{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:16:46Z","timestamp":1789496206251,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Obesity is a risk factor for hyperuricemia and gout, while weight reduction can reduce urate levels. The aim of this study was to examine the effect of bariatric surgery on longitudinal serum urate levels.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a retrospective observational study of 283 patients who had undergone bariatric surgery [237 (83.7%) gastric bypass, 34 (12.0%) sleeve gastrectomy and 12 (4.2%) gastric banding] and were followed up for 2 years. The results shown represent mean (standard deviation).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Bariatric surgery was associated with significant reduction in serum urate from baseline level of 0.343 (0.086) mmol\/L to 0.296 (0.076) mmol\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at 12 months and 0.286 (0.073) mmol\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) at 24 months, including in men and women, and in patients with or without diabetes. Patients with elevated urate levels at baseline, who comprised 27.2% of the total cohort, achieved reduction in levels by 4 months.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Bariatric surgery leads to significant reduction in serum urate levels at 12 and 24 months. This could reduce incidence of gout and need for prophylactic medication(s).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11695-024-07191-8","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T22:01:58Z","timestamp":1711404118000},"page":"1737-1741","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Changes in Serum Urate Levels after Bariatric Surgery in Patients with Obesity: An Observational Study"],"prefix":"10.1007","volume":"34","author":[{"given":"Daniel W.","family":"Mills","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan M.","family":"Woolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basil J.","family":"Ammori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector","family":"Chinoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8696-7121","authenticated-orcid":false,"given":"Akheel A.","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,25]]},"reference":[{"issue":"9","key":"7191_CR1","first-page":"533","volume":"102","author":"KT Clebak","year":"2020","unstructured":"Clebak KT, Morrison A, Croad JR. Gout: Rapid evidence review. Am Fam Physician. 2020;102(9):533\u20138.","journal-title":"Am Fam Physician"},{"issue":"7","key":"7191_CR2","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","volume":"16","author":"M Dehlin","year":"2020","unstructured":"Dehlin M, Jacobsson L, Roddy E. Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors. Nat Rev Rheumatol. 2020;16(7):380\u201390. https:\/\/doi.org\/10.1038\/s41584-020-0441-1.","journal-title":"Nat Rev Rheumatol"},{"key":"7191_CR3","doi-asserted-by":"publisher","unstructured":"Dalbeth N, Gosling AL, Gaffo A, et al. Gout. Lancet. 2021;397(10287):1843\u201355. https:\/\/doi.org\/10.1016\/S0140-6736(21)00569-9.","DOI":"10.1016\/S0140-6736(21)00569-9"},{"issue":"2","key":"7191_CR4","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s11926-013-0400-9","volume":"16","author":"MA Martillo","year":"2014","unstructured":"Martillo MA, Nazzal L, Crittenden DB. The crystallization of monosodium urate. Curr Rheumatol Rep. 2014;16(2):400. https:\/\/doi.org\/10.1007\/s11926-013-0400-9.","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"7191_CR5","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1172\/JCI42344","volume":"120","author":"A So","year":"2010","unstructured":"So A, Thorens B. Uric acid transport and disease. J Clin Invest. 2010;120(6):1791\u20139. https:\/\/doi.org\/10.1172\/JCI42344.","journal-title":"J Clin Invest"},{"issue":"4","key":"7191_CR6","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jbspin.2018.10.004","volume":"86","author":"G Chal\u00e8s","year":"2019","unstructured":"Chal\u00e8s G. How should we manage asymptomatic hyperuricemia? Joint Bone Spine. 2019;86(4):437\u201343. https:\/\/doi.org\/10.1016\/j.jbspin.2018.10.004.","journal-title":"Joint Bone Spine"},{"issue":"11","key":"7191_CR7","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.1136\/annrheumdis-2017-211472","volume":"76","author":"SM Nielsen","year":"2017","unstructured":"Nielsen SM, Bartels EM, Henriksen M, et al. Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies. Ann Rheum Dis. 2017;76(11):1870\u201382. https:\/\/doi.org\/10.1136\/annrheumdis-2017-211472.","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"7191_CR8","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1136\/annrheumdis-2013-204861","volume":"73","author":"HK Choi","year":"2014","unstructured":"Choi HK, Zhang Y. Bariatric surgery as urate-lowering therapy in severe obesity. Ann Rheum Dis. 2014;73(5):791\u20133. https:\/\/doi.org\/10.1136\/annrheumdis-2013-204861.","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"7191_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1111\/dme.14215","volume":"37","author":"BJ Ammori","year":"2020","unstructured":"Ammori BJ, Skarulis MC, Soran H, et al. Medical and surgical management of obesity and diabetes: what\u2019s new? Diabet Med. 2020;37(2):203\u201310. https:\/\/doi.org\/10.1111\/dme.14215.","journal-title":"Diabet Med"},{"key":"7191_CR10","doi-asserted-by":"publisher","unstructured":"Bashir B, Iqbal Z, Adam S, et al. Microvascular complications of obesity and diabetes-Role of bariatric surgery. 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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"For this type of retrospective service evaluation study formal consent does not apply.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Prof. Chinoy received consulting fees from PTC Therapeutics and AstraZeneca, and honoraria from UCB Pharma, GSK, Pfizer, Argenx and Galapagos. All other Authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}