{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:56:38Z","timestamp":1791593798936,"version":"4.3.4"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02466-21"],"award-info":[{"award-number":["APQ-02466-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-02466-21"],"award-info":[{"award-number":["APQ-02466-21"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1007\/s11686-025-01136-6","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T08:29:07Z","timestamp":1760603347000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In Vitro Action of Papaya (Carica Papaya) Latex and Pure Papain Against Eimeria Bovis Oocysts"],"prefix":"10.1007","volume":"70","author":[{"given":"Lucas Nogueira","family":"de Siqueira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Castro Toledo","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth Celestina Condori","family":"Mamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisseth Bibiana Puentes","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"La\u00edsa Bastos","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago Facury","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Ribeiro","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippe Elias","family":"de Freitas Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"1136_CR1","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/978-3-031-38589-6_11","volume-title":"Brazilian crops in the global market. Palgrave studies in economic history","author":"HS Klein","year":"2023","unstructured":"Klein HS, Luna FV (2023) Cattle. In: Brazilian crops in the global market. Palgrave studies in economic history. Springer, Cham, pp 295\u2013323. https:\/\/doi.org\/10.1007\/978-3-031-38589-6_11"},{"key":"1136_CR2","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.14202\/vetworld.2023.1489-1495","volume":"16","author":"B Keomoungkhoun","year":"2023","unstructured":"Keomoungkhoun B, Arjentinia IPGY, Sangmaneedet S, Taweenan W (2023) First report on the molecular prevalence and associated risk factors of Eimeria spp. in dairy cattle In Khon kaen, Thailand. Vet World 16:1489","journal-title":"Vet World"},{"key":"1136_CR3","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00436-019-06481-w","volume":"119","author":"S Lopez-Osorio","year":"2020","unstructured":"Lopez-Osorio S, Villar D, Failing K, Taubert A, Hermosilla C, Chaparro-Gutierrez JJ (2020) Epidemiological survey and risk factor analysis on Eimeria infections in calves and young cattle up to 1 year old in Colombia. Parasitology 119:255\u2013266","journal-title":"Parasitology"},{"key":"1136_CR4","first-page":"373","volume":"66","author":"SD Ola-Fadunsin","year":"2020","unstructured":"Ola-Fadunsin SD, Rabiu M, Hussain K, Sanda IM, Ganiyu IA (2020) Epidemiological studies of Eimeria species of cattle in ilorin, North-Central Nigeria. Ann Parasitol 66:373\u2013384","journal-title":"Ann Parasitol"},{"key":"1136_CR5","doi-asserted-by":"publisher","first-page":"2339","DOI":"10.14202\/vetworld.2021.2339-2345","volume":"14","author":"F Ekawasti","year":"2021","unstructured":"Ekawasti F, Nurcahyo RW, Firdausy LW, Wardhana AH, Sawitri DH, Prastowo J, Priyowidodo D (2021) Prevalence and risk factors associated with Eimeria species infection in cattle of different geographical regions of Indonesia. Vet World 14:2339\u20132345. https:\/\/doi.org\/10.14202\/vetworld.2021.2339-2345","journal-title":"Vet World"},{"key":"1136_CR6","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1007\/s00436-021-07338-x","volume":"121","author":"S Lopez-Osorio","year":"2022","unstructured":"Lopez-Osorio S, Velasquez ZD, Conejeros I, Taubert A, Hermosilla C (2022) Morphometric analysis of aerobic Eimeria Bovis sporogony using live cell 3D holotomographic microscopy imaging. Parasitol Res 121:1179\u20131189. https:\/\/doi.org\/10.1007\/s00436-021-07338-x","journal-title":"Parasitol Res"},{"key":"1136_CR7","doi-asserted-by":"publisher","first-page":"110286","DOI":"10.1016\/j.vetpar.2024.110286","volume":"331","author":"SM Razavi","year":"2024","unstructured":"Razavi SM, Soltan MS, Abbasian K, Karami A, Nazifi S (2024) Acute phase response and oxidative stress in coccidiosis: a review in domestic animals. Vet Parasitol 331:110286","journal-title":"Vet Parasitol"},{"key":"1136_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vetpar.2015.06.024","volume":"212","author":"B Lassen","year":"2015","unstructured":"Lassen B, Bangoura B, Lepik T, Orro T (2015) Systemic acute phase proteins response in calves experimentally infected with Eimeria Zuernii. Vet Parasitol 212:140\u2013146","journal-title":"Vet Parasitol"},{"key":"1136_CR9","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1146\/annurev.biochem.77.061606.161055","volume":"302","author":"C Hermosilla","year":"2012","unstructured":"Hermosilla C, Ruiz A, Taubert A (2012) Eimeria bovis: an update on parasite-host cell interactions. Int J Med Microbiol 302:210\u2013215. https:\/\/doi.org\/10.1146\/annurev.biochem.77.061606.161055","journal-title":"Int J Med Microbiol"},{"key":"1136_CR10","doi-asserted-by":"publisher","first-page":"703413","DOI":"10.3389\/fcimb.2021.703413","volume":"11","author":"ZD Vel\u00e1squez","year":"2021","unstructured":"Vel\u00e1squez ZD, L\u00f3pez-Osorio S, Mazurek S, Hermosilla C, Taubert A (2021) Eimeria Bovis macromeront formation induces glycolytic responses and mitochondrial changes in primary host endothelial cells. Front Cell Infect Microbiol 11:703413","journal-title":"Front Cell Infect Microbiol"},{"key":"1136_CR11","doi-asserted-by":"publisher","first-page":"100049","DOI":"10.1016\/j.napere.2023.100049","volume":"6","author":"HLB Castro","year":"2023","unstructured":"Castro HLB, Braga FR, de Freitas Soares FE (2023) Potential of plant cysteine proteases against crop pests and animal parasites. J Nat Pestic Res 6:100049","journal-title":"J Nat Pestic Res"},{"key":"1136_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2021.e00933","author":"JM Dotto","year":"2021","unstructured":"Dotto JM, Abihudi S (2021) Nutraceutical value of Carica papaya: a review. Sci Afr 13. https:\/\/doi.org\/10.1016\/j.sciaf.2021.e00933","journal-title":"Sci Afr 13"},{"key":"1136_CR13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/B978-0-323-91942-5.00010-0","volume-title":"Natural products in vector-borne disease management","author":"N Malviya","year":"2023","unstructured":"Malviya N, Saxena R, Gupta R, Malviya S (2023) Scientific and ethnopharmacological evidence of Carica Papaya for the effective management of vector-borne disease. Natural products in Vector-Borne disease management. Academic, Cambridge, pp 467\u2013497"},{"key":"1136_CR14","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/j.drudis.2019.12.007","volume":"25","author":"M Zaj\u00ed\u010dkov\u00e1","year":"2020","unstructured":"Zaj\u00ed\u010dkov\u00e1 M, Nguyen LT, Sk\u00e1lov\u00e1 L, Stuchl\u00edkov\u00e1 LR, Matou\u0161kov\u00e1 P (2020) Anthelmintics in the future: current trends in the discovery and development of new drugs against gastrointestinal nematodes. Drug Discov Today 25:430\u2013437. https:\/\/doi.org\/10.1016\/j.drudis.2019.12.007","journal-title":"Drug Discov Today"},{"key":"1136_CR15","first-page":"382","volume":"14","author":"FG Tchodo","year":"2024","unstructured":"Tchodo FG, Dakpogan HB, Gambogou B, N\u2019nanle O, Adjei-Mensah B, Tona K, Bakoma B (2024) Epidemiological investigation of Eimeria species and effectiveness of Togolese medicinal plants used against chicken coccidiosis. J World Poult Res 14:382\u2013398","journal-title":"J World Poult Res"},{"key":"1136_CR16","doi-asserted-by":"publisher","first-page":"375","DOI":"10.5694\/j.1326-5377.1921.tb60654.x","volume":"2","author":"HH Willis","year":"1921","unstructured":"Willis HH (1921) A simple levitation method for the detection of hookworm Ova. Med J Aust 2:375","journal-title":"Med J Aust"},{"key":"1136_CR17","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/S00436-013-3304-8","volume":"112","author":"FEF Soares","year":"2013","unstructured":"Soares FEF, Braga FR, Ara\u00fajo JV, Geni\u00ear HLA, Gouveia AS, Queiroz JH (2013) Nematicidal activity of three novel extracellular proteases of the nematophagous fungus Monacrosporium Sinense. Parasitol Res 112:1557\u20131565. https:\/\/doi.org\/10.1007\/S00436-013-3304-8","journal-title":"Parasitol Res"},{"key":"1136_CR18","doi-asserted-by":"publisher","first-page":"100077","DOI":"10.1016\/j.napere.2024.100077","volume":"8","author":"LBP Figueroa","year":"2024","unstructured":"Figueroa LBP, Mamani RCC, de Souza DC, de Souza Alves JC, de Souza SA, Ferreira CB, de Freitas Soares FE (2024) Enzyme production by the entomopathogenic fungi Beauveria Bassiana and Metarhizium anisopliae and their application in the control of nematodes (Haemonchus spp. and Meloidogyne incognita) in vitro. J Nat Pestic Res 8:100077. https:\/\/doi.org\/10.1016\/j.napere.2024.100077","journal-title":"J Nat Pestic Res"},{"key":"1136_CR19","volume-title":"BioEstat 3.0: aplica\u00e7\u00f5es estat\u00edsticas Nas \u00e1reas Das ci\u00eancias biol\u00f3gicas e m\u00e9dicas","author":"M Ayres","year":"2003","unstructured":"Ayres M, Ayres JR, Ayres DL, Santos AS (2003) BioEstat 3.0: aplica\u00e7\u00f5es estat\u00edsticas Nas \u00e1reas Das ci\u00eancias biol\u00f3gicas e m\u00e9dicas. Sociedade Civil Mamirau\u00e1, Bel\u00e9m; CNPq, Bras\u00edlia"},{"issue":"9","key":"1136_CR20","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1007\/s11746-010-1582-1","volume":"87","author":"N Barouh","year":"2010","unstructured":"Barouh N, Abdelkafi S, Fouquet B, Pina M, Scheirlinckx F, Carri\u00e8re F, Villeneuve P (2010) Neutral lipid characterization of non-water-soluble fractions of Carica Papaya latex. J Am Oil Chem Soc 87(9):987\u2013995. https:\/\/doi.org\/10.1007\/s11746-010-1582-1","journal-title":"J Am Oil Chem Soc"},{"issue":"7","key":"1136_CR21","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1080\/01647954.2021.1980611","volume":"47","author":"MD Filgueiras","year":"2021","unstructured":"Filgueiras MD, Barreto LP, Fernandes \u00c9KK, Soares FEF (2021) Activity of Papaya (Carica Papaya) latex on Rhipicephalus Microplus (Acari: Ixodidae) under laboratory conditions. Int J Acarol 47(7):638\u2013642","journal-title":"Int J Acarol"},{"issue":"1","key":"1136_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3923\/jp.2018.1.13","volume":"13","author":"Y Cedric","year":"2018","unstructured":"Cedric Y, Payne VK, Nadia NAC, Kodjio N, Kollins E, Megwi L, Kuiate JR, Mbida M (2018) In vitro anticoccidial, antioxidant activities and cytotoxicity of Psidium Guajava extracts. Res J Parasitol 13(1):1\u201313","journal-title":"Res J Parasitol"},{"issue":"1","key":"1136_CR23","first-page":"44","volume":"7","author":"A Abbas","year":"2019","unstructured":"Abbas A, Abbas RZ, Raza MA, Khan MK, Saleemi MK, Saeed Z (2019) In vitro anticoccidial activity of Trachyspermum Ammi (Ajwain) extract on oocysts of Eimeria species of chicken. Adv Life Sci 7(1):44\u201347","journal-title":"Adv Life Sci"},{"key":"1136_CR24","doi-asserted-by":"publisher","first-page":"397","DOI":"10.14202\/vetworld.2022.397-402","volume":"15","author":"AR Daiba","year":"2022","unstructured":"Daiba AR, Kagira JM, Ngotho M, Kimotho J, Maina N (2022) In vitro anticoccidial activity of nanoencapsulated Bromelain against Eimeria spp. Oocysts isolated from goats in Kenya. Vet World 15:397\u2013402. https:\/\/doi.org\/10.14202\/vetworld.2022.397-402","journal-title":"Vet World"},{"issue":"8","key":"1136_CR25","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1007\/s00436-022-07564-x","volume":"121","author":"B Bangoura","year":"2022","unstructured":"Bangoura B, Bhuiya MAI, Kilpatrick M (2022) Eimeria infections in domestic and wild ruminants with reference to control options in domestic ruminants. Parasitol Res 121(8):2207\u20132232","journal-title":"Parasitol Res"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01136-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-025-01136-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-025-01136-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:00:21Z","timestamp":1768813221000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-025-01136-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["1136"],"URL":"https:\/\/doi.org\/10.1007\/s11686-025-01136-6","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]},"assertion":[{"value":"9 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Ethics Committee on Animal Use approved the experimental procedures in experiments of the Federal University of Minas Gerais through protocol no 239\/2019.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"197"}}