synergy"},{"key":"839_CR47","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1080\/14786419.2019.1639182","volume":"35","author":"J-E Lan","year":"2021","unstructured":"Lan J-E, Li X-J, Zhu X-F et al (2021) Flavonoids from Artemisia rupestris and their synergistic antibacterial effects on drug-resistant Staphylococcus aureus. Nat Prod Res 35:1881\u20131886. https:\/\/doi.org\/10.1080\/14786419.2019.1639182","journal-title":"Nat Prod Res"},{"key":"839_CR48","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1021\/jf053071w","volume":"54","author":"CL C\u00e9spedes","year":"2006","unstructured":"C\u00e9spedes CL, Avila JG, Mart\u00ednez A et al (2006) Antifungal and antibacterial activities of Mexican Tarragon (Tagetes lucida). J Agric Food Chem 54:3521\u20133527. https:\/\/doi.org\/10.1021\/jf053071w","journal-title":"J Agric Food Chem"},{"key":"839_CR49","unstructured":"Higuera-Piedrahita RI (2016) Efecto De Artemisia cina 30CH y Artemisia cina en extracto etan\u00f3lico contra la infecci\u00f3n natural e inducida por Haemonchus Contortus. Universidad Nacional Aut\u00f3noma de M\u00e9xico"},{"key":"839_CR50","doi-asserted-by":"publisher","first-page":"580","DOI":"10.37360\/blacpma.20.19.6.41","volume":"19","author":"PY Villa-Silva","year":"2020","unstructured":"Villa-Silva PY, Ilin\u00e1 A, Ascacio-Vald\u00e9s JA et al (2020) Phenolic compounds of Tagetes lucida Cav. With antibacterial effect due to membrane damage. Bol Latinoam Caribe Plantas Med Aromat 19:580\u2013590. https:\/\/doi.org\/10.37360\/blacpma.20.19.6.41","journal-title":"Bol Latinoam Caribe Plantas Med Aromat"},{"key":"839_CR51","doi-asserted-by":"publisher","first-page":"589","DOI":"10.29312\/remexca.v9i3.1218","volume":"9","author":"J Zarate-Escobedo","year":"2018","unstructured":"Zarate-Escobedo J, Casta\u00f1eda-Gonz\u00e1lez EL, Cuevas-S\u00e1nchez JA et al (2018) Concentraciones e intervalos de aplicaci\u00f3n del aceite esencial de Tagetes lucida cav. Contra Nacobbus aberrans. Rev Mex De Cienc Agric 9:589\u2013600. https:\/\/doi.org\/10.29312\/remexca.v9i3.1218","journal-title":"Rev Mex De Cienc Agric"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-024-00839-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-024-00839-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-024-00839-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T08:18:36Z","timestamp":1718612316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-024-00839-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,3]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["839"],"URL":"https:\/\/doi.org\/10.1007\/s11686-024-00839-6","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,3]]},"assertion":[{"value":"16 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}