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On day 21st, the nucleoprotein-treated mice altogether, with six more mice, received subcutaneously <jats:italic>S. mansoni<\/jats:italic> cercariae (60\/mouse). Eight weeks later, the experimental mice were sacrificed for evaluation of certain parasitological, molecular and immunological responses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The data of mice immunized with the various types of nucleoproteins showed a significant increase of FAS\/R gene expressions in hepatic tissues and anti-IgG antibody levels in sera on the one hand and a significant decrease of worm loads and \u03b2-actin\/R gene expression levels on the other hand when compared to the infected control mice.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>These findings highlight the role of snails in immunomodulation and shed light on the possibility of antagonizing effects that might occur when the nucleoproteins of different species are mixed. Moreover, this research study might promote the literature spotting the importance of snail proteins against schistosomiasis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11686-025-00988-2","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T13:57:45Z","timestamp":1737727065000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Approaches of Inducing Tolerance to Murine Schistosomiasis mansoni applying Biomphalaria and Bulinus Proteins"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7030-0891","authenticated-orcid":false,"given":"Hanan S.","family":"Mossalem","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-3131","authenticated-orcid":false,"given":"Sami Mohamed","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4891-3357","authenticated-orcid":false,"given":"Azza Moustafa","family":"Fahmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3915-3453","authenticated-orcid":false,"given":"Shimaa","family":"Atta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-372X","authenticated-orcid":false,"given":"Gehan Labib","family":"Abuelenain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"issue":"3","key":"988_CR1","doi-asserted-by":"publisher","first-page":"85","DOI":"10.21608\/ejabf.2021.172770","volume":"25","author":"AS Dokmak Et Al","year":"2021","unstructured":"Dokmak Et Al AS, H.-A (2021) Impact of carbamide perhydrate on the snail Bulinus Truncatus, the intermediate host of Schistosoma haematobium. 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