{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:00:11Z","timestamp":1791295211721,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2014,6,28]],"date-time":"2014-06-28T00:00:00Z","timestamp":1403913600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1007\/s11695-014-1338-3","type":"journal-article","created":{"date-parts":[[2014,6,27]],"date-time":"2014-06-27T14:17:52Z","timestamp":1403878672000},"page":"2145-2151","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Vagal Innervation of Intestine Contributes to Weight Loss After Roux-en-Y Gastric Bypass Surgery in Rats"],"prefix":"10.1007","volume":"24","author":[{"given":"Zheng","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Leigh","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Mumphrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel M.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Rudolf","family":"Berthoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,28]]},"reference":[{"key":"1338_CR1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa1200111","volume":"366","author":"G Mingrone","year":"2012","unstructured":"Mingrone G, Panunzi S, De Gaetano A, et al. Bariatric surgery versus conventional medical therapy for type 2 diabetes. N Engl J Med. 2012;366:1577\u201385.","journal-title":"N Engl J Med"},{"key":"1338_CR2","doi-asserted-by":"crossref","unstructured":"Schauer PR, Bhatt DL, Kirwan JP, et al. Bariatric surgery versus intensive medical therapy for diabetes\u20143-year outcomes. N Engl J Med. 2014;370:2002\u201313.","DOI":"10.1056\/NEJMoa1401329"},{"key":"1338_CR3","doi-asserted-by":"crossref","first-page":"11052","DOI":"10.1523\/JNEUROSCI.2606-06.2006","volume":"26","author":"M Arnold","year":"2006","unstructured":"Arnold M, Mura A, Langhans W, et al. Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci. 2006;26:11052\u201360.","journal-title":"J Neurosci"},{"key":"1338_CR4","doi-asserted-by":"crossref","first-page":"R1005","DOI":"10.1152\/ajpregu.00646.2003","volume":"286","author":"RD Reidelberger","year":"2004","unstructured":"Reidelberger RD, Hernandez J, Fritzsch B, et al. Abdominal vagal mediation of the satiety effects of CCK in rats. Am J Physiol Regul Integr Comp Physiol. 2004;286:R1005\u201312.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1338_CR5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","volume":"403","author":"I Merchenthaler","year":"1999","unstructured":"Merchenthaler I, Lane M, Shughrue P. Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system. J Comp Neurol. 1999;403:261\u201380.","journal-title":"J Comp Neurol"},{"key":"1338_CR6","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.1523\/JNEUROSCI.23-07-02939.2003","volume":"23","author":"H Yamamoto","year":"2003","unstructured":"Yamamoto H, Kishi T, Lee CE, et al. Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites. J Neurosci. 2003;23:2939\u201346.","journal-title":"J Neurosci"},{"key":"1338_CR7","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1210\/en.2004-1266","volume":"146","author":"S Koda","year":"2005","unstructured":"Koda S, Date Y, Murakami N, et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology. 2005;146:2369\u201375.","journal-title":"Endocrinology"},{"key":"1338_CR8","first-page":"R638","volume":"249","author":"GP Smith","year":"1985","unstructured":"Smith GP, Jerome C, Norgren R. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats. Am J Physiol. 1985;249:R638\u201341.","journal-title":"Am J Physiol"},{"key":"1338_CR9","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1053\/gast.2002.35954","volume":"123","author":"Y Date","year":"2002","unstructured":"Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology. 2002;123:1120\u20138.","journal-title":"Gastroenterology"},{"key":"1338_CR10","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/nature00887","volume":"418","author":"RL Batterham","year":"2002","unstructured":"Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature. 2002;418:650\u20134.","journal-title":"Nature"},{"key":"1338_CR11","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.brainres.2005.03.011","volume":"1044","author":"CR Abbott","year":"2005","unstructured":"Abbott CR, Monteiro M, Small CJ, et al. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal\u2013brainstem\u2013hypothalamic pathway. Brain Res. 2005;1044:127\u201331.","journal-title":"Brain Res"},{"issue":"Suppl 1","key":"1338_CR12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1365-2982.2008.01104.x","volume":"20","author":"HR Berthoud","year":"2008","unstructured":"Berthoud HR. Vagal and hormonal gut\u2013brain communication: from satiation to satisfaction. Neurogastroenterol Motil. 2008;20 Suppl 1:64\u201372.","journal-title":"Neurogastroenterol Motil"},{"key":"1338_CR13","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1016\/j.neuroimage.2007.11.008","volume":"39","author":"GJ Wang","year":"2008","unstructured":"Wang GJ, Tomasi D, Backus W, et al. Gastric distention activates satiety circuitry in the human brain. Neuroimage. 2008;39:1824\u201331.","journal-title":"Neuroimage"},{"key":"1338_CR14","first-page":"R766","volume":"271","author":"RJ Phillips","year":"1996","unstructured":"Phillips RJ, Powley TL. Gastric volume rather than nutrient content inhibits food intake. Am J Physiol. 1996;271:R766\u20139.","journal-title":"Am J Physiol"},{"key":"1338_CR15","doi-asserted-by":"crossref","first-page":"R992","DOI":"10.1152\/ajpregu.00272.2003","volume":"285","author":"HR Kissileff","year":"2003","unstructured":"Kissileff HR, Carretta JC, Geliebter A, et al. Cholecystokinin and stomach distension combine to reduce food intake in humans. Am J Physiol Regul Integr Comp Physiol. 2003;285:R992\u20138.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1338_CR16","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuroscience.2009.05.042","volume":"162","author":"A Miranda","year":"2009","unstructured":"Miranda A, Mickle A, Medda B, et al. Altered mechanosensitive properties of vagal afferent fibers innervating the stomach following gastric surgery in rats. Neuroscience. 2009;162:1299\u2013306.","journal-title":"Neuroscience"},{"key":"1338_CR17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","volume":"85","author":"HR Berthoud","year":"2000","unstructured":"Berthoud HR, Neuhuber WL. Functional and chemical anatomy of the afferent vagal system. Auton Neurosci. 2000;85:1\u201317.","journal-title":"Auton Neurosci"},{"key":"1338_CR18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004290050037","volume":"195","author":"HR Berthoud","year":"1997","unstructured":"Berthoud HR, Patterson LM, Neumann F, et al. Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract. Anat Embryol (Berl). 1997;195:183\u201391.","journal-title":"Anat Embryol (Berl)"},{"key":"1338_CR19","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1469-7793.2001.00255.x","volume":"534","author":"VP Zagorodnyuk","year":"2001","unstructured":"Zagorodnyuk VP, Chen BN, Brookes SJ. Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. J Physiol. 2001;534:255\u201368.","journal-title":"J Physiol"},{"key":"1338_CR20","doi-asserted-by":"crossref","first-page":"R1273","DOI":"10.1152\/ajpregu.00343.2009","volume":"297","author":"H Zheng","year":"2009","unstructured":"Zheng H, Shin AC, Lenard NR, et al. Meal patterns, satiety, and food choice in a rat model of Roux-en-Y gastric bypass surgery. Am J Physiol Regul Integr Comp Physiol. 2009;297:R1273\u201382.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1338_CR21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000114966","volume":"40","author":"MW Furnes","year":"2008","unstructured":"Furnes MW, Stenstrom B, Tommeras K, et al. Feeding behavior in rats subjected to gastrectomy or gastric bypass surgery. Eur Surg Res. 2008;40:279\u201388.","journal-title":"Eur Surg Res"},{"key":"1338_CR22","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s11695-010-0192-1","volume":"20","author":"P Bjorklund","year":"2010","unstructured":"Bjorklund P, Laurenius A, Een E, et al. Is the roux limb a determinant for meal size after gastric bypass surgery? Obes Surg. 2010;20:1408\u201314.","journal-title":"Obes Surg"},{"issue":"Suppl 1","key":"1338_CR23","doi-asserted-by":"crossref","first-page":"i2","DOI":"10.1136\/gut.51.suppl_1.i2","volume":"51","author":"D Grundy","year":"2002","unstructured":"Grundy D. Neuroanatomy of visceral nociception: vagal and splanchnic afferent. Gut. 2002;51 Suppl 1:i2\u20135.","journal-title":"Gut"},{"key":"1338_CR24","doi-asserted-by":"crossref","first-page":"e52922","DOI":"10.1371\/journal.pone.0052922","volume":"8","author":"Z Hao","year":"2013","unstructured":"Hao Z, Zhao Z, Berthoud HR, et al. Development and verification of a mouse model for roux-en-Y gastric bypass surgery with a small gastric pouch. PLoS ONE. 2013;8:e52922.","journal-title":"PLoS ONE"},{"key":"1338_CR25","first-page":"R361","volume":"253","author":"TL Powley","year":"1987","unstructured":"Powley TL, Fox EA, Berthoud HR. Retrograde tracer technique for assessment of selective and total subdiaphragmatic vagotomies. Am J Physiol. 1987;253:R361\u201370.","journal-title":"Am J Physiol"},{"key":"1338_CR26","first-page":"R523","volume":"258","author":"HR Berthoud","year":"1990","unstructured":"Berthoud HR, Powley TL. Identification of vagal preganglionics that mediate cephalic phase insulin response. Am J Physiol. 1990;258:R523\u201330.","journal-title":"Am J Physiol"},{"key":"1338_CR27","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11695-012-0846-2","volume":"23","author":"AC Shin","year":"2013","unstructured":"Shin AC, Zheng H, Townsend RL, et al. Longitudinal assessment of food intake, fecal energy loss, and energy expenditure after Roux-en-Y gastric bypass surgery in high-fat-fed obese rats. Obes Surg. 2013;23:531\u201340.","journal-title":"Obes Surg"},{"key":"1338_CR28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s11695-010-0075-5","volume":"20","author":"M Bueter","year":"2010","unstructured":"Bueter M, Lowenstein C, Ashrafian H, et al. Vagal sparing surgical technique but not stoma size affects body weight loss in rodent model of gastric bypass. Obes Surg. 2010;20:616\u201322.","journal-title":"Obes Surg"},{"key":"1338_CR29","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s11695-009-9862-2","volume":"20","author":"Y Wang","year":"2010","unstructured":"Wang Y, Liu J. Combination of bypassing stomach and vagus dissection in high-fat diet-induced obese rats\u2014a long-term investigation. Obes Surg. 2010;20:375\u20139.","journal-title":"Obes Surg"},{"key":"1338_CR30","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s11695-008-9657-x","volume":"19","author":"A Perathoner","year":"2009","unstructured":"Perathoner A, Weiss H, Santner W, et al. Vagal nerve dissection during pouch formation in laparoscopic Roux-Y-gastric bypass for technical simplification: does it matter? Obes Surg. 2009;19:412\u20137.","journal-title":"Obes Surg"},{"key":"1338_CR31","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0014-2999(89)90584-0","volume":"167","author":"HE Raybould","year":"1989","unstructured":"Raybould HE, Tache Y. Capsaicin-sensitive vagal afferent fibers and stimulation of gastric acid secretion in anesthetized rats. Eur J Pharmacol. 1989;167:237\u201343.","journal-title":"Eur J Pharmacol"},{"key":"1338_CR32","doi-asserted-by":"crossref","first-page":"R1805","DOI":"10.1152\/ajpregu.2000.279.5.R1805","volume":"279","author":"L Kelly","year":"2000","unstructured":"Kelly L, Morales S, Smith BK, et al. Capsaicin-treated rats permanently overingest low- but not high-concentration sucrose solutions. Am J Physiol Regul Integr Comp Physiol. 2000;279:R1805\u201312.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"1338_CR33","first-page":"R1623","volume":"276","author":"GJ Schwartz","year":"1999","unstructured":"Schwartz GJ, Salorio CF, Skoglund C, et al. Gut vagal afferent lesions increase meal size but do not block gastric preload-induced feeding suppression. Am J Physiol. 1999;276:R1623\u20139.","journal-title":"Am J Physiol"},{"key":"1338_CR34","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.physbeh.2011.01.023","volume":"105","author":"HR Berthoud","year":"2011","unstructured":"Berthoud HR, Shin AC, Zheng H. Obesity surgery and gut\u2013brain communication. Physiol Behav. 2011;105:106\u201319.","journal-title":"Physiol Behav"},{"key":"1338_CR35","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00187819","volume":"191","author":"HR Berthoud","year":"1995","unstructured":"Berthoud HR, Kressel M, Raybould HE, et al. Vagal sensors in the rat duodenal mucosa: distribution and structure as revealed by in vivo DiI-tracing. Anat Embryol (Berl). 1995;191:203\u201312.","journal-title":"Anat Embryol (Berl)"},{"key":"1338_CR36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1002\/cne.22541","volume":"519","author":"TL Powley","year":"2011","unstructured":"Powley TL, Spaulding RA, Haglof SA. Vagal afferent innervation of the proximal gastrointestinal tract mucosa: chemoreceptor and mechanoreceptor architecture. J Comp Neurol. 2011;519:644\u201360.","journal-title":"J Comp Neurol"},{"key":"1338_CR37","first-page":"R1390","volume":"274","author":"JE Cox","year":"1998","unstructured":"Cox JE. Cholecystokinin satiety involves CCKA receptors perfused by the superior pancreaticoduodenal artery. Am J Physiol. 1998;274:R1390\u20136.","journal-title":"Am J Physiol"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-014-1338-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11695-014-1338-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-014-1338-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T00:20:40Z","timestamp":1565569240000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11695-014-1338-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,28]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1338"],"URL":"https:\/\/doi.org\/10.1007\/s11695-014-1338-3","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,28]]}}}