{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:23:16Z","timestamp":1792516996974,"version":"4.5.0"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T00:00:00Z","timestamp":1213833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1007\/s11695-008-9599-3","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T15:11:34Z","timestamp":1213801894000},"page":"1183-1187","source":"Crossref","is-referenced-by-count":46,"title":["Obesity, Pancreatitis, and Pancreatic Cancer"],"prefix":"10.1007","volume":"18","author":[{"given":"Andrew A.","family":"Gumbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,19]]},"reference":[{"key":"9599_CR1","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1381\/096089204323093345","volume":"14","author":"DR Cottam","year":"2004","unstructured":"Cottam DR, Mattar SG, Barinas-Mitchell E, et al. The chronic inflammatory hypothesis for the morbidity associated with morbid obesity: implications and effects of weight loss. Obes Surg. 2004;14:589\u2013600.","journal-title":"Obes Surg"},{"key":"9599_CR2","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1158\/0008-5472.CAN-05-4102","volume":"66","author":"NP Nunez","year":"2006","unstructured":"Nunez NP, Oh WJ, Rozenberg J, et al. Accelerated tumor formation in a fatless mouse with type 2 diabetes and inflammation. Cancer Res. 2006;66:5469\u201376.","journal-title":"Cancer Res"},{"key":"9599_CR3","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cyto.2005.05.003","volume":"31","author":"G Gonullu","year":"2005","unstructured":"Gonullu G, Ersoy C, Ersoy A, et al. Relation between insulin resistance and serum concentrations of IL-6 and TNF-alpha in overweight or obese women with early stage breast cancer. Cytokine. 2005;31:264\u20139.","journal-title":"Cytokine"},{"key":"9599_CR4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1467-789X.2004.00142.x","volume":"5","author":"DP Rose","year":"2004","unstructured":"Rose DP, Komninou D, Stephenson GD. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes Rev. 2004;5:153\u201365.","journal-title":"Obes Rev"},{"key":"9599_CR5","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1007\/s00125-005-1868-2","volume":"48","author":"S Nair","year":"2005","unstructured":"Nair S, Lee YH, Rousseau E, et al. Increased expression of inflammation-related genes in cultured preadipocytes\/stromal vascular cells from obese compared with non-obese Pima Indians. Diabetologia. 2005;48:1784\u20138.","journal-title":"Diabetologia"},{"key":"9599_CR6","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1056\/NEJMoa066603","volume":"357","author":"TD Adams","year":"2007","unstructured":"Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753\u201361.","journal-title":"N Engl J Med"},{"key":"9599_CR7","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1158\/1055-9965.EPI-05-0797","volume":"15","author":"EJ Duell","year":"2006","unstructured":"Duell EJ, Casella DP, Burk RD, Kelsey KT, Holly EA. Inflammation, genetic polymorphisms in proinflammatory genes TNF-A, RANTES, and CCR5, and risk of pancreatic adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2006;15:726\u201331.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9599_CR8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/jcp.2003.014498","volume":"57","author":"I Esposito","year":"2004","unstructured":"Esposito I, Menicagli M, Funel N, et al. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma. J Clin Pathol. 2004;57:630\u20136.","journal-title":"J Clin Pathol"},{"key":"9599_CR9","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1038\/sj.ijo.0802987","volume":"29","author":"JV Silha","year":"2005","unstructured":"Silha JV, Krsek M, Sucharda P, Murphy LJ. Angiogenic factors are elevated in overweight and obese individuals. Int J Obes (Lond). 2005;29:1308\u201314.","journal-title":"Int J Obes (Lond)"},{"key":"9599_CR10","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1381\/0960892053723367","volume":"15","author":"AA Gumbs","year":"2005","unstructured":"Gumbs AA, Modlin IM, Ballantyne GH. Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss. Obes Surg. 2005;15:462\u201373.","journal-title":"Obes Surg"},{"key":"9599_CR11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/jsre.1998.5560","volume":"83","author":"TP McDade","year":"1999","unstructured":"McDade TP, Perugini RA, Vittimberga FJ Jr, Carrigan RC, Callery MP. Salicylates inhibit NF-kappaB activation and enhance TNF-alpha-induced apoptosis in human pancreatic cancer cells. J Surg Res. 1999;83:56\u201361.","journal-title":"J Surg Res"},{"key":"9599_CR12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/S0022-4804(03)00166-5","volume":"113","author":"P Somasundar","year":"2003","unstructured":"Somasundar P, Yu AK, Vona-Davis L, McFadden DW. Differential effects of leptin on cancer in vitro. J Surg Res. 2003;113:50\u20135.","journal-title":"J Surg Res"},{"key":"9599_CR13","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.soard.2007.11.009","volume":"4","author":"AA Gumbs","year":"2008","unstructured":"Gumbs AA, Bessler M, Milone L, Schrope B, Chabot J. Contribution of obesity to pancreatic carcinogenesis. Surg Obes Relat Dis. 2008;4:186\u201393.","journal-title":"Surg Obes Relat Dis"},{"key":"9599_CR14","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1381\/0960892053923789","volume":"15","author":"GH Ballantyne","year":"2005","unstructured":"Ballantyne GH, Gumbs A, Modlin IM. Changes in insulin resistance following bariatric surgery and the adipoinsular axis: role of the adipocytokines, leptin, adiponectin and resistin. Obes Surg. 2005;15:692\u20139.","journal-title":"Obes Surg"},{"key":"9599_CR15","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/13651820701286177","volume":"9","author":"HA Pitt","year":"2007","unstructured":"Pitt HA. Hepato-pancreato-biliary fat: the good, the bad and the ugly. HPB (Oxford). 2007;9:92\u20137.","journal-title":"HPB (Oxford)"},{"key":"9599_CR16","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/13651820701504157","volume":"9","author":"A Mathur","year":"2007","unstructured":"Mathur A, Marine M, Lu D, et al. Nonalcoholic fatty pancreas disease. HPB (Oxford). 2007;9:312\u20138.","journal-title":"HPB (Oxford)"},{"key":"9599_CR17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/MPA.0b013e3180547709","volume":"35","author":"MC Chang","year":"2007","unstructured":"Chang MC, Chang YT, Su TC, et al. Adiponectin as a potential differential marker to distinguish pancreatic cancer and chronic pancreatitis. Pancreas. 2007;35:16\u201321.","journal-title":"Pancreas"},{"key":"9599_CR18","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000092689","volume":"6","author":"GI Papachristou","year":"2006","unstructured":"Papachristou GI, Papachristou DJ, Avula H, Slivka A, Whitcomb DC. Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response. Pancreatology. 2006;6:279\u201385.","journal-title":"Pancreatology"},{"key":"9599_CR19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000092104","volume":"6","author":"J Martinez","year":"2006","unstructured":"Martinez J, Johnson CD, Sanchez-Paya J, et al. Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis. Pancreatology. 2006;6:206\u20139.","journal-title":"Pancreatology"},{"key":"9599_CR20","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/ncpgasthep0881","volume":"4","author":"H Algul","year":"2007","unstructured":"Algul H, Treiber M, Lesina M, Schmid RM. Mechanisms of disease: chronic inflammation and cancer in the pancreas\u2014a potential role for pancreatic stellate cells? Nat Clin Pract Gastroenterol Hepatol. 2007;4:454\u201362.","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"9599_CR21","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1002\/cncr.20672","volume":"101","author":"B Ebrahimi","year":"2004","unstructured":"Ebrahimi B, Tucker SL, Li D, Abbruzzese JL, Kurzrock R. Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. Cancer. 2004;101:2727\u201336.","journal-title":"Cancer"},{"key":"9599_CR22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1097\/01.sla.0000128681.76786.07","volume":"239","author":"B Farrow","year":"2004","unstructured":"Farrow B, Sugiyama Y, Chen A, et al. Inflammatory mechanisms contributing to pancreatic cancer development. Ann Surg. 2004;239:763\u20139; discussion 69\u201371.","journal-title":"Ann Surg"},{"key":"9599_CR23","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/carcin\/bgl018","volume":"27","author":"JI Fenton","year":"2006","unstructured":"Fenton JI, Hursting SD, Perkins SN, Hord NG. Interleukin-6 production induced by leptin treatment promotes cell proliferation in an Apc (Min\/+) colon epithelial cell line. Carcinogenesis. 2006;27:1507\u201315.","journal-title":"Carcinogenesis"},{"key":"9599_CR24","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1158\/1055-9965.EPI-06-0446","volume":"15","author":"W Cozen","year":"2006","unstructured":"Cozen W, Gebregziabher M, Conti DV, et al. Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. Cancer Epidemiol Biomarkers Prev. 2006;15:2285\u201391.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"9599_CR25","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/jjco\/28.1.12","volume":"28","author":"S Okada","year":"1998","unstructured":"Okada S, Okusaka T, Ishii H, et al. Elevated serum interleukin-6 levels in patients with pancreatic cancer. Jpn J Clin Oncol. 1998;28:12\u20135.","journal-title":"Jpn J Clin Oncol"},{"key":"9599_CR26","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1093\/jnci\/94.15.1168","volume":"94","author":"KE Anderson","year":"2002","unstructured":"Anderson KE, Johnson TW, Lazovich D, Folsom AR. Association between nonsteroidal anti-inflammatory drug use and the incidence of pancreatic cancer. J Natl Cancer Inst. 2002;94:1168\u201371.","journal-title":"J Natl Cancer Inst"},{"key":"9599_CR27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/00000658-199404000-00001","volume":"219","author":"JS Falconer","year":"1994","unstructured":"Falconer JS, Fearon KC, Plester CE, Ross JA, Carter DC. Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg. 1994;219:325\u201331.","journal-title":"Ann Surg"},{"key":"9599_CR28","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1038\/sj.bjc.6601712","volume":"90","author":"MD Barber","year":"2004","unstructured":"Barber MD, McMillan DC, Wallace AM, et al. The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer. Br J Cancer. 2004;90:1129\u201332.","journal-title":"Br J Cancer"},{"key":"9599_CR29","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1046\/j.1365-2168.1998.00938.x","volume":"85","author":"T Makino","year":"1998","unstructured":"Makino T, Noguchi Y, Yoshikawa T, Doi C, Nomura K. Circulating interleukin 6 concentrations and insulin resistance in patients with cancer. Br J Surg. 1998;85:1658\u201362.","journal-title":"Br J Surg"},{"key":"9599_CR30","first-page":"881","volume":"21","author":"SJ Wigmore","year":"2002","unstructured":"Wigmore SJ, Fearon KC, Sangster K, et al. Cytokine regulation of constitutive production of interleukin-8 and -6 by human pancreatic cancer cell lines and serum cytokine concentrations in patients with pancreatic cancer. Int J Oncol. 2002;21:881\u20136.","journal-title":"Int J Oncol"},{"key":"9599_CR31","doi-asserted-by":"crossref","first-page":"5802","DOI":"10.1158\/1078-0432.CCR-05-0185","volume":"11","author":"ME Martignoni","year":"2005","unstructured":"Martignoni ME, Kunze P, Hildebrandt W, et al. Role of mononuclear cells and inflammatory cytokines in pancreatic cancer-related cachexia. Clin Cancer Res. 2005;11:5802\u20138.","journal-title":"Clin Cancer Res"},{"key":"9599_CR32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1471-4159.2006.03857.x","volume":"98","author":"ME Amaral","year":"2006","unstructured":"Amaral ME, Barbuio R, Milanski M, et al. Tumor necrosis factor-alpha activates signal transduction in hypothalamus and modulates the expression of pro-inflammatory proteins and orexigenic\/anorexigenic neurotransmitters. J Neurochem. 2006;98:203\u201312.","journal-title":"J Neurochem"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-008-9599-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11695-008-9599-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-008-9599-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T20:46:03Z","timestamp":1559421963000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11695-008-9599-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6,19]]},"references-count":32,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["9599"],"URL":"https:\/\/doi.org\/10.1007\/s11695-008-9599-3","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6,19]]}}}