{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T17:02:44Z","timestamp":1758042164720,"version":"3.44.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11686-025-01104-0","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T12:16:16Z","timestamp":1753186576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sequence Localization of SeGPx in S. digitata Genome Contigs and Determination of its Presence in the Whole Worm Extract"],"prefix":"10.1007","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1203-7342","authenticated-orcid":false,"given":"Jefrillah","family":"Jebaseelan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sankar","family":"Natesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-4987","authenticated-orcid":false,"given":"Anand Setty","family":"Balakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,7,22]]},"reference":[{"key":"1104_CR1","doi-asserted-by":"publisher","first-page":"662766","DOI":"10.3389\/fcimb.2021.662766","volume":"11","author":"A Hotterbeekx","year":"2021","unstructured":"Hotterbeekx A, Perneel J, Vieri MK, Colebunders R, Kumar-Singh S (2021) The secretome of filarial nematodes and its role in host-parasite interactions and pathogenicity in onchocerciasis-associated epilepsy. Front Cell Infect Microbiol 11:662766. https:\/\/doi.org\/10.3389\/fcimb.2021.662766","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"1104_CR2","first-page":"164","volume":"10","author":"A Altuhafi","year":"2021","unstructured":"Altuhafi A et al (2021) The correlation between selenium-dependent glutathione peroxidase activity and oxidant\/antioxidant balance in sera of diabetic patients with nephropathy. Rep Biochem Mol Biol 10(2):164\u2013172","journal-title":"Rep Biochem Mol Biol"},{"issue":"1","key":"1104_CR3","first-page":"49","volume":"13","author":"W Sun","year":"2012","unstructured":"Sun W, Song X, Yan R, Xu L, Li X (2012) Cloning and characterisation of a selenium-independent glutathione peroxidase (HC29) from adult Haemonchus contortus. J VetSci 13(1):49\u201358","journal-title":"J VetSci"},{"issue":"5","key":"1104_CR4","doi-asserted-by":"publisher","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","volume":"1830","author":"R Brigelius-Floh\u00e9","year":"2013","unstructured":"Brigelius-Floh\u00e9 R, Maiorino M (2013) Glutathione peroxidases. BiochimBiophysActa 1830(5):3289\u20133303. https:\/\/doi.org\/10.1016\/j.bbagen.2012.11.020","journal-title":"BiochimBiophysActa"},{"key":"1104_CR5","first-page":"108332","volume":"207","author":"ML doCarmo Santos","year":"2024","unstructured":"doCarmo Santos ML et al (2024) The selenium-independent phospholipid hydroperoxide glutathione peroxidase from Theobroma cacao (TcPHGPX) protects plant cells against damage and cell death. Plant PhysiolBiochem 207:108332","journal-title":"Plant PhysiolBiochem"},{"issue":"9","key":"1104_CR6","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.3390\/nu13093238","volume":"13","author":"DE Handy","year":"2021","unstructured":"Handy DE, Joseph J, Loscalzo J (2021) Selenium, a micronutrient that modulates cardiovascular health via redox enzymology. Nutrients 13(9):3238. https:\/\/doi.org\/10.3390\/nu13093238","journal-title":"Nutrients"},{"issue":"4","key":"1104_CR7","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/j.bbrc.2005.03.235","volume":"331","author":"A Singh","year":"2005","unstructured":"Singh A, Rathaur S (2005) Identification and characterisation of a selenium-dependent glutathione peroxidase in Setaria cervi. BiochemBiophys Res Commun 331(4):1069\u20131074. https:\/\/doi.org\/10.1016\/j.bbrc.2005.03.235","journal-title":"BiochemBiophys Res Commun"},{"issue":"8","key":"1104_CR8","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.trstmh.2010.02.007","volume":"104","author":"A Singh","year":"2010","unstructured":"Singh A, Kamal S, Rathaur S (2010) Filarial selenium glutathione peroxidase: a probable immunodiagnostic marker for lymphatic filariasis. Trans R Soc Trop Med Hyg 104(8):524\u2013528. https:\/\/doi.org\/10.1016\/j.trstmh.2010.02.007","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"9","key":"1104_CR9","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.25258\/phyto.v9i09.10309","volume":"9","author":"DR Behera","year":"2017","unstructured":"Behera DR, Bhatnagar S (2017) Macrofilaricidal activity of leaf extracts of Rauvolfia tetraphylla L. against bovine filarial parasite Setaria cervi. Int J Pharm Phytochem Res 9(9):1217\u20131222. https:\/\/doi.org\/10.25258\/phyto.v9i09.10309","journal-title":"Int J Pharm Phytochem Res"},{"issue":"2","key":"1104_CR10","first-page":"493","volume":"52","author":"S Gupta","year":"2005","unstructured":"Gupta S, Rathaur S (2005) Filarial glutathione S-transferase: its induction by xenobiotics and potential as drug target. Acta Biochim Pol 52(2):493\u2013500","journal-title":"Acta Biochim Pol"},{"issue":"35","key":"1104_CR11","doi-asserted-by":"publisher","first-page":"25198","DOI":"10.1039\/D4RA03461A","volume":"14","author":"S Kumar","year":"2024","unstructured":"Kumar S et al (2024) Anti-filarial efficacy of Centratherumanthelminticum: unravelling the underlying mechanisms through biochemical, HRAMS proteomics and MD simulation approaches. RSC Adv 14(35):25198\u201325220. https:\/\/doi.org\/10.1039\/D4RA03461A","journal-title":"RSC Adv"},{"issue":"4","key":"1104_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.cbpb.2010.04.007","volume":"156","author":"JL Thompson","year":"2010","unstructured":"Thompson JL, See VHL, Thomas PM, Schuller KA (2010) Cloning and characterization of two glutathione peroxidase cDNAs from southern bluefin tuna (Thunnus maccoyii). Comp BiochemPhysiol B BiochemMolBiol 156(4):287\u2013297. https:\/\/doi.org\/10.1016\/j.cbpb.2010.04.007","journal-title":"Comp BiochemPhysiol B BiochemMolBiol"},{"key":"1104_CR13","first-page":"158","volume":"70","author":"DE Paglia","year":"1967","unstructured":"Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 70:158\u2013169","journal-title":"J Lab Clin Med"},{"issue":"4","key":"1104_CR14","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1002\/1522-2683(200202)23:4<513::AID-ELPS513>3.0.CO;2-J","volume":"23","author":"CL Lin","year":"2002","unstructured":"Lin CL, Chen HJ, Hou WC (2002) Activity staining of glutathione peroxidase after electrophoresis on native and sodium dodecyl sulfate polyacrylamide gels. Electrophoresis 23(4):513\u2013516. https:\/\/doi.org\/10.1002\/1522-2683(200202)23:4%3c513::AID-ELPS513%3e3.0.CO;2-J","journal-title":"Electrophoresis"},{"issue":"5","key":"1104_CR15","first-page":"215","volume":"9","author":"M Alaa","year":"2016","unstructured":"Alaa M, Abbas MS, Aly UI, El-Shabrawi HM (2016) In vitro selection and characterisation of salt-tolerant cell lines in cassava plant (Manihot esculenta Crantz). Int J ChemTech Res 9(5):215\u2013227","journal-title":"Int J ChemTech Res"},{"key":"1104_CR16","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"SF Altschul","year":"1997","unstructured":"Altschul SF, Madden TL, Sch\u00e4ffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389\u20133402. https:\/\/doi.org\/10.1093\/nar\/25.17.3389","journal-title":"Nucleic Acids Res"},{"key":"1104_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12859-021-04070-6","volume":"22","author":"Y Jin","year":"2021","unstructured":"Jin Y, Tamura T, Aoki Y, Kuroda M, Katoh K (2021) PSI-BLAST enhances the sensitivity and selectivity of homology searches. BMC Bioinformatics 22:113. https:\/\/doi.org\/10.1186\/s12859-021-04070-6","journal-title":"BMC Bioinformatics"},{"key":"1104_CR18","doi-asserted-by":"publisher","first-page":"101518","DOI":"10.1016\/j.redox.2020.101518","volume":"32","author":"JM Stolwijk","year":"2020","unstructured":"Stolwijk JM et al (2020) Simultaneous detection of the enzyme activities of GPx1 and GPx4 guides optimisation of selenium in cell biological experiments. Redox Biol 32:101518. https:\/\/doi.org\/10.1016\/j.redox.2020.101518","journal-title":"Redox Biol"},{"key":"1104_CR19","doi-asserted-by":"publisher","first-page":"102719","DOI":"10.1016\/j.redox.2023.102719","volume":"63","author":"DM Cheff","year":"2023","unstructured":"Cheff DM et al (2023) Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4. Redox Biol 63:102719. https:\/\/doi.org\/10.1016\/j.redox.2023.102719","journal-title":"Redox Biol"},{"issue":"3","key":"1104_CR20","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S1016-8478(23)13126-8","volume":"18","author":"CW Kho","year":"2004","unstructured":"Kho CW, Park SG, Cho S, Oh GT, Kang S, Park BC (2004) Activity staining of glutathione peroxidase after two-dimensional gel electrophoresis. Mol Cells 18(3):369\u2013373","journal-title":"Mol Cells"},{"issue":"4","key":"1104_CR21","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3390\/biomedicines10040891","volume":"10","author":"K Weaver","year":"2022","unstructured":"Weaver K, Skouta R (2022) Theselenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities. Biomedicines 10(4):891. https:\/\/doi.org\/10.3390\/biomedicines10040891","journal-title":"Biomedicines"},{"key":"1104_CR22","doi-asserted-by":"publisher","first-page":"1147414","DOI":"10.3389\/fphar.2023.1147414","volume":"14","author":"J Pei","year":"2023","unstructured":"Pei J, Pan X, Wei G, Hua Y (2023) Research progress of glutathione peroxidase family (GPX) in redoxidation. Front Pharmacol 14:1147414. https:\/\/doi.org\/10.3389\/fphar.2023.1147414","journal-title":"Front Pharmacol"},{"key":"1104_CR23","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1007\/s11686-022-00523-7","volume":"67","author":"P Joshi","year":"2022","unstructured":"Joshi P, Mishra PKK (2022) Functional diversity of the excretory\/secretory proteins of nematode parasites. Acta Parasitol 67:619\u2013627. https:\/\/doi.org\/10.1007\/s11686-022-00523-7","journal-title":"Acta Parasitol"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01104-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-025-01104-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01104-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T14:03:36Z","timestamp":1757599416000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-025-01104-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,22]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["1104"],"URL":"https:\/\/doi.org\/10.1007\/s11686-025-01104-0","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"type":"print","value":"1230-2821"},{"type":"electronic","value":"1896-1851"}],"subject":[],"published":{"date-parts":[[2025,7,22]]},"assertion":[{"value":"19 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"166"}}