{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:52:44Z","timestamp":1770295964338,"version":"3.49.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Besides lifestyle interventions, medication, and surgery, endoscopic options are becoming part of the current treatment landscape for people with obesity. With the POSE (Primary Obesity Surgery Endoscopic) procedure, endoluminal folds are created in the stomach with full-thickness sutures. Recently, the modified version, POSE-2, was introduced in clinical practice. This study aims to evaluate the safety and effectiveness of the POSE-2 procedure after one year in patients with obesity.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Materials and Methods<\/jats:title>\n                <jats:p>All patients treated with the POSE-2 procedure between March 2019 and November 2022 in the Zuyderland Medical Center and the Dutch Obesity Clinic were included in this retrospective data study. Inclusion criteria are as follows: age between 18 and 65\u00a0years and a BMI\u2009&gt;\u200930\u00a0kg\/m<jats:sup>2<\/jats:sup>. All patients with contraindications for the POSE-2 procedure were excluded.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Forty-nine patients were included of which 86% were female, with a mean age of 46\u00a0years and mean BMI of 34.6\u00a0kg\/m<jats:sup>2<\/jats:sup>. Total weight loss was evaluated at 3, 6, and 12\u00a0months and was 11.5%, 13.2%, and 14.8%, respectively. A median of 14 anchor sutures was used in a median procedure time of 50\u00a0min. All patients except one had same day discharge. Postprocedural complaints were mild and consisted of nausea and vomiting (36.7%) and pain (54.2%). No complications were recorded in this group. One week postprocedure, most patients (95.9%) reported feeling satisfied between meals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The POSE-2 procedure can be applied as a safe and effective treatment for people with obesity. This study presents a positive effect on weight reduction and no complications after 1\u00a0year of follow-up.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical Abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s11695-024-07488-8","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T07:05:36Z","timestamp":1725519936000},"page":"3686-3693","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The POSE-2 Procedure for People with Obesity: A Safe and Effective Treatment Option"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3943-2890","authenticated-orcid":false,"given":"Marijn T. F.","family":"Jense","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tymen","family":"Hodde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge H.","family":"Palm-Meinders","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul H. A.","family":"Bours","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalida","family":"Soufidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evert-Jan G.","family":"Boerma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Willem M.","family":"Greve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"issue":"3","key":"7488_CR1","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41366-021-01019-6","volume":"46","author":"G Calderon","year":"2022","unstructured":"Calderon G, Gonzalez-Izundegui D, Shan KL, et al. Effectiveness of anti-obesity medications approved for long-term use in a multidisciplinary weight management program: a multi-center clinical experience. Int J Obes (Lond). 2022;46(3):555\u201363.","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"7488_CR2","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1053\/j.gastro.2017.01.044","volume":"152","author":"S Sullivan","year":"2017","unstructured":"Sullivan S, Edmundowicz SA, Thompson CC. Endoscopic bariatric and metabolic therapies: new and emerging technologies. Gastroenterology. 2017;152(7):1791\u2013801.","journal-title":"Gastroenterology"},{"issue":"3","key":"7488_CR3","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41573-021-00337-8","volume":"21","author":"TD M\u00fcller","year":"2021","unstructured":"M\u00fcller TD, Bl\u00fcher M, Tsch\u00f6p MH. Anti-obesity drug discovery: advances and challenges. Nat Rev Drug Discovery. 2021;21(3):201\u201323.","journal-title":"Nat Rev Drug Discovery"},{"issue":"4","key":"7488_CR4","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.soard.2014.09.026","volume":"11","author":"G Lopez-Nava","year":"2015","unstructured":"Lopez-Nava G, Bautista-Castano I, Jimenez A. The Primary Obesity Surgery Endolumenal (POSE) procedure: one-year patient weight loss and safety outcomes. Surg Obes Relat Dis. 2015;11(4):861\u20135.","journal-title":"Surg Obes Relat Dis"},{"issue":"1","key":"7488_CR5","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00464-020-08267-z","volume":"36","author":"S Singh","year":"2022","unstructured":"Singh S, Bazarbashi AN, Khan A, et al. Primary obesity surgery endoluminal (POSE) for the treatment of obesity: a systematic review and meta-analysis. Surg Endosc. 2022;36(1):252\u201366.","journal-title":"Surg Endosc"},{"issue":"11","key":"7488_CR6","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1055\/a-1324-8498","volume":"53","author":"G Lopez Nava","year":"2021","unstructured":"Lopez Nava G, Asokkumar R, Laster J, et al. Primary obesity surgery endoluminal (POSE-2) procedure for treatment of obesity in clinical practice. Endoscopy. 2021;53(11):1169\u201373.","journal-title":"Endoscopy"},{"issue":"3","key":"7488_CR7","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.vgie.2019.11.010","volume":"5","author":"G Lopez-Nava","year":"2020","unstructured":"Lopez-Nava G, Asokkumar R, Turro Arau R. Modified primary obesity surgery endoluminal (POSE-2) procedure for the treatment of obesity. VideoGIE. 2020;5(3):91\u20133.","journal-title":"VideoGIE"},{"issue":"1","key":"7488_CR8","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cgh.2022.04.019","volume":"21","author":"G Lopez Nava","year":"2023","unstructured":"Lopez Nava G, Arau RT, Asokkumar R, et al. Prospective Multicenter Study of the Primary Obesity Surgery Endoluminal (POSE 2.0) procedure for treatment of obesity. Clin Gastroenterol Hepatol. 2023;21(1):81-9 e4.","journal-title":"Clin Gastroenterol Hepatol."},{"issue":"2","key":"7488_CR9","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s11695-016-2295-9","volume":"27","author":"K Miller","year":"2017","unstructured":"Miller K, Turro R, Greve JW. MILEPOST multicenter randomized controlled trial: 12-month weight loss and satiety outcomes after pose (SM) vs. medical therapy. Obes Surg. 2017;27(2):310\u201322.","journal-title":"Obes Surg"},{"issue":"3","key":"7488_CR10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.gie.2015.03.1964","volume":"82","author":"ABET Force","year":"2015","unstructured":"Force ABET, Committee AT, Abu Dayyeh BK, et al. ASGE Bariatric Endoscopy Task Force systematic review and meta-analysis assessing the ASGE PIVI thresholds for adopting endoscopic bariatric therapies. Gastrointest Endosc. 2015;82(3):425-38 e5.","journal-title":"Gastrointest Endosc"},{"key":"7488_CR11","doi-asserted-by":"publisher","unstructured":"ASGE\/ASMBS Task Force on Endoscopic Bariatric Therapy. A pathway to endoscopic bariatric therapies. Surg Obes Relat Dis. 2011;7(6):672\u201382. https:\/\/doi.org\/10.1016\/j.soard.2011.09.008.","DOI":"10.1016\/j.soard.2011.09.008"},{"issue":"2","key":"7488_CR12","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1097\/SLA.0b013e3181b13ca2","volume":"250","author":"PA Clavien","year":"2009","unstructured":"Clavien PA, Barkun J, de Oliveira ML. The Clavien-Dindo classification of surgical complications: five-year experience. Ann Surg. 2009;250(2):187\u201396.","journal-title":"Ann Surg"},{"key":"7488_CR13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/bmjopen-2017-017583","volume":"7","author":"KM Pantalone","year":"2017","unstructured":"Pantalone KM, Hobbs TM, Chagin KM, et al. Prevalence and recognition of obesity and its associated comorbidities: cross-sectional analysis of electronic health record data from a large US integrated health system. BMJ Open. 2017;7:11.","journal-title":"BMJ Open"},{"issue":"11","key":"7488_CR14","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1055\/a-2117-6274","volume":"55","author":"M AlKhatry","year":"2023","unstructured":"AlKhatry M, Rapaka B, Maselli DB, et al. Improvements in hepatic steatosis, obesity, and insulin resistance in adults with nonalcoholic fatty liver disease after the Primary Obesity Surgery Endoluminal 2.0 procedure. Endoscopy. 2023;55(11):1028\u201334.","journal-title":"Endoscopy"},{"issue":"5","key":"7488_CR15","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1007\/s11695-015-1863-8","volume":"26","author":"JC Espinos","year":"2016","unstructured":"Espinos JC, Turro R, Moragas G, et al. Gastrointestinal physiological changes and their relationship to weight loss following the POSE procedure. Obes Surg. 2016;26(5):1081\u20139.","journal-title":"Obes Surg"},{"issue":"8","key":"7488_CR16","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1111\/dom.14725","volume":"24","author":"JPH Wilding","year":"2022","unstructured":"Wilding JPH, Batterham RL, Davies M, et al. Weight regain and cardiometabolic effects after withdrawal of semaglutide: the STEP 1 trial extension. Diabetes Obes Metab. 2022;24(8):1553\u201364.","journal-title":"Diabetes Obes Metab"},{"issue":"3","key":"7488_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1001\/jamasurg.2013.3654","volume":"149","author":"SH Chang","year":"2014","unstructured":"Chang SH, Stoll CR, Song J. The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003\u20132012. JAMA Surg. 2014;149(3):275\u201387.","journal-title":"JAMA Surg"},{"issue":"2","key":"7488_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/s12328-020-01322-1","volume":"14","author":"G Lopez-Nava","year":"2021","unstructured":"Lopez-Nava G, Laster J, Negi A. Endoscopic gastroplasty: an effective solution in a high-risk patient with morbid obesity. Clin J Gastroenterol. 2021;14(2):489\u201393.","journal-title":"Clin J Gastroenterol"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-024-07488-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-024-07488-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-024-07488-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T14:11:54Z","timestamp":1728483114000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-024-07488-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,5]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["7488"],"URL":"https:\/\/doi.org\/10.1007\/s11695-024-07488-8","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"value":"0960-8923","type":"print"},{"value":"1708-0428","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,5]]},"assertion":[{"value":"20 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Informed consent does not apply.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}