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Roux-en-Y bariatric surgery reduces hyperinsulinemia and improves insulin sensitivity and hence benefits morbidly obese patients.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Aim<\/jats:title>\n<jats:p>To determine changes in markers of metabolic syndrome, pancreatic function, and hepatic insulin sensitivity in patients before and 1\u00a0year after undergoing Roux-en-Y gastric bypass surgery.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>We enrolled 43 consecutive patients in a single center. Markers for metabolic syndrome included proinsulin, insulin, C-peptide, liver enzymes, and serum levels of selected microRNAs hsa-miR-122, hsa-miR-130, hsa-miR-132, and hsa-miR-375.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>After surgery, all patients showed a significant 37% drop of body mass index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Furthermore, proinsulin (59% reduction, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), insulin (76% reduction, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and C-peptide (56% reduction, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were all reduced 1\u00a0year after surgery. Using the hepatic insulin clearance score, we determined a significant increase in hepatic insulin clearance after surgery (76% increase, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Especially diabetic patients showed a marked 2.1-fold increase after surgery. Hepatic enzymes ALT (35% reduction, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) and \u03b3GT (48% reduction, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) were significantly reduced in all patients with similar improvement in diabetic and non-diabetic patients. miRNAs hsa-miR-122, hsa-miR-130, and hsa-miR-132 were all significantly reduced whereas hsa-miR-375 was increased after gastric bypass surgery (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for all miRNAs).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Both liver and pancreatic stress parameters were reduced significantly 1\u00a0year after Roux-en-Y gastric bypass surgery suggesting an overall amelioration of the metabolic syndrome in all patients regardless of previous health status.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s11695-019-04190-y","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T05:41:27Z","timestamp":1573796487000},"page":"391-400","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Roux-en-Y-Bariatric Surgery Reduces Markers of Metabolic Syndrome in Morbidly Obese Patients"],"prefix":"10.1007","volume":"30","author":[{"given":"G.","family":"Rega-Kaun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kaun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Jaegersberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Prager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hackl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Demyanets","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1282-9276","authenticated-orcid":false,"given":"J.","family":"Wojta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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