{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T01:48:16Z","timestamp":1766627296268,"version":"3.44.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"The Science and Technology Bureau of the Corps","award":["2022ZD090"],"award-info":[{"award-number":["2022ZD090"]}]},{"name":"Health Commission of Xinjiang Production and Construction Corps","award":["CZ001219"],"award-info":[{"award-number":["CZ001219"]}]},{"name":"The First Affiliated Hospital of Shihezi University","award":["BS202207"],"award-info":[{"award-number":["BS202207"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11686-025-01087-y","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:38:19Z","timestamp":1751881099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of Calcifying Nanoparticles Isolated and Cultured in the Outer Capsule Wall of Hepatic Hydatid Cyst and their Correlation with Autophagy"],"prefix":"10.1007","volume":"70","author":[{"given":"Haojie","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanqiang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanli","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangwei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"1087_CR1","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3760\/cma.j.cn115610-20221225-00713","volume":"22","author":"XY Peng","year":"2023","unstructured":"Peng XY, Zhang SJ, Wu XW, Zhang HW, Yang J, Li J (2023) The natural decline and death course of hepatic cystic echinococcsis. Chin J Digest Surg 22:219\u2013225. https:\/\/doi.org\/10.3760\/cma.j.cn115610-20221225-00713","journal-title":"Chin J Digest Surg"},{"key":"1087_CR2","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/S1473-3099(18)30466-3","volume":"18","author":"M Qian","year":"2018","unstructured":"Qian M, Zhou XN (2018) Walk together to combat echinococcosis. Lancet Infect Dis 18:946. https:\/\/doi.org\/10.1016\/S1473-3099(18)30466-3","journal-title":"Lancet Infect Dis"},{"key":"1087_CR3","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/bs.apar.2016.11.001","volume":"95","author":"P Deplazes","year":"2017","unstructured":"Deplazes P, Rinaldi L, Alvarez Rojas CA, Torgerson PR, Harandi MF, Romig T, Antolova D, Schurer JM, Lahmar S, Cringoli G, Magambo J, Thompson RC, Jenkins EJ (2017) Global distribution of alveolar and cystic echinococcosis. Adv Parasit 95:315\u2013493. https:\/\/doi.org\/10.1016\/bs.apar.2016.11.001","journal-title":"Adv Parasit"},{"key":"1087_CR4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1089\/sur.2023.335","volume":"25","author":"A Trigui","year":"2024","unstructured":"Trigui A, Toumi N, Fendri S, Saumtally MS, Zribi I, Akrout A, Mzali R, Ketata S, Dziri C, Amar MB, Boujelbene S (2024) Cystic echinococcosis of the liver: correlation between Intra-Operative ultrasound and Pre-Operative imaging. Surg Infect 25:213\u2013220. https:\/\/doi.org\/10.1089\/sur.2023.335","journal-title":"Surg Infect"},{"key":"1087_CR5","doi-asserted-by":"publisher","first-page":"e0006422","DOI":"10.1371\/journal.pntd.0006422","volume":"12","author":"M Siles-Lucas","year":"2018","unstructured":"Siles-Lucas M, Casulli A, Cirilli R, Carmena D (2018) Progress in the Pharmacological treatment of human cystic and alveolar echinococcosis: compounds and therapeutic targets. PLoS Negl Trop Dis 12:e0006422. https:\/\/doi.org\/10.1371\/journal.pntd.0006422","journal-title":"PLoS Negl Trop Dis"},{"key":"1087_CR6","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.4254\/wjh.v8.i28.1169","volume":"8","author":"M Mihmanli","year":"2016","unstructured":"Mihmanli M, Idiz UO, Kaya C, Demir U, Bostanci O, Omeroglu S, Bozkurt E (2016) Current status of diagnosis and treatment of hepatic echinococcosis. World J Hepatol 8:1169. https:\/\/doi.org\/10.4254\/wjh.v8.i28.1169","journal-title":"World J Hepatol"},{"key":"1087_CR7","doi-asserted-by":"publisher","first-page":"8274","DOI":"10.1073\/pnas.95.14.8274","volume":"95","author":"EO Kajander","year":"1998","unstructured":"Kajander EO, Cift\u00e7ioglu N (1998) Nanobacteria: an alternative mechanism for pathogenic intra-and extracellular calcification and stone formation. Proc Natl Acad Sci U S A 95:8274\u20138279. https:\/\/doi.org\/10.1073\/pnas.95.14.8274","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1087_CR8","doi-asserted-by":"publisher","first-page":"e885","DOI":"10.1002\/cre2.885","volume":"10","author":"S Wang","year":"2024","unstructured":"Wang S, Yang L, Bai G, Gu Y, Fan Q, Guan X, Yuan J, Liu J (2024) A preliminary study on calcifying nanoparticles in dental plaque: isolation, characterization, and potential mineralization mechanism. Clin Exp Dent Res 10:e885. https:\/\/doi.org\/10.1002\/cre2.885. -n\/a","journal-title":"Clin Exp Dent Res"},{"key":"1087_CR9","doi-asserted-by":"publisher","first-page":"3165","DOI":"10.3892\/etm.2017.4864","volume":"14","author":"Z He","year":"2017","unstructured":"He Z, Jing Z, Jing-Cun Z, Chuan-Yi H, Fei G (2017) Compositional analysis of various layers of upper urinary tract stones by infrared spectroscopy. Exp Ther Med 14:3165\u20133169. https:\/\/doi.org\/10.3892\/etm.2017.4864","journal-title":"Exp Ther Med"},{"key":"1087_CR10","unstructured":"Jun ZM, Hong FC, Chun ZD (2015) The cytotoxic effect of nanobacteria on human osteoblast cells. 14\u201318"},{"key":"1087_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10495-021-01687-9","volume":"26","author":"S Das","year":"2021","unstructured":"Das S, Shukla N, Singh SS, Kushwaha S, Shrivastava R (2021) Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis 26:1\u201322. https:\/\/doi.org\/10.1007\/s10495-021-01687-9","journal-title":"Apoptosis"},{"key":"1087_CR12","doi-asserted-by":"publisher","first-page":"e0181528","DOI":"10.1371\/journal.pone.0181528","volume":"12","author":"MC Nicolao","year":"2017","unstructured":"Nicolao MC, Loos JA, Rodriguez Rodrigues C, Beas V, Cumino AC (2017) Bortezomib initiates Endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage. PLoS ONE 12:e0181528. https:\/\/doi.org\/10.1371\/journal.pone.0181528","journal-title":"PLoS ONE"},{"key":"1087_CR13","doi-asserted-by":"publisher","first-page":"e0126009","DOI":"10.1371\/journal.pone.0126009","volume":"10","author":"JA Loos","year":"2015","unstructured":"Loos JA, Cumino AC (2015) In vitro anti-echinococcal and metabolic effects of Metformin involve activation of AMP-activated protein kinase in larval stages of Echinococcus granulosus. PLoS ONE 10:e0126009. https:\/\/doi.org\/10.1371\/journal.pone.0126009","journal-title":"PLoS ONE"},{"key":"1087_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00240-003-0304-7","volume":"31","author":"EO Kajander","year":"2003","unstructured":"Kajander EO, Ciftcioglu N, Aho K, Garcia-Cuerpo E (2003) Characteristics of nanobacteria and their possible role in stone formation. Urol Res 31:47\u201354. https:\/\/doi.org\/10.1007\/s00240-003-0304-7","journal-title":"Urol Res"},{"key":"1087_CR15","unstructured":"Liu X, Chen J, Zhu YS, JI MY, Chen CM, Chen KF, SU HW (2020) Mechanism of autophagy on the formation of kidney stones caused by calcified nanoparticles. J Med Postgrad 2020:44\u201349"},{"key":"1087_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.3892\/ijmm.2021.4982","volume":"48","author":"Z Wang","year":"2021","unstructured":"Wang Z, Zhang Y, Zhang J, Deng Q, Liang H (2021) Recent advances on the mechanisms of kidney stone formation. Int J Mol Med 48:149. https:\/\/doi.org\/10.3892\/ijmm.2021.4982","journal-title":"Int J Mol Med"},{"key":"1087_CR17","first-page":"51","volume":"3","author":"T Kang","year":"2023","unstructured":"Kang T, Mao H, Lin J, Zhu T, Zhang L, Zhang D, Wu W, Ou S (2023) Effects of autophagy on vascular calcification in chronic kidney disease. Chin J Compar Med 3:51\u201360","journal-title":"Chin J Compar Med"},{"key":"1087_CR18","first-page":"507","volume":"38","author":"J Yang","year":"2022","unstructured":"Yang J, Peng X, Zhang H, Yang J, Zhang Y, Wu X (2022) Isolation culture and morphological observation of calcifying nanoparticles in the pericyst wall of hepatic hydatid cyst. J Shihezi University(Natural Science) 38:507\u2013512","journal-title":"J Shihezi University(Natural Science)"},{"key":"1087_CR19","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1080\/13102818.2015.1052761","volume":"29","author":"S Yaghobee","year":"2015","unstructured":"Yaghobee S, Bayani M, Samiei N, Jahedmanesh N (2015) What are the nanobacteria? Biotechnol Biotec Eq.\u00a029:826\u2013833","journal-title":"Biotechnol Biotec Eq"},{"key":"1087_CR20","doi-asserted-by":"crossref","unstructured":"Yang J, Wang M, Chu Z, Zhang Y, Yang J, Chen X, Wu X, Peng X (2022) Role of calcified nanoparticles in the calcification of cystic hepatic hydatid in Northern xinjiang, china: a preliminary study. Acta Med Mediterr 1335\u20131346","DOI":"10.1515\/biol-2022-0503"},{"key":"1087_CR21","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","volume":"13","author":"J Liu","year":"2022","unstructured":"Liu J, Gao J, Liang Z, Gao C, Niu Q, Wu F, Zhang L (2022) Mesenchymal stem cells and their microenvironment. Stem Cell Res Ther 13:429. https:\/\/doi.org\/10.1186\/s13287-022-02985-y","journal-title":"Stem Cell Res Ther"},{"key":"1087_CR22","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.rvsc.2020.11.010","volume":"135","author":"ID Woolsey","year":"2021","unstructured":"Woolsey ID, Miller AL (2021) Echinococcus granulosus sensu Lato and Echinococcus multilocularis: A review. Res Vet Sci 135:517\u2013522. https:\/\/doi.org\/10.1016\/j.rvsc.2020.11.010","journal-title":"Res Vet Sci"},{"key":"1087_CR23","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.actatropica.2018.02.027","volume":"182","author":"M Conchedda","year":"2018","unstructured":"Conchedda M, Caddori A, Caredda A, Capra S, Bortoletti G (2018) Degree of calcification and cyst activity in hepatic cystic echinococcosis in humans. Acta Trop 182:135\u2013143. https:\/\/doi.org\/10.1016\/j.actatropica.2018.02.027","journal-title":"Acta Trop"},{"key":"1087_CR24","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.2147\/IJN.S63189","volume":"9","author":"LW Hunter","year":"2014","unstructured":"Hunter LW, Charlesworth JE, Yu S, Lieske JC, Miller VM (2014) Calcifying nanoparticles promote mineralization in vascular smooth muscle cells: implications for atherosclerosis. Int J Nanomed 9:2689\u20132698. https:\/\/doi.org\/10.2147\/IJN.S63189","journal-title":"Int J Nanomed"},{"key":"1087_CR25","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1038\/cr.2014.84","volume":"24","author":"B Ma","year":"2014","unstructured":"Ma B, Cao W, Li W, Gao C, Qi Z, Zhao Y, Du J, Xue H, Peng J, Wen J, Chen H, Ning Y, Huang L, Zhang H, Gao X, Yu L, Chen YG (2014) Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation. Cell Res 24:912\u2013924","journal-title":"Cell Res"},{"key":"1087_CR26","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/cdd.2010.191","volume":"18","author":"R Kang","year":"2011","unstructured":"Kang R, Zeh HJ, Lotze MT, Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ 18:571\u2013580. https:\/\/doi.org\/10.1038\/cdd.2010.191","journal-title":"Cell Death Differ"},{"key":"1087_CR27","doi-asserted-by":"crossref","unstructured":"Xie Y, Kang R, Tang D (2016) Role of the Beclin 1 network in the cross-regulation between autophagy and apoptosis. Autophagy: cancer, other pathologies, inflammation, immunity, infection, and aging. Elsevier, pp 75\u201388","DOI":"10.1016\/B978-0-12-802937-4.00002-8"},{"key":"1087_CR28","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1002\/pro.2984","volume":"25","author":"Y Mei","year":"2016","unstructured":"Mei Y, Glover K, Su M, Sinha SC (2016) Conformational flexibility of BECN1: essential to its key role in autophagy and beyond. Protein Sci 25:1767\u20131785. https:\/\/doi.org\/10.1002\/pro.2984","journal-title":"Protein Sci"},{"key":"1087_CR29","doi-asserted-by":"publisher","first-page":"75","DOI":"10.30699\/IJP.2021.530887.2649","volume":"17","author":"NS Holah","year":"2022","unstructured":"Holah NS, El-Dien MMS, Mahmoud SF (2022) Expression of autophagy markers Beclin1 and LC3B in prostatic carcinoma: an immunohistochemical case-control study. Iran J Pathol 17:75. https:\/\/doi.org\/10.30699\/IJP.2021.530887.2649","journal-title":"Iran J Pathol"},{"key":"1087_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-021-00639-9","volume":"11","author":"X Zhou","year":"2021","unstructured":"Zhou X, Xu SN, Yuan ST, Lei X, Sun X, Xing L, Li HJ, He CX, Qin W, Zhao D, Li PQ, Moharomd E, Xu X, Cao HL (2021) Multiple functions of autophagy in vascular calcification. Cell Biosci 11:1\u201314. https:\/\/doi.org\/10.1186\/s13578-021-00639-9","journal-title":"Cell Biosci"},{"key":"1087_CR31","doi-asserted-by":"publisher","first-page":"e108863","DOI":"10.15252\/embj.2021108863","volume":"40","author":"DJ Klionsky","year":"2021","unstructured":"Klionsky DJ, Petroni G, Amaravadi RK et al (2021) Autophagy in major human diseases. EMBO J 40:e108863. https:\/\/doi.org\/10.15252\/embj.2021108863","journal-title":"EMBO J"},{"key":"1087_CR32","unstructured":"Wu Chengwen 2019 AGEs induce autophagy and promote calcification of human aortic smooth muscle cells (Master\u2019s thesis, Southwest Medical University)"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-025-01087-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01087-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:32:20Z","timestamp":1757485940000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-025-01087-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,7]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1087"],"URL":"https:\/\/doi.org\/10.1007\/s11686-025-01087-y","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"type":"print","value":"1230-2821"},{"type":"electronic","value":"1896-1851"}],"subject":[],"published":{"date-parts":[[2025,7,7]]},"assertion":[{"value":"18 February 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Science and Technology Ethics Committee of the First Affiliated Hospital of Shihezi University School of Medicine (Approval number: KJ2022-221-02). All experimental procedures were conducted in accordance with the relevant guidelines and regulations. Written informed consent was obtained from the research subjects included in this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"148"}}