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Sex hormones play an important role in body composition and glucose and lipid metabolism. However, whether pre-operative gonadal dysfunction impacts weight loss after bariatric surgery is not fully known.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 49 men and 104 women were included in a retrospective analysis. Anthropometric characteristics, glucose and lipid metabolism, and androgen concentrations were assessed pre-operatively and 17.9\u2009\u00b1\u200911 or 19.3\u2009\u00b1\u200912\u00a0months post-operatively in men and women. Men with (HYPO<jats:sub>male<\/jats:sub>) and without (controls: CON<jats:sub>male)<\/jats:sub> pre-operative hypogonadism, as well as women with (HYPER<jats:sub>female<\/jats:sub>) and without (controls: CON<jats:sub>female)<\/jats:sub> pre-operative hyperandrogenemia, were compared.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In men, pre-operative hypogonadism was present in 55% and linked to a higher body mass index (BMI): HYPO<jats:sub>male<\/jats:sub> 50\u2009\u00b1\u20096\u00a0kg\/m<jats:sup>2<\/jats:sup> vs. CON<jats:sub>male<\/jats:sub> 44\u2009\u00b1\u20095\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u20090.001. Bariatric surgery results in comparable changes in BMI in HYPO<jats:sub>male<\/jats:sub> and CON<jats:sub>male<\/jats:sub> \u2212\u200916\u2009\u00b1\u20096\u00a0kg\/m<jats:sup>2<\/jats:sup> vs. \u2212\u200914\u2009\u00b1\u20095\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u20090.30. Weight loss reversed hypogonadism in 93%. In women, androgen excess was present in 22%, independent of pre-operative BMI: CON<jats:sub>female<\/jats:sub> 44\u2009\u00b1\u20097\u00a0kg\/m<jats:sup>2<\/jats:sup> vs. HYPER<jats:sub>female<\/jats:sub> 45\u2009\u00b1\u20097\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u20090.57. Changes in BMI were comparable in HYPER<jats:sub>female<\/jats:sub> and CON<jats:sub>female<\/jats:sub> after bariatric surgery \u2212\u200915\u2009\u00b1\u20096\u00a0kg\/m<jats:sup>2<\/jats:sup> vs. \u2212\u200915\u2009\u00b1\u20095\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u00a0=\u20090.88. Hyperandrogenemia was reversed in 61%.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Besides being frequently observed, hypogonadism in men and androgen excess in women have no impact on post-surgical improvements in body weight and glucose and lipid metabolism. Weight loss resulted in reversal of hypogonadism in almost all men and of hyperandrogenemia in the majority of women.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s11695-020-04761-4","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T09:02:42Z","timestamp":1592038962000},"page":"3947-3954","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pre-operative Obesity-Associated Hyperandrogenemia in Women and Hypogonadism in Men Have No Impact on Weight Loss Following Bariatric Surgery"],"prefix":"10.1007","volume":"30","author":[{"given":"Hannes","family":"Beiglb\u00f6ck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Fellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Ranzenberger-Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Itariu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Prager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kautzky-Willer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9265-7274","authenticated-orcid":false,"given":"Michael","family":"Krebs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,13]]},"reference":[{"key":"4761_CR1","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1056\/NEJMoa1813909","volume":"380","author":"TH Inge","year":"2019","unstructured":"Inge TH, Courcoulas AP, Jenkins TM, et al. 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