{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:36:57Z","timestamp":1740137817934,"version":"3.37.3"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T00:00:00Z","timestamp":1611014400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s11695-021-05228-w","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T20:04:16Z","timestamp":1611086656000},"page":"1957-1966","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intestinal Electrical Stimulation Enhances Release of Postprandial Incretin Hormones Via Cholinergic Mechanisms"],"prefix":"10.1007","volume":"31","author":[{"given":"Yan","family":"Dong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6823-6253","authenticated-orcid":false,"given":"Jiande D. Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,19]]},"reference":[{"issue":"4","key":"5228_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/nrendo.2011.183","volume":"8","author":"L Chen","year":"2011","unstructured":"Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nat Rev Endocrinol. 2011;8(4):228\u201336.","journal-title":"Nat Rev Endocrinol"},{"issue":"4","key":"5228_CR2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1172\/JCI10842","volume":"106","author":"BB Kahn","year":"2000","unstructured":"Kahn BB, Flier JS. Obesity and insulin resistance. J Clin Invest. 2000;106(4):473\u201381.","journal-title":"J Clin Invest"},{"issue":"5","key":"5228_CR3","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1002\/dmrr.2501","volume":"30","author":"HM Tasyurek","year":"2014","unstructured":"Tasyurek HM, Altunbas HA, Balci MK, et al. Incretins: their physiology and application in the treatment of diabetes mellitus. Diabetes Metab Res Rev. 2014;30(5):354\u201371.","journal-title":"Diabetes Metab Res Rev"},{"issue":"3","key":"5228_CR4","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/dom.12591","volume":"18","author":"M Nauck","year":"2016","unstructured":"Nauck M. Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes Obes Metab. 2016r;18(3):203\u201316.","journal-title":"Diabetes Obes Metab"},{"issue":"1","key":"5228_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1177\/1457496914561140","volume":"104","author":"A Maleckas","year":"2015","unstructured":"Maleckas A, Venclauskas L, Wallenius V, et al. Surgery in the treatment of type 2 diabetes mellitus. Scand J Surg. 2015;104(1):40\u20137.","journal-title":"Scand J Surg"},{"issue":"8","key":"5228_CR6","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1007\/s11695-016-2271-4","volume":"26","author":"M De Luca","year":"2016","unstructured":"De Luca M, Angrisani L, Himpens J, et al. Indications for surgery for obesity and weight-related diseases: position statements from the International Federation for the Surgery of obesity and metabolic disorders (IFSO). Obes Surg. 2016;26(8):1659\u201396.","journal-title":"Obes Surg"},{"issue":"6","key":"5228_CR7","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1210\/en.2009-0367","volume":"150","author":"JP Thaler","year":"2009","unstructured":"Thaler JP, Cummings DE. Minireview: hormonal and metabolic mechanisms of diabetes remission after gastrointestinal surgery. Endocrinology. 2009;150(6):2518\u201325.","journal-title":"Endocrinology"},{"issue":"4","key":"5228_CR8","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1381\/0960892053723402","volume":"15","author":"K Wickremesekera","year":"2005","unstructured":"Wickremesekera K, Miller G, Naotunne TD, et al. Loss of insulin resistance after Roux-en-Y gastric bypass surgery: a time course study. Obes Surg. 2005;15(4):474\u201381.","journal-title":"Obes Surg"},{"issue":"2","key":"5228_CR9","doi-asserted-by":"publisher","first-page":"94","DOI":"10.7326\/0003-4819-150-2-200901200-00007","volume":"150","author":"ML Vetter","year":"2009","unstructured":"Vetter ML, Cardillo S, Rickels MR, et al. Narrative review: effect of bariatric surgery on type 2 diabetes mellitus. Ann Intern Med. 2009;150(2):94\u2013103.","journal-title":"Ann Intern Med"},{"issue":"1","key":"5228_CR10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1210\/jc.2004-1076","volume":"90","author":"J Korner","year":"2005","unstructured":"Korner J, Bessler M, Cirilo LJ, et al. Effects of Roux-en-Y gastric bypass surgery on fasting and postprandial concentrations of plasma ghrelin, peptide YY, and insulin. J Clin Endocrinol Metab. 2005;90(1):359\u201365.","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"5228_CR11","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1002\/bjs.1800820606","volume":"82","author":"PM Sagar","year":"1995","unstructured":"Sagar PM. Surgical treatment of morbid obesity. Br J Surg. 1995;82(6):732\u20139.","journal-title":"Br J Surg"},{"key":"5228_CR12","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.med.56.062904.144928","volume":"57","author":"PF Crookes","year":"2006","unstructured":"Crookes PF. Surgical treatment of morbid obesity. Annu Rev Med. 2006;57:243\u201364.","journal-title":"Annu Rev Med"},{"issue":"8","key":"5228_CR13","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1038\/oby.2004.157","volume":"12","author":"Y Sun","year":"2004","unstructured":"Sun Y, Chen J. Intestinal electric stimulation decreases fat absorption in rats: therapeutic potential for obesity. Obes Res. 2004;12(8):1235\u201342.","journal-title":"Obes Res"},{"key":"5228_CR14","doi-asserted-by":"crossref","unstructured":"Aberle J, Busch P, Veigel J, Dupr\u00e9e A, Roesch T, Zu Eulenburg C, et al. Duodenal electric stimulation: results of a first-in-man study. Obes Surg 2016;26(2):369\u2013375.","DOI":"10.1007\/s11695-015-1774-8"},{"issue":"1","key":"5228_CR15","first-page":"R78","volume":"293","author":"J Yin","year":"2007","unstructured":"Yin J, Zhang J, Chen JDZ. Inhibitory effects of intestinal electrical stimulation on food intake, weight loss and gastric emptying in rats. Am J Phys Regul Integr Comp Phys. 2007;293(1):R78\u201382.","journal-title":"Am J Phys Regul Integr Comp Phys"},{"issue":"1","key":"5228_CR16","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1007\/s11695-016-2238-5","volume":"27","author":"S Li","year":"2017","unstructured":"Li S, Chen JDZ. Pulse width-dependent effects of intestinal electrical stimulation for obesity: role of gastrointestinal motility and hormones. Obes Surg. 2017;27(1):70\u20137.","journal-title":"Obes Surg"},{"issue":"5","key":"5228_CR17","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.cmet.2006.09.008","volume":"4","author":"D Gautam","year":"2006","unstructured":"Gautam D, Gavrilova O, Jeon J, et al. Beneficial metabolic effects of M3 muscarinic acetylcholine receptor deficiency. Cell Metab. 2006;4(5):363\u201375.","journal-title":"Cell Metab"},{"issue":"5","key":"5228_CR18","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1080\/17474124.2017.1298441","volume":"11","author":"JDZ Chen","year":"2017","unstructured":"Chen JDZ, Yin J, Wei W. Electrical therapies for gastrointestinal motility disorders. Expert Rev Gastroenterol Hepatol. 2017;11(5):407\u201318.","journal-title":"Expert Rev Gastroenterol Hepatol"},{"issue":"6","key":"5228_CR19","first-page":"R1580","volume":"298","author":"S Li","year":"2010","unstructured":"Li S, Chen JDZ. Cellular effects of gastric electrical stimulation on antral smooth muscle cells in rats. Am J Phys Regul Integr Comp Phys. 2010;298(6):R1580\u20137.","journal-title":"Am J Phys Regul Integr Comp Phys"},{"issue":"6","key":"5228_CR20","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1002\/oby.21852","volume":"25","author":"S Li","year":"2017","unstructured":"Li S, Zhu W, Zhang S, et al. Chronic intestinal electrical stimulation improves glucose intolerance and insulin resistance in diet-induced obesity rats. Obes Silver Spring Md. 2017;25(6):1061\u20138.","journal-title":"Obes Silver Spring Md"},{"issue":"2","key":"5228_CR21","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s11695-010-0326-5","volume":"21","author":"J Liu","year":"2011","unstructured":"Liu J, Xiang Y, Qiao X, et al. Hypoglycemic effects of intraluminal intestinal electrical stimulation in healthy volunteers. Obes Surg. 2011;21(2):224\u201330.","journal-title":"Obes Surg"},{"issue":"1","key":"5228_CR22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41387-019-0072-2","volume":"9","author":"X Ouyang","year":"2019","unstructured":"Ouyang X, Li S, Tan Y, et al. Intestinal electrical stimulation attenuates hyperglycemia and prevents loss of pancreatic \u03b2 cells in type 2 diabetic Goto-Kakizaki rats. Nutr Diabetes. 2019;9(1):4.","journal-title":"Nutr Diabetes"},{"issue":"Pt 1","key":"5228_CR23","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1113\/jphysiol.2008.164012","volume":"587","author":"G Tolhurst","year":"2009","unstructured":"Tolhurst G, Reimann F, Gribble FM. Nutritional regulation of glucagon-like peptide-1 secretion. J Physiol. 2009;587(Pt 1):27\u201332.","journal-title":"J Physiol"},{"issue":"3","key":"5228_CR24","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s004240050913","volume":"438","author":"Y Anini","year":"1999","unstructured":"Anini Y, Fu-Cheng X, Cuber JC, et al. Comparison of the postprandial release of peptide YY and proglucagon-derived peptides in the rat. Pflugers Arch. 1999;438(3):299\u2013306.","journal-title":"Pflugers Arch"},{"issue":"1","key":"5228_CR25","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1136\/gut.44.1.81","volume":"44","author":"JP Gutzwiller","year":"1999","unstructured":"Gutzwiller JP, G\u00f6ke B, Drewe J, et al. Glucagon-like peptide-1: a potent regulator of food intake in humans. Gut. 1999;44(1):81\u20136.","journal-title":"Gut"},{"issue":"6","key":"5228_CR26","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","volume":"132","author":"LL Baggio","year":"2007","unstructured":"Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132(6):2131\u201357.","journal-title":"Gastroenterology"},{"issue":"9","key":"5228_CR27","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.2337\/diacare.24.9.1640","volume":"24","author":"E Rask","year":"2001","unstructured":"Rask E, Olsson T, S\u00f6derberg S, et al. Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men. Diabetes Care. 2001;24(9):1640\u20135.","journal-title":"Diabetes Care"},{"issue":"8","key":"5228_CR28","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/nmo.12152","volume":"25","author":"D Sandoval","year":"2013","unstructured":"Sandoval D, Dunki-Jacobs A, Sorrell J, et al. Impact of intestinal electrical stimulation on nutrient-induced GLP-1 secretion in vivo. Neurogastroenterol Motil. 2013;25(8):700\u20135.","journal-title":"Neurogastroenterol Motil"},{"issue":"3","key":"5228_CR29","doi-asserted-by":"publisher","first-page":"E550","DOI":"10.1152\/ajpendo.00326.2004","volume":"290","author":"MJ Theodorakis","year":"2006","unstructured":"Theodorakis MJ, Carlson O, Michopoulos S, et al. Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP. Am J Physiol Endocrinol Metab. 2006;290(3):E550\u20139.","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"4","key":"5228_CR30","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1210\/endo.140.4.6643","volume":"140","author":"AS Rocca","year":"1999","unstructured":"Rocca AS, Brubaker PL. Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion. Endocrinology. 1999;140(4):1687\u201394.","journal-title":"Endocrinology"},{"key":"5228_CR31","unstructured":"Christensen MB. Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans. Dan Med J. 2016;63(4)"},{"issue":"2","key":"5228_CR32","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s00125-008-1202-x","volume":"52","author":"HE Parker","year":"2009","unstructured":"Parker HE, Habib AM, Rogers GJ, et al. Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells. Diabetologia. 2009;52(2):289\u201398.","journal-title":"Diabetologia"},{"issue":"7","key":"5228_CR33","doi-asserted-by":"publisher","first-page":"3244","DOI":"10.1210\/en.2003-0143","volume":"144","author":"Y Anini","year":"2003","unstructured":"Anini Y, Brubaker PL. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology. 2003;144(7):3244\u201350.","journal-title":"Endocrinology"},{"issue":"2","key":"5228_CR34","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.autneu.2011.07.009","volume":"165","author":"J Cellini","year":"2011","unstructured":"Cellini J, Jukic AMZ, LePard KJ. Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs. Auton Neurosci Basic Clin. 2011;165(2):178\u201390.","journal-title":"Auton Neurosci Basic Clin"},{"issue":"6","key":"5228_CR35","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1210\/endo.143.6.8840","volume":"143","author":"Y Anini","year":"2002","unstructured":"Anini Y, Hansotia T, Brubaker PL. Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats. Endocrinology. 2002;143(6):2420\u20136.","journal-title":"Endocrinology"},{"issue":"2","key":"5228_CR36","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/oby.2010.247","volume":"19","author":"X Xu","year":"2011","unstructured":"Xu X, Lei Y, Chen JDZ. Duodenum electrical stimulation delays gastric emptying, reduces food intake and accelerates small bowel transit in pigs. Obes Silver Spring Md. 2011;19(2):442\u20138.","journal-title":"Obes Silver Spring Md"},{"issue":"3","key":"5228_CR37","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/1751-2980.12220","volume":"16","author":"WF Wang","year":"2015","unstructured":"Wang WF, Yin JY, De Dz Chen J. Acceleration of small bowel transit in a canine hypermotility model with intestinal electrical stimulation. J Dig Dis. 2015;16(3):135\u201342.","journal-title":"J Dig Dis"},{"issue":"6","key":"5228_CR38","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.cmet.2006.04.009","volume":"3","author":"D Gautam","year":"2006","unstructured":"Gautam D, Han S-J, Hamdan FF, et al. A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab. 2006;3(6):449\u201361.","journal-title":"Cell Metab"},{"issue":"1","key":"5228_CR39","doi-asserted-by":"publisher","first-page":"16180","DOI":"10.1038\/s41598-019-52691-8","volume":"9","author":"Y Ito","year":"2019","unstructured":"Ito Y, Kaji M, Sakamoto E, et al. The beneficial effects of a muscarinic agonist on pancreatic \u03b2-cells. Sci Rep. 2019;9(1):16180.","journal-title":"Sci Rep"},{"issue":"5","key":"5228_CR40","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1210\/endo.134.5.8156901","volume":"134","author":"J Abello","year":"1994","unstructured":"Abello J, Ye F, Bosshard A, et al. Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line. Endocrinology. 1994;134(5):2011\u20137.","journal-title":"Endocrinology"},{"issue":"1","key":"5228_CR41","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neulet.2009.04.007","volume":"457","author":"J Zhang","year":"2009","unstructured":"Zhang J, Zhu H, Chen JDZ. Central neuronal mechanisms of intestinal electrical stimulation: effects on duodenum distention-responsive (DD-R) neurons in the VMH of rats. Neurosci Lett. 2009;457(1):27\u201331.","journal-title":"Neurosci Lett"},{"issue":"1","key":"5228_CR42","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.neulet.2005.05.008","volume":"385","author":"Y Sun","year":"2005","unstructured":"Sun Y, Qin C, Foreman RD, et al. Intestinal electric stimulation modulates neuronal activity in the nucleus of the solitary tract in rats. Neurosci Lett. 2005;385(1):64\u20139.","journal-title":"Neurosci Lett"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-021-05228-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-021-05228-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-021-05228-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,12]],"date-time":"2021-04-12T15:03:23Z","timestamp":1618239803000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-021-05228-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["5228"],"URL":"https:\/\/doi.org\/10.1007\/s11695-021-05228-w","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"type":"print","value":"0960-8923"},{"type":"electronic","value":"1708-0428"}],"subject":[],"published":{"date-parts":[[2021,1,19]]},"assertion":[{"value":"15 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institutional and\/or national research committee. This article does not contain any studies with human performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}}]}}