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The larval stage causes human toxocariasis, especially in children, and may result in neurological disorders and blindness. Quercetin is a flavonoid with strong secondary metabolites and possesses medicinal advantages and antiparasitic qualities.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The assay involved \u00a0four groups, each of \u00a010 young adult <jats:italic>T. canis<\/jats:italic>; Group I was incubated in concentrations of an ethanolic extract of quercetin, Group II in  albendazole (0.2 mM\/ml) (+ve control), Group III in RPMI 1640 medium with ethanol (control), and\u00a0Group IV in RPMI 1640 medium only (-ve control). The potential action of quercetin against adult <jats:italic>T. canis<\/jats:italic> in vitro was detected using scanning electron microscopy, histological investigations, and enzyme analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>SEM declared that exposure to LC90 of quercetin caused body shrinkage, cuticle and caudal papillae swelling, and disfigurement and erosion of cuticular annulations. Compared to albendazole's effect on the treated worm's body wall, results showed that quercetin generates oxidative stress and has an extensive and variable effect on <jats:italic>T. canis<\/jats:italic> organs, including the body wall, the gut, and the genitalia.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Quercetin may set the stage for a new class of medications with remarkable potential for treating parasitic nematodes in dogs and could be extended to humans. This is the first time to employ a comprehensive study illuminating the potential action of quercetin against adult <jats:italic>Toxocara canis<\/jats:italic> in vitro.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s11686-025-01026-x","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T12:24:59Z","timestamp":1745411099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In vitro Evaluation of the Nematicidal Efficacy of Quercetin on Adult Toxocara canis"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0487-5659","authenticated-orcid":false,"given":"Rasha A.","family":"Elmahy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-2635","authenticated-orcid":false,"given":"Nahla A.","family":"Radwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"issue":"3","key":"1026_CR1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.3390\/ani13030496","volume":"13","author":"I Abbas","year":"2023","unstructured":"Abbas I, Baghdadi HB, Rizk MA, El-Alfy ES, Elmishmishy B, Gwida M (2023) Gastrointestinal parasites of dogs in Egypt: an update on the prevalence in Dakahlia governorate and a meta-analysis for the published data from the country. 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