{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:37:26Z","timestamp":1740137846051,"version":"3.37.3"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T00:00:00Z","timestamp":1729123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["OBES SURG"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s11695-024-07547-0","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T16:03:34Z","timestamp":1729181014000},"page":"4203-4210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Leptin-Melanocortin Pathway Genetic Variants on Weight Loss Outcomes After Endoscopic Transoral Outlet Reduction"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4749-1735","authenticated-orcid":false,"given":"Khushboo","family":"Gala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wissam","family":"Ghusn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sima","family":"Fansa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Anazco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew C.","family":"Storm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barham K.","family":"Abu Dayyeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andres","family":"Acosta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,17]]},"reference":[{"issue":"6778","key":"7547_CR1","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/35007519","volume":"404","author":"GS Barsh","year":"2000","unstructured":"Barsh GS, Farooqi IS. O\u02bcRahilly S. Genetics of body-weight regulation Nature. 2000;404(6778):644\u201351. https:\/\/doi.org\/10.1038\/35007519.","journal-title":"Genetics of body-weight regulation Nature"},{"key":"7547_CR2","doi-asserted-by":"publisher","unstructured":"Singh RK, Kumar P, Mahalingam K. Molecular genetics of human obesity: a comprehensive review. C R Biol. 2017;340(2):87\u2013108. https:\/\/doi.org\/10.1016\/j.crvi.2016.11.007.","DOI":"10.1016\/j.crvi.2016.11.007."},{"key":"7547_CR3","doi-asserted-by":"publisher","unstructured":"Yeo GSH, Chao DHM, Siegert AM et al. The melanocortin pathway and energy homeostasis: from discovery to obesity therapy. Mol Metab. 2021;48:101206. https:\/\/doi.org\/10.1016\/j.molmet.2021.101206.","DOI":"10.1016\/j.molmet.2021.101206"},{"key":"7547_CR4","doi-asserted-by":"publisher","unstructured":"Fairbrother U, Kidd E, Malagamuwa T et al Genetics of severe obesity. Curr Diab Rep. 2018;18(10):85. https:\/\/doi.org\/10.1007\/s11892-018-1053-x.","DOI":"10.1007\/s11892-018-1053-x"},{"issue":"10","key":"7547_CR5","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1210\/clinem\/dgab404","volume":"106","author":"S Courbage","year":"2021","unstructured":"Courbage S, Poitou C, Le Beyec-Le BJ, et al. Implication of heterozygous variants in genes of the leptin-melanocortin pathway in severe obesity. J Clin Endocrinol Metab. 2021;106(10):2991\u20133006. https:\/\/doi.org\/10.1210\/clinem\/dgab404.","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"7547_CR6","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1001\/jama.2017.20449","volume":"319","author":"D Arterburn","year":"2018","unstructured":"Arterburn D, Gupta A. Comparing the outcomes of sleeve gastrectomy and Roux-en-Y gastric bypass for severe obesity. JAMA. 2018;319(3):235\u20137. https:\/\/doi.org\/10.1001\/jama.2017.20449.","journal-title":"JAMA"},{"key":"7547_CR7","doi-asserted-by":"publisher","unstructured":"Sjostrom L. Review of the key results from the Swedish Obese Subjects (SOS) trial - a prospective controlled intervention study of bariatric surgery. J Intern Med. 2013;273(3):219\u201334. https:\/\/doi.org\/10.1111\/joim.12012.","DOI":"10.1111\/joim.12012"},{"issue":"16","key":"7547_CR8","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1056\/NEJMoa2002449","volume":"383","author":"LMS Carlsson","year":"2020","unstructured":"Carlsson LMS, Sjoholm K, Jacobson P, et al. Life expectancy after bariatric surgery in the Swedish Obese Subjects Study. N Engl J Med. 2020;383(16):1535\u201343. https:\/\/doi.org\/10.1056\/NEJMoa2002449.","journal-title":"N Engl J Med"},{"key":"7547_CR9","doi-asserted-by":"publisher","unstructured":"Perdomo CM, Cohen RV, Sumithran P et al Contemporary medical, device, and surgical therapies for obesity in adults. Lancet. 2023;401(10382):1116\u201330. https:\/\/doi.org\/10.1016\/S0140-6736(22)02403-5.","DOI":"10.1016\/S0140-6736(22)02403-5"},{"key":"7547_CR10","doi-asserted-by":"publisher","unstructured":"Uhe I, Douissard J, Podetta M et al. Roux-en-Y gastric bypass, sleeve gastrectomy, or one-anastomosis gastric bypass? A systematic review and meta-analysis of randomized-controlled trials. Obesity (Silver Spring). 2022;30(3):614\u201327. https:\/\/doi.org\/10.1002\/oby.23338.","DOI":"10.1002\/oby.23338"},{"key":"7547_CR11","doi-asserted-by":"publisher","unstructured":"Ju Z, Anderson W, Istfan N et al. Comparison of weight loss outcomes between Roux-en-Y gastric bypass and sleeve gastrectomy in a racially mixed urban patient population. Surg Obes Relat Dis. 2022;18(10):1218\u201327. https:\/\/doi.org\/10.1016\/j.soard.2022.05.025.","DOI":"10.1016\/j.soard.2022.05.025"},{"issue":"3","key":"7547_CR12","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1172\/JCI76305","volume":"125","author":"S Manning","year":"2015","unstructured":"Manning S, Pucci A, Batterham RL, et al. gastric bypass: effects on feeding behavior and underlying mechanisms. J Clin Invest. 2015;125(3):939\u201348. https:\/\/doi.org\/10.1172\/JCI76305.","journal-title":"J Clin Invest"},{"key":"7547_CR13","doi-asserted-by":"publisher","unstructured":"Celio AC, Wu Q, Kasten KR et al Comparative effectiveness of Roux-en-Y gastric bypass and sleeve gastrectomy in super obese patients. Surg Endosc. 2017;31(1):317\u201323. https:\/\/doi.org\/10.1007\/s00464-016-4974-y.","DOI":"10.1007\/s00464-016-4974-y."},{"key":"7547_CR14","doi-asserted-by":"publisher","unstructured":"Feris F, McRae A, Kellogg TA et al Mucosal and hormonal adaptations after Roux-en-Y gastric bypass. Surg Obes Relat Dis. 2023;19(1):37\u201349. https:\/\/doi.org\/10.1016\/j.soard.2022.08.020.","DOI":"10.1016\/j.soard.2022.08.020."},{"key":"7547_CR15","doi-asserted-by":"publisher","unstructured":"Hany M, Demerdash HM, Zidan A et al Effect of weight regain on body composition and metabolic biomarkers after sleeve gastrectomy: a cross-sectional study from a hospital database. Obes Surg. 2023;33(1):268\u201378. https:\/\/doi.org\/10.1007\/s11695-022-06384-3.","DOI":"10.1007\/s11695-022-06384-3."},{"key":"7547_CR16","doi-asserted-by":"publisher","unstructured":"Athanasiadis DI, Martin A, Kapsampelis P et al Factors associated with weight regain post-bariatric surgery: a systematic review. Surg Endosc. 2021;35(8):4069\u201384. https:\/\/doi.org\/10.1007\/s00464-021-08329-w.","DOI":"10.1007\/s00464-021-08329-w"},{"key":"7547_CR17","doi-asserted-by":"publisher","unstructured":"Campos A, Cifuentes L, Hashem A et al. Effects of heterozygous variants in the leptin-melanocortin pathway on Roux-en-Y gastric bypass outcomes: a 15-year case-control study. Obes Surg. 2022;32(8):2632\u201340. https:\/\/doi.org\/10.1007\/s11695-022-06122-9.","DOI":"10.1007\/s11695-022-06122-9."},{"key":"7547_CR18","doi-asserted-by":"publisher","unstructured":"Abu Dayyeh BK, Lautz DB, Thompson CC. Gastrojejunal stoma diameter predicts weight regain after Roux-en-Y gastric bypass. Clin Gastroenterol Hepatol. 2011;9(3):228\u201333. https:\/\/doi.org\/10.1016\/j.cgh.2010.11.004.","DOI":"10.1016\/j.cgh.2010.11.004"},{"key":"7547_CR19","doi-asserted-by":"publisher","unstructured":"Vargas EJ, Bazerbachi F, Rizk M et al. Transoral outlet reduction with full thickness endoscopic suturing for weight regain after gastric bypass: a large multicenter international experience and meta-analysis. Surg Endosc. 2018;32(1):252\u20139. https:\/\/doi.org\/10.1007\/s00464-017-5671-1.","DOI":"10.1007\/s00464-017-5671-1"},{"key":"7547_CR20","doi-asserted-by":"publisher","unstructured":"Gala K, Ghusn W, Fansa S et al. Effects of heterozygous variants in the leptin-melanocortin pathway on transoral outlet reduction after Roux-en-Y gastric bypass: a case-control study and review of literature. Obes Surg. 2023. https:\/\/doi.org\/10.1007\/s11695-023-06462-0.","DOI":"10.1007\/s11695-023-06462-0"},{"key":"7547_CR21","doi-asserted-by":"publisher","unstructured":"Ghazi R, Vargas EJ, Baroud S et al. ID: 3526666 Tubular pouchplasty transoral outlet reduction (tTORe) is superior to and more durable than traditional tore in a large cohort study. Gastrointestinal Endoscopy. 2021;93(6):AB1. https:\/\/doi.org\/10.1016\/j.gie.2021.03.074.","DOI":"10.1016\/j.gie.2021.03.074"},{"key":"7547_CR22","doi-asserted-by":"publisher","unstructured":"Dhindsa BS, Saghir SM, Naga Y et al. Efficacy of transoral outlet reduction in Roux-en-Y gastric bypass patients to promote weight loss: a systematic review and meta-analysis. Endosc Int Open. 2020;8(10):E1332-E40. https:\/\/doi.org\/10.1055\/a-1214-5822.","DOI":"10.1055\/a-1214-5822."},{"key":"7547_CR23","doi-asserted-by":"publisher","unstructured":"Hao Z, Munzberg H, Rezai-Zadeh K et al. Leptin deficient ob\/ob mice and diet-induced obese mice responded differently to Roux-en-Y bypass surgery. Int J Obes (Lond). 2015;39(5):798\u2013805. https:\/\/doi.org\/10.1038\/ijo.2014.189.","DOI":"10.1038\/ijo.2014.189."},{"issue":"3","key":"7547_CR24","doi-asserted-by":"publisher","first-page":"810","DOI":"10.2337\/db10-0566","volume":"60","author":"K Chandarana","year":"2011","unstructured":"Chandarana K, Gelegen C, Karra E, et al. Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY. Diabetes. 2011;60(3):810\u20138. https:\/\/doi.org\/10.2337\/db10-0566.","journal-title":"Diabetes"},{"issue":"3","key":"7547_CR25","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1007\/s40265-021-01470-9","volume":"81","author":"A Markham","year":"2021","unstructured":"Markham A. Setmelanotide: first approval. Drugs. 2021;81(3):397\u2013403. https:\/\/doi.org\/10.1007\/s40265-021-01470-9.","journal-title":"Drugs"},{"key":"7547_CR26","doi-asserted-by":"publisher","unstructured":"Meyers MH, Swei EC, Tarter W et al. Factors associated with weight loss after endoscopic transoral outlet reduction (TORe). J Gastrointest Surg. 2023:1\u20137. https:\/\/doi.org\/10.1007\/s11605-023-05695-9.","DOI":"10.1007\/s11605-023-05695-9."},{"key":"7547_CR27","doi-asserted-by":"publisher","unstructured":"Brunaldi VO, Farias GFA, de Rezende DT et al. Argon plasma coagulation alone versus argon plasma coagulation plus full-thickness endoscopic suturing to treat weight regain after Roux-en-Y gastric bypass: a prospective randomized trial (with videos). Gastrointest Endosc. 2020;92(1):97\u2013107 e5. https:\/\/doi.org\/10.1016\/j.gie.2020.03.3757.","DOI":"10.1016\/j.gie.2020.03.3757"},{"key":"7547_CR28","doi-asserted-by":"publisher","unstructured":"Jirapinyo P, Thompson CC. Combining transoral outlet reduction with pharmacotherapy yields similar one-year efficacy with improved safety compared to surgical revision for weight regain following Roux-en-Y gastric bypass. Gastrointest Endosc. 2023. https:\/\/doi.org\/10.1016\/j.gie.2023.04.2092.","DOI":"10.1016\/j.gie.2023.04.2092"}],"container-title":["Obesity Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-024-07547-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11695-024-07547-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11695-024-07547-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T15:07:57Z","timestamp":1730905677000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11695-024-07547-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,17]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["7547"],"URL":"https:\/\/doi.org\/10.1007\/s11695-024-07547-0","relation":{},"ISSN":["0960-8923","1708-0428"],"issn-type":[{"type":"print","value":"0960-8923"},{"type":"electronic","value":"1708-0428"}],"subject":[],"published":{"date-parts":[[2024,10,17]]},"assertion":[{"value":"29 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 October 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Informed consent was obtained from all individual participants included in the study prior to procedures and genetic testing.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed Consent"}},{"value":"Andres Acosta and Mayo Clinic hold equity in Phenomix Sciences Inc. and are inventors of intellectual property licensed to Phenomix Sciences Inc. AA served as a consultant for Rhythm Pharmaceuticals, General Mills, Amgen, Bausch Health, and RareStone and has contracts with Vivus Inc, Satiogen Pharmaceutical, and Rhythm pharmaceutical. No other disclosure to be reported. The Mayo Clinic Biobank is supported by the Mayo Clinic Center for Individualized Medicine. Andrew C. Storm has research grants from Apollo Endosurgery, Boston Scientific, Endogenex, Enterasense, and OnePass and is a consultant for Apollo Endosurgery, Boston Scientific, Endogenex, Endo-TAGSS, MGI Medical, Olympus, Intuitive, Medtronic, and Microtech. Barham Abu Dayehh is a consultant for DyaMx, Boston Scientific, USGI Medical, and Endo-TAGSS; gets research support from Boston Scientific, USGI Medical, Apollo Endosurgery, Spatz Medical, GI Dynamics, Cairn Diagnostics, Aspire Bariatrics, and Medtronic; and is a speaker for Johnson and Johnson, Endogastric Solutions, and Olympus.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}