{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:09:30Z","timestamp":1788808170866,"version":"build-2803163510"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Central Public-interest Scientific Institution Basal Research Fund","award":["2026JB16"],"award-info":[{"award-number":["2026JB16"]}]},{"name":"Shanghai Sailing Program","award":["24YF2756800"],"award-info":[{"award-number":["24YF2756800"]}]},{"DOI":"10.13039\/501100012421","name":"the Agricultural Science and Technology Innovation Program","doi-asserted-by":"crossref","award":["CAAS-ASTIP-2026-SHVRI"],"award-info":[{"award-number":["CAAS-ASTIP-2026-SHVRI"]}],"id":[{"id":"10.13039\/501100012421","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Parasit."],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s11686-026-01380-4","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:21:33Z","timestamp":1788762093000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["sja-miR-2a-3p is Associated with Apoptosis-Related Responses in Schistosoma japonicum"],"prefix":"10.1007","volume":"71","author":[{"given":"Yuanzhao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"1380_CR1","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1007\/s00436-015-4468-1","volume":"114 7","author":"H Han","year":"2015","unstructured":"Han H, Peng J, Hong Y, Fu Z, Lu K, Li H et al (2015) Comparative characterization of microRNAs in Schistosoma japonicum schistosomula from Wistar rats and BALB\/c mice. Parasitol Res 114 7:2639\u20132647. https:\/\/doi.org\/10.1007\/s00436-015-4468-1","journal-title":"Parasitol Res"},{"key":"1380_CR2","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1186\/s13071-019-3450-7","volume":"12","author":"X Yu","year":"2019","unstructured":"Yu X, Zhai Q, Fu Z, Hong Y, Liu J, Li H et al (2019) Comparative analysis of microRNA expression profiles of adult Schistosoma japonicum isolated from water buffalo and yellow cattle. Parasit Vectors 12:1196. https:\/\/doi.org\/10.1186\/s13071-019-3450-7","journal-title":"Parasit Vectors"},{"key":"1380_CR3","doi-asserted-by":"publisher","first-page":"e21109","DOI":"10.1371\/journal.pone.0021109","volume":"6 6","author":"J Peng","year":"2011","unstructured":"Peng J, Gobert GN, Hong Y, Jiang W, Han H, McManus DP et al (2011) Apoptosis governs the elimination of Schistosoma japonicum from the non-permissive host Microtus fortis. PLoS ONE 6 6:e21109. https:\/\/doi.org\/10.1371\/journal.pone.0021109","journal-title":"PLoS ONE"},{"issue":"1","key":"1380_CR4","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.gene.2016.07.054","volume":"592","author":"T Wang","year":"2016","unstructured":"Wang T, Guo X, Hong Y, Han H, Cao X, Han Y et al (2016) Comparison of apoptosis between adult worms of Schistosoma japonicum from susceptible (BALB\/c mice) and less-susceptible (Wistar rats) hosts. Gene 592(1):71\u201377. https:\/\/doi.org\/10.1016\/j.gene.2016.07.054","journal-title":"Gene"},{"key":"1380_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2026.150235","author":"H Zhong","year":"2026","unstructured":"Zhong H, Li D, Jin Y (2026) Non-coding RNAs in schistosome reproductive maturation. Gene 1004. https:\/\/doi.org\/10.1016\/j.gene.2026.150235","journal-title":"Gene 1004"},{"key":"1380_CR6","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1186\/s13567-019-0642-2","volume":"50","author":"J Yu","year":"2019","unstructured":"Yu J, Yu Y, Li Q, Chen M, Shen H, Zhang R et al (2019) Comprehensive analysis of miRNA profiles reveals the role of Schistosoma japonicum miRNAs at different developmental stages. Vet Res 50:123. https:\/\/doi.org\/10.1186\/s13567-019-0642-2","journal-title":"Vet Res"},{"issue":"11\u201312","key":"1380_CR7","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.ijpara.2023.03.007","volume":"53","author":"C Sun","year":"2023","unstructured":"Sun C, Luo F, You Y, Gu M, Yang W, Yi C et al (2023) MicroRNA-1 targets ribosomal protein genes to regulate the growth, development and reproduction of Schistosoma japonicum. Int J Parasitol 53(11\u201312):637\u2013649. https:\/\/doi.org\/10.1016\/j.ijpara.2023.03.007","journal-title":"Int J Parasitol"},{"key":"1380_CR8","doi-asserted-by":"publisher","first-page":"107724","DOI":"10.1016\/j.actatropica.2025.107724","volume":"268","author":"H Zhong","year":"2025","unstructured":"Zhong H, Zhu D, Dong B, Li H, Fu Z, Liu J et al (2025) Role of sja-let-7 in egg production and reproductive development in female Schistosoma japonicum. Acta Trop 268:107724. https:\/\/doi.org\/10.1016\/j.actatropica.2025.107724","journal-title":"Acta Trop"},{"issue":"1\u20132","key":"1380_CR9","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.molbiopara.2011.12.007","volume":"182","author":"S Liu","year":"2012","unstructured":"Liu S, Cai P, Hou N, Piao X, Wang H, Hung T et al (2012) Genome-wide identification and characterization of a panel of house-keeping genes in Schistosoma japonicum. Mol Biochem Parasitol 182(1\u20132):75\u201382. https:\/\/doi.org\/10.1016\/j.molbiopara.2011.12.007","journal-title":"Mol Biochem Parasitol"},{"key":"1380_CR10","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25 4","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 4:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"1380_CR11","doi-asserted-by":"publisher","first-page":"e3000254","DOI":"10.1371\/journal.pbio.3000254","volume":"17 5","author":"J Wang","year":"2019","unstructured":"Wang J, Chen R, Collins JJ 3rd (2019) Systematically improved in vitro culture conditions reveal new insights into the reproductive biology of the human parasite Schistosoma mansoni. PLoS Biol 17 5:e3000254. https:\/\/doi.org\/10.1371\/journal.pbio.3000254","journal-title":"PLoS Biol"},{"key":"1380_CR12","doi-asserted-by":"publisher","first-page":"402","DOI":"10.3389\/fendo.2018.00402","volume":"9","author":"J O\u2019Brien","year":"2018","unstructured":"O\u2019Brien J, Hayder H, Zayed Y, Peng C (2018) Overview of MicroRNA biogenesis, mechanisms of actions, and circulation. Front Endocrinol (Lausanne) 9:402. https:\/\/doi.org\/10.3389\/fendo.2018.00402","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Acta Parasitologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-026-01380-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11686-026-01380-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11686-026-01380-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:02:36Z","timestamp":1788807756000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11686-026-01380-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["1380"],"URL":"https:\/\/doi.org\/10.1007\/s11686-026-01380-4","relation":{},"ISSN":["1230-2821","1896-1851"],"issn-type":[{"value":"1230-2821","type":"print"},{"value":"1896-1851","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,7]]},"assertion":[{"value":"22 June 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal procedures in this study were carried out in compliance with the ethical guidelines set forth by the Committee for the Care and Use of Laboratory Animals at the Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (Shanghai, China, permit no. SYXK- 20160010). Furthermore, the research protocol was reviewed and approved by the Ethics and Animal Welfare Committee of the Shanghai Veterinary Research Institute (experiment no. SV- 20241011\u201301).","order":2,"name":"Ethics","label":"Ethical Approval","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Consent to Participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Consent for Publication","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"203"}}